Methods for generating new hair follicles, treating baldness, and hair removal

ABSTRACT

The present invention provides methods of treating baldness in a subject and generating new hair follicles, comprising epidermal disruption and administration of a compound that promotes a differentiation of an uncommitted epidermal cell into a hair follicle cell. The present invention also provides methods for hair removal and inducing hair pigmentation.

FIELD OF INVENTION

The present invention provides methods of treating baldness in a subject and generating new hair follicles, comprising epidermal disruption and administration of a compound that promotes a differentiation of an uncommitted epidermal cell into a hair follicle cell. The present invention also provides methods for hair removal and inducing hair pigmentation.

BACKGROUND OF THE INVENTION

Follicular neogenesis is defined as the generation of new hair follicles (HF) after birth. Humans are born with a full complement of HF, which can change in size and growth characteristics as in early baldness or can ultimately degenerate and disappear as in late stages of baldness or in permanent scarring (cicatricial) alopecias. Therefore, the generation of new HF is desirable in the treatment of common baldness as well as less common hair loss conditions, such as discoid lupus erythematosis, congenital hypotrichosis, lichen planopilaris and other scarring alopecias.

SUMMARY OF THE INVENTION

The present invention provides methods of treating baldness in a subject and generating new hair follicles (HF), comprising epidermal disruption and administration of a compound that promotes a differentiation of an uncommitted epidermal cell into a hair follicle cell. The present invention also provides methods for hair removal and inducing hair pigmentation.

In one embodiment, the present invention provides a method for generating a hair follicle in a scalp, eyebrow, or scarred region of a subject, comprising the steps of: (a) disrupting the epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a compound that promotes a differentiation of an uncommitted epidermal cell into a hair follicle cell, thereby generating a hair follicle in a scalp, eyebrow, or scarred region of a subject.

In another embodiment, the present invention provides a method for generating a hair follicle in a scalp, eyebrow, or scarred region of a subject, comprising the steps of: (a) disrupting the epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a factor that promotes a differentiation of an uncommitted epidermal cell into a hair follicle cell, thereby generating a hair follicle in a scalp, eyebrow, or scarred region of a subject.

In another embodiment, the present invention provides a method for treating baldness in a scalp, eyebrow, or scarred region, comprising the steps of: (a) disrupting the epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a compound that promotes a differentiation of an uncommitted epidermal cell into a hair follicle (HF) cell, thereby treating baldness in a scalp, eyebrow, or scarred region.

In another embodiment, the present invention provides a method for treating baldness in a scalp, eyebrow, or scarred region, comprising the steps of: (a) disrupting the epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell, thereby treating baldness in a scalp, eyebrow, or scarred region. In another embodiment, the baldness is an androgenetic alopecia (AGA)-induced baldness. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the present invention provides a method for removal of an HF from a skin or scalp of a subject, comprising the steps of: (a) disrupting an epidermis of the skin or scalp: and (b) contacting the skin or scalp with either: (i) an EGF protein; (ii) an EGF receptor; (iii) a nucleotide encoding an EGF protein or EGF receptor; or (iv) a compound or factor that activates a EGF protein or EGF receptor, thereby removing an HF from a skin or scalp of a subject.

In another embodiment, the present invention provides a method for increasing a size of a hair follicle in a scalp, eyebrow, or scarred region of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a compound or factor that promotes a differentiation of an uncommitted epidermal cell into a hair follicle cell, thereby increasing a size of a hair follicle in a scalp, eyebrow, or scarred region of a subject.

In another embodiment, the present invention provides a method for generating a hair follicle in a scalp, eyebrow, or scarred region of a subject, comprising the steps of: (a) disrupting an epidermis of said scalp, eyebrow, or scarred region: and (b) contacting said scalp, eyebrow, or scarred region with a cell selected from (a) a precursor cell that is capable of differentiation into a hair follicle cell; (b) an inductive cell that is capable of inducing differentiation of an uncommitted epidermal cell into a hair follicle cell; or (c) a hair follicle or portion thereof, thereby generating a hair follicle in a scalp, eyebrow, or scarred region of a subject. In another embodiment, step (b) is performed 3-12 days after step (a). Each possibility represents a separate embodiment of the present invention.

In another embodiment, the present invention provides a method for treating an AGA in a scalp, comprising the steps of: (a) disrupting an epidermis of said scalp; and (b) contacting said scalp with a cell selected from (a) a precursor cell that is capable of differentiation into a hair follicle cell; (b) an inductive cell that is capable of inducing differentiation of an uncommitted epidermal cell into a hair follicle cell; or (c) a hair follicle or portion thereof, thereby treating an AGA in a scalp. In another embodiment, step (b) is performed 3-12 days after step (a). Each possibility represents a separate embodiment of the present invention.

BRIEF DESCRIPTION OF THE FIGURES

FIG. 1: Epidermal abrasion results in de novo hair follicle (HF) formation. HF at progressive stages of development are depicted in the left, center, and right panels. The arrow in the left panel indicates a hair germ. The dark stained cells are progeny of HF stem cells in the bulge.

FIG. 2: BrdU labeling of HF following epidermal abrasion. HF at progressive stages of development are depicted in the left, center, and right panels.

FIG. 3. The wound site did not contain HF immediately after re-epithelialization. Top view (left panel) and tissue section (right panel) of the site 10 days after wound induction.

FIG. 4. Appearance of hair germs 12 days after wound induction. Arrow indicates hair germ.

FIG. 5. Epidermal Disruption-Induced HF neogenesis (EDIHN)-induced hair germs express K17. Two different hair germs are depicted in the left and right panels.

FIG. 6. EDIHN-induced hair germs contain dermal papilla (DP) cells, as evidenced by alkaline phosphatase (AP) staining. Arrows indicate DP cells. Left panel: hair germs. Right panel: HF at a further developmental stage.

FIG. 7. Histological comparison between EDIHN-induced and embryonic HF. Top left, second from left, third from left, and right panels: Progressive stages of EDIHN-induced HF development. Bottom left, center, and right panels: Progressive stages of and embryonic HF development.

FIG. 8. Induction of several markers of embryonic HF development, Lef1 (left panel), wingless/int (Wnt) 10b (center panel), and sonic hedgehog (Shh; right panel), by EDIHN. HF structures are indicated by arrowheads.

FIG. 9. Proliferative activity during EDIHN, as evidenced by BrdU pulse-labeling. Progressive stages of HF development are depicted in the left, center, and right panels.

FIG. 10. Induction of HF markers S100A3 (left panel; tissue section parallel to HF axis) and S100A6 (right panel; cross-sectional view of follicle) by EDIHN.

FIG. 11. New hair growth 25 days (left panel) and 45 days (right panel) after wound induction.

FIG. 12. Schematic of whole-mount EDIHN assay.

FIG. 13. Repopulation of stem cells in the bulge of EDIHN-induced HF, as evidenced by retention of BrdU label following a chase period. Left panel: lower magnification: 50×. Right panel: higher magnification: 400×.

FIG. 14. FIG. 14A. Stem cells in EDIHN-induced HF express K15. Left top panel: Top view of wound site. Bottom, far left panel: epidermis whole mount; bottom, second from left panel: same as [bottom, far left] panel but viewed under white light; right panel: tissue sections. FIG. 14B. Neogenesis HF proceed to next hair cycle.

FIG. 15. Schematic of creation of new HF by EDIHN.

FIG. 16. No new HF are evident 11 days after wound induction in 21-day-old mice. Top panel: macroscopic examination: bottom left panel: AP staining of the dermis; bottom right panel: K17 staining of the epidermis.

FIG. 17. 14 days after wound induction, new HF have begun to form as evidenced by AP staining of the dermis (left panel) and K17 staining of the epidermis (right panel). Main panels: 10× magnification. Inserts: 80× magnification.

FIG. 18. 17 days after wound induction, new HF are more developed. Left panel: AP staining of the dermis; right panel: K17 staining of the epidermis. Main panels: 10× magnification. Inserts: 80× magnification.

FIG. 19. Wounds closed similar in mice subjected to depilation, then wounding (left 3 mice in each panel) vs. wounding alone (right 4 mice in each panel). Left panel: immediately following wounding. Right panel: 10 days following wounding.

FIG. 20. Anagen induction by depilation prior to wounding enhances the efficiency of EDIHN. A. Top panel: lower left panel AP staining of the dermis; lower right panel: K17 staining of the epidermis. B. Graphical representation of enhancement of EDIHN by depilation.

FIG. 21. FIG. 21A. EDIHN in human skin grafted to immunodeficient (scid) mice, seven days after induction of an excisional wound. Arrows indicate new HF. FIG. 21B. Dermal abrasion of human skin grafts results in EDIHN. Human adult skin (W) was grafted onto mice, abraded, and examined seven days later, by staining for S100A6 (first, second, and fourth rows) or S100A4 (third row). Hair germs (HG) and dermal papilla (DP) are indicated. Human fetal skin (F) with normal developing hair follicles is shown for comparison. Mouse skin 17d post wounding was included as a control (top left panel).

FIG. 22. Transcripts up-regulated at least 2-fold in activated HF cells, as assessed by dChip analysis. (FIG. 22A). Mean values and standard errors of the up-regulated transcripts in non-activated (“bs-line”) and activated (“expt”) samples and fold-changes and differences between non-activated and activated values are depicted. (FIG. 22B). Raw data for up-regulated transcripts in non-activated and activated cells. “Ctrl” denotes non-activated and “High-dep” denotes activated cells. (FIG. 22C). Additional information about up-regulated transcripts.

FIG. 23. Pigmented hair follicle neogenesis observed in the skin of Dkk1-expressing mice following EDIHN FIG. 23A. 3.2× magnification. FIG. 23B. 8× magnification.

FIG. 24. Control mice lacked pigmented HF.

FIG. 25. EGF inhibits HF formation by EDIHN. FIG. 25A. K17 staining of wounded skin of representative mouse treated with EGF. Magnification is 4×. FIG. 25B. High magnification view (10×) of skin depicted in (FIG. 25A). FIG. 25C. K17 staining of wounded skin of representative control mouse that received no EGF after wounding. Magnification is 4×. FIG. 25D. Higher magnification view (10×) of skin depicted in (FIG. 25D).

FIG. 26. Administration of an EGF receptor inhibitor (AG1478) leads to generation of more and larger HF compared with controls. FIG. 26A. Top: skin of 2 control mice. Outer dashed line indicates the extent of the wounded area after contraction and healing; inner dashed line indicates the area of neogenesis. Bottom: skin of 2 treated mice, in which the wounded area and area of neogenesis largely coincide, with the exception of a small area on the left side of the encircled area in each panel. FIG. 26B. Large hair follicles developed in the wounded area in the AG1478-injected mice. Left panel: epidermis stained for K17, with three large hair follicles next to each other. Right panel: dermis stained for AP with large coalescing DP areas. Scale Bars: 200 μm.

FIG. 27. FIG. 27A. Increased hair follicle formation in K14-Wnt7a mice. Left panel: Wnt7a transgenic mice. Right panel: control (wild-type) mice. FIG. 27B. Quantiation of experiment with 4 week old mice. FIG. 27C. Quantiation of experiment with 3 week old mice

DETAILED DESCRIPTION OF THE INVENTION

The present invention provides methods of treating baldness in a subject and generating new HF, comprising epidermal disruption and administration of a compound that promotes a differentiation of an uncommitted epidermal cell into a hair follicle cell. The present invention also provides methods for hair removal and inducing hair pigmentation.

In one embodiment, the present invention provides a method for generating a hair follicle (HF) in a scalp, eyebrow, or scarred region of a subject, comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a compound that promotes a differentiation of an uncommitted epidermal cell into an HF cell, thereby generating an HF in a scalp, eyebrow, or scarred region of a subject.

In another embodiment, the present invention provides a method for generating an HF in a scalp, eyebrow, or scarred region of a subject, comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a factor that promotes a differentiation of an uncommitted epidermal cell into an HF cell, thereby generating an HF in a scalp, eyebrow, or scarred region of a subject.

In another embodiment, the present invention provides a method for generating a new IF in a scalp, eyebrow, or scarred region of a subject, comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a compound or factor that promotes a differentiation of an uncommitted epidermal cell into a hair follicle cell, thereby generating a new HF in a scalp, eyebrow, or scarred region of a subject.

In another embodiment, the present invention provides a method for increasing the number of HF in a scalp, eyebrow, or scarred region of a subject, comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a compound or factor that promotes a differentiation of an uncommitted epidermal cell into an HF cell, thereby increasing the number of HF in a scalp, eyebrow, or scarred region of a subject.

In another embodiment, the present invention provides a use of a compound or factor that promotes a differentiation of an uncommitted epidermal cell into an HF cell, for the preparation of a pharmaceutical composition for use in a method for generating a hair follicle in a scalp, eyebrow, or scarred region of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with the compound or factor.

In another embodiment, the present invention provides a use of a compound or factor that promotes a differentiation of an uncommitted epidermal cell into an HF cell, for the preparation of a pharmaceutical composition for use in a method for treating baldness in a scalp, eyebrow, or scarred region of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with the compound or factor.

In another embodiment, the present invention provides a use of a compound or factor that promotes a differentiation of an uncommitted epidermal cell into an HF cell, for the preparation of a pharmaceutical composition for use in a method for treating AGA in a scalp of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp with the compound or factor.

In another embodiment, the present invention provides a method for increasing a size of a hair follicle in a scalp, eyebrow, or scarred region of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a compound or factor that promotes a differentiation of an uncommitted epidermal cell into an HF cell, thereby increasing a size of a hair follicle in a scalp, eyebrow, or scarred region of a subject. In another embodiment, the factor is an inhibitor of an EGF protein or an EGFR. In another embodiment, the factor is a Hedgehog protein, a nucleotide encoding same or an activator of same. In another embodiment, the factor is an androgen antagonist. In another embodiment, the factor is any other compound or factor that promotes a differentiation of an uncommitted epidermal cell into an HF cell. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the present invention provides a method for generating a hair follicle in a scalp, eyebrow, or scarred region of a subject, comprising the steps of: (a) disrupting an epidermis of said scalp, eyebrow, or scarred region: and (b) contacting said scalp, eyebrow, or scarred region with a cell selected from (a) a precursor cell that is capable of differentiation into a hair follicle cell; (b) an inductive cell that is capable of inducing differentiation of an uncommitted epidermal cell into a hair follicle cell; or (c) a hair follicle or portion thereof, thereby generating a hair follicle in a scalp, eyebrow, or scarred region of a subject. In another embodiment, step (b) is performed 3-12 days after step (a). Each possibility represents a separate embodiment of the present invention.

The precursor cell of methods and compositions of the present invention, is, in another embodiment, a HF stem cell. In another embodiment, the precursor cell is an epidermal cell. In another embodiment, the precursor cell is a dermal papilla cell. In another embodiment, the precursor cell is a connective tissue sheath cell. In another embodiment, the precursor cell is any other type of cell known in the art that is capable of differentiation into a hair follicle cell. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the present invention provides a method for generating a hair follicle in a scalp, eyebrow, or scarred region of a subject, comprising the steps of: (a) disrupting an epidermis of said scalp, eyebrow, or scarred region; and (b) contacting said scalp, eyebrow, or scarred region with a precursor cell that is capable of differentiation into a hair follicle cell, thereby generating a hair follicle in a scalp, eyebrow, or scarred region of a subject.

In another embodiment, the present invention provides a method for treating an AGA in a scalp, comprising the steps of: (a) disrupting an epidermis of said scalp; and (b) contacting said scalp with a cell selected from (a) a precursor cell that is capable of differentiation into a hair follicle cell; (b) an inductive cell that is capable of inducing differentiation of an uncommitted epidermal cell into a hair follicle cell; or (c) a hair follicle or portion thereof, thereby treating an AGA in a scalp. In another embodiment, step (b) is performed 3-12 days after step (a). Each possibility represents a separate embodiment of the present invention.

In another embodiment, the present invention provides a method for treating an AGA in a scalp, comprising the steps of: (a) disrupting an epidermis of said scalp; and (b) contacting said scalp with a precursor cell that is capable of differentiation into a hair follicle cell, thereby treating an AGA in a scalp.

In another embodiment, the inductive cell is a mesenchymal cell. In another embodiment, the inductive cell is any other type of inductive cell enumerated herein. In another embodiment, the inductive cell is any other type of inductive cell known in the art. Each possibility represents a separate embodiment of the present invention.

“Contacting” as used herein refers, in another embodiment, to bringing the scalp, eyebrow, etc, into to contact with the compound, factor, cell, etc. In another embodiment, the term refers to embedding the compound, factor, cell, etc into the scalp, eyebrow, etc. In another embodiment, the term refers to injecting the compound, factor, cell, etc into the scalp, eyebrow, etc. In another embodiment, term refers to any other type of contacting known in the art. Each possibility represents a separate embodiment of the present invention.

“Promotes a differentiation” refers, in another embodiment, to the act of increasing the percentage of cells that will differentiate as indicated. In another embodiment, the term refers to increasing the number of cells per unit area of skin that will differentiate. In another embodiment, the promoter of differentiation is active in the milieu of the skin. Each possibility represents a separate embodiment of the present invention.

“Uncommitted epidermal cell” refers, in another embodiment, to an epidermal stem cell. In another embodiment, the epidermal cell is a bulge cell. In another embodiment, the epidermal cell is a bulge-derived cell. In another embodiment, the epidermal cell is any other type of cell known in the art that can be induced to differentiate into an HF cell.

The “HF cell” that results from the differentiation is, in another embodiment, an HF stem cell. In another embodiment, the HF cell is a dermal papilla cell. In another embodiment, the HF cell is a bulb cell. In another embodiment, the HF cell is a matrix cell. In another embodiment, the HF cell is a hair shaft cell. In another embodiment, the HF cell is an inner root sheath cell. In another embodiment, the HF cell is an outer root sheath cell. In another embodiment, the HF cell is a melanocyte stem cell. In another embodiment, the HF cell is a melanocyte. Each type of uncommitted epidermal cell and HF cell represents a separate embodiment of the present invention.

In another embodiment, the present invention provides a method for treating baldness in a scalp, eyebrow, or scarred region, comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a compound that promotes a differentiation of an uncommitted epidermal cell into a hair follicle (HF) cell, thereby treating baldness in a scalp, eyebrow, or scarred region. In another embodiment, the baldness is an androgenetic alopecia (AGA)-induced baldness. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the present invention provides a method for treating baldness in a scalp, eyebrow, or scarred region, comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell, thereby treating baldness in a scalp, eyebrow, or scarred region. In another embodiment, the baldness is an androgenetic alopecia (AGA)-induced baldness. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is administed in a solution. In another embodiment, the compound or factor is administed in a cream. In another embodiment, the compound or factor is administed in an ointment. In another embodiment, the compound or factor is administed in a slow release formulation. In another embodiment, the compound or factor is administed in a liposome encapsulated formulation. In another embodiment, the compound or factor is directly injected. In another embodiment, the compound or factor is administed by any other method known in the art. Each possibility represents a separate embodiment of the present invention.

The compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is, in another embodiment, an inhibitor of an Epidermal Growth Factor (EGF). In another embodiment, the compound or factor is an inhibitor of an EGF receptor. Each possibility represents a separate embodiment of the present invention.

As provided herein (Example 11), activating one or more pathways in which EGF is involved (by injection of EGF) blocks the formation of HF. Thus, antagonizing the pathway increases HF formation, as demonstrated in Example 12.

In another embodiment, the inhibitor of an EGF or an EGF receptor is panitumumab. In another embodiment, the inhibitor is AG1478. In another embodiment, the inhibitor is nimotuzumab. In another embodiment, the inhibitor is an antibody that binds EGF or EGFR. In another embodiment, the inhibitor is HuMax-EGFR® (Genmab, Copenhagen, Denmark). In another embodiment, the inhibitor is cetuximab. In another embodiment, the inhibitor is IMC 11F8. In another embodiment, the inhibitor is matuzumab. In another embodiment, the inhibitor is SC 100. In another embodiment, the inhibitor is ALT 110. In another embodiment, the inhibitor is PX 1032. In another embodiment, the inhibitor is BMS 599626. In another embodiment, the inhibitor is MDX 214. In another embodiment, the inhibitor is PX 1041. In another embodiment, the inhibitor is any other inhibitor of an EGF or an EGF receptor known in the art. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is an inhibitor of a tyrosine kinase activity of an EGF receptor. In another embodiment, the inhibitor is gefitinib. In another embodiment, the inhibitor is erlotinib. In another embodiment, the inhibitor is canertinib. In another embodiment, the inhibitor is leflunomide. In another embodiment, the inhibitor is A77 1726. In another embodiment, the inhibitor is pelitinib. In another embodiment, the inhibitor is ZD 1839. In another embodiment, the inhibitor is CL 387785. In another embodiment, the inhibitor is EKI 785. In another embodiment, the inhibitor is vandetanib. In another embodiment, the inhibitor is any other inhibitor of a tyrosine kinase activity of an EGF receptor known in the art. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the EGF or EGFR antagonist is a carboxypeptidase inhibitor from potato (PCI) protein or a homologue, fragment or mimetic thereof. In another embodiment, the EGF or EGFR antagonist is a sprouty protein or a homologue, fragment or mimetic thereof. In another embodiment, the EGF or EGFR antagonist is an Argos protein or a homologue, fragment or mimetic thereof. In another embodiment, the EGF or EGFR antagonist is a lefty protein or a homologue, fragment or mimetic thereof. In another embodiment, the EGF or EGFR antagonist is an antibody that recognizes EGF or EGFR, or a fragment or mimetic thereof. In another embodiment, the EGF or EGFR antagonist is small molecule inhibitor that binds and reduces the activity of EGF or EGFR. In another embodiment, the EGF or EGFR antagonist is CRM197. In another embodiment, the EGF or EGFR antagonist is IMC-C225 (ImClone Systems, New York, N.Y.). In another embodiment, the EGF or EGFR antagonist is any other antagonist of EGF or EGFR known in the art. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the present invention provides a use of an inhibitor of an EGF protein or an EGF receptor for the preparation of a pharmaceutical composition for use in a method for generating a hair follicle in a scalp, eyebrow, or scarred region of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with the inhibitor of an EGF protein or an EGF receptor.

In another embodiment, the present invention provides a use of an inhibitor of an EGF protein or an EGF receptor for the preparation of a pharmaceutical composition for use in a method for treating baldness in a scalp, eyebrow, or scarred region of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with the inhibitor of an EGF protein or an EGF receptor.

In another embodiment, the present invention provides a use of an inhibitor of an EGF protein or an EGF receptor for the preparation of a pharmaceutical composition for use in a method for treating AGA in a scalp of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp with the inhibitor of an EGF protein or an EGF receptor.

In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is a β-catenin protein. In another embodiment, the compound or factor is a nucleotide that encodes a β-catenin protein. In another embodiment, the compound or factor is an activator of a β-catenin protein. In another embodiment, the compound or factor is an inhibitor of a protein that suppresses an activity of the β-catenin protein. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the present invention provides a use of (a) a β-catenin protein; (b) a nucleotide encoding a β-catenin protein; or (c) a compound or factor that activates a β-catenin protein, for the preparation of a pharmaceutical composition for use in a method for generating a hair follicle in a scalp, eyebrow, or scarred region of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with the β-catenin protein, nucleotide, compound or factor.

In another embodiment, the present invention provides a use of (a) a β-catenin protein; (b) a nucleotide encoding a β-catenin protein; or (c) a compound or factor that activates a β-catenin protein, for the preparation of a pharmaceutical composition for use in a method for treating baldness in a scalp, eyebrow, or scarred region of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with the β-catenin protein, nucleotide, compound or factor.

In another embodiment, the present invention provides a use of (a) a β-catenin protein; (b) a nucleotide encoding a β-catenin protein; or (c) a compound or factor that activates a β-catenin protein, for the preparation of a pharmaceutical composition for use in a method for treating AGA in a scalp of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp with the β-catenin protein, nucleotide, compound or factor.

In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is a fibroblast growth factor (FGF) protein. In another embodiment, the compound or factor is a nucleotide that encodes an FGF protein. In another embodiment, the compound or factor is an FGF receptor. In another embodiment, the compound or factor is a nucleotide that encodes an FGF receptor. In another embodiment, the compound or factor is an activator of an FGF protein. In another embodiment, the compound or factor is an activator of FGF receptor. In another embodiment, the compound or factor is an inhibitor of a protein that suppresses an activity of the FGF protein or FGF receptor. In another embodiment, the protein that is inhibited is an FGF binding protein. In another embodiment, the protein that is inhibited is FGF-bp1. Each possibility represents a separate embodiment of the present invention.

Is provided herein, FGF and its receptor are upregulated, under the conditions utilized herein, upon HF stem cell differentiation (Example 9). Moreover, FGF-bp1 is downregulated, under the conditions utilized herein, upon HF stem cell differentiation. Thus, FGF and its receptor promote differentiation of uncommitted epidermal cells into HF cells.

In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is an ectodysplasin protein (referred to, in another embodiment, as “eda”; in another embodiment, as “ectodermodysplasin protein.”) In another embodiment, the ectodysplasin protein is Eda-A1. In another embodiment, the compound or factor is an ectodysplasin receptor (referred to, in another embodiment, as “edar”). In another embodiment, the compound or factor is an activator of an ectodysplasin protein. In another embodiment, the compound or factor is an activator of an ectodysplasin receptor. In another embodiment, the compound or factor is an inhibitor of a protein that suppresses an activity of the ectodysplasin protein or ectodysplasin receptor. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the eda protein of methods and compositions of the present invention has the sequence: MGYPEVERRELLPAAAPRERGSQGCGCGGAPARAGEGNSCLLFLGFFGLSLALHLLTLCC YLELRSELRRERGAESRLGGSGTPGTSGTLSSLGGLDPDSPITSHLGQPSPKQQPLEPGEAA LHSDSQDGHQMALLNFFFPDEKPYSEEESRRVRRNKRSKSNEGADGPVKNKKKGKKAGP PGPNGPPGPPGPPGPQGPPGIPGIPGIPGTTVMGPPGPPGPPGPQGPPGLQGPSGAADKAGTR ENQPAVVHLQGQGSAIQVKNDLSGGVLNDWSRITMNPKVFKLHPRSGELEVLVDGTYFIY SQVEVYYINFTDFASYEVVVDEKPFLQCTRSIETGKTNYNTCYTAGVCLLKARQKIAVKM VHADISINMSKHTTFFGAIRLGEAPAS (GenBank Accession No: NM_001399; SEQ ID No: 274). In another embodiment, the eda protein has a sequence selected from the sequences set forth in GenBank entries NM_001005609, NM_001005610, NM_001005611, NM_001005612, NM_001005613, NM_001005614, NM_001005615, AF040628, AF061194, AF061193, AF061192, AF061191, AF061190, AF061189, and AF060999. In another embodiment, the eda protein is encoded by a nucleic acid molecule having a sequence set forth in the one of the above GenBank entries. In another embodiment, a biologically active fragment of an Eda protein is utilized in a method of the present invention. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the edar protein of methods and compositions of the present invention has the sequence: MAIVGDCTQTPWLPVLVVSLMCSARAEYSNCGENEYYNQTTGLCQECPPCGPGEEPYLS CGYGTKDEDYGCVPCPAEKFSKGGYQICRRIHKDCEGFFRATVLTPGDMENDAECGPCLP GYYMLENRPRNIYGMVCYSCLLAPPNTKECVGATSGASANFPGTSGSSTLSPFQHAIIKEL SGQGHLATALIIAMSTIFIMAIAIVLIIMFYILKTKPSAPACCTSHPGKSVEAQVSKDEEKKE APDNVVMFSEKDEFEKLTATPAKPTKSENDASSENEQLLSRSVDSDEEPAPDKQGSPELCL LSLVIILAREKSATSNKSAGIQSRRKKILDVYANVCGVVEGLSPTELPFDCLEKTSRMLSST YNSEKAVVKTWRHLAESFGLKRDEIGGMTDGMQLFDRISTAGYSIPELLTKLVQIERLDA VESLCADILEWAGVVPPASQPHAAS (GenBank Accession No: BC093872; SEQ ID No: 275). In another embodiment, the edar protein has a sequence selected from the sequences set forth in GenBank entries BC093870; BC034919; NM_021783; NM_022336; AY152724; AF298812; AH008077; AF130996; AF130988. In another embodiment, the edar protein is encoded by a nucleic acid molecule having a sequence set forth in the one of the above GenBank entries. In another embodiment, a biologically active fragment of an Edar protein is utilized in a method of the present invention. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is a Noggin protein. In another embodiment, the compound or factor is a nucleotide encoding a Noggin protein. In another embodiment, the compound or factor is an activator of a Noggin protein. In another embodiment, the compound or factor is an inhibitor of a protein that suppresses an activity of the Noggin protein. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the Noggin protein of methods and compositions of the present invention has the sequence: MERCPSLGVTLYALVVVLGLRATPAGGQHYLHIRPAPSDNLPLVDLIEHPDPIFDPKEKDLN ETLLRSLLGGHYDPGFMATSPPEDRPGGGGGAAGGAEDLAELDQLLRQRPSGAMPSEIKGL EFSEGLAQGKKQRLSKKLRRKLQMWLWSQTFCPVLYAWNDLGSRFWPRYVKVGSCFSKR SCSVPEGMVCKPSKSVHLTVLRWRCQRRGGQRCGWIPIQYPIISECKCSC (GenBank Accession No: NM_005450; SEQ ID No: 276). In another embodiment, the Noggin protein has a sequence selected from the sequences set forth in GenBank entries BC034027 and U31202. In another embodiment, the Noggin protein is encoded by a nucleic acid molecule having a sequence set forth in the one of the above GenBank entries. In another embodiment, a biologically active fragment of a Noggin protein is utilized in a method of the present invention. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is a Hedgehog protein. In another embodiment, the compound or factor is a nucleotide encoding a Hedgehog protein. In another embodiment, the compound or factor is an activator of a Hedgehog protein. In another embodiment, the compound or factor is a sonic Hedgehog protein. In another embodiment, the compound or factor is a nucleotide encoding a sonic Hedgehog protein. In another embodiment, the compound or factor is an activator of a sonic Hedgehog protein. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the Hedgehog protein of methods and compositions of the present invention has the sequence set forth in GenBank Accession No. NM_000193. In another embodiment, the Hedgehog protein has a sequence selected from those set forth in GenBank entries L38518 and NP_000184. In another embodiment, the Hedgehog protein has any other Hedgehog sequence known in the art. In another embodiment, the Hedgehog protein has any other sonic Hedgehog sequence known in the art. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is a Transforming Growth Factor (TGF)-beta1 protein. In another embodiment, the compound or factor is a nucleotide encoding a TGF-beta1 protein. In another embodiment, the compound or factor is an activator of a TGF-beta1 protein. In another embodiment, the compound or factor is a TGF-beta3 protein. In another embodiment, the compound or factor is a nucleotide encoding a TGF-beta3 protein. In another embodiment, the compound or factor is an activator of a TGF-beta3 protein. In another embodiment, the compound or factor is an antagonist of a TGF-beta1 protein. In another embodiment, the compound or factor is an antagonist of a TGF-beta3 protein. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the TGF-beta1 protein of methods and compositions of the present invention has the sequence set forth in GenBank Accession No. BC000125. In another embodiment, the Hedgehog protein has a sequence selected from those set forth in GenBank entries BC001180, BC022242, and NM_000660. In another embodiment, the TGF-beta1 protein has any other TGF-beta1 sequence known in the art. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the TGF-beta3 protein of methods and compositions of the present invention has the sequence set forth in GenBank Accession No. J03241. In another embodiment, the Hedgehog protein has a sequence selected from those set forth in GenBank entries NM_003239, BC018503, BT007287 and X14149. In another embodiment, the TGF-beta3 protein has any other TGF-beta3 sequence known in the art. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell acts directly on the uncommitted epidermal cell. In another embodiment, the compound or factor acts on the uncommitted epidermal cell via a mesenchymal cell. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the mesenchymal cell is a dermal condensate cell. In another embodiment, the mesenchymal cell is a DP cell. In another embodiment, the mesenchymal cell is another cell type or differentiation stage in the dermal condensate-DP lineage. In another embodiment, the mesenchymal cell is any other type of mesenchymal cell known in the art. Each possibility represents a separate embodiment of the present invention.

The EGFR of methods and compositions of the present invention has, in another embodiment, the sequence: MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEV VLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVL SNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQN HLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTG PRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVV TDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKN CTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEI IRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQK TKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPRE FVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVW KYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFM RRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGL WIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQL MPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQH VKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMT FGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMAR DPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPL LSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSV PKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHW AQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA (GenBank Accession No: NM_005228; SEQ ID No: 277). In another embodiment, the EGFR has a sequence selected from the sequences set forth in GenBank entries NM_201282, NM_201283, NM_201284, BC094761, AF288738, AY588246, AY573061, X17054, AF125253, U48722, K03193, and AY698024. In another embodiment, the EGFR is encoded by a nucleic acid molecule having a sequence set forth in the one of the above GenBank entries. In another embodiment, a biologically active fragment of an EGFR is utilized in a method of the present invention. Each possibility represents a separate embodiment of the present invention.

The EGF of methods and compositions of the present invention has, in another embodiment, the sequence: MLLTLIILLPVVSKFSFVSLSAPQHWSCPEGTLAGNGNSTCVGPAPFLIFSHGNSIFRIDTEGT NYEQLVVDAGVSVIMDFHYNEKRIYWVDLERQLLQRVFLNGSRQERVCNIEKNVSGMAIN WINEEVIWSNQQEGIITVTDMKGNNSHILLSALKYPANVAVDPVERFIFWSSEVAGSLYRAD LDGVGVKALLETSEKITAVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHISKHPTQHN LFAMSLFGDRIFYSTWKMKTIWIANKHTGKDMVRINLHSSFVPLGELKVVHPLAQPKAEDD TWEPEQKLCKLRKGNCSSTVCGQDLQSHILCMCAEGYALSRDRKYCEDVNECAFWNHGCT LGCKNTPGSYYCTCPVGFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPLCFCPEGSVLE RDGKTCSGCSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSCAASGPQPFLLFANSQ DIRHMHFDGTDYGTLLSQQMGMVYALDHDPVENKIYFAHTALKWIERANMDGSQRERLIE EGVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLF WTDTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLDGSKR RRLTQNDVGHPFAVAVFEDYVWFSDWAMPSVIRVNKRTGKDRVRLQGSMLKPSSLVVVH PLAKPGADPCLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTCLALDGHQLLAGGEV DLKNQVTPLDILSKTRVSEDNITESQHMLVAEIMVSDQDDCAPVGCSMYARCISEGEDATC QCLKGFAGDGKLCSDIDECEMGVPVCPPASSKCINTEGGYVCRCSEGYQGDGIHCLDIDEC QLGVHSCGENASCTNTEGGYTCMCAGRLSEPGLICPDSTPPPHLREDDHHYSVRNSDSECPL SHDGYCLHDGVCMYIEALDKYACNCVVGYIGERCQYRDLKWWELRHAGHGQQQKVIVV AVCVVVLVMLLLLSLWGAHYYRTQKLLSKNPKNPYEESSRDVRSRRPADTEDGMSSCPQP WFVVIKEHQDLKNGGQPVAGEDGQAADGSMQPTSWRQEPQLCGMGTEQGCWIPVSSDKG SCPQVMERSFHMPSYGTQTLEGGVEKPHSLLSANPLWQQRALDPPHQMELTQ (GenBank Accession No: NM_001963; SEQ ID No: 278). In another embodiment, the EGF has a sequence selected from the sequences set forth in GenBank entries BC093731, AY548762, and X04571. In another embodiment, the EGF is encoded by a nucleic acid molecule having a sequence set forth in the one of the above GenBank entries. In another embodiment, a biologically active fragment of an EGF is utilized in a method of the present invention. Each possibility represents a separate embodiment of the present invention.

The beta-catenin protein of methods and compositions of the present invention has, in another embodiment, the sequence: MATQADLMELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPEEEDVDT SQVLYEWEQGFSQSFTQEQVADIDGQYAMTRAQRVRAAMFPETLDEGMQIPSTQFDAAHP TNVQRLAEPSQMLKHAVVNLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQL SKKEASRIIAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLIINLSHIIREGLLAIFKSGGIPA LVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTD CLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAG GMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCA AGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEM AQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLV RAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQL LYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMS EDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFHSGGY GQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTDL (GenBank Accession No: NM_001904; SEQ ID No: 279). In another embodiment, the beta-catenin protein has a sequence selected from the sequences set forth in GenBank entries BC058926, X87838, AF130085, AB062292, Z19054, and NP_001895. In another embodiment, the beta-catenin protein is encoded by a nucleic acid molecule having a sequence set forth in the one of the above GenBank entries. In another embodiment, a biologically active fragment of a beta-catenin protein is utilized in a method of the present invention. Each possibility represents a separate embodiment of the present invention.

The Wnt protein of methods and compositions of the present invention has, in another embodiment, the sequence: MNRKARRCLGHLFLSLGMVYLRIGGFSSVVALGASIICNKIPGLAPRQRAICQSRPDAIIVIGE GSQMGLDECQFQFRNGRWNCSALGERTVFGKELKVGSREAAFTYAIIAAGVAHAITAACT QGNLSDCGCDKEKQGQYHRDEGWKWGGCSADIRYGIGFAKVFVDAREIKQNARTLMNLH NNEAGRKILEENMKLECKCHGVSGSCTTKTCWTTLPQFRELGYVLKDKYNEAVHVEPVRA SRNKRPTFLKIKKPLSYRKPMDTDLVYIEKSPNYCEEDPVTGSVGTQGRACNKTAPQASGC DLMCCGRGYNTHQYARVWQCNCKFHWCCYVKCNTCSERTEMYTCK (GenBank Accession No: BC008811; SEQ ID No: 280). In another embodiment, the Wnt protein has a sequence selected from the sequences set forth in GenBank entries NM_004625, D83175, U53476, and NP_004616. In another embodiment, the Wnt protein is a Wnt7 protein. In another embodiment, the Wnt protein is a Wnt7a protein. In another embodiment, the Wnt protein is Wnt1 protein. In another embodiment, the Wnt protein is a Wnt3 protein. In another embodiment, the Wnt protein is a Wnt3a protein. In another embodiment, the Wnt protein is a Wnt10 protein. In another embodiment, the Wnt protein is a Wnt10a protein. In another embodiment, the Wnt protein is a Wnt10b protein. In another embodiment, the Wnt protein is encoded by a nucleic acid molecule having a sequence set forth in the one of the above GenBank entries. In another embodiment, a biologically active fragment of a Wnt protein is utilized in a method of the present invention. In another embodiment, a biologically active fragment of a Wnt7 protein is utilized in a method of the present invention. In another embodiment, a biologically active fragment of a Wnt7a protein is utilized in a method of the present invention. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is a protein encoded by a ribonucleic acid (RNA) molecule having a sequence selected from the sequences set forth in SEQ ID No: 1-232. In another embodiment, the compound or factor is an RNA molecule having a sequence selected from SEQ ID No: 1-232. In another embodiment, the RNA molecule is homologous to a sequence selected from SEQ ID No: 1-232. In another embodiment, the RNA molecule is an isoform of a sequence selected from SEQ ID No: 1-232. In another embodiment, the compound or factor increases an activity of a protein encoded by an RNA molecule having a sequence selected from SEQ ID No: 1-232. In another embodiment, the compound or factor increases an expression or level of a protein encoded by an RNA molecule having a sequence selected from SEQ ID No: 1-232. Each possibility represents a separate embodiment of the present invention.

As provided herein, the transcripts depicted in Table 3 (Example 8; SEQ ID No: 1-232), the proteins they encode, and the pathways in which the proteins participate contribute significantly to HF stem cell activation. Accordingly, under the conditions utilized herein, anagen can be induced by activation of these transcripts, proteins, and pathways. Activation of the transcripts, proteins, and pathways depicted in Table 3 is thus a method for enhancing EDIHN. In another embodiment, activation of these transcripts, proteins, and pathways represents a method for enhancing hair growth in a subject.

In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is a protein encoded by an RNA molecule having a sequence selected from the sequences set forth in SEQ ID No: 233-257. In another embodiment, the compound or factor is an RNA molecule having a sequence selected from SEQ ID No: 233-257. In another embodiment, the RNA molecule is homologous to a sequence selected from SEQ ID No: 233-257. In another embodiment, the RNA molecule is an isoform of a sequence selected from SEQ ID No: 233-257. In another embodiment, the compound or factor increases an activity of a protein encoded by an RNA molecule having a sequence selected from SEQ ID No: 233-257. In another embodiment, the compound or factor increases an expression or level of a protein encoded by an RNA molecule having a sequence selected from SEQ ID No: 233-257. Each possibility represents a separate embodiment of the present invention.

As provided herein, the transcripts depicted in Table 4 (Example 9; SEQ ID No: 233-257), the proteins they encode, and the pathways in which the proteins participate, contribute significantly, under the conditions utilized herein, to induction of epidermal cells to differentiate into HF stem cells. Activation of the transcripts, proteins, and pathways depicted in Table 4 is thus a method for enhancing EDIHN. In another embodiment, activation of these transcripts, proteins, and pathways represents a method for enhancing hair growth in a subject.

In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is a compound or factor that decreases an activity of a protein encoded by an RNA molecule having a sequence selected from the sequences set forth in SEQ ID No: 258-273. In another embodiment, the compound or factor decreases an expression or level of a protein encoded by an RNA molecule having a sequence selected from SEQ ID No: 258-273. Each possibility represents a separate embodiment of the present invention.

As demonstrated by findings of the present invention, the transcripts depicted in Table 5 (Example 9; SEQ ID No: 258-273), the proteins they encode, and the pathways in which the proteins participate, contribute significantly, under the conditions utilized herein, to preventing induction of epidermal cells to differentiate into HF stem cells. Inhibition of the transcripts, proteins, and pathways depicted in Table 5 is thus a method for enhancing EDIHN. In another embodiment, inhibition of these transcripts, proteins, and pathways represents a method for induction of hair growth in a subject.

In one embodiment, the compound that modulates a protein encoded by an RNA molecule having a sequence selected from the sequences set forth in SEQ ID No: 233-273 or the nucleic acid encoding same is administered before the compound that modulates a protein encoded by an RNA molecule having a sequence selected from the sequences set forth in SEQ ID No: 1-232 or the nucleic acid encoding same. In another embodiment, the two compounds are administered simultaneously. Each possibility represents a separate embodiment of the present invention.

In one embodiment, a protein encoded by an RNA sequence selected from SEQ ID No: 1-273, or a compound that modulates the protein, is administered before other proteins encoded by same or compounds that modulate them, in order to further enhance their effect in generating an HF or stimulating hair growth. In another embodiment, the wnt pathway is stimulated before the hedgehog pathway. In another embodiment, the two pathways are stimulated in an overlapping fashion. In another embodiment, the two pathways are stimulated simultaneously. Each possibility represents a separate embodiment of the present invention.

In another embodiment, activating or decreasing expression of an RNA transcript in methods of the present invention occurs via a transcription mechanism (e.g. activation of expression of the RNA). In another embodiment, activating or decreasing expression of the RNA transcript occurs via a translational mechanism. In another embodiment, activating or decreasing expression of the RNA transcript occurs via a post-translational mechanism. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the nucleic acid molecule utilized in methods of the present invention is a deoxyribonucleic acid (DNA) molecule that encodes an RNA molecule having a sequence selected from the sequences set forth in the present invention.

In one embodiment, an RNA molecule of the present invention encodes a protein that plays a role in HF regeneration. In another embodiment, the RNA molecule is itself catalytically active, e.g., a ribozyme, etc. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is a compound or factor that promotes placodal cell fate. As provided herein, factors that promote placodal cell fate enhance EDIHN, as exemplified in the Examples herein. In another embodiment, the compound or factor acts at the placode stage of HF development.

In another embodiment, the compound or factor inhibits a biological factor that inhibits a differentiation of an uncommitted epithelial cell into an HF cell.

In another embodiment of methods and compositions of the present invention, a composition comprising one of the above compounds or factors is administered. Each of the above types of compounds, factors, and compositions represents a separate embodiment of the present invention.

In one embodiment, the present invention provides a method for generating an HF in a scalp, eyebrow, or scarred region of a subject, comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with minoxidil, thereby generating an HF in a scalp, eyebrow, or scarred region of a subject.

In one embodiment, the present invention provides a method for treating baldness in a scalp, eyebrow, or scarred region of a subject, comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with minoxidil, thereby treating baldness in a scalp, eyebrow, or scarred region of a subject.

In another embodiment, the present invention provides a use of minoxidil for the preparation of a pharmaceutical composition for use in a method for an HF in a scalp, eyebrow, or scarred region of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with the minoxidil.

In another embodiment, the present invention provides a use of minoxidil for the preparation of a pharmaceutical composition for use in a method for treating baldness in a scalp, eyebrow, or scarred region of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with the minoxidil.

In another embodiment, the present invention provides a method for removal of an HF from a skin or scalp of a subject, comprising the steps of: (a) disrupting an epidermis of the skin or scalp; and (b) contacting the skin or scalp with either: (i) an EGF protein; (ii) an EGF receptor; (iii) a nucleotide encoding an EGF protein or EGF receptor: or (iv) a compound or factor that activates a EGF protein or EGF receptor, thereby removing an HF from a skin or scalp of a subject.

In another embodiment, the present invention provides a method for hair removal from a skin or scalp of a subject, comprising the steps of: (a) disrupting an epidermis of the skin or scalp: and (b) contacting the skin or scalp with either: (i) an EGF protein: (ii) an EGF receptor, (iii) a nucleotide encoding an EGF protein or EGF receptor: or (iv) a compound or factor that activates a EGF protein or EGF receptor, thereby removing hair from a skin or scalp of a subject. In another embodiment, the epidermal disruption is light dermabrasion. In another embodiment, the epidermal disruption is a non-scarring method. In another embodiment, administration of the EGF protein, EGF receptor, nucleotide, compound, or factor suppresses HF formation. In another embodiment, the EGF protein, EGF receptor, nucleotide, compound, or factor is administered within several days of healing. In another embodiment, the EGF protein, EGF receptor, nucleotide, compound, or factor is administered within about 1 day of healing. In another embodiment, the EGF protein, EGF receptor, nucleotide, compound, or factor is administered according to any of the timing embodiments enumerated herein for Dkk1 protein. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the present invention provides a use of either: (i) an EGF protein; (ii) an EGF receptor: (iii) a nucleotide encoding an EGF protein or EGF receptor: or (iv) a compound or factor that activates a EGF protein or EGF receptor, for the preparation of a pharmaceutical composition for use in a method for removal of an HF from a skin or scalp of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with the EGF protein, EGF receptor, nucleotide, compound, or factor.

In another embodiment, a composition or method of the present invention is utilized on human skin. In another embodiment, the composition or method is utilized on an area of unwanted hair growth. In another embodiment, the area is the face. In another embodiment, the area is the bikini area. In another embodiment, the area is the legs. In another embodiment, the area is the arms. In another embodiment, the area is the chest.

An “inhibitor” utilized in methods and compositions of the present invention is, in another embodiment, an antibody that binds the protein or biological factor that is the target of the inhibitor. In another embodiment, the inhibitor is a pharmacologic inhibitor. In another embodiment, the inhibitor is any other type of inhibitor known in the art. Each possibility represents a separate embodiment of the present invention.

The step of disrupting the epidermis in methods of the present invention is performed, in another embodiment, by abrading the scalp, eyebrow, or scarred region. In another embodiment, the term “abrading” refers to an act of creating an abrasion. In another embodiment, “abrading” refers to rubbing. In another embodiment, “abrading” refers to wearing away by friction. As provided herein (Example 1), epidermal abrasion causes, under the conditions utilized herein, de novo HF neo-genesis. In another embodiment, the epidermal layer is disrupted.

In one embodiment, “abrasion” has the same meaning as “abrading.” In another embodiment. “abrasion” refers to an area of the scalp or skin from which the epidermis is removed. In another embodiment, “abrasion” refers to an area of the scalp or skin from which the epidermis and dermis are removed. Each definition of “abrading” and “abrasion” represents a separate embodiment of the present invention.

As provided herein, under the conditions utilized, epidermal disruption by a method of the present invention converts the skin back, in another embodiment, to an embryonic-like state, in which the follicle regenerates. In another embodiment, a subsequent window of opportunity is created, during which the number and size of new HF in the skin can be manipulated. In another embodiment, the administration of a compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell during this window causes regeneration of larger and more numerous HF. The morphology of HF in abraded skin is similar to that of embryonic HF (Example 1-2 and subsequent Examples), and the markers expressed are similar as well.

In another embodiment, the present invention provides a method of stimulating hair growth in a scalp, eyebrow, or scarred region of a subject, comprising performing a method of present invention, thereby stimulating hair growth in a scalp, eyebrow, or scarred region of a subject. As demonstrated in Example 3, EDIHN-induced HF are capable of generating hairs. Thus, methods of the present invention can be used to stimulate hair growth.

“EDIHN,” in another embodiment, refers to HF neogenesis induced by disruption of the epithelial layer. In another embodiment, the term refers to HF neogenesis induced by abrasion. In another embodiment, the term refers to HF neogenesis induced by wounding. In another embodiment, the term refers to HF neogenesis induced by disruption of the epithelial layer, followed by administration of a compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the present invention provides a method of testing an ability of a compound to modulate HF generation in vivo, comprising (a) disrupting an epithelial layer of a first scalp, eyebrow, or scarred region, whereby the first scalp, eyebrow, or scarred region has been contacted with the compound; (b) measuring a first HF generation in the first scalp, eyebrow, or scarred region; (c) disrupting an epithelial layer of a second scalp, eyebrow, or scarred region, wherein the second scalp, eyebrow, or scarred region is a scalp, eyebrow, or scarred region of the first subject or a second subject, whereby the second scalp, eyebrow, or scarred region has not been contacted with the compound; (d) measuring a second HF generation in the second scalp, eyebrow, or scarred region; and (e) comparing the first HF generation to the second HF generation, whereby a difference between the first HF generation and the second HF generation indicates that the compound modulates an HF generation in vivo (Examples).

In another embodiment, the present invention provides a method of testing an ability of a compound to stimulate hair growth in vivo, comprising disrupting an epithelial layer of a first scalp, eyebrow, or scarred region, whereby the first scalp, eyebrow, or scarred region has been contacted with the compound; measuring a first HF generation in the first scalp, eyebrow, or scarred region; disrupting an epithelial layer of a second scalp, eyebrow, or scarred region, whereby the second scalp, eyebrow, or scarred region has not been contacted with the compound; measuring a second HF generation in the second scalp, eyebrow, or scarred region; and comparing the first HF generation to the second HF generation, whereby a difference between the first HF generation and the second HF generation indicates that the compound stimulates a hair growth in vivo.

In one embodiment, the methods of the present invention of testing a compound are repeated using a plurality of subjects, until a statistically significant sample has been tested.

In another embodiment of methods for testing compounds of the present invention, the first scalp, eyebrow, or scarred region is a scalp, eyebrow, or scarred region of a first subject. In another embodiment, the subject is a subject in need of generation of a new HF. The second scalp, eyebrow, or scarred region, in another embodiment, is a scalp, eyebrow, or scarred region of the first subject. In another embodiment, the second scalp, eyebrow, or scarred region is a scalp, eyebrow, or scarred region of a second subject. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the excisional wounds of methods of the present invention are created using a surgical tool. In one embodiment, the surgical tool is a dermal biopsy punch (Example 2). In another embodiment, the excisional wounds are induced by freezing or cryoinjury. The use of freezing or cryoinjury is well known in the art, and is used, for example by dermatologists to injure skin. In one embodiment, the freezing or cryoinjury results in a blister. In another embodiment, the blister is used as a “chamber” to introduce drugs and or cells into the reepithelialized area. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the excisional wounds of methods of the present invention are not surgically closed. In another embodiment, the excisional wounds are not contacted with a bandage or dressing before they heal or during a period of time after wound induction. In another embodiment, the excisional wounds are not contacted with an ointment before they heal or during a period of time after wound induction. In another embodiment, the excisional wounds are allowed to heal by secondary intention. Each possibility represents a separate embodiment of the present invention.

The subject of methods of the present invention, is, in another embodiment, a human. As provided herein (Example 7) human skin responds to EDIHN in the same manner as mouse skin. In another embodiment, the subject is a male. In another embodiment, the subject is a female. In another embodiment, the subject is any other type of subject known in the art. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the subject is an adult. In one embodiment, “adult” refers to an age greater than about 18 years. In another embodiment, “adult” refers to an age greater than about 20 years. In another embodiment, “adult” refers to an age greater than about 25 years. In another embodiment, “adult” refers to an age greater than about 30 years. In another embodiment, “adult” refers to an age greater than about 35 years. In another embodiment, “adult” refers to an age greater than about 40 years. In another embodiment, “adult” refers to an age greater than about 45 years.

In another embodiment, the subject is elderly. In one embodiment, “elderly” refers to an age greater than about 45 years. In another embodiment, “elderly” refers to an age greater than about 50 years. In another embodiment, “elderly” refers to an age greater than about 55 years. In another embodiment, “elderly” refers to an age greater than about 60 years. In another embodiment, “elderly” refers to an age greater than about 65 years. In another embodiment, “elderly” refers to an age greater than about 70 years.

In another embodiment, the first subject, or, where applicable, both the first subject and the second subject, is a laboratory animal. In another embodiment, the subject(s) is/are mice. In another embodiment, the subject(s) is/are rats. In another embodiment, the subject(s) is/are gerbils. In another embodiment, the subject(s) is/are hamsters. In another embodiment, the subject(s) is/are guinea pigs. In another embodiment, the subject(s) is/are rabbits. In another embodiment, the subject(s) is/are pigs. In another embodiment, the subject(s) is/are dogs. In another embodiment, the subject(s) is/are cats. In another embodiment, the subject(s) is/are primates. In another embodiment, the subject(s) is/are any other laboratory animal known in the art. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the subject(s) has a disease or disorder comprising balding. In another embodiment, the subject(s) does not have a disease or disorder comprising balding. In another embodiment, the disease or disorder is androgenetic alopecia (AGA). In another embodiment, the disease or disorder is male pattern baldness. In another embodiment, the disease or disorder is female pattern baldness. In another embodiment, the disease or disorder is a discoid lupus erythematosis. In another embodiment, the disease or disorder is a congenital hypotrichosis. In another embodiment, the disease or disorder is a lichen planopilaris. In another embodiment, the disease or disorder is a scarring alopecia. In another embodiment, the disease or disorder is any other disease or disorder comprising balding known in the art.

In another embodiment, the scalp, eyebrow, or scarred region(s) has a majority of HF in the telogen stage of the hair cycle. The findings of Examples 5-6 show that (a) EDIHN can restore hair growth to the scalp, eyebrow, or scarred region at the telogen stage; and (b) the efficiency of EDIHN at the telogen stage can be enhanced by depilation prior to abrasion or wound induction. In another embodiment, the scalp, eyebrow, or scarred region(s) has more than about 60% of HF in the telogen stage of the hair cycle. In another embodiment, the scalp, eyebrow, or scarred region(s) has more than about 70% of HF in the telogen stage of the hair cycle. In another embodiment, the scalp, eyebrow, or scarred region(s) has more than about 80% of HF in the telogen stage of the hair cycle. In another embodiment, the scalp, eyebrow, or scarred region(s) has more than about 90% of HF in the telogen stage of the hair cycle. In another embodiment, the scalp, eyebrow, or scarred region(s) does not have a majority of HF in the telogen stage of the hair cycle. Each possibility represents a separate embodiment of the present invention.

In another embodiment of methods and compositions of the present invention, the first step (e.g. epithelial disruption) is performed 3-12 days prior to the second step (e.g. addition of an active compound, factor, cell, etc). In another embodiment, the interval is 4-12 days. In another embodiment, the interval is 5-12 days. In another embodiment, the interval is 4-11 days. In another embodiment, the interval is 6-11 days. In another embodiment, the interval is 6-10 days. In another embodiment, the interval is 6-9 days. In another embodiment, the interval is 6-8 days. In another embodiment, the interval is 7-8 days. In another embodiment, the interval is 5-11 days. In another embodiment, the interval is 5-10 days. In another embodiment, the interval is 7-10 days. In another embodiment, the interval is about 1 week. Each possibility represents a separate embodiment of the present invention.

In another embodiment, a method of the present invention further comprises the step of suppressing an activity or expression of a Wnt protein in the scalp, eyebrow, or scarred region. As provided herein, suppressing Wnt activity induces pigmentation in HF generated by methods of the present invention. In another embodiment, the step of suppressing Wnt activity or expression is performed within about 10 days of epidermal disruption. In another embodiment, the step of suppressing Wnt activity or expression is performed prior to the second step (e.g prior to addition of a compound or factor that promotes HF cell differentiation. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the present invention provides a method for inducing pigmentation of a hair, comprising suppressing expression of a Wnt protein in a follicle of the hair. In another embodiment, the Wnt protein is Wnt1. In another embodiment, the Wnt protein is a Wnt7. In another embodiment, the Wnt protein is a Wnt7a. In another embodiment, the Wnt protein is a Wnt3. In another embodiment, the Wnt protein is a Wnt3a. In another embodiment, the Wnt protein is a Wnt10. In another embodiment, the Wnt protein is a Wnt10a. In another embodiment, the Wnt protein is any other Wnt protein known in the art. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the present invention provides a method for inducing growth of a pigmented scalp hair or eyebrow of a subject, comprising generating a hair follicle in the scalp, eyebrow, or scarred region according to a method of the present invention and suppressing expression of a Wnt protein in the hair follicle, thereby inducing a growth of a pigmented scalp hair or eyebrow of a subject.

In another embodiment, the step of suppressing expression of a Wnt protein comprises inducing an expression of a Dkk1 protein. In another embodiment, the step of suppressing expression of a Wnt protein comprises inducing an expression of any other Wnt inhibitor known in the art. In another embodiment, the step of suppressing expression of a Wnt protein is performed immediately or shortly after epidermal disruption. In another embodiment, the step of inducing expression of a Dkk1 protein is performed immediately or shortly after epidermal disruption. In another embodiment, the step of suppressing expression of a Wnt protein is performed at the time of epidermal disruption. In another embodiment, the step of inducing expression of a Dkk1 protein is performed at the time of epidermal disruption. In another embodiment, the step of suppressing expression of a Wnt protein is performed several days before generation of the follicle. In another embodiment, the step of inducing expression of a Dkk1 protein several days before generation of the follicle. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the step of suppressing expression of a Wnt protein is performed for about 8 days. In another embodiment, the step of inducing expression of a Dkk1 protein is performed for about 8 days. In another embodiment, the step of suppressing expression of a Wnt protein is performed for about 9 days. In another embodiment, the step of inducing expression of a Dkk1 protein is performed for about 9 days. In another embodiment, the step of suppressing expression of a Wnt protein is performed for about 10 days. In another embodiment, the step of inducing expression of a Dkk1 protein is performed for about 10 days. In another embodiment, the step of suppressing expression of a Wnt protein is performed for about 12 days. In another embodiment, the step of inducing expression of a Dkk1 protein is performed for about 12 days. In another embodiment, the step of suppressing expression of a Wnt protein is performed during the period of re-epithelialization. In another embodiment, the step of inducing expression of a Dkk1 protein is performed during the period of re-epithelialization. In another embodiment, expression of a Dkk1 protein is halted after several days. In another embodiment, halting expression of Dkk1 protein after several days induces, or enables induction of Wnt protein expression. In another embodiment, the expression of a Wnt protein is induced about 9 days after the abrating or wounding. In another embodiment, the expression of a Wnt protein is induced following the period of re-epithelialization. In another embodiment, induction of Wnt protein expression is necessary for formation of new HF. Each possibility represents a separate embodiment of the present invention.

In another embodiment, “several” refers to about 1 day. In another embodiment, “several” refers to about 2 days. In another embodiment, “several” refers to about 3 days. In another embodiment, “several” refers to about 5 days. In another embodiment, “several” refers to about 7 days. In another embodiment, “several” refers to about 10 days. In another embodiment, “several” refers to about 12 days. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the step of contacting in methods of the present invention comprises directly contacting the scalp, eyebrow, or scarred region with the compound, RNA, protein, etc. In another embodiment, the step of contacting comprises indirectly contacting the scalp, eyebrow, or scarred region via contacting another site or tissue of the subject, after which the compound, RNA, or protein is transported to the scalp, eyebrow, or scarred region by a biological process; e.g, diffusion, active transport, or circulation in a fluid such as the blood, lymph, interstitial fluid, etc. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the epidermal disruption in methods of the present invention further removes dermal tissue from the scalp, eyebrow, or scarred region. In another embodiment, the epidermal disruption does not remove dermal tissue from the scalp, eyebrow, or scarred region. Each possibility represents a separate embodiment of the present invention.

“Disrupting” an epidermis or epidermal layer refers, in another embodiment, to removing part of the epidermis or epidermal layer. In another embodiment, the term refers to disturbing the intactness of the epidermis or epidermal layer. In another embodiment, the term refers to perforating the epidermis or epidermal layer. In another embodiment, only part of the epidermal layer need be removed. In another embodiment, the entire epidermal layer is removed. In another embodiment, the term refers to abrading the epidermis or epidermal layer (Examples). In another embodiment, the term refers to wounding the epidermis or epidermal layer (Examples). Each possibility represents a separate embodiment of the present invention.

In another embodiment, the epidermal disruption is performed with a tool that comprises sandpaper. In another embodiment, the epidermal disruption is performed with a laser. In another embodiment, the laser is a Fraxel laser. In another embodiment, the laser is a CO₂ laser. In another embodiment, the laser is an excimer laser. In another embodiment, the laser is any other type of laser capable of inducing trans-epithelial injury. In another embodiment, the epidermal disruption is performed with a felt wheel. In another embodiment, the epidermal disruption is performed with a surgical tool. In another embodiment, the epidermal disruption is performed with any other tool known in the art that is capable of epidermal disruption. In another embodiment, the epidermal disruption comprises use of a micro-dermabrasion device. In another embodiment, the epidermal disruption comprises a burn treatment.

In another embodiment, the epidermal disruption comprises a disruption of a follicle of said epidermis and a disruption of an interfollicular region of said epidermis. In another embodiment, the epidermal disruption comprises a disruption of a follicle of said epidermis and does not comprise a disruption of an interfollicular region of said epidermis. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the epidermal disruption comprises a light-based method. In another embodiment, the epidermal disruption comprises irradiation with visible light. In another embodiment, the epidermal disruption comprises irradiation with infrared light. In another embodiment, the epidermal disruption comprises irradiation with ultraviolet radiation. In another embodiment, the epidermal disruption comprises orthovoltage irradiation. In another embodiment, the epidermal disruption comprises X-ray irradiation. In another embodiment, the epidermal disruption comprises any other type of irradiation known in the art.

In another embodiment, the epidermal disruption is performed by mechanical means. In another embodiment, “mechanical means” refers to abrading. In another embodiment, the term refers to wounding. In another embodiment, the term refers to ultrasound. In another embodiment, the term refers to radio-frequency. In another embodiment, the term refers to ab electrical process or the use of an electrical current. In another embodiment, the term refers to electroporation. In another embodiment, the term refers to exision. In another embodiment, the term refers to tape-stripping. In another embodiment, the term refers to microdermabrasion. In another embodiment, the term refers to the use of peels. In another embodiment, the term refers to any other type of mechanical means known in the art. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the epidermal disruption comprises chemical treatment. In another embodiment, the chemical is phenol. In another embodiment, the chemical is trichloracetic acid. In another embodiment, the chemical is ascorbic acid. In another embodiment, the chemical is any other chemical capable of epidermal disruption that is known in the art.

Each method or type of method of epidermal disruption represents a separate embodiment of the present invention.

In another embodiment, epidermal trauma is utilized in a method of the present invention.

Each type of epidermal abrasion and epidermal trauma represents a separate embodiment of the present invention.

In another embodiment, the epidermal disruption of methods of the present invention creates an abrasion at least about 1-1.5 centimeters (cm) in width. In another embodiment, the abrasion is at least about 1 cm in width. In another embodiment, the abrasion is at least about 1.5 cm in width. In another embodiment, the abrasion is at least about 2 cm in width. Each type of abrasion represents a separate embodiment of the present invention.

In another embodiment, the scalp, eyebrow, or scarred region is not contacted with a bandage or dressing following the epidermal disruption. In another embodiment, the scalp, eyebrow, or scarred region is not contacted with an ointment following the epidermal disruption. In another embodiment, the scalp, eyebrow, or scarred region is allowed to heal for a period of time without being contacted by any substance, device, ointment, etc., that is ordinarily administered to an abrasion or wound to facilitate healing. In another embodiment, the scalp, eyebrow, or scarred region is allowed to heal for a period of time without being contacted by any substance, device, ointment, etc., that is ordinarily administered to an abrasion or wound to prevent infection. In another embodiment, the period of time is the time it takes the epidermal disruption to heal. In another embodiment, the period of time is any time or range of times between 2 days and 3 weeks. Each possibility represents a separate embodiment of the present invention.

In one embodiment, “following” refers to a period of time of about 2 days. In another embodiment, “following” refers to a period of time of about 3 days. In another embodiment, “following” refers to a period of time of about 4 days. In another embodiment, “following” refers to a period of time of about 5 days. In another embodiment, “following” refers to a period of time of about 7 days. In another embodiment, “following” refers to a period of time of about 10 days. In another embodiment, “following” refers to a period of time of about 2 weeks. In another embodiment, “following” refers to a period of time of about 3 weeks. Each possibility represents a separate embodiment of the present invention.

In another embodiment, a method of the present invention further comprises the step of depilating the scalp, eyebrow, or scarred region. As provided herein, the findings of Example 6 show that the efficiency of EDIHN can be enhanced by depilation prior to abrasion or wound induction.

In another embodiment, the depilation is epilation. In another embodiment, the depilation comprises the step of waxing. In another embodiment, the depilation comprises the step of plucking. In another embodiment, the depilation comprises the use of an abrasive material. In another embodiment, the depilation comprises the use of a laser. In another embodiment, the depilation comprises the use of electrolysis. In another embodiment, the depilation comprises the use of a mechanical device. In another embodiment, the depilation comprises the use of thioglycolic acid. In another embodiment, the depilation comprises the use of any other method of depilation or epilation known in the art. Each possibility represents a separate embodiment of the present invention.

In another embodiment, a method of the present invention further comprises the step of administering a topical retinoid to the scalp, eyebrow, or scarred region. In one embodiment, the topical retinoid induces resting (telogen) HF in the scalp, eyebrow, or scarred region to enter anagen. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the additional step (depilation or administration of a retinoid) is performed prior to the step of disrupting the epidermis. In another embodiment, the additional step is performed following the step of disrupting the epidermis, but prior to the addition of the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell. In another embodiment, the additional step is performed concurrently with the addition of the differentiation-promoting compound or factor. In another embodiment, the additional step is performed following the addition of the differentiation-promoting compound or factor. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the additional step is performed between about two days and about three weeks before the step of abrading. In another embodiment, the additional step is performed about two days before the step of abrading. In another embodiment, the additional step is performed about three days before the step of abrading. In another embodiment, the additional step is performed about four days before the step of abrading. In another embodiment, the additional step is performed about one week before the step of abrading. In another embodiment, the additional step is performed about ten days before the step of abrading. In another embodiment, the additional step is performed about two weeks before the step of abrading. In another embodiment, the additional step is performed about three weeks before the step of abrading. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the methods of the present invention further comprise the step of contacting the scalp, eyebrow, or scarred region with an inductive cell capable of inducing an epidermal cell to differentiate into an HF cell. In another embodiment, the HF cell is an HF stem cell. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the inductive cell is a dermal papilla cell. In another embodiment, the inductive cell is a follicular papilla cell. In another embodiment, the inductive cell is a dermal sheath cell. In another embodiment, the inductive cell is a cell that has been genetically modified; for example, with a gene encoding a factor that activates one of the proteins or pathways shown in the present invention to be up-regulated in HF stem cells. In one embodiment, the factor is hedgehog. In another embodiment, the factor is a DP cell protein. In another embodiment, the factor is wingless/int (wnt). In another embodiment, the factor is a Noggin protein. In another embodiment, the factor is a bone morphogenic protein (BMP). In another embodiment, the factor is a fibroblast growth factor (FGF). In another embodiment, the factor is a transforming growth factor beta (TGF-beta) protein. In another embodiment, the factor is sonic hedgehog protein. In another embodiment, the factor is a neurotropin. In another embodiment, the factor is any other factor known in the art that can contribute to induction of an epidermal cell to differentiate into an HF cell. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the inductive cell has been genetically modified with a gene encoding a factor that represses one of the proteins or pathways shown in the present invention to be down-regulated in HF stem cells. In another embodiment, the inductive cell has been genetically modified with a gene encoding a factor that activates one of the proteins or pathways shown in the present invention to be up-regulated in HF stem cells upon their activation.

In another embodiment, the inductive cell is an autologous cell. In another embodiment, the inductive cell is an allogenic cell.

In another embodiment, the inductive cell is derived from a mesenchymal stem cell. In another embodiment, the inductive cell is derived from a mesodermal progenitor cell. In another embodiment, the inductive cell is derived from a hematopoietic stem cell. In another embodiment, the inductive cell is derived from an embryonic stem cell. In another embodiment, the inductive cell is derived from an embryonic carcinoma cell. In another embodiment, the inductive cell is one of the cell types disclosed in United States Patent Application No. 2003/0201815. In another embodiment, the inductive cell is any other type of cell known in the art with inductive properties for an epidermal cell. Each type of inductive cell represents a separate embodiment of the present invention.

In another embodiment, the epidermal cell (e.g. the epidermal cell that is induced to differentiate into an IF cell) is an epidermal stem cell. In another embodiment, the epidermal cell is a bulge cell. In another embodiment, the epidermal cell is any other type of cell known in the art that can be induced to differentiate into an HF stem cell. Each possibility represents a separate embodiment of the present invention.

In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with an anti-androgen compound. In one embodiment, the anti-androgen compound is finasteride. In another embodiment, the anti-androgen compound is Fluridil®. In another embodiment, the anti-androgen compound is dutasteride. In another embodiment, the anti-androgen compound is spironolactone. In another embodiment, the anti-androgen compound is cyproterone acetate. In another embodiment, the anti-androgen compound is bicalutamide. In another embodiment, the anti-androgen compound is flutamide. In another embodiment, the anti-androgen compound is nilutamide. In another embodiment, the anti-androgen compound is an inhibitor of an androgen receptor. In another embodiment, the anti-androgen compound is any other anti-androgen compound known in the art. Each possibility represents a separate embodiment of the present invention.

In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with an estrogen compound. In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with an estrogen receptor agonist. In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with an estrogen analogue. In one embodiment, the estrogen analogue is estradiol. In another embodiment, the estrogen analogue is 17 beta-estradiol. In another embodiment, the estrogen analogue is 17 alpha-estradiol. In another embodiment, the estrogen analogue is ZYC3. In another embodiment, the estrogen compound, estrogen receptor agonist, or estrogen analogue is any other estrogen compound, estrogen receptor agonist, or estrogen analogue known in the art. Each possibility represents a separate embodiment of the present invention.

In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with an inhibitor of an EGF protein. In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with an inhibitor of an EGFR. In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with a compound that reduces an expression of an EGF protein or an EGFR. Each possibility represents a separate embodiment of the present invention.

In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with a Hedgehog protein. In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with a nucleotide encoding a Hedgehog protein. In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with an activator of a Hedgehog protein. Each possibility represents a separate embodiment of the present invention.

In one embodiment, a scalp is treated by a method of the present invention. In another embodiment, an eyebrow is treated. In another embodiment, any other hair-bearing area or region of the skin is treated. Each possibility represents a separate embodiment of the present invention.

In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with a lithium compound. In one embodiment, the lithium compound contains a lithium ion. In another embodiment, the lithium compound contains a lithium atom.

In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with (2′Z,3′E)-6-bromoindirubin-3′-oxime (BIO). In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with any other compound known in the art that is capable of inducing an epidermal cell to differentiate into an HF stem cell. Each compound represents a separate embodiment of the present invention.

In one embodiment, the compound administered as part of methods of the present invention is administered systemically. In another embodiment, the compound is administered topically. In another embodiment, the compound is administered to the site of the abrasion. In another embodiment, the compound is administered to the site of the wound induction. In another embodiment, the compound is administered to the site of the depilation. In another embodiment, the compound is administered during wound healing. In another embodiment, the compound is administered prior to HF neo-genesis. In another embodiment, the compound is administered during HF neo-genesis. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the present invention provides a method of inducing formation of an HF stem cell, comprising performing a method of the present invention. In another embodiment, the present invention provides a method of inducing formation of a DP cell, comprising performing a method of the present invention. Each possibility represents a separate embodiment of the present invention.

In another embodiment, homologues and variants of transcripts and proteins of the present invention are administered in methods of the present invention. In another embodiment, homologues and variants of transcripts and proteins of the present invention are targeted in methods of the present invention. Each possibility represents a separate embodiment of the present invention.

The terms “homology,” “homologous,” etc, when in reference to any protein or peptide, refer in one embodiment, to a percentage of amino acid residues in the candidate sequence that are identical with the residues of a corresponding native polypeptide, after aligning the sequences and introducing gaps, if necessary, to achieve the maximum percent homology, and not considering any conservative substitutions as part of the sequence identity. Methods and computer programs for the alignment are well known in the art.

In another embodiment, the term “homology,” when in reference to any nucleic acid sequence similarly indicates a percentage of nucleotides in a candidate sequence that are identical with the nucleotides of a corresponding native nucleic acid sequence.

In another embodiment, “homology” refers to identity of greater than 70%. In another embodiment, “homology” refers to identity of greater than 75%. In another embodiment, “homology” refers to identity of greater than 80%. In another embodiment, “homology” refers to identity of greater than 82%. In another embodiment, “homology” refers to identity of greater than 85%. In another embodiment, “homology” refers to identity of greater than 87%. In another embodiment, “homology” refers to identity of greater than 90%. In another embodiment, “homology” refers to identity of greater than 92%. In another embodiment, “homology” refers to identity of greater than 95%. In another embodiment, “homology” refers to identity of greater than 97%. In another embodiment, “homology” refers to identity of greater than 98%. In another embodiment, “homology” refers to identity of greater than 99%. In another embodiment, “homology” refers to identity of 100%.

Protein and/or peptide homology for any amino acid sequence listed herein is determined, in one embodiment, by methods well described in the art, including immunoblot analysis, or via computer algorithm analysis of amino acid sequences, utilizing any of a number of software packages available, via established methods. Some of these packages may include the FASTA, BLAST, MPsrch or Scanps packages, and may employ the use of the Smith and Waterman algorithms, and/or global/local or BLOCKS alignments for analysis, for example. Each method of determining homology represents a separate embodiment of the present invention.

In another embodiment, the present invention provides a kit, comprising a tools and/or a compound suitable for performing a method of the present invention.

In another embodiment, the present invention provides a device, comprising a tool suitable for epidermal disruption and a means of delivering a compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell.

In other embodiments, the present invention provides a method of treating any disease, disorder, or symptom associated with balding. In other embodiments, the present invention provides a method of treating any disease, disorder, or symptom associated with balding. In other embodiments, the present invention provides a method of treating any disease, disorder, or symptom associated with balding. Each disease, disorder, or symptom represents a separate embodiment of the present invention.

Pharmaceutical Compositions

In another embodiment, methods of the present invention comprise administering a pharmaceutical composition comprising the HF stem cell-inducing or -activating compound and/or its analog, derivative, isomer, metabolite, pharmaceutically acceptable salt, pharmaceutical product, hydrate, N-oxide, or any combination thereof: and a pharmaceutically acceptable carrier. Each possibility represents a separate embodiment of the present invention.

The pharmaceutical compositions containing the HF stem cell-inducing or -activating compound can, in another embodiment, be administered to a subject by any method known to a person skilled in the art, such as topically, parenterally, paracancerally, transmucosally, transdermally, intramuscularly, intravenously, intradermally, subcutaneously, intraperitonealy, intraventricularly, intracranially, intravaginally or intratumorally. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the pharmaceutical compositions are administered orally, and are thus formulated in a form suitable for oral administration, i.e. as a solid or a liquid preparation. Suitable solid oral formulations include tablets, capsules, pills, granules, pellets and the like. Suitable liquid oral formulations include solutions, suspensions, dispersions, emulsions, oils and the like. In one embodiment of the present invention, the HF stem cell-inducing or -activating compounds are formulated in a capsule. In another embodiment, the compositions of the present invention comprise, in addition to the HF stem cell-inducing or -activating compound active compound and the inert carrier or diluent, a hard gelating capsule.

In another embodiment, the pharmaceutical compositions are administered topically to body surfaces and are thus formulated in a form suitable for topical administration. Suitable topical formulations include gels, ointments, creams, lotions, drops and the like. For topical administration, the HF stem cell-inducing or -activating compound or its physiologically tolerated derivatives such as salts, esters, N-oxides, and the like are prepared and applied as solutions, suspensions, or emulsions in a physiologically acceptable diluent with or without a pharmaceutical carrier.

In another embodiment, the pharmaceutical compositions are administered by subcutaneous implantation of a pellet. In another embodiment, the pellet provides for controlled release of HF stem cell-inducing or -activating compound agent over a period of time.

For liquid formulations, pharmaceutically acceptable carriers are, in another embodiment, aqueous or non-aqueous solutions, suspensions, emulsions or oils. Examples of non-aqueous solvents are propylene glycol, polyethylene glycol, and injectable organic esters such as ethyl oleate. Aqueous carriers include, in another embodiment, water, alcoholic/aqueous solutions, emulsions or suspensions, including saline and buffered media. Examples of oils are those of petroleum, animal, vegetable, or synthetic origin, for example, peanut oil, soybean oil, mineral oil, olive oil, sunflower oil, and fish-liver oil.

In one embodiment, the pharmaceutical compositions are controlled-release compositions, i.e. compositions in which the HF stem cell-inducing or -activating compound is released over a period of time after administration. Controlled- or sustained-release compositions include, in another embodiment, formulation in lipophilic depots (e.g. fatty acids, waxes, oils). In another embodiment, the composition is an immediate-release composition, i.e. a composition in which all the HF stem cell-inducing or -activating compound is released immediately after administration.

EXPERIMENTAL DETAILS SECTION Example 1 Depilation and Epidermal Abrasion Causes De Novo Hair Follicle Formation Materials and Experimental Methods Depilation and Epidermal Abrasion

Mice were anesthetized with an injection of sodium pentobarbital before the hair on the back was clipped and depilated with Nair (Carter-Wallace, New York, N.Y.), then epidermis was removed using a rotating felt wheel as described by Argyris T, J Invest Dermatol, 75: 360-362, 1980). After scrubbing with 70% ethanol and drying under an incandescent lamp, the basal and supra-basal layers in an area of (1.5 cm)² cm of the inter-follicular epidermis were removed by careful abrasion with a felt wheel mounted on a Dremel Moto-tool (Racine, Wis.). After abrasion, the skin was shiny and smooth, and there was no blood. One day later, the abraded area was covered by a fibrin crust, which fell off after 3-7 days, exposing the newly regenerated epidermis. A group of control mice was sacrificed immediately after abrasion to confirm microscopically the complete removal of the interfollicular epidermis.

Immunohistochemistry

Skin samples were fixed in PBS-buffered 10% formalin. Six-micron thick paraffin sections were cut and stained, where applicable, with antibodies.

BrdU Labeling

The protocol described by Bickenbach and colleagues (Bickenbach et al, Cell Tiss Kinet 19: 325-333, 1986; Bickenbach et al, Exp Cell Res 244, 184-195, 1998) was used. Mice were injected with 50 milligrams per kilogram (mg/kg) bodyweight 5-bromo-2′-deoxyuridine (BrdU) every 12 hours for a total of four injections.

Results

An area of the backs of 50-day old mice was subjected to depilation and removal of the epidermis using a rotating felt wheel. Fifteen days later, HF placodes, hair germs and other signs of follicle neogenesis were present (FIG. 1; arrow indicates a hair germ). Morphology of the follicles was similar to embryonic follicle development. To further characterize proliferation in the new follicles, the skin was labeled with BrdU 60 minutes before sacrifice. As depicted in FIG. 2, the proliferation pattern was similar to developing follicles in the embryo.

These findings demonstrate that (a) disruption of the epidermis causes generation of new HF, and that this generation of new HF can occur (b) in adult subjects and (c) during telogen (50-day-old mice are in the second telogen stage of the hair cycle).

Example 2 Induction of a Large Excisional Wound, but not a Small Punch Wound, Causes De Novo Hair Follicle Formation Materials and Experimental Methods Punch Wound and Excisional Wound Induction

The backs of 21-day-old mice were depilated as described for Example 1 and sterilized with alcohol, followed by 1% iodine solution. Punch wounds, 4 mm in diameter, were induced using a dermal biopsy punch, down to, but not through, the muscle fascia. Excisional wounds were full thickness and 1 cm in diameter; skin and panniculus carnosus was excised using fine surgical scissors.

Results

To test whether wounding could induce HF formation, punch wounds or excisional wounds were induced in mice. Both types of wounds exhibited contraction and re-epithelialization following wound induction; however, unlike the mice receiving punch wounds, the mice receiving excisional wounds also exhibited scar formation within 10 days of wound induction (FIG. 3, left panel). No follicles were evident at this time point (FIG. 3, right panel). 12 days after wound induction, hair germs, with similar morphology to fetal hair germs, were observed in the wound site, following BrdU pulse labeling (FIG. 4). Several markers were used to verify that the observed structures were HF. The structures exhibited staining with anti-keratin 17 (K 17), an HF marker (FIG. 5), and staining with anti-alkaline phosphatase at the 12 day time point verified that the structures had dermal papilli containing fibroblasts, as expected for HF (FIG. 6; HF at earlier and later stages are depicted in the left and right panels, respectively).

The HF generated by wound induction were further characterized by morphological comparison to embryonic HF, following BrdU staining; a clear correspondence in morphology was observed at various stages (FIG. 7). In addition, several markers of embryonic HF development, namely Lef1, wingless/int (Wnt) 10b, and sonic hedgehog (Shh), were also induced in the epidermal disruption-induced HF neogenesis (EDIHN) (FIG. 8). Additional BrdU staining (FIG. 9) and staining for HF markers S100A3 and S100A6 (FIG. 10; left panel: tissue section parallel to HF axis; right panel: cross-sectional view of follicle) provided further verification that the development of the EDIHN follicles closely paralleled embryonic HF development.

These findings provide further evidence that disruption of the epidermis causes generation of new HF, and that this generation of new HF can occur (b) in adult subjects and (c) during telogen (21-day-old mice are in the first telogen stage of the hair cycle).

Example 3 EDIHN-Induced Hair Follicles Generate Hairs

At 25 and 45 days after wound induction, wound sites contained new hairs (FIG. 11, left and right panels, respectively). New hairs appeared to lack pigmentation, except when the wnt pathway was inhibited, using Dkk-1 (Dickkopf-1) during the first nine days after wounding (see Example 10).

These findings indicate that EDIHN-induced HF function normally; i.e. are capable of generating hairs.

Example 4 EDIHN Hair Follicles Retain the Ability to Enter into Cyclical Hair Growth Materials and Experimental Methods BrdU Labeling

50 mg/kg bodyweight BrdU (Sigma) was injected twice per day for 3 days beginning 20 days after wounding. BrdU was detected 40 days after wounding (17 day chase).

Whole Mounting and Immunofluorescence

HF whole mounts were obtained by incubating fresh skin with EDTA (20 mM in PBS) at 37° C. overnight, then separating the epidermis and dermis. Epidermis was then fixed in 10% formalin for 10 min, room temperature (RT). Dermis was fixed in acetone overnight, RT. After rinsing with PBS, whole mounts were stained with antibodies for immunohistochemistry (schematically depicted in FIG. 12) and were imaged using a Leica confocal microscope.

Results

To determine whether EDIHN-induced HF contain normal levels of HF stem cells, mouse skin was examined for the presence of label-retaining cells at 21 days after wound induction. Retention of BrdU during a long chase period is, under these conditions, one of the hallmarks of HF stem cells. Normal numbers and placement of label-retaining cells (in the bulge of the HF) were observed (FIG. 13). To verify that the label-retaining cells were HF stem cells, K15-eGFP mice were utilized. In these mice, eGFP (enhanced green fluorescent protein) is expressed from the K15 promoter; thus, expression of eGFP identifies HF stem cells. As depicted in FIG. 14A, eGFP-expressing cells were observed in in tissue sections (right side) of newly formed hair follicles 35 days following wound induction. eGFP-expressing cells were also seen in the epidermis whole mounts (bottom, far left panel) indicating the conversion of epidermal cells into cells with hair follicle stem cell characteristics. ([bottom, second from left] panel is same as [bottom, far left] panel but viewed under white light) This finding shows that the observed label-retaining cells exhibited HF stem cell properties.

To determine whether EDIHN-induced HF cycle normally, mounts were prepared from additional mice at 35, 38 and 45 days after wounding. As depicted in FIG. 14B, the EDIHN-induced HF entered the resting phase, telogen, and then re-entered a new anagen stage.

In summary, the findings of this Example show that EDIHN-induced HF contain HF stem cells, as do embryonically generated HF. The presence of the HF stem cells shows that EDIHN-induced HF retain the ability to enter into cyclical hair growth in the same manner as embryonically generated HF. The findings also show that wounding induces epidermal cells to assume a hair follicle stem cell state (expressing K15-eGFP). This model is shown schematically in FIG. 15. The findings of Examples 2, 3, and 4 show that EDIHN-induced HF are fully functional and thus able to restore hair growth to a subject in need.

Example 5 EDIHN-Induces New Hair Follicles in Mice at the Telogen Stage of the Hair Cycle

To determine whether EDIHN was induced new hair follicles in mice wounded at the telogen stage of the hair cycle, 21-day-old mice were subjected to EDIHN using a 1-cm excisional wound, as described in Example 2. Skin was then examined by whole-mount assay for indications of new HF. As depicted in FIG. 16, after 11 days, new HF were not evident by macroscopic examination (top panel), AP staining of the dermis (bottom left panel), or K17 staining of the epidermis (bottom right panel). After 14 days, as depicted in FIG. 17, dermal papilla cells were detected in the dermis (left panel) and HF stem cells in the epidermis (right panel), demonstrating that new follicles were being formed. After 17 days, the new follicles were more developed, as shown by examination of the dermis and epidermis (FIG. 18, left and right panels, respectively). This method induced formation of an average of 49 new follicles in the wound, a number that was consistent over three separate experiments, as depicted in Table 1.

TABLE 1 Results of three separate experiments performed on 21-day-old mice. Sample Expt 1 Expt 2 Expt 3 Avg of expts Std dev of expts 1 24 70 55 2 29 52 25 3 27 85 53 4 102 25 80 5 53 27 23 Average 47 51.8 47.2 48.67 2.71 Std dev 32.8 26.3 23.7

The findings of this Example demonstrate that EDIHN is capable of inducing formation of new HF in mice at the telogen stage of the hair cycle, despite that fact that these mice do not contain HF at the anagen stage during wounding.

Example 6 In Adult Mice, Induction of Anagen Increases the Efficiency of EDIHN

The experiment described in Example 5 was repeated with mice of different ages, and therefore at different stages of the hair cycle. To ensure that wound scarring occurred, larger wounds were in induced in the older mice. As depicted in Table 2, adult mice at telogen, such as 8-week-old mice, exhibited lower efficiencies of HF formation by EDIHN.

TABLE 2 Efficiency of HF formation by EDIHN in adult mice at various stages of the hair cycle. Wound Days after Mice exhibiting Age size wound EDIHN Hair cycle 3 wk 1 cm 20 25/25 (100%) Telogen 4 wk 1 cm 20 5/5 (100%) Early anagen 5 wk 1 cm 20 1/2 (50%) Anagen 8 wk 1.5 cm 30 16/35 (46%) Telogen 14 wk 1.5 cm 30 1/2 (50%) N/A* 20 wk 1.5 cm 30 2/2 (100%) N/A* *The second telogen lasts approximately 40 days in mice. Thus, 14-week-old and 20- week-old mice contained a mixture of telogen and anagen HF.

To determine whether experimental induction of anagen increased the efficiency of EDIHN, 8-week-old mice were depilated several days prior to wound induction. As depicted in FIG. 19, the wounds closed similarly whether or not they were preceded by depilation. As depicted in FIG. 20A-B, the depilated mice exhibited enhanced EDIHN relative to the non-depilated mice depicted in the previous Example by a factor of 11-fold.

The findings of this Example demonstrate that anagen induction enhances EDIHN. In addition, these findings show that EDIHN is capable of not only forming new HF, but also of activating anagen in pre-existing HF in the telogen stage.

Example 7 EDIHN-Induces New Hair Follicles in Human Skin Materials and Experimental Methods Grafting

Discarded human adult scalp from the preauricular area obtained from plastic surgery was grafted onto immunodeficient (scid) mice. The graft was bandaged and allowed to heal, then was used in the wound healing study 3 months after grafting.

Results

To determine whether human skin responded to EDIHN as did mouse skin, human skin was grafted onto SCID (immuno-deficient) mice and subjected to depilation by plucking and wound induction three days later. Seven days following wound induction, formation of new HF was observed in the human skin (FIG. 21A; arrows indicate new HF) by hematoxylin and eosin staining of paraffin embedded tissue sections.

In additional experiments, adult human skin was grafted onto mice, abraded, and examined at 7 days post-abrasion. New HF were generated in the human skin, which mimicked normal hair follicle formation during fetal development, as evidenced by staining for S100A6 or S100A4 (FIG. 21B).

The results of this Example show that EDIHN can be used to generate hair growth in human skin as for mouse skin.

Example 8 Molecular Pathways Activated During HF Stem Cell Activation Materials and Experimental Methods Isolation and Activation of HF Stem Cells

K15-eGFP mice were depliated in order to induce formation of new HF. Activated hair follicle stem cells were isolated from K15-eGFP mice using fluorescence-activated cell sorting (FACS) two days after depilation and 5 μg (micrograms) total RNA from the cell population was isolated, reverse-transcribed and hybridized to an Affymetrix (Santa Clara, Calif.) array MG_U74v2 chip. Scanned chip images were analyzed using Affymetrix Microarray Suite 5.0 and GeneSpring software (Silicon Genetics) to detect fold-change differences between activated HF stem cells (HFSCs) and non-activated (telogen) HFSCs. Values were normalized before computing fold-changes and differences between non-activated “bs-line” and activated (“expt”) samples.

Results

To identify molecular pathways up-regulated during HF stem cell activation, activated HF stem cells were isolated, and the gene expression patterns of the cells were analyzed to detect up-regulated transcripts. The transcripts depicted in Table 3 were up-regulated at least 2-fold in the activated HF stem cells relative to the cells prior to activation. In some cases, the sequence in Table 3 is a genomic sequence that contains the sequence of the transcript. Data pertaining to the up-regulation of the transcripts and further information about them is provided in FIG. 22.

TABLE 3 RNA transcripts up-regulated during HF stein cell activation. SEQ ID No: Access. # Sequence 1 AW047343 uuuuuuuuuuuuuuuuucuuaaaaauauaaauguauuugucugcaucaugacguucuucg ggcaccuagcuggccagaccacuggccaugggacaaggaggaagucagguguaagucugag caaggaacagucucugcccuggcaggguggagguggccucacagugucccaugcugggcc ugguagcgugaaagcacagcacgguagugggaacagcuccugccgcacagccaccaccuccu gccgcaacagggcguuuuccuucuccaggaaggcauccgcacagauauccgguucuccuu gagucuucuugcaucuc 2 AF053235 Sequence below. caguuccucagcauggccaccugcagccgccaguucaccuccuccagcuccaugaagggcuccuguggcaucggugguggc ucuagccgcauguccuccauccuggcuggaggauccugccgggcucccagcaccugcgggggcaugucaguuaccuccucu cacuucuccucugggggagucuguguauugggagguggacuaugguggggagcugggagcagcagcaguuuuggugaaggac uugguaguggauuugguggucgauuugauggauuugguggugguuuuggugcuggucuuggugguggucuuggcggu gguauuggugaugggcuccuggugggcagugagaaagugaccaugcagaaccucaaugaccgccuggccaccuaccuggac aagguugugcccuggaagaggccaacagauccuggaggugaagauccgggacuuguaccagaguagcggcccacugau aucaaagacuacagccccuacuucaagaccauugaggaccugaagagcaagaucauuauugccacccaggagaaugcacagu ucacuuugcagauugacaaugccaggcuggcagcugaugacuucaggaccaaguacgagaaugagcuguucuugcggcag uccguugagguugacaucaauggccugcuaaugugcuagaugagcugacccuguccagauugaccuggaaaugcagau ugaaaaccucagagaaggagcuggccuuccugaagaaggaaccaugaagagggagaugcuugcggugaggggucagacugggug gggacgucaauguggagauggacgcauccccgguguggaccucagccgcauucugaaugagaugagggaccaguaugag cagauggcagagaagaaccgcagagauguguggccuuguuccugagaaagacugaggagcuuucaaagaggugucacu aacauagaucuaauccaaagcaaccacaacgagguucugagcuccggcagggguguuccagggccugggagauugaacuacag ucccagcucagcaugaaagcauccuuggagaacagccuagaagagaccaaaggcagauacuguaugcagcugucccagaucc aggguuugaucagcaguguggaggagcagcuggcucagcuucgcugcgagauggagcagcagagccaggaguacaacauc uuguuggaugugaagacaaggcuggagcaggagaucgccaccuaccaccgucuacuggauggcgaguauauccacuccucc agcaagguucaaccagcuucagccagagccaaagucagaguuccagggacuaauguuuugccuagagccuccucacccacaa cugccucucaagcugagugcuggggggcaggacccuguuuucuuugcgcauuccccaucugucuccccuacccucucaugg ugguaggcuaauaaaccuuuuugguugaugcaaaaaaaaaaaaaaaaaa 3 M26005 gcgccaguccuccgauagacugagucgcccggguacccguauucucaauaaagccucuug cuguuugcauccgaaucguggucucgcugguccuugagagggucuccucagauugauuga cuacccacgucgggggucuuucauuuggaggccccagcgagauuuggagaccccugcccag guaccaccgaccccccgucuggagguaagcuugccagcggucguuucgugucugucucugu cuucgugcguguuugugccggcauuuaauguuugcgccugcgucuguacuaguuagcuaa cuagaucuguaucuggcgguuccgcggaagaacugacgaguucguauucccggccgcagcc ccugugagacgucccauggccucggggucccguuuuguggcccauucuguaucaguaacc acccaugucggacuuuuuggagcuccgccacuguacauggcuuuguugagggacgagagac agagacacuucccgcccccgucugaauuuuugcuuucggugggacgccgaaaccgcgccgc gcgucugauuuguuuguuguucuuuuguucuucguuaguuuucuucugucuuuaagugu uuuucgagaucaugggacagaccguaacuaccccucugaguuuaaccuugcagcacugggg agauguccagcgcauugcauccaaccagucuguggaugucaagaagaggcgcuggauuacc uucuguuccucugaauggccaacuuucaaugugugauggccucaggauuguacuuucaauu uaaguauuaucucucaaguuaagucuagaguguuuuguccugguccccacggacacccaga ucaggucccauauaucgucaccugggaggcacuugccuaugaccccccuccgugggucaaac cguuugugucuccuaaacuuccucccucgccgacagcucccguccucccgcccgguccuucu gcgcaaccuccgucccgaucugcccuuuacccugcccuuacccccucuauaaaguccaaacc uccuaagccccagguucucccugauagcggcggaccccucauugaccuucucacagaggacc ucccgccguacggagcacaaccuuccuccucugccagagagaacgauaaagaagaggcggcc accaccuccaugguuucccccccuucucccauggugucucgacugcagggaaggagagaccc ucccgcagcggacuccaucaucucccaggcauucccacuccgcauggggggagauggccagc uucaguacuggccguuuuccuccucugauuuaacccuuccuuuucugaagauccagc uugacggccuuga 4 AA681998 gacguagagccccuugcgcccgguuuccugaucccgcuuacuccucugcgcgccggcagga uggcccacaagcagaucuacuacucagacaaguacuucgaugagcacuacgaguaccugcau gucauguuacccagagaacucucuaaacaaguacccaaaacucaucugauguccgaagagga guggaggagacuugguguccaacagagucuaggauggguucauuacaugauucaugagcca gaaccgcauauucuucucuuuagacgaccucuuccaaaagaacaacaaaaaugaagugcagc ugggaucaucuaaucuuuuucaaauuuaauguauauguguauauaagguaguauucagug aauacuugaaaaguguacaaaccuuucauccauaccugugcaugcgcuguauucuucacagc aacagagcucagucaaaugcaacugcaaguagg 5 AF057156 auuaaaaaaccagcugcccaaugccuacacacaggaauccacaccaacagagaaccugcucuuc 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cuucugcuaaucauguuuaaaaguccagaaaugaucauaccauauuuuauuuucaagugug gaagucagcauggauagggucucugggauucucuaaaggguccugaaauuaaaggggacuggau guugagguaccuucucuuucaaugaaucacuaaauugucuuuucuguuucccaggaccca agugcuaucuaaccaugaguucccaccagcagaagcagcccugcacuguaccuccucagcug caccagcagcaggugaagcagccuugccagccaccaccccaggaaccuugugcccccaaaacc aaggaucccugccacccuguuccugagcccugcaaccccaaggggccagagcccugccaccc caaggcacccgagcccugccaccccaaggcaccugagcccugcaaccccaaggugccagagcc cugccagccuaaggugccagagcccugccagccuaaggugccagagcccugcaaccccaagg ugccagagcccugccaaccuaaggcaccagagccuugccaccccaaggcgccugagcccugc cacccuguuguucccgagcccugccccucaacugucacuccaucaccauaccagcagaagac aaagcagaaguaauauuguccagagccaugccugaagaccugaucaccagaugcugaggcug cugucuauccugcuuauuagucccaugggucccuugugcuaccaaugcugugaccuucagucuu aaucccucucuccuugcaccaccuaaaaaguugacucucauccucaucuucaagggcuccug agccucuuaacauugcccaaagucauauugaauggcuacacuuuucauggcucaggauuca ucuuaaggggguuaggagugagacaaguguauggucaauauuuuccccccauuaaaugcca uuuaacucc 6 A1845584 uuuuuuuuuuuuuuuuuagccaaaauaguuauuuauuaauaauuuaagguuuuacauucu uauaauaaauuccagcucaaaacgguacaccacgaacaucauggagcaaguuaauucucccu uccucucaaccuguugcauccaccaaaugggcgcucauacucgcacacauacacacacuucc aguuucguauuuuuuuuuaaaaggaaagaaaccaacccaaaguauugcauuugaggugaca cucccugaa 7 AA614971 aagauucccuuuggauuggauuggauugaucauguuuaacucagcguauuuuauggauga aagcuaaauacagauauuuggcaucucuaagguggaaugagcccacuccacacacugauaaa auucaugcauuuguuu 8 AV374591 aaccaaaugggaauggauuccccaacnuuncuguggguaccagccggguuucucuugcauug gaaacaaacaccuuuguaggcauuugcguauucgugaagagacuguuuuaugaaucaccuc uuauauuuaunuaauuaaccuaaguuguugaauuuucuguuucuccuuaagauaaauuaca aaaauaucaucauugaagcauaguuucuuguuuucuguugucaaauagguaauaaugugcugu gauguuuaugcuuauucauaaagauguuuuacuuuuuaguguaauguuaguucuuuuuaa cauuauuuugcuuaaauuugauaaugcccgacaagaauauauuuugcuuugauuuauacac uggauucuuuguggacaaauaugacccauaaaaaugccuuuuaauagacuaacuuaccuuuu guagcuagguacucauguucuuuuuuaaaagaugcccuuuggauuggauuggauugauca uguuuaacucagcguauggggauggaugaaagcuaaauacagauauuuggcaucucuaaggu guaaugagcccacuccacacacugauaaaauucaugcauaguggggaaaunacauuaauaaa cucauguugucuu 9 U04443 gaauucaaggaggcuuuccagcuguuugaccgaacaggugauggcaagauccuguacagcc aguguggggaugugaugcgggcccugggccagaacccuaccaacgccgaggugcucaaggu ucuaggaacccccaagagngaugagaugaaugugaagguacuggacuuugagcacuuccug cccaugcugcagaccguggcgaagaacaaggcccagggaaccuacgaggauuauguugaag gccuucguguguuugacaaggaaggaaauggcaccgucaugggugcugaaauccgucaugu ccuagucacacugggcgagaagaugacagaggaagaaguagagaugcuaguggcagggcau gaggacagcaaugguugcaucaacuaugaagcauuugugaggcauauccugucggggugac gggcccgauggggcggagcucguccggauggugcugaauggcugagacauucuguauccc gagucuguucccugcccagugugauuucuguguggcuccagacgcuccccugucacagcac cuugucccauuugguuucuuuggaugauguuugccuucaccaaauaaaauuugcucucuu 10 Y07836 caaccaccuccuaccugccugcccaaagcuccagggcuggagcacggagaccugucaggg caaccaccuccuaccugccugcccaaagcuccagggcuggagcacggagaccugucaggg auggauuuugcccacauguaccaaguguacaaguccaggcggggaauaaaacggagcgaa gacagcaaggaaacuuacaaacugccgcaccggcugauugagaaaangagacgugaccgg auuaacgagugcauugcccagcugaagcaucuccuacccgaacaucucaaacuuacuacu uugggucacggguggaaaaagcagugguucuggagcuuacguugaagcacgugaaagcauuga caaaucuaauugaucagcagcagcagaaaaucauugcccugcagagcgguuuacaagcuggu gaggggggucgggaagaaaucucgaggcagggcaagaaauguucugcucagguuuccagacuu gugcccgugagguacuucaguaccuggcgaagcaugagaacacucgggaccugaaaucuuc ccagcucgucacucaucuccaucguguggucucggagcugcugcaggguggugcuuccagg aaaccauuggacucggcucccaaagccgucgacuugaaagagaagcccagcuuccuagccaa gggaucagaaggcccagggaaaaacugugugccagucauccagcggacuuuugcucccucg gguggggagcagagcggcagugacacggacacagacaguggcuauggaggugaauuggaga aaggggacuugcgcagugaacagccguacuucaaaagcgaccauggacgcagguucgccgu gggagaacgugucagcacaauuaagcaagaauccgaagagccccccaccacaaagagccgaa ugcagcucucagaagaggaaggccacuucgcgggcagugaucugauggguuccccauuucu ugggccacacccacaucagccuccuuuuugccuucccuucuaucucaucccaccaucggcca cugccuaccugccuaugcuggagaaaugcugguaccccaccucugugccaguguauaccc aggccucaacaccucagcugcagcccucuccagcuucaugaacccagacaagauaccgacucc cuugcuucugccccagagacucccuucuccuuuggcacauucgucccuugacucuucggcc uugcuccaggcuuugaagcagaucccuccuuuaaacuuagaaaccaaagacuaaacucugga gggaucuccugcugccuugcuuucuuuccucccuaauuccaaaaaccacgaagguuucccu gagugcagagagaucagcccacccugcagacccacagagaagauucagagugugugugaga gugagugagugugcgugcgugcgugcuuguauguauguuuguauauguaggacaauaagu uccuucugacacaagggagacacgagaaggauagccugacaucagaugacagacuggaggac ucuaccacaucucucccccuuucccuacccaaauaauaacc 11 M21285 Sequence below. uugcaggcgagggcuuccacaacuaccaccacaccuuccccuucgacuacucugccagugaguaccgcuggcacaucaacuu caccacguucuucaucgacugcauggcugcccugggccuggcuuacgaccggaagaaaguuucuaaggcuacugucuuagc caggauuaagagaacuggagacgggagucacaagaguagcugagcuuugggcuucugaguuccuguuuucaaacguuucu ggcagagauuuaauauucuguugauuaacuaacaacuggauauugcuaucgggguguuaaugaugcauuuaaccuauucc gguacaguauucuuauaaaaugagaaagcuuugaucacguuuugagguaauaauuauuuauuuagcuaggauuaaccau gccacaagacauuauauauuucuaagcacacaugauaaaugcauauacaauuuugcacaacagcuuuaaauaauaacaauaa auuugaacauucuauacagagaggaucaaagccaaggaacaugcuguuuugaugcuagggugagcauggugcucaguccc uguuuguuugcaugguguccagcuuuguuucuuucucugucaucaccaccuucaggcaaauaguugaccaaccacuggccu gugucuguccacccuccaaagcccaggccaccuuucuguuuucugaaauacugauccuuccuccugaauacaucccuccuu guuccuagcuucaagacugcugccucaaauagggauagagcaaguccccgcugcagguugugcuagaugggauggagaaa uuaucuucauuugauacagagcaaguagauuugucucgagagaaaaguuagcaugcgugguaugauuuguaaguaaagaug gaagagagagagagagagagagagagagagagagagagagagagagagguagccauaucuaacagccuacuuaccaaagac cccaggccucucugcuuggcaugccuccuuucuguccauccucugaaccccagagauuagugagauuugaauaauuaaauc auuuucagagugaaggggguuaaugcagggucugugcuaggggaggguuuuagcuuuugguaucugaagauuuuuucau ggaaaaagucuucguguucaaugugccuagaacugauaauuaaacagcugacauuugucggggacagauauggugugaaac uaugaaaauauaagcaaaaucuucacuuggaacaugaaacuauuucacuuagaaaauaaucgaaggacccgagguguugcc uggguugccaguuuucuuucguggcugggcaggaacuagugaggugaggggcagugucuguaaguagcugcuaagaggu gcauuuccagaugaagcccuuggggaacaucugccagggauccgcaugguguuggcuccauccauugcuuuaguuuccuc cuuggauuguguagnaacuuggcuucccaugguuuugaaccuuccaugccuucuuugcuuuguggccucccugccugccu agugcugccuaggaagcucuuacccaccugauuuucugacauuucuuucuggccuggugggucuuucuccggacaug cagcuaguugccugaguguaucaagagcacccaggacgggucaacaaaccgcggcgagagccaggaaccaaggggaca uggaagagcuguguagcuucaggaagcagagccaggugccaccuuucuguggcuuccagauccucccuaccuccaacucau gugccucugucacagugauuucaggaaagcuugguagacccucuagcaacaucucgguucagaaagucucucugguuugu gaguuaacagcucagcuaagugcuguuuugucucagugaguuaaccacugaaugcgaggguugguuguugaucugucucg gugugugucggaguagacagcauaugcacuucucccugugcgcuuugcaagguaauguggcuuuggcugauccaugcagg cagguagugguacagugcugcugaaaggaagaaguuccccauuuuaucuguuaagcccgcgcccggaacaggaacaccg uggaccucacuucaggaagagggucugcuuccugaagccagugugugaugaaaagugacugagaccugauaucuaaggug agaccugauaccuaacacucugucacacaguccagggccaacagugcuauaggaaagucuagaagaaaacaucacaucagua uuuuagaaccaucaaccaucucuugucccuauagcccaauccagaggccugguuuuuagaacuggcuguguaaggugccaa acacucaguucacuuguagaaucagagccuuuuuuccccccuauguuaauugaacacgcgcucugagcuguuuuguugaa guagaaaaucucauagaaaaaucacuguagaucuacugaccuauagcccucuggaaaugccuuugagaugguuuuacuuuu cuaggucauagaugccugauuauaaagaugaacaauaaaaucagcuuucuuucuuucucuucugaucuuauuccccagauc ugauucaggccauguuccaaagcaaggcuacauugagguccuggugucuuuaagggaaggacaucuuucagauccucucaa agaaggauuuauaacaguuuccagaugaauguacuaauagcuuugggugccuuaucucuuuccuaaucugugugccugu gagcucagucucacuccuucccuuagcccggagaccccuuagaucgagugggaauagucaagaggcuggcuggagagucau caguacauugguugcagaaaucuuuuacaggcuacauuuuggaauuuuuuuuuuuuaguaagugaucaaauuuggug ggaaguaauucgaguguauucgauuguauugucguccucguuaucauugucaaacauguuauagacggcaguuggcacug gggcugcuaaucucuggguguagucucugaaacuguagcuccagugagguggugugaaagguuagcaaagccaccaucug cuggugcuccagccaaggugccucuagccacugaauugcuauguuauccuuucucuuguaacaaacccaccccagagaua aagccuuuaaucaacccaagaaacuccugggcuaaguaucugacagucucacaucucaacagugugaauuaaguguccaua gcaucagcucaggaggacacucugggagagugcugacaaaaaaggguuuuuaauacugaccuacuacuucaagggcaguuc ugaggugauuagagcuuuuuuuaaaaaccaaguauuuggggauccucagcagagguauucauacagacucccaaagaacua uauauguuccugagaccaucguuuagucuacauugcucuucccagagacugacagauaugaccagucaaagugcaagacua ccuacccacugcaugaaaaccauugcaggaaaccuuucccuuccugaaugagauuuuuuuuuucccuuuuuaugugggg uaauuauuugugacuaaguguaauuuggaugauuuccauuaauaucaacucuugaagccuacuuguacugauugagauu guauuuguuccuaauaaaaguggaucugguuguacuguc 12 V00756 accacuugcagacaaaugaauuccuucgaaauguauuugagguuggacccccugugaugcu unugcugcaacacuuaaaaccauguauauuucucguuuugaaaggcauuuauauaacucu gcagcuuucaaagcucgaacaaaagcucgaagcaaaugccgagauaagagagcagauguugg agaauucuuguagaugucugaauuugauggcuguuuucuaaucucuuccuuuauuauuau uuuugcuacuucuaauuuauauaagcuuuuagugacaguuuuuggaucuuggucaacuuaaa uaauuuuugauguaggggguggguuguauuuuaauuuaauguacaguguuacaaauuaaug aguucuuuauucucuguaaaaauaacugguaaccacaaauaaaguguuugugauguuuggu cgu 13 Y14296 auguccgcggccgccuacauagacuucauggcugcccagugucugguuuccaucuccaacc gcgccgccgugccggagcacgggggcgcuccggaagccgagcggcugcgacuaccugagcg cgaggugaccaaggaacacguugacccgggggacaccuggaaggauuauugcacgcugguc acuaucgccaagagcuuguugggaccucaacaaauaccgacccauccagacccccucuugug cagcgacagucuggagagucccgaugaggauauaggauccgacagcgacgugaccaccgaau cuggucgaguccuucccacagcccggaugagagacaguauucuggcagcgcgcccagccca cucucccuccuccacucuagaguagcuucgaaggauaaacacggccuccaaaaaaaggcacaa gugccccuacaguggcugugggaaagucuauggaaaauuccucccaucuuaaagcccauuaca gagugcauacaggugaacggcccuuucccugcacguggccagacugccuuaaaaaguucuc gcgcucggaugagcugacccgccacuaccggacccacacuggggaaaagcaguuccgggggcc cacugugugagaagagauucaugaggagugaccaucucaccaagcaugcccggcgucacacc guguuccaucccagcaugaucaagagaucaaaaaaggcucuugccugccccuugugaggug cuccccaugucagccaggcagagauggguccccggaaggacagaucucccaggaaacagacu gacacauggggaaaucugccacagcagaggcacgcuggccacagggagggucacugcuucuuugg ccaauauucugauaucucccugcacuguuuccaaaaagcacaugguagcccuaaggucaaag ucaacaugggugguccccuugcagagucaacucugaaccgucucugacugaagauucagacug gugguuuuacauacgucuuacugauugagguugaccccuauccucccacaaugcagaaccacu cucuugaaucacauuaacuuuugagagguaaaaaaaacccaaacccaacccguucaaaacucca gauacaccgaaacucuggauccucuaugcugggcugacucucagaauuguuuuuucuucuca uuaugcaagcuaggagcacaccuacuccaacaugauuugucaucuaaagacuuggaaaacaaa acaacaacaacauaaaguuacuuauagucaauggauaagcagaguccgaauuuaca aagacagaccuucgaggggucacgauaaguccggaacuuucaaaccuugcuucguaugaau uguacuaucuggaacauaaacuacacuuuuauuguucuaauaccgagauugaauacgguaaau acaugcuuugaggguagaauccgacggucuguuuggcaccacguuauaaucugcuuuuu uaacgaguaccaccuuggagggcaggcaaauaaaugcuuuuggguauuuucuccuuugugg uugacaaauacugcggauggggggaucaggaucggaggggagugcuggggaaagauaauaaaa aaugagguaaauaauuuuaacuuaugaauuuguuugaauuc 14 X16490 gagauugaaacaauggaagaacuuuccaucacaaacaccauguuuacccucaaucuccuu gagauugaaacaauggaagaacuuuccauggcaaacaccaugugggcccucaaucuccuu aagcagauagaaaaaucaaacucuacccagaacaucuuuaucucuccauggagcaucuca ucaacauuggccauaguucuccucggugcuggggguaacacugaacagcagauggccaaa gugcugcaguuuaaugaaauuggcaguuaugguaucaccacaagaaacccagagaacuuc aguggcugugauuucgcacaacagauacagaaggaaaauuauccuagugcuauuuuacagg cacaagcaggagauaaaauccauucagccuucuccucucucagcucaacaaucaacaca ccacagggggauuauuuguuagaaagugcaaacaagcuguuuggagagaagucugcaagau ucaaagaagaauacauccaacucucuaagaaauauuacucaacagaaccagaagcagug gacuuccuugaaugugcugaagaagcuagggaaaagauuaauucuugggucaagacucaaa ccaaaggugaaaucccaaaccugcuacccgaagguucuguagaugaagacaccaagauggug cuggugaaugcugucuacuucaaaggaaaguggaaaacuccauuugagaagaaacuuaaug ggcuuuauccuuuccgugugaacucgcaugagagcauaccuguccagaugauguuccucca ugcaaagcugaacauuggauacauaaaggaccugaagacucagauccuagaacuuccgcaua cuggaaacaucagcaugcuccuguugcuucccgaugagauugaggacgcauccacuggcuu ggaauugcuggaaagugaaauaaacuuugccaacuucaacaaguggaucagcaaagacacac uggaugaagaugauguuguggucuacauucccaaguucauacuggcacaaagcuacgaacu caaguccauucuucaaagcaugggcauggaggaugccuucaacaagggcaaggccaacuucu caggaaugucugagaggaaugaccuuuuucuuucugagguguuccaucaagccagcgugga ugucaccgaggagggcacuguggcagcuggugggacuggggcaguuaugacaggaagaacu ggccaugguggcccacaguuuguggccgaucaucccuuucuuuucuuuaucauggacaaaa uuacccacacgauacuauuugaugguagauucuccucacccuaaaaggggaagaccuauuu ccacaugagguuuuguagcaugaacuauaagccucagaauugcaucuucaagugccaaaag uuuaaauacuuucuuacacauuuuuauacuucugcuauacacuaaauauaaccuaaaagcaa uuguauagcagucuucagugcuuacaguauaacucuauuaaugauuuuguuuccuaaaguc agaugaugucuauuuaguucauccuuauuacugcuuugucuuuauaacuuuaguuuuuac aguguuauuuauuguuuauauaaugguuguuuuacuaauuguuguccucuguuaaugaa acuguaacacuacagaagcagaaaauuagauaauuucuauuuaaagaaaaucagccauuua auuuaauaaugaaggaaaaauaugagucuuccauacuuucccaugauauucacccagaaaaa auguacuuaacaaaagacauguuauaucucuaucauuauauaucauauguacguaucugca acucaucuauaauuaggacuacaucauaaguaagcaugcuuacuuacacacugcuaucuguu guauaaaacuuagcaauccuuauuuguuaguuaucuuucuaucacuguaacaaaauaccug auauaauaaaguucaaagauuuauuuugaaaaaaaaaaaa 15 AW120868 uunuuuuuuunuuuuuuuaagaauuaacuunuauunuugcuuaguuuuauuaaaaaaauua auaugucauaaagcuuuuguuuccuuuagggagaaaaaaaaggaacaaguuccauaaaauca aacaagcaaugguaacaugucuuaacuugaaaacaacuggggucacugguuuacaaguuau aacugaaugaaugacugccacaguugcccauuuccuccugccaauggcagcaaacaacagga ucaacuagggcaaaauaaauaauuguguggaagcccuga 16 C78850 aacuaaacuuccuuguaacuuuugagaacucagcucugguacuuuuucaugccuugcaaaa uggcguuanugcagcuagcuugcuaanccuuaugguggggucuuucauuccccccucuuu cuggaaacuguauaaaaucauuuuucacgugauucuauuucuucuggaucuauugauuug aguugguuauacuguugggucanaaccagggccuguu 17 D67076 Sequence below. gcagcuccgagcuaggugcuaucgcaagcccagagcgcacagcccggcggagagagcagauccuugcucagaucgagucaa aucgggccaaggcggaggacgaagaguccaggcuccuauucuggacuuguuccccagcuccgggggcgcuucuagguccu gcagcagccagcagugcguagccaccaacucggugcuggaaugaaaaaauucccgcgcgccagugcagaaucuuucuaagu gacccggagcuucgggugcuagcucugcacgaacuuucccaucaaagugaucgugaauuuuaagcaucaggagcaggccag cgaagcucuacgcgucuaaacgucuauccagaccaagaguucucugcggugcagggugcggugccaugcagccaaaagucc cuuuuggggucacgcaagcagaagcccugcuccgacaugggggacguccagcgggcagcgagaucucggggcucucuguc cgcacacaugcuguugcugcuccucgcuuccauaacaaugcugcuaugugcgcggggcgcacacgggcgccccacggagga agaugaggagcugguccugcccucgcuggagcgcgccccgggccacgauuccaccaccacacgccuucgucuggacgccuu uggccagcagcuacaucugaaguugcagccggacagcgguuucuuggcgccuggcuucacccugcagacuguggggcgca gucccggguccgaggcacaacaucuggaccccaccggggaccuggcucacugcuucuacucuggcacggugaacggugauc ccggcucugccgcagcccucagccucugugaaggugugcguggugccuucuaccuacaaggagaggaguucuucauucag ccagcgccuggaguggccaccgagcgccuggccccugccgugcccgaggaggagucauccgcacggccgcaguuccacauc cugaggcgaaggcggcggggcaguggcggcgccaagugcggcgucauggacgacgagacccugccaaccagcgacucgcga cccgagagccagaacacccggaaccaguggccugugcgggaccccacgccucaggacgcgggaaagccaucaggaccaggaa gcauaaggaagaagcgauuuguguccagcccccguuauguggaaaccaugcucguagcugaccaguccauggccgacuucc acggcagcggucuaaagcauuaccuucuaacccuguucucgguggcagccagguuuuacaagcaucccagcauuaggaauu caauuagccuggugguggugaagaucuuggucauauacgaggagcagaagggaccagaaguuaccuccaaugcagcucuca cccuucggaauuucugcagcuggcagaaacaucacaacagccccagugaccgggauccagagcacuaugacacugcaauucu guucaccagacaggauuuauguggcucccacacgugugacacucucggaauggcagauguuggaaccguaugugaccccag caggagcugcucagucauagaagaugaugguugcaagccgccuucaccacagcccaugaauugggccauguguuuaacau gccgcacgaugaugcuaagcacugugccagcuugaauggugugaguggcgauucucaucugauggccucgaugcucucca gcuuagaccauagccagcccuggucaccuugcagugccuacauggucacguccuuccaagauaauggacacggggaauguu ugauggacaagccccagaauccaaucaagcucccuucugaucucccgguaccuuguacgaugccaaccgccagugucagu uuacauucggagaggaauccaagcacugcccugaugcagccagcacauguacuacccuguggugcacuggcaccuccggug gcuuacuggugugccaaacaaaacacuucccuugggcagauggcaccagcuguggagaagggaaguggugugucaguggc aagugcgugaacaagacagacaugaagcauuuugcuacuccuguucauggaagcuggggaccauggggaccguggggaga cugcucaagaaccuguggugguggaguucaauacacaaugagagaaugugacaacccagucccaaagaacggagggaagua cugugaaggcaaacgaguccgcuacagguccuguaacaucgaggacuguccagacaauaacggaaaaacguucagagagga gcagugcgaggcgcacaaugaguuuuccaaagcuucuuugggaaugagcccacuguagaguggacacccaaguacgccgg cgucucgccaaaggacaggugcaagcucaccugugaagccaaaggcauuggcuacuuuucgucuuacagcccaagguugu agauggcacucccuguaguccagacucuaccucugucugugugcaagggcagugugugaaagcuggcugugaucgcauca uagacuccaaaaagaaguuugauaaguguggcguuuguggaggaaacgguuccacaugcaagaagaugucaggaauaguca cuaguacaagaccuggguaucaugacauugucacaauuccugcuggagccaccaacauugaagugaaacaucggaaucaaa ggggguccagaaacaauggcagcuuucuggcuauuagagccgcugaugguaccuauauucugaauggaaacuucacucug uccacacuagagcaagaccucaccuacaaagguacugucuuaagguacagugguuccucggcugcgcuggaaagaauccgc agcuuuaguccacucaaagaacccuuaaccauccagguucuuaugguaggccaugcucuccgacccaaaauuaaauucaccu acuuuaugaagaagaagacagagucauucaacgccauucccacauuuucugagugggugauugaagaguggggggagugc uccaagacaugcggcucagguuggcagagaagaguagugcagugcagagacauuaacggacacccugcuuccgaaugugca auggaugugaagccagccaguaccagaccuugugcagaccuuccuugcccacacuggcaggugggggauuggucaccaugu uccaaaacuugcgggaaggguuacaagaagagaaccuugaaaugugugucccacgaugggggcguguuaucaaaugagagc ugugauccuuugaagaagccaaagcauuacauugacuuuugcacacugacacagugcaguuaagaggcguagaggacaag guagcguggggaggggugauacacugagugcaagaguacuggagggauccagugagucaaaccaguaagcagugaggug uggcaaggagguguguguaggggauacauagcaaaggagguagaucaggacacuacccugccaguuacauucugauaagg uaguuaaugaggcacaguagcaucugaaagaccauacagagcacuaaggagccccaaagcacuauuaguaucucuuuucuu auaucuaucgcccaaauaauuuucagagucuggcagaagcccuguugcacuguacuaacuagauacuucuuaucacaauga uugggaaaggcaaagcagaaagaugguaagacuggguuucaaacaaggcuugguuucaaucacuggaggcaaggaggagg 18 M61007 ccgcgggcccgcguucaugcaccgccugcuggccugggacgcagcaugccucccgccgcc ccgcgggcccgcguucaugcaccgccugcuggccugggacgcagcaugccucccgccgcc gcccgccgccuuuagacccauggaaguggccaacuucuacuacgagcccgacugccuggc cuacggggccaaggcggcccgcgccgcgccgcgcgcccccgccgccgagccggccauugg cgagcacgagcgcgccaucgacuucagccccuaccuggagccgcucgcgcccgccgcgga cunucgccgcgcccgcgcccgcgcaccacgacuuccucuccgaccucuucgccgacgacua cggcgccaagccgagcaaagccggccgacuacgguuacgugagccucggccgcgcggg cgccaaggccgcgccgcccgccugcuuuccgccgccgccucccgccgcgcucaaggcgga gccgggcuucgaacccgcggacugcaagcgcgcggacgacgcgcccgccauggcggccgg uuucccguucgcccugcgcgccuaccugggcuaccaggcgacgccgagcggcagcagcgg cagccuguccacgucgucgucguccagcccgcccggcacgccgagccccgccgacgccaa ggccgcgcccgccgccugcuucgcggggccgccggccgcgcccgccaaggccaaggccaa gaagacgguggacaagcugagcgacgaguacaagaugcggcgcgagcgcaacaacaucgc ggugcgcaagagccgcgacaaggccaagaugcgcaaccuggagacgcagcacaaggugcu ggagcugacggcggagaacgagcggcugcagaagaagguggagcagcugucgcgagagcu cagcacccugcggaacuuguucaagcagcugcccgagccgcugcuggccucggcgggcca cugcuagcgcggcgcgguggcguggggggcgccgcggccaccgugcgcccugccccgcgc gcuccggccccgcgcgcgcgcccggaccaccgugcgugcccugcgcgcaccugcaccugc accgaggggacaccgcgggcacaccgcgggcacgcgcggcgcacgcaccugcacagcgca ccggguuucgggacuugaugcaauccggaucaaacguggcugagcgcguguggacacggg acuacgcaacacacguguaacugucuagccgggcccugaguaaucaccuuaaagauguuc cucgggguuguugauguuuuugguuuuguuuuuguuuuuuguuuuguuuuguuuuuu uuuuuggucuuauuauuuuuuuuguauuauauaaaaaaguucuauuucuaugagaaaaga gg cguauguauauuuugagaaccuuuuccguuucgagcauuaaagugaagacauuuuaauaa acuuuuuuuuauaauuuuaaauccaaaaaaaaaa 19 C85523 aaaauguagaaggcaagauuuaauaaggcagcaacaugaaagcacacagaccagagcucu ggggucgaaauaaagcagcaacauggaagcacacagagcucuggggucgaaacucauaca ccuuagcacaggguagaggagucucgacggucauccagaauuuuucacaggcuuauauag uaaaacucaaagggggagaacugggcagggaaaguacaaguuuacancacuagggaguuc ugccaaaggacaauggguucuuucagaggaaucuacguaacuaaggugucauguccuauc aagguaucuacguaacuaaggagucauguccuaucauuuggcaauguacccgguucuuuu gagguuguuccggagggucaauucucaaaauguuuuucagauuggaagggguggguguc cgguaaaaaguucuguuuucaaagaggcnguaauuuucuauucuucauuccccauucucc uguaaguauucnnaucuuagaauuucagaaguccauauucncuauguggggaauaacugg cuuuaacccnaucuuuaaaauggggg 20 AW122030 uuuuuuuuuuuuuuuaugaaacaguuuuguucngcccaugacugugcaugacuguc guccguucuagucaccugugcucuccaucuacugccuuuuaaagcugcgucaugagaagg aucuacacguuccaccaugacucucguuucuugccacaaguagaagaaaugguugauucu uggcuuuucgguuaggccguuaaacaaaacucagucacaccccugccuuccacccucaaa cugugaucacguggcuguucuuguaguunaaccagggcaacacuauauauuccaggucua uacauucuaggucuuuuucuguuuuguucauuauaguguuuucaaccucguuccg 21 1557524 Sequence below. gcggccgcggcuccagaccccggccuugcgcacccuccccccaccuccagcccgcgccucccccccccccacgcauggcucac caccccucggguuucccugucaucccucagguuccugcacuuggcaaucauccacgaagagaagccgcugaccauggaagu cauuggucaggugaagggagaccuggccuuccucaacuuccagaacaaccugcagcaggugcgcugcuugcuugccccgcg gugccccucuuugaccccuugguggagucagauguggcacggucgcccccaaagcguuucuaaauuaauagucacuuaguu cuuaucugccuuggcuuuuuugcauucaaaucagccaacgucuuagaaccagaagaaaaaucccuugguuuuagugagguc uuuaugacccaccuagggccuccuguuugccugaucuccuaagagacuaaugggaggaucagauuccauagcgggaggug ucugggguucaggaaacucaagacuauggguuugcuccauggcuuaucccuucuguuccucuuuccauuugagacucc acuccacuuggcugugaucaccaaccagccaggaaugcugaggcacuucugaaagcuggcugugauccugagcuccgaga cuucgaggaaauaccccucuacaucuugccugugagcagggcugccuggccaguguagcagucuugacgcagaccugcac accccagcaucuccacuccguccugcaggccaccaacuacaaugguaggucugccaguccauccaaggaugcagaggaggga gagagauggggccacuugagucuuaaacuccgaacguauacaaaguucagacacugugaucuuuuuuaaaaaguuuucuccu cgaugccuauaugauauucacucagaacccagauucugaguucuucaaaacugaugaugugggugguuguccucaagacaa uagacaugaguugugugaggauugaaacacguaguacaguuuuugucuccuccuccaggccacacgugucugcaccuag ccucuacucacggcuaccuggccaucguggagcacuuggugacuuugggugcugaugucaacgcucaggugaguacaucu cccuuccaccuaaucucuguugggcuggcucugauggugagcagguuuccagaugcagccguaaacuaacgccugauugc uuuugguuucaggagcccugcaauggccggacagcccuccaccuugcgguggaccugcagaauccugaccugguuucgcu cuuguugaaauguggggcugaugucaacaggguaaccuaccaaggcuacucccccuaccagcuuaccuggggccgcccaag uacccggauacagcagcagcugggccagcugacccuggaaaaucuccagaugcuacccgagagcgaggaugaggagagcua ugacacggagucagaauucacagaggaugaggugaguguuccuccccucagcacgcugacggcuguucuagggcugcuuu ggaucagagggauuucagggguuuaacuucucagacucggcuugcaaagcaggaucccaagaauugucucugguuuguu uuaagagcuuacccuuuugguugaggaaugagggaauucuagaaauugaacccaggcuuagcacauggugauaagcacac guuaccauuaagcuccacccccucaauagcuuagacuuuuuuuuuuuuuaaggaaagaauagguaagggaaacuccuac agccuggugcccuuguucuauuuggguuaaggagaaaaagagcccaagaauaggaguuauuucagcagcagcucuccccuu aucccauugucuuggugaaguucuaggaauuuauaugucuuuuuccccucucuuguuuuagcugcccuaugaugacugu guguuuggaggccagcgucugacuuauaaguggaaaguggcaaaaaagaauguggacuuguauauuuguacaaauagag uuuuauuuuucuaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaguauacuuagcaccacaccacacagcgccuagaccc aggcauuuuacuggggugaucggcuguugucuugugaaauccgggg 22 U05809 cucucggucacugccggucgcuuccugagccgcugcuggcucugugucucuguccucagc guucucuuccucguccucguccuaccacgccauggaagguuaccauaagccagaucagca gaagcuccaggcccugaaggacacagccaaucgccugcgcaucagcuccauccaggccac caccgcggcaggcucaggccaccccacaucaugcugcagcgcugccgagaucauggcugu ccuguuuuuccauaccaugcgcuacaaggcccuggauccccgaaacccucacaaugaucg cuuugugcucucuaagggccaugcagcuccauuuuauaugcagucugggcugaagcugg cuuccugcccgaggccgagcugcugaaccugaggaagaucagcucugacuuggacgggca uccugucccgaaacaagccuucaccgauguggccacuggcucccugggccagggccuggg agcugcuugcgggauggcauacacaggcaaauacuugggacaaagccagcuaccgagucua uugcaugcugggagacggggaggucuccgagggcuccgucugggaggccauggccuuugc uggaauuuucaagcuggacaaccucguugccauuuuugacaucaaccgccugggccagag cgacccagccccgcugcagcaccagguggacaucuaccagaagcgcugugaggccuuugg cuggcacaccaucaucguggacggacacagcguggaggagcugugcaaggccuuugguca ggccaagcaccaaccaacagccaucaucgccaagaccuucaagggccgagggaucacagg gauugaagacaaggaggcguggcacgggaagccccuccccaaaaacauggccgagcagau uauccaggagauuuacagccagguucagagcaaaaagaagauccuggccacgcccccuca ggaggaugccccauccguggacauugcuaacauccgaaugccuacgccacccagcuacaa agugggggacaagauagccacccggaaggccuauggacuggcccucgcuaagcugggcca cgccagugaccguaucauugcccuggauggagacaccaagaauuccaccuucucggagcu cuucaaaaaggagcacccagaccgguucauugagugcuacauugccgagcaaaacauggu gagcauugccgugggcugugccacacgugaccggacagugcccuucugcaguacuuucgc ggccuucuucacacgggccuucgaccagauucgcauggccgccaucucugagagcaacau caaccucuguggcucccacugugguguguccauuggggaagacgggcccucucagauggc ccucgaagaccuggccauguuccggucaguccccauguccaccgucuuuuacccaagcga uggaguugcaacagagaaggcaguggaguuagcagccaacacaaagggcauuugcuucau ccggaccagccgcccagagaaugccauuauuuauagcaacaaugaggauuuccaggucgg ccaagccaaggugguccugaagagcaaggaugaccaagugacagugaucggggcuggugu aacucugcaugaggccuuggcugcugcagagagucuaaagaaagauaagaucagcauccg ggugcuggaucccuucacuaucaagccccuggacaggaaacucauccuagacucugcccg agcaaccaaaggcaggauccucaccguggaggaccacnacuacgaagguggcauaggaga ggcagugucugcugccguagugggugaaccuggagugacggucacucgccuggcugucag ccaaguaccacgaaguggcaagccagcugagcuacugaagauguucgguauugacaagga cgccauugugcaagcugugaaaggccuugucaccaagggcuagggagggcaugggaugcu gggugggugaacuacacauuccagggagguucuggcagagguggcgaagguguacugagu ggggagguaaauauauguuuug 23 AW212475 uuacggugucauaaauaaguaauauaacuuuauuaaaaugaaaagacaauauucaaaau aaugcaacaaaaugaauaaauccuuuguccaauacuguacacacagugcggagaucagug cauuuucuaaagcauguuuuaaccuucauuuaguucauacuaaaguaagcuuuaaauag cucaaauaauuucauucagcaguuuaaacugaacagcuuuuuacau 24 V00835 uguguucucguaaucuccagagcagcguuaggccguauuaucggggaaagcacuauaggg acaugauguuccacacgucacaugggucguccuauccgagccagucgugccaaaggggcg gucccgcugugcacacuggcgcuccagggagcucugcacuccgcccgaaaagugcgcucg gcucugccaggacgcggggcgcgugacuaugcgugggcuggagcaaccgccugcugggug caaacccuugcgcccggacucguccaacgacuuaaagagggcaggcuguccucuaagc gucaccacgacuucaacguccugaguaccuucuccucacuuacuccguagcuccagcuuc accagaucucggaauggaccccaacugcuccugcuccaccgguaagacucccgauccuug gcuuuagaauaccaaguugggaccgcagagcggaauccccgaguuguagaggcuuggcg ggaauaggcaccuuuaguuggcgauucauuccgguucuuucuagaauccgcucuugcaaa agccuucauuaguuacgaguauuggaacggguccuuuggcgggguuggggcuaggauu uagacgcgcaaauguccgguuccugaucacccaguuaguggggacaucuggguugagucc caggcauuacuaaacuuacugugaauugcuugaauuaagaaagaggugaaggaccuuuau gucuugggacucaaagacauaaucccugacuuaaccugugaggagaaaaguggggcuagg cucccugcagcuccgaggaggacggagugaacugagccgggacucgugguguuggccacu gcuguaaugcugccucccucaugcugucuucuuucuccucccaggcggcuccugcacuug caccagcuccugcgccugcaagaacugcaagugcaccuccugcaagaagagugaguuggg acaccuuggguggcggcuaaggcuaggggcggggaacuccuacaaaacuggcucugagaa auguccggggcuucccggaggccauuguauugucucggggacagaacuauacagagaacu auaaaaaaaccgaggucuucucuguuggggacaggaagcagaggucuucagccaggcu gccucuuccuccuucuucuaggcugcugcuccugcugucccgugggcugcuccaaaugug cccagggcugugucugcaaaggcgccgcggacaagugcacgugcugugccugaugugacg aacagcgcugccaccacguguaaaguaucggaccaacccagcgucuuccuauacaguu ccacccuguuuacuaaacccccguuuucuaccgaguacguuaauaauaaaagccuguuug agucuaacucugguuucuuggugugguuuggcaauaagaaacuggggugacuugauaguc uggggaucugguuuuggacccccucgugccuuuaccuccgcccucuggcccucacagagg gguaaugucuuuggguaaagccaagcuauaucccauaagcuuccucauggaaaacagcug 25 AV374868 gcggcacgaguguccggguggcuuuuuuuuuuuuguuugaauaauguuuacaauuu cccucaaucacuuauagaaauccaccuccaggccccccccuuccccacuaggccuu cgaggcugucugaagaugcuugagaaacucaaccaaaucccaguucaauucagacuuugc acauauauuuauauuuanaaucagaaaagaaacauuucaguaauuuauaauaaaagagca cuauuuuuuaacg 26 M21285 See above (same Accession Number). 27 U74683 acugccaucgagugguguuccaguugaacuugcucucucugccaucugcuccgcgggcgc cgucagcaugggucccuggacccacuccuugcgcgccguccugcugcuggugcuuuggg agucugcaccgugcgcuccgacacuccugccaacugcaccuacccugaucugcugggcac cuggguguuccaggugggcccuagaaguucccgaagcgacauuaacugcucggugaugga agcaacagaagaaaagguagugguacaccuuaagaaguuggauacugccuacgacgagcu gggcaauuccgggcauuuuacccucauuuacaaccaaggcuucgagauuguguugaauga cuacaaaugguuugcguuuuucaaguaugaagucagaggccacacagcuaucaguuacug ccaugagaccaugacuggguggguccaugaugugcugggccggaacugggcuugcuuugu uggcaagaagguggaaagucacauugagaagguuaauaugaaugcagcacaucuuggagg ucuccaggaaagauauucugaaagacucuacacucacaaccacaacuuugugaaggccau caauaccguucagaagucuuggacugcaacugcauauaaggaauaugagaaaaugagccu gcgagaucugauaaggagaaguggccacagccaaaggaucccaaggcccaaaccugcccc gaugacugaugaaauacagcaacaaauuuuaaauuugccagaaucuugggacuggagaaa cguccaaggcgucaauuauguuagcccuguucgaaaccaagaaucuuguggaagcugcua cucauuugccucuauggguaugcuagaagcaagaauucguauauuaaccaacaauucuca gacaccaauccugaguccucaggagguuguaucuugcagccccuaugcccaagguuguga ugguggauucccauaccucagcagggaaguaugcccaagauuuuggggugguggaaga aagcugcuuucccuacacagccaaagauucuccaugcaaaccaagggagaauugccuccg uuacuauucuucugacuacuacuauguggguggucuaugguggcugcaaugaagcccu gaugaagcuugagcuggucaaacauggacccauggcaguugccuuugaaguccacgauga cuuccuacacuaccacaguggaaucuaucaccacacugggcugagugacccuuucaaccc cuucgagcugacaaaucaugcuguugcuugugggcuauggaagagauccaguuacugg gauagaauacuggauuauaaagaacagcuggggcucuaacuggggggagaguggcuacuu ccguauccgcagaggaacugaugaaugugcaauugagaguauagccguggcggccauacc gauuccuaaauuauaggacauagcucccaguguuacauacgggucuuuaucacucacaga gugauagucacaugcugaagacuuuuucagagcaauaucagaagcuuaccacuaagca ucuuuaaagaauugucuuugaacuuaaaaccauccuugauuugguuucuuuuaauaucu uccccaucaacuacugaacuacuuuucuuuaaagacuugguuaaguaauacuuuuau gagcagugguucaguuguccaauaugggguugcaggucaucuacaaugcaaccagauguuu caguucuaaaaaucuauguaaaaguacaagcucguuuuuaaauuauguaagucacaugaa aacauggcaaaaaaauuaguuaaauuuuuuacaaagaguuuuaaauaaauguuuauguaa ucaguaccauagucuuucuauguguguacaugaauuuuugucaccuacuucuucccuu agaagcauuuaugcuccauggacguacuucuuuauggagaaaaaaaaaa 28 X61800 gagcucgaucccuguuccgccuuugcuaugucugaaggcguuccugcuuugcgcgugucgg ggccaaauccagauuuucauuucgcuccaggcuuggacggcuaaguagguccaaaccgca caaacaggaaggagggaaggcaaggagugcgggcagagggcgggucguucccagcagcac cccagucccuccccgcuccgucuccgacccacuggggccggggcgggcgugcgcgucagc uggggcuagaaaaggcggcgguccggcccggcgaggugacagccaacuuggacgccaggu ccggccgacgccgccaugagcgccgcgcuuuucagccuggacagcccggugcgcggcaca cccuggcccacagaacccgcggccuucuacgagccaggcaggguggacaagcccggccga gggcccgagccaggggaacugggggagcugggcuccacgacuccugccauguacgacgac gagagcgccaucgaccagcgccuacauugacuccauggccgccgugcccacccuagag cugugccacgacgaacucuucgccgaccucuucaacagcaaccacaaagcggccggcgcg ggcggccuggagcugcugcagggcggcccuacgcgacccccggguguggggucugucgcu agggggccgcucaagcgcgaacccgacuggggcgacggcgacgcgccgggcucccuccg ccggcgcaaguggcggugugcgcgcagacaguggugagcuuggcggccgcggcucagccc acuccacccacuucgccggagccuccucgaggcagcccggggccgagccucgcgcccggc acaguccgagaaaagggcgcgggcaagagggguccggaccgcggcagcccggaguaccgg cagcggcgcgagcgcaacaacaucgcugugcgcaagagccgcgacaaggccaagcgccgc aaccaggagaugcagcagaagcugguggagugucggccgagaacgagaagcugcaucag cgcguggagcagcucacccgggaccuggcuggccuccggcaguucuucaaaaaacugccc agcccgccuuuccngccgcccaccggcgccgacugccgguaacgcgcggcgugggccuuu gagacucugaacgaccuauaccucagaccccgacagcggggagcagacgccgcccgaauc gcuaguuucuuugggaccugcgagcgacaggaagcugcagcuugggcacuggacugcgag agaagcuauuaaucuuuccccuuaaauuauuuuuuauaaugguagcauuuucuacguc uuauuaccaugcagcuaagguacauguagaaaagacauuuccgacagacuuuuguag auaagaggaagagacugcgcaugcuuuuuauauucauuuuuacaguauuuguaugauuaa caauaacaauaaaaaaacauuuaaaucgcaaaaaaaaa 29 U20735 Sequence below. uugaggguggccaggccagcguaggaggccagcguaggauccugcugggagcggggaacugagggaagcgacgccgagaa caggcguaccacggagggagagaaaagcuccggaagcccagcagcgccuuuacgcacagcugcaacuggccgcugccga ccgucuccagcucccgaggacgcgcgaccggacaccggguccugccacagccgaggacagcucgccgcucgccgcagcgagc ccggggcggcccuucagggggaccuuucccagaucgcccaggccgcccggaugugcacgaaaauggaacagccuuucuauc acgacgacucuuacgcagcggcgggauacggucggagcccuggcagccugucucuacacgacuacaacuccugaaacccac cuuggcgcucauccuggcggaucccuaucggggucucaaggguccuggggcgcgggguccaggcccggagggcagugggg caggcagcuacuuuucgggucagggaucagacacaggcgcaucucugaagcuagccuccacggaacuggagcgcuugaucg uccccaacagcaacggcgugaucacgacgacgcccacgccuccgggacaguacuuuuacccccguggggguggcagcggug gagguacagggggcggcgucaccgaggagcaggagggcuuugcggacgguuuugucaaagcccuggacgaccugcacaag augaaccacgugacgccccccaacgugucccugggcgccagcggggguccccaggccggcccagggggcgucuaugcuggu ccggagccgccucccgucuacaccaaccucagcaguuacucuccagccucugcacccucuggaggcuccgggaccgccgugc ggacugggagcucauacccgacggccaccaucagcuccucccacaugcaccacccuuuguccuugaagaagggacuca ggguuugagucguggcgcuuccgccuuuaaugaggaaccgcagaccguaccggaggcacgcagccgcgacgccacgccgcc ugugucccccaucaacauggaagaccaggagcgcaucaaaguggagcgaaagcggcugcggaacaggcuggcggccaccaa ggccggaagcggaagcuggagcgcaucgcgcgccuggaggucaaggugaagacacucaaggcugagaacgcggggcuguc gagugcugccggucuccuaagggagcaaguggcgcagcucaagcagaaggucaugacccaugucagcaacggcugccaguu gcugcuaggggucaagggacacgccuucugagagccucccuugccccauacggacacccccagccuugaaggcugggcgcc ugccccccacuggggugaggggggcaggcgaugggcacccgccaaaaggccuggggcgcagcucacacacuggacuccggc ccgcccgccugcgcccaguccuuccaccucgagguuuacauggcccccuucagcguauuuuguauguuuuuuuuuucug caaagagacugaauucauauugaauauaauauauuuguguauuuaacaggagggagaagggggcugucgcggcggagcug gccgccgcagguacucagcugcggggauacuagggagggaccuccgcccccugcccucccccucugcauaguacugug gaagaaacacgacuucgugucuaaagucuauuuuaagauguguuuguguguguguguuugacuuuuuauugaaucuauu uaagua 30 U19118 Sequence below. gaauucggcacgagcagcgagacgccgcgcacggugcuuccccaguggagccaaucggcuaacccgcgcuccggcagaguc cuuggcgcucgcccgccggcgggacagaccacccgccucuggccgcucucuggacccuggccgccccgagcgaagacugga gcaaaaugaugcuucaacauccaggccaggucucugccucagaagucagugcgaccgccauuguccccugccucucaccucc ugggucacugguauuugaggauuuugcuaaccugacacccuugucaaggaagagcugagauucgccauccagaauaaaca ccucugccaucggauguccucugcgaggagucaguuaccgucaacaacagaccccuggagaugucagucaccaagucuga ggcggccccugaagaagaugagaggaaaaggaggcggcgagaaagaaauaaaauugcugcugccaagugucgaaacaagaa aaaggagaagacagagugccugcagaaagagucagagaaacuggagagugugaaugcugagcugaaggcccagauugagga gcugaagaaugagaaacagcaugauacaugcucaaccugcaccggcccaccuguaucguccgggcucagaauggacg gacaccggaagacgagaggaaccucuuuauccaacagauaaaagaaggaacauugcagagcuaagcagagguggcacggag gcaauuggggaguucuuacugaauccuccuuuccaccccacacccugaagccauuggaaaacuggcuuccugugcacuuc uagaaucccagcagccaagagccguuggggcaggagggccuguggugaccuacugcauugacccacucugcccccgaguga accguggagcaggcaggagcauccuuugucucaccaauuccaggauuuaggccuuaucaucccggccagucucagaugacc uagcuggccccaggcugggguccuaugcaaagcaggaucccacuaaugggauucaggcagaagugucuaccuugauaggu ggggugggaccacauccuccacuguggcgacaacgcccuuccaagggaauauggaaugagaacauucauuauugagguug uccaauggccaggguaugcuuucuagaaaauaugcuguucugucccagaaugacugugcauaggguauccguuucagagc cuggguugugcuauuuagauguuugucuugcacaacauuggcauggaacggaagacccacagagaccaggcaacgag gagagucuggggaucugccaugguggaaagugccccucaaaagcauuuguguggccacaugaacuggcuggcaccagggg agugaaacuggcugaugaccagcugagccacuuugugccaacagaggauggacgacaccuuucccuguacccacugcagag gaagaacccugggcacagcagcuuuguccuuggcuacacuguuacaacgucacacaaugauggcacaguccaacuuuc aaaggguguaggacuccauacucagugacagggcaggaagagccaaagauaaccacagccacagccuguggagaccagggu uggaagccaggugcagggccaggcaucugcauugugggauguuaauggcacuuuugucuuguagcuauuuugagaugug guccagagcauuucagcugggagaucuccccuggccaccaggacucuggcuacuguuaaaauccugauguuucugugga auccucaguguuuuaucccacucaauaguaucauuacaguuucuguaagagaaaauauuacuuauuuaucccaguauucc uagccugucaacauaauaaauaucggaacaaaaccuggua 31 AW049031 uuuuuuuuuuuuuuuugcugauaagaauucuuuuuuuguuauucgauaaaauaca uucauacagaaauauaacaaucucgcaaaaaacaauucaaauaaaaucuuguaaaacaaa auuuuacaaaaaucuuacaaagauucuuuagauaacagggugcuucaaaaaaaaagaaau aaagaaauuucacuauuagaaauuuuuuuuuuuaauuucaagcauaaguuccugcuugau ugaggcucaguugucaccugaccagaauggacugcuuaguauuaaaguuacagcaucgac acggacggcacccagccccagccaguccagcaacgucgcuguguuucauaagugagacgc gccagcacaaguuuccucucucuucuguuaccuucuuacuuaauggaauugcuauggau aagcacacagcagggccaaaaaaggaguuuuccaaaauccaccaaaucaagu 32 M93275 uaguggugaucuggaccgugcggacuugcucgucccucagcucuccuguuaggcgucuc u ucuccaggaggaaaaaauggcagcagcaguaguggauccgcaacagagcguggugaug agaguggccaaccugcccuuggugagcucuaccuacgaccuguguccuccgcuuauguc aguacaaaggaucaguacccguauuugagauccgugugugagauggccgggaagggcgug aagaccgugaccucugcggccaugacaagugcccugcccaucauccagaagcuggagcca caaauugcgguugccaauaccuaugccugcaaggggcuagacaggauggaggaaagacug ccuauucugaaccagccaacguccgagauuguugccagugccagaggugccguaacuggg gcgaaggauguggugacgacuaccauggcuggagccaaggauucuguagccagcacaguc ucaggggugguggauaagaccaaaggagcagugacuggcagcguggaaaggaccaagucu guggucaauggcagcaucaauacaguuuuggggauggugcaguncaugaacaguggagu a gauaaugccaucaccaagucggagaugcugguagaccaguacuucccucucacucaggag gagcuggagauggaagcaaaaaagguggaaggauuugauaugguucagaagccgagcaac uaugaacggcuggagucccugucuaccaagcucugcucucgggcuuaucaccaggcucuc agcaggguuaaagaggccaaacaaaagagccaggagaccauuucucagcuccacuccacu guccaccugaugaauucgccaggaagaauaugcacagugccaaccagaaaauucagggu gcucaggauaagcucuaugucucguggguggaguggaagagaagcaucggcuacgacgac accgaugagucccacuguguugagcacaucgagucacguacucuggcuaucgcccgcaac cugacccagcagcuccagacuacaugccagacuguccuggucaacgcccaaggguacca cagaacauucaagaucaggccaaacacuugggggugauggcaggcgacaucuacuccgua uuccgcaaugcugccuccuuuaaggaaguguccgauggcguccucacaucuagcaagggg cagcugcagaaaaugaaggaauccuuagaugaaguuauggaunacuuuguuaacaacacg ccucucaucuggcugguaggucccuuuuauccucagucuaccgaggugaacaaggccagc cugaagguccagcagucugaggucaaagcucaguaaaccccuccuugucaccagagcaug auguugcuggccagaugaccccuuuugcuguauugaaauuaacuugguagauggcuuua g cuuagaaaagcagcuucuuagaaccaagggccucauuauggucacucacagcucaguuau ggucuugccccagcuggcccuggcacaggaguucucuuaccuggcuggugaguggccug u guuagucuugugaggaccuggaggaaccuaaaagcucagaugcacuuacagucuugucug uggccuuuguauuguuauuggcuguaaucgucugucuggaccgaauauagauucacgug a 33 AB000713 ggcacgagggagcugcaguguucgcgcuugguagcuggugcaucggacucagcuggcuu u gugucccugaggcucaccgaaaaacacuuucucagcccucugacuccagagagagagaga gagagguacuuuuuguggucaccgacuuugaccccugcagaggcugagcgauggcgucu a ugggacuacagguccugggaaucuccuuggcaguccugggcuggcuggggaucauccug a guugugcgcuccccauguggcgggugaccgccuucaucggcagcaacaucgucacggcac agaccagcugggagggccucuggaugaacugcguggugcagagcacaggucagaugcagu gcaagauguacgacucgaugcucgcccugccgcaggaccugcaggccgcccgagcccuua uggucaucagcaucaucgugggugcucuggggaugcuucucucagugguagggggcaag u gcaccaacugcauggaggacgagaccgucaaggccaagaucaugaucaccgccggagccg uguucaucguggcaagcaugcugauuauggugcccguguccuggaccgcucacaacguca uccgcgacuucuacaacccuaugguggcuuccgggcagaagagggaaaugggggccucgc uuuacgucggcugggcggccuccgggcugcugcuccugggaggaggccuccucugcugc a guugcccaccucguagcaacgacaagcccuacucggccaaguacuccgccgcccgcucug uccccgccagcaacuauguguaaggugggccacucuguccacauugccuuuguuauuuuu ucggauugagcucauaacagccuguggccccucacauucuccaggaccugcccugcua ugggccacuaacugcuugcuggggacaggcaaacccggacugugcaaaguuacuagcccg ugcucuugggcugcuccacauggcuccuuacggccggcaagaauggauguaaaaauauc uugcugcuuacauccaaauugcgguggauaugggcugaaggcagaagcagcugggaagg g caguagaggcgcaagcuggguccugcuggccgggguagcucagcugugacuuuggacuc gaguggauguccucauguuagcaaacguccacuguccuuucucuaucccccucacucagc cuacacguuacuccagcgcuacucuugccauuacgccccguguuuccgagcacagcuggu ccuaccccaagucauggugugcugagugacugaugaggggccauugagagccggugggc u cugccauggaacccuuccguugauuagcaaugacugugcuugacccacccaccuacccua cuaaugaauuucuguagaguggauggacggguuugagggaagaaggguggagguggauu aaacugguuuggggagggcuggggaccuagaagcagcccaguguguccccaccccuuuuc c gcacugucuugcuaauguucugaucacugugcgcccccucccucuucagauggacccugg gccucuugaguuggccccucugaguucccucccuuugcccauuucaaggacaccggccag ucugcggaaggaagguacggggggggggggggggggugauggcauuguaccagggaguc uccuggacuccccugccuucucugugguuucuuguuuuguaauuaaggucuguucacag cuguaauuauuauuauuuucuacaauaaauggcaccugcauacag 34 U20735 See above (same Accession Number). 35 U83148 augcagcugagaaaaaugcagaccaucaaaaaggagcccgcaccccuagauccuaccagc agcucagacaagaugcugcugcugaacucugccuuagcugagguggccgaggaccuagcc ucaggugaagauuugcuugaacgaagggagcauggggaaaaacaaauccucggcgugu cggagaaaacgggaaucauuccggacgagaagaaagacgccauguauugggagaaacgg cggaaaaacaacgaagcugccaaaagaucucgggagaagcgccgccucaaugaccugguu uuggagaacaagcugauugcccugggagaagaaaaugccacuaaaagcugagcugcuc ucccugaaauuaaaguuugguuuaauuagcuccacggcguaugcccaagaaauccagaaa cucaguaauuccacagcugucuacuuucaggacuaccagacauccaaggcugccgugagc ucuuuuguggacgagcaugagccugcgaugguagccggaaguugcaucucagucaucaag cacucuccccagagcucgcucuccgaugugucagagguguccucgguggagcacacucag gaaagccccgcacagggaggcugccggagcccugagaacaaguucccugugaucaagcag gagcccguggaguuggagagcuuugccagggaggccagggaggagcggggcacguauuc c accuccaucuaccagagcuacaugggaagcucuuucuccacuuacucccacuccccaccc cucuugcagguccauggguccacuagcaacuccccaagaaccucagaggccgaugagggu guaugggcaagucuucugauggggaagacgaacaacaggucccuuagggccccauccau ucuccaguggagcugcaacggguucacgccacgguggugaaggccggaagugaacccu ucugccuuaccgcacaagcuucggaaaaagccaaggccaugcaggucaaaguggaggcu uuggacagcgaguuugaaggcaugcagaaacucucuucacccgccgaugcgaucgccaaa agacauuuugaccuggagaaacauggaaccucggguauggcccauuccucccucccuccu uucucagugcaggugacgaacauucaagauuggucccucaaaucggaacacuggcaucac aaagaacugagcagcaaaacucagaguagcuucaaaacaggugugguggaagucaaagac gguggcuauaagguuuccgaagcugagaauuuguauuugaagcagggaauagcaaacuua ucugcagagguggucucgcucaagagauucauagccacacaaccgaucucggcuucggac uccagguaa 36 L10244 gcucccgggaaacgaaugaggaaccaccuccuccugcuguucaaguacaggggccuggug cgcaaagggaagaaaagcaaaagacgaaaauggcuaaauuuaagauccguccagccacug ccucugacugcagugacauccugcgacugaucaaggaacuggcuaaauaugaauacaugg aagaucaagucauuuuaacugagaaagaucuccaagaggauggcuuuggagaacaccccu ucuaccacugccugguugcagaagugccuauagagcacuggaccccugaaggacauagca uuguugggucgccauguacuauuuuaccuaugacccauggauuggcaaguugcuguau c uugaagacuucuucgugaugaguganuacagaggcuuugguauaggaucagaaauuuug a agaaucuaagccagguugccaugaagugucgcugcagcaguaugcacucuugguagcag aauggaaugaaccaucuaucaacuucuacaaaagaagaggugcuucggaucuguccagug aagagggauggaggcucuucaagauugacaaagaguacuugcuaaaaauggcagcagagg agugaggcgugccgguguagacaaugacaaccuccauugugcuuuagaauaauucucagc uucccuugcuuucuaucuuguguguagugaaauaauagagcgagcacccauuccaaagcu uuauuaccagugacguuguugcauguuugaaauucggucuguuuaaaguggcagucaug uaugugguuuggaggcagauuucuugaacaucuuuugaugaugaacaaggugguaugau cuuacuauauaagaaaaacaaaacuucauucuugugagucauuuaaauguguacaaugna ca cacugguacuuagaguuucuguuugauucuuuuuuuaaauaaacucgcucuuugau uu 37 U88328 cgcuggcuccgugcgccauggucacccacagcaaguuucccgccgccgggaugagccgcc cccuggacaccagccugcgccucaagaccuucagcuccaaaagcgaguaccagcuggugg ugaacgccgugcgcaagcugcaggagagcggauucuacuggagcgccgugaccggcggcg aggcgaaccugcugcucagcgccgagcccgcgggcaccuuucuuauccgcgacagcucgg accagcgccacnucuucacguugagcgucaagacccagucggggaccaagaaccuacgca uccagugugaggggggcagcuuuucgcugcagagugacccccgaagcacgcagccaguuc cccgcuucgacuguguacucaagcuggugcaccacuacaugccgccuccagggacccccu ccuuuucuuugccacccacggaacccucguccgaaguuccggagcagccaccugcccagg cacuccccgggaguacccccaagagagcuuacuacaucuauucugggggcgagaagauuc cgcugguacugagccgaccucucuccuccaacguggccacccuccagcaucuuugucgga agacngucaacggccaccuggacuccuaugagaaagugacccagcugccuggacccauuc gggaguuccuggaucaguaugaugcuccacuuuaaggagcaaaagggucagaggggggcc ugggucggucggucgccucuccuccgaggcacauggcacaagcacaaaaauccagcccca acggucgguagcucccagugagccaggggcagauuggcuucuuccucaggcccuccacuc ccgcagaguagagcuggcaggaccuggaauucgucugaggggagggggagcugccaccug cuuuccccccucccccagcuccagcuucuuucaaguggagccagccggccuggccuggug ggacaauaccuuugacaagcggacucuccccuccccuuccuccacacccccucugcuucc caagggagguggggacaccuccaaguguugaacuuagaacugcaaggggaaucuucaaac uuucccgcggaacuuguuugcgcuuugauuugguuugaucaagagcaggcaccugggg g aaggauggaagagaaaagggugugugaaggguuuuuaugcuggccaaagaaauaaccacu cccacugcccaaccuaggugaggagugguggcuccuggcucuggggagaguggcaaggg g ugaccugaagagagcuauacuggugccaggcuccucuccauggggcagcuaaugaaaccu cgcagaucccuugcaccccagaacccuccccguugugaagaggcaguagcauuuagaagg gagacagaugaggcuggugagcuggccgccuuuuccaacaccgaagggaggcagaucaac agaugagccaucuuggagcccagguuuccccuggagcagauggaggguucugcuuuguc u cuccuauguggggcuaggagacucgccunaaaugcccucugucccagggauggggauug g cacacaaggagccaaacacagccaauaggcagagaguugagggauucacccagguggcua caggccaggggaaguggcugcaggggagagacccagucacuccaggagacuccugaguua acacugggaagacauuggccaguccuagucaucucucggucaguagguccgagagcuucc aggcccugcacagcccuccuuucucaccuggggggaggcaggaggugauggagaagccuu cccaugccgcucacaggggccucacgggaaugcagcagccaugcaauuaccuggaacugg uccuguguuggggagaaacaaguuuucugaagucagguauggggcuggguggggcagcu guguguugggguggcuuuuuucucucuguuuugaauaaugugggacaauugccucaauc acuuuuauaaaaauccaccuccagcccgccccucuccccacucaggccuucgaggcugucu gaagaugcuugaaaaacucaaccaaaucccaguucaacucagacuuugcacauauauuuau auuuanacucagaaaagaaacauuucaguaauuuauaauaaaagagcacuauuuuuaau gaaaaaaaaaaaaaaaaaaaaaaaaaa 38 X82786 Sequence below. aaggaaccaguacagaaacaagacccaaguguaaguuaacuggcaggaggaaccaaccaaggacaguuaagga gaaaacccaacccuuagaagaacucaccaguuuccaagaggaaacugccaaaagaauaucuuccaaaucuccacaacc ggaagagaaggaaaccuuagcaggggaaagaggcagcucagaauacaacuaaucaacgaugguguaaaagaagagc ccacagcacagagaaagcaaccauccagggaaaccaggaacacacucaaagagccuguaggugacaguauaaauguu gaagagguuaugaagucuacaaagcagaaaauugauccaguagcaugugugccugucagcaagaggccacggaggg uacccaaggaaaaggcacaggcccuagaauuggcuggucucaaaggaccaauccaaacccuaggccacacugaugaa ucagcaagugauaaaggacccacacagaugcccuguaauucucuacaaccagagcaaguugacagcccaaagcuc accaaggcgacccaggacaagacgugggaaaguagaggcagaugaagagccuucagcaguaagaaagacaguaucaa caucaaggcaaacuaugcgaucccgcaaggucccugaaauugguaacaaugguacccaaguuucaaaggccuccaua aagcagacauuagauacaguagccaaaguaacuggcagcaggaggcagcuaaggacacauaaaggaugggguucaac ccucuugaaguguuaggugacuccaaagaaauaacccaaauaucagaucacgagaaacuagcacaugacacca guauccuuaagagcacucaacagcaaaagccagacucaguaaccucugagaacaugcagaagagugcugagggcc ucuaaagagguccccaaggaaguguugguggacaccagagaccaugcaacauuacaaagcaaaagcaacccuuugcu guccccgaagaggaagucugcaagagauggaagcauugugagaaccagggcuuugcgcucuuuagcaccaaagcag gaagcaacagaugagaagccuguaccugagaaaaaaagggcugcuuccagcaagagguauguaucaccugagccug ugaagaugaaacaccugaaaaucgugucaaacaaacuugaaucuguggaccagacaaugacaguuuggau gaagaaauggaagccaaaagagaaaauccugucacuccagaucagaacucuagguaccgaaagaaaaccaauguaaaa cagccaaggcccaaguugaugcaucugcagagaaugucgggauaaagaaaaacgagaagacuaugaagacugccuc ccaggagacagagcugcagaauccagaugauggagccaagaaaucuacaucucggggccaagucagugggaaaagaa caugcugaggucuagaggaacgacugagaugccccagccuugugaagcagaagagaaaacaagcaaaccagcugca gaaaucuugauaaagccucaggaagagaaaggagucucuggagagucugauguuagguguuugagguccagaaa cuagagucgcuuuggacagugaaccuaagccaaggguaacucguggaaccaagaaagaugcaaaaacucugaaggag gaugaagacauuguaugcaccaagaaguuaagaacaagaaguuaagaacaagaaguuaccagaaaagugaaacuaug uagcaaagacauuuaagaaggaaaaguaaauuugacuuagugauaaguuccagugugguuuucaccuccaguguaa agaugaacuguuaauacuacugcuacugccugaguuuaaggaaggaagcuuugagcuuuccuggucauacucucuu cagacgccaauggaggucaugaggaagaucaccagggaucucagcgcaauuacaguaggggugagcaggcagaa auccccucuccuauccaauaaauucucuaauucccccaaaa 39 AW122523 uuuuuuuuuuuuuuuaanucaaaaguuaugaugacuuuauuuuaaaucuuaauacac c aaaaauauuuuucaauguugugagauaagcacuugaaaauaagaauuccaucacugcugu gaucgcugugaggcuugauagugaauuucccucugaauauggguuuagggccuagg a agcagaaugccagucauuuuccaaguagcagugagcuaagcccagcccggucaugcucag acccacacuuaacugaaauauucacacuaggaggcggcaccaccaggcaacaccuugauc aaccaggagaacaaaagucugaagugccaccaagcauuggggaaaugauauuguuuagau gcuagugagucagguucuuucaaaugnguccuaacuggguugcaaacauaguugcauccu uau 40 AI642048 aauacaacauauacaacauuacaagaaggcgacacagaccaguugggggcgacuuuu aagcacaugccacugaacaccuggcucuuacaugggaggacacacugggcucacuuacua ggucuauggugguucaaucaaaagcacaauaaauaaaacgugguccuuucauuagguucu ggaaaaucaccucccccccccccaaauaaaaucccacauacaugaaccuuaagagacauu uucuuugaauuucagugaucuguuuccccggauuucacaaagacaacagccgaaucaccc caguaaaaugccugggucuaggcgcugugugguguggugcuaaguauacccuuucucau u uuuuuucuuuuucu 41 L07264 cggccgccagaccuucaagggcuggaguggacgcgcggaccgacucugaac aaccgcggccgcaagguucccagacaggaucucacccagaggcaggcagcggacagugcc uuaguggaaccucgcguccuccaccgccuggccccggugcaggcguccaguggccgccg cauccaaagugaucgcugccuccccgucuccgccagcucgggaccaugaagcugcugccg ucggugaugcugaagcucuuucuggccgcaguguuguccgcguuggugaccggugagag u cuggagcggcuucggagaggucuggcggcagcauccagcaacccugacccucccacugga uccacaaaccagcugcuacccacgggaggugaucgugcucaggggguccaggacuuggaa gggacagaucugaaccuuuucaaaguugcuuucuccuccaagccacaaggccuggccacc ccaagcaaagaaaggaaugggaaaaagaagaagaaaggaaagggguuagggaagaagaga gacccaugccucaggaaauacaaggacuacugcauccacggggagugcagauaccugcag gaguuccguacucccucuugcaaaugccucccugguuaccacggacacaggugucauggg cugacucuaccaguggagaauccccuauacacauaugaccacacuacagucuuggcugug guggcuguaguacugucguccgucugucuucuugucaucgugggacuucucauguuuag guaccacaggagaggagguuaugacuuggaaagugaagagaaagugaaguugggcgugg cuagcucccacugaggaggaccugagcuauaggaaccuucagaggcuacuucugagacag ug guucguuacacguucuacauagaggagaaauauucaccagcagccaugaaaacgucuuc auucauuuccaguugcuacccugacugggccuccuguaau 42 M15668 ucgaccucacggucuugccaaaaugucgcuuuccaacaagcugacuuggacaagcugga cgugaaggggaagcgggucgugaugaggguggacuucaacguuccuaugaagaacaacca gguaacaaacaaccaaaggaucaaggcugcuguuccaagcaucaaauucugcuuggacaa uggagccaacuccguuguccuuaugagccaccugggccggccugaugguguucccaugcc ugacaaguacucuuagagccaguugcgcugaacucaaaucucugcugggcaaggaugu ucuguucuugaaggauugugugggcccagaagucgagaaugccugugccaacccagcggc ugggacugucauccugcuggaaaaccuccgcuuucauguagaggaagaagggaagggaaa agaugcuucugggaacaagguuaaagcugagccggccaaaauugaugcuuuccgagccuc acuguccaaacuaggagaugucuaugucaaagaugcuuuugggacugcacaccgagccca uagcuccauggugggugugaaucugccacagaaggcugguggauuuuugaugaagaagg a gcugaacuacuuugccaaggcuuuggagaguccugagcgacccuuccuggcuaucuuggg aggcgcuaaaguugcagacaagauccagcugaucaauaauaugcuagacaaagucaauga gaugaucauuggugguggaauggccuuuaccuuccuuaagguccucaacaacauggagau uggcacaucucuguaugaugaagaaggagccaagauugucaaagaucucauguccaaagc ugagaaauauggugugaagauuaccuugccuguugacuuugucacugcugacaauuuuga ugagaaugccaagacuggccaagcuacuguggccucugguauaccugcuggcuggauggg cuuggacugugguacugagagcagcaagaaauaugccgaggcugugggucgagcuaagca gauuguuuggaaugguccugugggguauuugaaugggaagccuuugccaggggaacca u gucacucauggaugagguggugaaagccacuucuagggguugcaucacuaucauaggug g uggagacacugccacuugcugugccaaauggaacacagaggauaaagucagccaugugag cacugggggcggugccagucuagagcuccuggaagguaaaguccuuccugggguggaug c ucucagcaauguuuaguauuugguccugccuuugguuccugugcuccuaagcuaacc u gcuguuuuccacaucuccauuugguguuagcgcaagauucagcuaguggcugagaugug u cacagaccuuaacagugcaagcaucucagcucgucuuacugcaucagaugcugguucuuc aagaucccauuuaaauuccuuagugacuaaaaccauugugcauuguagagggcgucuauu uauauucugccugagaaaggaagugagcuguaaaggcugagcucucucucugacguaugu agccucugguuagcuucgucacucacuguucuugacucagcauggcaaucugaugaaauu cccagcuguaagucugcagaaauuuccgaauuc 43 AI1047508 uuuuuuuuuuuuuuuucauguuuaauaguuuauuucuuauuuuguugcuuauaucuuc aauaaaucauunugcagguuuuguuacagauuuuugauaagccaacucaaguacugauuu uucauccucucugaaaguuuuaaaccaggaaaggaaaacguuccauggaauccaucuucca cauggugaugagucacaugaacuccaacauucugaagccgcuugacauacaugaguccau c aucucuuaggacaucauacuggcuugugaugauauaggucuuagguaaaugaugcaauau auugucauuggccaacugagggcaugccuucacaucuaugaacccuggauacuuuugagc cagcucagaacuaccaggagugggauuuuuguaaacgggacuuuucuuguaucucucagg gagcaaggaacuccaauucacaaacuguaacaaguggcuagauuccauggguacauguug guuga 44 AJ001418 Sequence below. gagcacccgggacccugggaccacaacgcacuugcucccucucgaccgcgcuccugacccgcagcccucgccaacccuacgg auccuaaccaccgccagccuaggugggcgucaggaugaaggcagcccgcuucgugaugcgcagcgccagcucgcuga cgccagccugguccccagggaggucgagcuguucucccgcuacagcccguccccgcuguccaugaagcagcugcuggacuu ugguucagaaaaugccugugaaaacguccuuugcuuuucugcggcaagagcugcccgucgccuggccaauauccugaa ggagauugacauccugccugaccgcuuagugaacacuccuucggugcagcuggugaagagcugguauauccagagccuga uggauuugguggagnuccaugagaagagcccagaagaccagaaagcccugucagaguuuguagacacgcuggacaaaguuc gaaacagacaucauaauguggucccuacaauggcucaaggcauccuggacuauaaagacaccugcacaguggaccccguuac caaucaaaaucuucaguauuuuuuagaccgguuuuacaugaaccgcauuucuacucggaugcucaugaaucagcacauccu cauauucagugacucaaagacgggaaacccaagccacauuggaaguaucgacccaaacugugaugugguagcaguagucca agaugccuuugagugugcaaagaugcucugcgaccaguauuaucuaacaucgccagaauuaaaccucacacaagucaaugg aaaauuuccaggccaaccaauccacauuguguacguuccuucacaccuucaccacaugcucucgaacucuucaagaaugcc augagggccacggucgagcaucaagaaaaccguccuuccuugaccccaguagaggccacugucgucuugggaaaagaagac cuuacaaucaagauuucugaccgaggaggcgguguuccucugaggauuacugaccgccucuuuaguuacacguacuccacu gcuccaacaccugugauggacaauucccggaaugccccuuuggcugguuuugguuauggcuugccaauuucucgucucua cgccaaguauuuucaaggagaucugaaucucuuacucuaugucagguuaugggacagacgcuaucaucuacuuaaaggcuuu auaucugagucuguagaaaagcucccagucauuaacaagucagccuucaaacauuaucagaugagcuccgaagcugauga cugguguaucccaagcagggaaccgaagaaccuggcgaaggagaagcuggcagugugaagcggaugacgccugacauuuua cgggaucaaagugggucuguggcauugcugcuucgugaauguguguggacucuaguuuccgcaaaacaacgcaacacaaaa ccaagcaagcaaaacacaaacacgaguacaaaccuugaccugaugagggacagagcuugguuggaugacccgggagaaguca gggcagggcuccaggggauaacagguguccugcuucuccuuuggcaaugcaauuugacuccugacuguuccaaauacugaa aagaagucugccucugaguuacagcucuuucucaacaaguacagaguuugaggcuugcaguugcaacagcuggauguuug gugguucuugcugccagccaaauaaauugguguuuagugaacauuuucaguguuuccccgccaugcaaagcuuggcgccu ugggagaaauguguguaaauguacauuguauagguauuagugugcucuagaacccaccagcaggccaggaccag uuaucgagcuuguggcugagcauugcagccuaugugcaaacccagaggaaaaguaucucugucaagacagcuccaguauca ugcagcuuuuuauguuugcacucaaaaagccagugccuucuggcuggugccgaggcuugggugaaauguuaaauaugcac ugaccucagaaagucgaguucaaaagggagauaaaauugccaaagugauccaaggauugugcauguugggaaacccauaug agagaaaggauucucauacuuagaacuuuccuaugaagaaauggugguaaacuuucucuaccuagaaguaguggaaauuuc aaggucaucuuaaaaaagaugugcguuguauauuuuaacuacauucucuacacucuaacauuaacauaucuauucaaauuu gucuaguugccaauugucuucagagugugaaaauuuaaauccuucuugaaguaucuuucgugagaguaguauggaaguaa aacguucucauaucaggaggaugucauuugugaagcaugggacggcggcaagaagggacccagaaga ugaaggguaaggaucagcgggaggccauccauguaggagagagaauuaaaucgaggagcgagggaagcaauggagagagg gaagcaagaaaggaaccagaaggcuggcaucauccuauuucccacaggcuaacccaagggaugcucugugccuuuccuggg gagggaagggggugaacugguagauuugaaagcaguauggcuucuucugugggucucccucuuacuagacaaggugaaau gauaauucgugucaaauuaaugugaaauuuuuuuccugcauuguaauauuaugaggccugagucgcaguugaguuugaaa uuuguauuuaauucacagugaccuagagcuaaggugcucccgguuguggcaauaggagccacaaguauuuucuuucuuu cuuucguucuuucuuucuuucuuucuuucuggcggcaacgcggccgcacacgagaccaaccaaacggca uccuuccuuccuuccuucuuccuuuccuuucuuuucucuucucuucuuucuuuuuucuguuucuuuuucuuuuuggg cauuguagauguuguccuuaaaagaucagggcagugacuuucacagcaggacuuugacucccacauugguugaucacacaa aacugucagcauuuggguaaucugauguauaguuguuuuguugcugauguuuccauugaaauucagcucugaguuugu gcacaugaauacuuacuuguggguaccaaaggucuaaggcauuugacuuaacccaaauauccugaacugugcguaaag uaauagagaaaagcuuuagggucucaauagugucaccuguguaaaucaaaucaaaauagccuucccuauuauuuaugaacc caugggagacuuuaaacucuuguagaaagaugcuaaaugcccaggcccacuuaacuuauuaaugugugaauuacauuuaug uuuuuaguuuauaugcaaagaauugugauaauuuuauaauaaauauuuuuauuauuauagu 45 AI838080 uuuucuuuuuuuuuuuucuucucuuuuuucugccaccaacagcacugugcaguuuauua accauucauguacaguagccaucuggggagauugggacagaauugggaucgcaaagugga uagauauucagcaucuaauggguuggcagaagccgccauauacucuucacaaauaucuuc c acagucaauacagaacuagccauaucccagcacaccgauuugugc 46 AF072127 agccaggagccucgccccgcagcugcncagagagcaaggguauaggcacuaacuuguuug cagauaccccaucaccuucgggagcucaggugcgcaccuugcaaacuccacuuucugcau cugccacugagcccgcgggagccucggaaagagccauggccaacgcggggcugcagcugc uggguuucauccuggcuucucugggauggaucggcuccaucgucagcacugcccugcccc aguggaagauuuacuccuaugcuggggacaacaucgugaccgcucaggccaucnacgagg gacuguggauguccugcguuucgcaaagcaccgggcagauacagugcaaagucuucgacu ccuugcugaaucugaacaguacuuugcaggcaacccgagccuugaugguaauuggcaucc ugcuggggcugaucgcaaucuuuguguccaccauuggcaugaagugcaugaggugccug g aagaugaugaggugcagaagauguggauggcugucauugggggcauaauauuuuuaauu u caggucuggcgacauuaguggccacagcaugguauggaaacagaauuguucaagaauucu augaccccuugacccccaucaaugccagguaugaagggggggccaggcccucuuuacuggcu gggccgcugccucccucugccuucugggagguguccaacuuuccugcuccuguccccgga aaacaaccucuuacccaacaccacggccuuaucccaagccaacaccuucuagugggaaag acuaugugugacagaggcaaaggagagaucuuccuggagcaaauacaaaauggacauug aaccuaggauugacauuaacgccuuagacuguugaugaugguuaucggaacugugguaga acagaaggaagcauauuuuuauacauccccauggcuauncaugccuuggcug 47 X80417 Sequence below. cggcacgagcggccacugaccgagaagugcccccgccuggagucagccugggggcaggccaggguccaccagaccc cgggaugaccgcagccagucgggccaaccccuacagcaucguaucaucagaggaggacgggcugcaccugguuacca ugucaggcgccaacgguuuuggcaauggcaaggugcauacacggcgccggugccgcaaccgcuucgucaagaagaa cggucagugcaacauugaauucgccaacauggacgagaagucacaacgcuaccuggcugacauguuuaccacgugu guggacauccgcuggcgcuacaugcugcucaucuucucucuggccuuucuugccuccugguuguuguuuggcauc aucuucugggucauugcugucgcccacggggaccuggagccagccgagggccguggccguacacccugugugcugc agguccacggcuucauggcagccuuucucuucuccauugagacacagaccaccauuggcuacgggcuacgcugugu gacugaagagugcccgguggcugucuucauggugguggcgcaguccauugugggcugcaucauugacuccuucau gaauggugccaucauggccaagauggcacggcccaagaagcgcgcacagacucugcuuuucagccauaaugccgug guggcucugcgugacggcaagcucugccucauguggcgcgugggcaaccugcguaagagucacaucguggaggccc augugcgggcccagcucaucaagcccagggucacagaggagggugaguacaucccacuggaccagauugacaucga ugucggcuuugacaagggccugaccguaucuccugguaucacccaucaccaucuugcacgagauuguugaggcc agcccacuguuuggcauuagccgucaggaccuugagacagacgacuuugagauuguggucanccuggagggcaug gugaggccacagccaugaccacacggcucgcaguuccuaccuggcuuucgagaucuguggggccaccgcuuug agccagugcucuucgaagagaagaaccaguacaagauugacuauucacacuuccacaagaccuacgaggugccaucu acaccccgcugcagcgccaaggaccugguggagaacaaguuccuccugcccagcgccaacucuuucugcuaugagaa cgagcuggccuuccugaucagagaugaggaggacgaggugucuaccgaccgggauguccgcaccccucagcccgag caugacuuugacagacugcaggccagcagcgcugcccuugugcggcccuacagacgggagucggagauuugaaugc ccuuggcuuagaugcagcaccacccugaccacaauaggucccaugucccuugggggccugcguuugagcagagcag gccgaaagccucgggucacagacucaguagcaucuuagucuuuuucauguuuuuucgcaguagcuugggaaaguu ggcgggagcguggauggcccaaaugacuggcucacggccucggaggcugauguauacccaugggcaaggaggugac uucuugggguagggnugcucaggaguuagggacucugcuggaggccuuaggugcaggucccauccccggugggag gaggcuguguauguacacuucauugguuuuuaacuugggcaagacuguuuacaaaccaaaacaaacaaacaaacaau c caaaaaaaaaaaaaaaaaaaaaaaaaaaa 48 AI847051 uuuuuuuuuuuuuuguuccuuuuuuggaauucccaaagcugguuuuaauuucaaaaaau uaugaggucucuucccacacuggggauaaugggaugggauagcccaaacuauuaucccag u ucaaccccagccugguccaaacaccau 49 U09504 uccucguccucgucuguuccaucuucuccaaauagcucuaacugugaugccaacggcaau cccaagaacgcugauaucucuagcaucgaugguguucugaagagugaccgcacagauugu ccugugaaaacaggcaaaaccagugcuccuggcaugacuaagagucacaguggaaugaca aaauuuaguggcaugguucuacuguguaaagucuguggggauguggcaucaggauucca c uauggaguucaugcuugugaaggcuguauggguuucuuucggaggagcauucagcaaaa c auccuauaagaagugccugaagaaugagaacuguuccaucaugaggaugaacaggaac cggugccagcagugccgcuuuaagaagugucugucuguggggaugucacgagaugcugu u cgauuuggccgaauuccuaagcgugaaaaacagagaaugcuaauugaaaugcaaagugca augaagaccaugaugaacacccaguucaguggccaccugcagaaugacaccuuagcagaa cagcaugaucagucagcacuaccagcucaggaacagcugcggcccaagucccagcuggag caagaaaacaucaaaaacacuccuucugauuuugcaaaggaggaagugauugguauggug accagagcccacaaggauaccuuucuguauaaucaggaacaucgagaaaacucaucugag agcauguaccucagagaggagaacggauucccaggaacauggagcaauauaauuuaaau caagaccaucguggcagugggauucacaaccacuuccccuguagugagaggcagcaacau cucaguggacaguacaaagggaggaacauaaugcauuacccaaacggccaugccguuugu auugcaaauggacacuguaugaacuucuccagugcuuauacucaaagagucugugauaga auuccagaagguggauguucucagacugagaacagaaauaguuaccugugcaacacugga gggaggaugcaucugguguguccuaugagcaagucuccauauguggacccucagaagucu ggacaugaaaucugggaagaauuuucaaugaguuuuaccccagcaguaaaagagguggug gaauuugcaaagaggauuccuggcuuccgagaucugucucagcaugaucaggucaaucug uuaaaagcugggacuuuugagguuuuaaugguacgauuugcuucauuuuuugaugcaaa g gaacggaccgucaccuuucuaagugguaagaaguacaguguggaugaccugcacucaaug ggagcaggggaucugcucagcucuauguuugaguucagugagaagcugaaugcccuccag cucagugaugaggaaaugagcuuguucacagcaguuguucugguaucugcagaucgauc u ggaauugaaaaugucaacucaguggaggcuuugcaggaaacacucauccgugcacuaagg accuuaauaaugaaaaaccauccaaaugaggccuccauuuuuacaaaauuacuucuaaag uugccagaucuucgaucuuuaaacaacaugcacucugaggaacucuuggccuuuaaaguu cauccuuaa 50 U22033 auggcguuacuggaucugugcggugccgcucgggggcagcggcccgagugggcugcccu g gaugcgggaagcgggggucgcucggacccgggacacuacaguuucuccgcgcaagcuccg gagcucgcacuuccccggggaaugcagcccaccgcauuccugagguccuuuggugguugac caggaaaggaauguucaaauugagauggcccacggcacaaccacacucgccuucaaguuc cagcauggcgucaucguggcuguggacuccagggccacugcagggaguuacauuagcucc uuaaggaugaacaaagugaucgagauuaacccuuaccugcuuggcaccaugucugguugu gcagccgacugccaguacugggagaggcuguuggccaaggagugcagguuguauuaucu u cggaauggggaacgcaucuccgugucugcagcauccaagcugcuuuccaacaugaugcug caguaccgggggaugggccucuccaugggcagcaugaucuguggcugggacaagaaggga ccaggacuuuacuacguagaugacaaugggacucggcucucgggacagauguuuuccacu ggcagcgggaacaccuaugccuacggggugauggacagugguuaccggcaggaccucagu ccugaagaggccuacgaccuuggccgcagagguauugcuuaugcuacccacagagacaac uauucuggaggagucgucaacauguaccacaugaaggaagacgguugggugaaaguggag aguuccgaugucagugaccugcuguacaaguaccgagaggccgcucuguga 51 AF033034 Sequence below. auuccaggaguuccagcugcuggagaggacuguguagaagguaaccuaccccaucucucuuacuucgucucuagauggga gcagacaaguacauauagccugcuuggagcgaggacuuugaaaggcugagacuugcguccacucugagggcaacuagucca gacucugacaggucagcauuuccugacugggugcacugaaugccaagcaccagaggucugucaccuuccgacauuggacca agagagucccagagacccucaaagacacaggaacagagguguccuuugggugagagaccugugcccugccaagccucucag ccccuagaaaggcggcagggcugaguagcugagugugugcaacuugggagcagccugauuucagugcuugucaccuguga gggcaaaggcagcaugcuuaaugccaucaguccuacucuucucacccguggaacagacgcauaacugaccuuuuuucguga ccacuauuagggugcauuuuaaaaucaagggaccaccagacagccgaacaccgcggacaccaaccccaccggcggac guguguguguuucugugugugugugcgugcaccauacagguaugugccaugacaugugugcaggucaguagacagcc uugguugucagucccugccuucuacuuuguucaaggcagggucuauucuuuauuauugacugcuauccagguacaccaag acaguuggccugugagguuccagggagucuccugucucuggcccccaucuuuauagcaggaguugugagauuucagaaaug ugcacccacaucuagcuuuauuuggcaucuuggcacccaaacuuggguucucaugcuuuccaagcaaggacuucaccacu gaaccaucucaccagcuccacuauggcgguuuugaaacugaagggagaacccacaggacacgggccaaacaccagacc ggaaggcggguauaaccuuuaaggcuggcugguucugagagaggaaagccggcuugugucccauucaggugccaggugca gcaucaaauguggcuccacccaacggucaguaacuccgcagacagcaccgugguuaucugccucacagagggggcccaggg accuaguuccuuaaagcccacuuaguuuugagagacgacauggaggggcaagcccagcccuguccagcugcauucacacga ggccccuccuccgaggacccuaccuguguuuaguggcugaggcuguguggcucugcuugaagcucuggcuaucagg aaggaccuggcccaccggcuggcaggacaaacuggcccagugaaggcacuguccggucuccugguggaucacaaggaaagg ggcguggcauguccagauuugaacccuggaugccucuucccaggguaggaagucuaagggucaacaugaauaggugaggg uggugguggaaagaaucugcaugcaaaaucaggcacucaugucugacaucgucaaacacuauauuuauguagauuuauaug ggggugaggcuuggggagcacuuguauuuuugugugcaauugcaagagcuuccuccacauugcaguguuaaauaucauau ggugcuggaccaaccaucucuggaacgagggugaggguuugguacccgugacuaugguucucuguguaguagaaacggc ucuugggaagagagaggaagugcuuugaaaugcauccucucuuguuucauucugcaucauggccagguuucucugcacaa agaugcaauagacauucaggaaaauaagcgcauugcaagaugucaaaagucaugaaaaaugaaaagcaaggucacugcagcu gggguguaguguggcuguugaagcacguuuauguuguucugguuccgggagagggaggaugagugagggagggaaggag gaauggaggaagagagggagagggagcaagagaggggggagggagggaggggagaagggagagagagagagaagaaagag agggagggaagaaggaauggaggaagagagagaaagaggggaagaaagagagggagggaaggagggguggaggaagagag aggugugagggauggagggacagagagggagggaaggagaaauggaggaagagagaaacagagagauggaggaagagaga uaagucaccaauuauuuucuccccagucgcccccugcccucacaccaaggguucccccacuuuucuuucacucaugcacac acacuacacccaauguuuagguaacacauguagggcaggcagagccuuugugaaugugcgguaguuuucugccuuacu ucuaaauaaccaaucacacggaugccacaggguuccuuagacuguccagggcuccggggcucuuagacuguucccaaugu gggugucacaugcaaacaguaagcaccuucuuguuuguggugcccaggaugcugcagguacuagaaauuccugcacagacc uuugcuacuucuacacagacuuacccuuuaaaacauuuaauuauauguuauuucagcauaaagaucuauuuugauuauu uuuaguugcguguaugggugugugccugugugugauuguguaauugucuguaugggaguguaagugccuacagaggcau cggauccccuggagcugccguuacaaguaagggacugggacucagaccugagugguuuggaugagcagugaaugagcgug gugagccaucccaccaugcccuauaaacacuuucaagaggacuuugcuggguauggucaaguugucccccugcgacagcca ccccaacuugccauccucagguuacguacuggaagcagcaaccaccucugcaauuuugcacaagaaccugagagucugaaag acuuuuguuggcacuggccuguguuccacugggguggacacauuaaucuaaaagcuaagaagcucacuucagcuuugcca ggcaaccagcacguugagcacaacgguguagccaggaagggugugugggaauuuugaugcuaguuuuucuuuaauuagg uugagagugaaaucauggucuguaugcauccaacaacuuaauccaaaaaguugguugcacggcuccuggaagguuuaccgg caaggaaccugucccauuuuguaaguaggugggacuggagaguugccaagaagccccccucccugcccccuuccuuggc agauucugcuuaaaaugagugugguucacugcagaauagugucaccugucuucagaugucuaaagacauaagaaaggccua gccagcuaagucagaaaaggggacuuuccggugggaaugcauuuccagucucuaggagaagucuuuauccaaauaaaauu agcauagugguggagucacugccagggcgcuggugcggaagcacagcccagagccgaggacguggccauccuccuuccucu gaugcaaaguguucucuauccccaguuaccaugagcaauaucaguagcaucgugaaccgggcccgugaugccuuuaacuca ggcaagacucgaccgcugcaguuccggguugagcagcuggaggcguugcagcgcaugac 52 AA960603 uuuuuuuuuuccaaaaaauuuuauugggggaaacuacaaaacauuuacaguacaauguuua cagucacaauuuguagugaacugauuccccaaaauauauuacaacucaaguugacuuaau cuuuguuacauucaaaaaccuacuucugucaaaguaguccagagugcacacgcggugcucc aacuguaccuacauacaaacuaaacaacugcucauuuaucugccauccaggaaagccgga gacauuccugccucuuuacauugaaaaauaauaguacaaguuuuuggacugucauugaac aaggcauauucauguaccaccaacauuuc 53 U47737 Sequence below. ggugauccuccaggaccuaagguucgguauuaucuucggggccucuucacccggaggugagucugcugagcccgaccuc agguguucacucgucacgcgagggccuggccacggcggggaagcacugggagagagcgggaggccuugaccgcagcgugu aggaucuggggucccggcgcucugcucccgggugcagagugguucccagggaccagagaggaaacccacacgagacac uaccaucaccccacccccaccccaguccuuccugcacguuucuggagaggcaaaggccccugcugagccuucacuggguacc ccuaucucgacuccacuugucugcuugggaucuccaaagggggauacacccucguaaacuagagcaggaggcuggggggu ggggguagggguagggucugaccaguuagauugaggcuggacccuccccagagugaggagcgggaagcucuuugucuuau ccaggaugggggggcauaucaaugcugaggugggcuggugaagccacacaggcgacacagcgcgccagagccagagacc cuccgcuggccgcuagccaauagauccuggcuccgcggaugagcccuuugaguuuguggagguguuccucaggucccc agggcccugccccguugccugcagauguguggacagacaaaacauuggacucguuuuccaaccacuucaccccuuccuucg cuaguccuccgguggacgaugggaugccucauugacuuguuuguggcugugcaugccagagcuuccuagcagacagcuca gggcuccaucguuccuaaaucccacuguguaacgaaaaaaaaaaaaacaaaaacaacaacaacaacaacaacaaaaacaaaacc agaaaugaggacaggcccagcugggcuuggcacugaacuuggccaccuggagcuuuuggcuacccacuacaagaugucagca agucucaggauagaagaggccuaaggccaguccuggaagauaccaaaacuucaccuccucuauaccccguuccucuaggaga acuguaagccaccuuugucucugggacgcccucucccacucaacagauggcaccagucaucuuccuccucaagaggccagu gguauucaaaauaggauaugaaaccaagcaagcugguccucuccucuacccuaugccaaagacuucugcccaaagggccca gaaaagucccauagccaucuggcuggcuagugugcugacugcuacaggugucaguguccccagcgagcagguaguggagu ggaggugucuucuuguggaaauggguccugagccucuaccuuguacagaaaggaauuagugaagcccagaggccuccagc ccgugucucugccacuuugagagaggggguggggguggggcuguauuugguucccagggcucagggaagguuuucgguuc augcaugcucauuuaucugaccacugucuuuaccccaggacaaccacuuaacuguccacuuccauaucagaguucuugguu ccccuuacuucgucuauggagccccugaguuugggaagggguauuaacugaaagguaccauuagaugaacuuggagaaa gauguaggugccacgggagauuucagguaaaagcucuuuaauaauuggcuacaauagcagcaggaggaggccaggaa uucugagguagagauuugauuagcagcacguggagcaaaggagacuucugacuccuacagguuucagaaaguggggagag gcucucagaugaauggcuuggacugugagguaaguguuaguguagcacgagacuagcuuaaggcuguacaaauuguccgu cugauuggugcauugggccagguagacacuagauaagcaauugggccuuaacucgaguugucuuaauggcuacccccagg gcagcagggagucaauacugcucuuugucuggggccugaaugcugaaaccaucuacaaaggggacauaaggcauauuggg gagguguagagugggccaggcccagggucugcugguaucuaugccaggauccugaguggugguggcgugccugucuuu uaaccaacugccucucucacaguaggcuuucuuuggcuugcgaaccuucagcagaugucugccacuuccaacaugagagucu ucagccugugcuguuggcagcccuucugggcauggagcaaggaauggagcucugagauaacccugcagccugguccucc uccugaucucucauucuuucuccugaguagaugcccagggcuccuccugagccagcccuccuaggaacgucuggccuuccc accuccuacucucuagccaacugaccuaguuccccugaugcugugcuggcccagcuacaccuuugucaccucguguugacu uuagccacuccaguaccaaagucugaagucaguugucauuggcuggcauuuuucccugacccagggcugagcaugcuguu gcuucuugucaguggguuggggaucaagggccccacuggaaagucaccuuacccuggaaggcuuccccaggcaauaggcag gugucaccuacagcauugucccuuuugcaguucauucccugaugugcuucucauguaccgaucagaagaacaauauaaacu gccuguggccaguuucaugccaggagaaagaccauuacuguaucacguuaucugccgcugcgggcuuuggugaguagcug ccuguuucccuagccagggccagggaccugcggggcuuuccccauuuccugcuacccugucugucuguccccucauccuca cuuuccaugcagggaaugucaaccuuggcuacacccugaacaagggcugcuccccgaucugccccagugaaaaugucaauc ucaaucucgguguggcguccgugaacagcuacugcugccaaagcuccuucugcaacuucagcgcagcuggccucggacuuc gugccaguaucccacuacugggcauuggacuccugcuuagcuuguuggcucugcugcagcugagccccugaccauccccca uguguucuccauauccccccagcucaggaaaagcccagcuccuuuuuaggucccaggggacccuaggaaccuucagcuccuc cugggugugucuaguucccccuccacacucucucaacgucagggcuaaguaccaaacucacccauaccugcucuguugaag ugguacuggcuacccuugcuuccagagccaauccuauaaccucccuuggggaaccagcgaaggggugaagaucuccuugga gucucaagaguuccagagucagcgccgaaucuuguggacacacugacaaggaugucuaauccaaauagauguauaucugug ugcucaguguaucccugugugaaugaagccacuuggauucuggggugggcaaagaagaccugaaaagauucuacagcagaa ggccugugucgccaccaaaaccccucccccugguaucauuguacccaccuuguacucuguucaggaggcugcccauggagg acugccaccccuccagaugaaggcucccacuacccgaugcaguugagucccauccugcccucucugcccacacuggcuccu gcugcuauucuagugccucaaauaaaccguucacacccu 54 L00039 cuuccucccucuacagaagaagagcaagaagaugaggaagaaauugauguggugucugug gagaagaggcaaaccccugccaagaggucggagucgggcucaucuccauuccgaggccac agcaagccuccgcacagcccacugguccucaagaggugccacgucuccacucaccagcac aacuacgccgcaccccccuccacaaggaaggacuauccagcugccaagagggccaaguug gacaguggcaggguccuggagcagaucagcaacaaccgcaagugcuccagccccaggucc uuagacacggaggaaaacgacaagaggcggacacacaacgucuuggaacgucagaggagg aacgagcugaagcgcagcuuuuuugcccugcgugaccagaucccugaauuggaaaacaac gaaaaggcccccaagguagugauccucaaaaaagccaccgccuacauccuguccauucaa gcagacgagcacaagcucaccucugaaaaggacuuauugaggaaacgacgagaacaguug aaacacaaacucgaacagcuucgaaacucuggugcauaaacugaccuaacucgaggagga gcuuggaaucucucgugagagcuaaggagaacgguccuucugacagaacugaugcgcugg aauuaaaaugcaugccaaagccuaaccucacaaccuuggcuggggcuuugggacuguaag cuucagccauaauuuuuaacugcucaacuaaauaguauaaaagaacuuuuuuuuaugcuuc ccacucuuuuuucuuuuuccuuuuaacagauuuguauuuaauuguuuuuuuaaaaaauc g uuaaaaucuauccaauuuucauguaaauagggccuugaaauguaaacaacuuuauuaaa accuuaauaacasuuacaaaasauuuuaacacauuuuuuuuuu 55 D21099 guaggacgggccccccucgagggucgacccacgcguccgggaguacccccgaccuuagcugg cgucugacuucgcuuccuucugccugcccaggcuugcacuccccggggaucugccuugc aucucuugccuucucuguuguucccucucuguccagcuccccucccgcucucucccugg agaauggcucagaaggaaaacgccuacccgugggcccuacggcucaaagacgucucagucu ggccugaacacguugucccagagaguccuacggaaggagccugccacgacaucugcgcuu gcucucgugaacuuguccaacagccaguccacagcuucccuggccagaaguuggcugag aacaaaagucagaucuccacugccucgcaagggaucccagaacaagcagccuuucacuauu gacaacuauugagauugggcguccuuuggggcaaaggcaaauuuuggaaacguguacuuggc u cgggagaagaagagccuuuucaucuuggcacucaagauccucuucaagucucagauugag aaggaggggguagagcaccagcuucgccgagagaucgaaauccaggcgcaccugaaacau cccaacauccuucaacucuacaacuacuucuacgaccagcagaggaucuacuuaauccug gaauacgccccucgcggggaacucuacaaggaacugcagaagagucguaccuucgaugag cagcgggacuaccacaaucauauaggaacugucagaugcccuaaccuacugccacaagaag aagguauuucacagagacauaaagccggagaaccugcuguuaggucugcagggagaacug aagauugcagacuuuggcuugucggugcaugccccaucccugaggaugaagaccaugugc ggcacggcuggacuaucugcccccaaagaugauugaauggcggcaugcauaaugaaauagua gaucuauggugcaucggggugcucugcuaugaacugaugguggguacccccccuucga g agcccuagccacagugagacguaucgucggauugucaaaguggaccugaaguuccccucu ucugugccuucgggcgcccaggaccucaucuccaagcugcucaaacauaaccccuggcaa cggcugccccuggcggagguucagcucacccuuggguccgggccaacucaaggaggguu cugccucccucugcccuuuagccugcuccuugguuuuuugucccugucauuuuucagug u ucuuuguaugucuguguauguguucugagaaggggugggaacuggauacuauuccuagc uccaguucuaggggaucuaaucucucuucugaccucuacaaucaaaauaggcaccccug u ggugcacaauaugcacgccaaacacauguaguuacaaacagggcaacaaacacacagaua gugcuggagagauggcucggcauuuaaaagcacuugcugcucuucccaggaaccuagau ucaauucuagcacuacauggugcuucacggccacugucuguaacacccaguccuggggaau cuggggccuucgagccucugcaggcacuaggcauggaugugguauacauguaugcaggca aaacacccaugcacugacuuuaagaaacccucuagucugauuccuuucaggguugucaaa ugguugaauguuauuuuuaaaauauuuauaagccauuuaauacaaugguucuuugaaacaug guauagccuagucugucuuaaaguucagaaaaauuaugaagaacaacauguuauaauaaag ucuuaaauguuucauguuuuug 56 AF02648 Sequence below. uugccuaggaagggcgcgucgucucuucugcucguccggcugugacggggaagggucccgcugcguuuuggucacuguga uaccaaguuugggggauccccgagggacucucgagagcucauuuuagggaugcaggggcuacuccccggugguagagag cuuucuaguuuugcaggauguuucguauuuggaggaguccagcuuagucauaaagcacauguucucagagaugaggacaag acuaagacccuaaucccugaucuuuaccuuccuucccgcugaccugggccuggaugcuaaagcccucugcuuucgucua aacagcgcuaaauaguauacaguauugccuaagauaaaugcggauuauuacccgauucagugucgggaaaaggcagcuagg agagagcggcuguacgugguaagcacacgguaaguuucguuuaaauuuaaacaaccauccguugagcaucucuuagcaag cuccuuccacccuucaaacaaucagugauaguacgucuguuucacugauggaugagcuaaggcuccaacaacagcaaagga acuaauccgccucugaucaacauggcguuucuuacagggcauuccuuauacgcuuucccacgugcguaacaggaaucgggu gugggcccuggguuuuguuuguuguuguuguuuuguuuguuuucuuagugaaagagugcagggugggcuccaggccgcu gaggauuaauaaagagauucuaugaauaggaaauaacaggcagguggguauaacgagggcaaggcccugagaaaagcuuag guggggugaguagaaccagagccggaaguccacucagcagccuggggcacuuaaagcuucugcuuggggcaaaugguuaagg Cggcguaaggucacauuccuucauuucuuccagacucaggaggagaccacaccuuccggagaaccaggccugaaccgagg uacuauuauuguagcucucagaauccaggacucugcaacacuguugggcugccuuggaucuucuauauucacaguuuccca guugcuucuugaucuaccacuguuagauacuucugccacccauccuaagaguauaguuuguucuuggaaaggaguucucagcu gcugucagcaggagucccucauucgacuccugugguugcccuuuccaccaugccaaagaauaaaggcaaaggaggcaaaaa caggcgcagauguaaaaaugaaaauuaaucugagaaaagauaguuguguuuaaagaugaugggcaggaguaugcucagg ugaucaaaaugcugggaaauggacgguauaaacaauguacuuuaacggugugaggaggcuaugccauauaagaaggaag cugagaaagaagguuuggauaaauaccucggacauuauauugauuggucuacgagacuaucaagauaacaaagcugaugua aucuuaaaguauaaugcagaugaagcaagaagucugaaggccuauggagaacuuccagaacaugccaaaaucaaugaaacgg acacauuuggguccuggggaugaugauggaaauccaauuuggaugauauuggaggaugaugauaaagacauuggaugacaucuag ccugaccuaagcaugcuaccuuccaaguuucucugaagauagcuccacacaguggcaucuugaccuucaucuguuaaguaaa acuucauggcauguguaugacuuguuaaugcaagcuaaugaauuuugguuggaaguacuauauuucuuugaaaaccaa agauguugaguuaucaucuuaaaugacauauuaacacuuugugcuuuugaauauaaugaaccuagcgcacagcaggugag Cacuguuaagagacugccuuuccauuuguagcuucauuucuggcacgggaguguuuugugucagcagucugccaggugg ccaucgaugagcugaaguaaguccuaguccagcacaucugcuucaggccuguacucuagucaucuggcugcguucgaga cuucucagcagaacuuauagauauguacggcugcacuuggaggucagacaagauauggcuacuuuugguacuuauauagcca ugccauuuuauacuuucacguuguauacauucguuuugacccuuuaaguuuguugccacccauaaaaaggcaucuuacaguugc aguuuuuaaauuacauggguagcaauuuugaguuuuaaaaauuagucauugcagaaauuaaauacuuagaggagauaauc cauuaucuugauuuuaggaauauaauaguugacaauguuuauauauaauuuuacuucucuaaggcauacccaaaaauagaa aaugaaaaagagcagugaguucuguuucugaugcuugcauugcauagagaaguuuuccaacaaagcagcuguuaauaacacau aaaauauguuuuacuuugcaaaguagguuguguuaagucauuuucaaaaaguuaccuacuauaucgaggcucuggauaau uacuauuuguugauaauuuaguuacagaauuuacaagcuaaguuuuccaaacuaagcagaaaggagaggaggccaagga aaccacagcucaaugaaaacacgguccuguuuucuaaauggaggcacccaaaaacacaauaaaacaugguuggacaaaaaa aaaaaaaaa 57 J04596 caugaucccagccacccgcucgcuucucugugcaucgcugcugcugcuggccaccagccg ccuggccacaggggcgccuaucgccaaugagcugcgcuugucagugccugcagaccauggc ugggauucaccucaagaacauccagagcuugaagguguugcccucagggccccacugcac ccaaaccuaagucauagccacacucaagaauggucgauaggcugccuuuacccugaagc ucccuugguucagaaaauuuguccaaaagaugcuaaaagguguccccaaguaacggagaaa gaagacagacugcucugauggcaccgucuggugaacgcuggcuucugacaacacuauaca aucuuaugaggguccuauauauuauguaggggauuuauuccacaaaguguugguuu uuauuuuacauuaauauuuaacaauguggauacauuucaucgaugguaguucaguucg cuuguucaguuuaaagaugguaggcuuaaaauauggucauuaaaacuaauagggauuggga gaccacuaagugucaaccacugugcuaguagaaggguguugugcgaaaagaagugcagag ag auagaguuuaguauuauguuuguauguauuagggugaggacaugugugggaggcugu guuuguaugucuugaaaagaaugucaguuauuuauugaaaguaucuuucauauuuuau ggucaacacgcacggugugacgcuucccuuggacauuuugugucuaguugguagcccaua augggcuuuacauucuuuaacccuguuucuccuggucucgucucgcucgggacagagac guucaaaggacuguuacaaaugaaguaaaaauaaaaguuuauuaag 58 X81580 cgucucccgcaugggcgucugggccgugcaccuggcccgcuagcucgcugcacuaccguuacc cacaagccaacaugcugccgagauugggcggccccgcgcugccgcugcuccugccgucgu ugcucuucugcugcucuugggcgcgggcggcugcggccccggggugcgcgccgaggug c uguuccgcugcccacccugcacgcccgaggcucuggccgcuugcgggcccccacccgacg cgcccugcgccgagcuggugcgagagcccggcugcggcugcugcuccuugugcgcacggc aggaaugcgaagcauacggcgucuacaucccgcgcugcacccaucgcuacgcugcuauc ccaacccgggcuccgagcugccccugaaggcgcuugucacaggcgcggguaccugugaaa agagacgcgugggcaccaccccacagcagguugcagacagugaugacgaccacucugagg gaggccugguggauaccacguggaugggaccaugaacauguugggaguugguagcagu g cuggcggaagccccucaagucaggcaugaaggagcuggcuguguuccgggagaagguca augauagcaccggcagaugggcaagggugccaaacaccucagucuggaggagcccaaga aguugcgcccgccucccgccaggaccccuugccagcagggaguuauaccaaguccuggagc ggaucuccaccaugcgccuuccggaugaucggggcccccuggaacaucucuacucccugc acauccccaacugugacaagcauggccgguacaaccuuaagcagugcaagaugucucuga acggacagcgcggggagugcuggugugugaaccccaauaccgggaagcccauccagggag cucccaccauccggggagaccccgagugccaucucuucuacaacgagcagcaggagacug guggggcccaugcccaaagugugcaguaaaccccagccagucggugccuggcuuccccau cccgaacaccaacauaauagggcgucagggugacggguguagagggaguucccaguuu ugacacauguauuuauauuggaaagagaccaacacugagcucagaagccccccucugacc ccccccagcggcuguuauugaaccucccuugcuucuguuagagaggggaagggugguau ggaggggcacuauguacaauccugggaaugggggaaagaaauuuuggauuuuuuaucccug u 59 AI314958 gucucuuuuuuacuuaagauuaaaggaaggaaaaaauaaaaaaaaaaaaa gaugugaaaaacguuuuuauuauaaucucuuaaacuuucaguguauauuuucauuacaau cauugguacaauaaauauggaaaugcugagcagacagggaucacaguggccuaugggcug agggacaaggacccaaauacuguuacccuggauacuuccucagggccaaucaauaggu cuucaaagaguauugagagggagagggauagaaauauuauuaagacugucagugcagcaa cuuggagaaugucuauuaaagccauggauacaggauuuacgauauagaagauggauacu aaaaaagaacagagacucaaguucuccuguaagaggcagaagaaacauugcagaagccag ugccuuccucggguccccagugugugcccccauccacccacgcauuguguuggucaucuc caccugcccugugcccagcccugugcccacccagguucuccuaggcacccaccuugcacc ucgcacg 60 AF0058798 gaauucugcgcaggguuugcauuuuauggggucagaagcuuuuuacauaaacgaagc uccaacgacuagaccacagggaccgucguggcggccgagcagcguauccaacagg a gacagccaguucgccguaugucugucuauccuucacacagucauggagaggagccaucu gauccagaaggccaagaggcugaacaggccgaacgguuaugaagacauggcagcuuacau gaagaucgccguguaaaagggcgaggagcucuccugcgaguagcgaaaccuggggauccgu agccuacaagaacguagugggcggccaaagagcgggccuggaauguccuguccagcaucga gcagaagagcaacgaggaggggucagaagagaagggccccgagguugaaagaguaccggga gaagguagagaccgagcucagaggugugugcgacaccguacucggccagcuggacucgca ccucaucaaaggggcuugagaugcagagagccgcgacuucuaccugaagaugaaggguua cuacuaccgcuaccuagccgagguggccacuggcgaugacaagaagcgcaucaucgauuc ugcccggucagccuaccaggaggccauggacaucagcaagaaggagaugccgccuaccaa ccccauccgccugggccuguccugaacuuaucagugggaccacuacgagauagccaacag ccccgaggaggccaucucgcuggccaagaccaccuucgacgaggccauggccgaccugca cacccucagugaggacuccuacaaggacagcacccucaucaugcagcuccugagagacaa ccugacucuguugacagccgacagugcuggggaagaggguguugagucuccggaugaccc ccacaucugaagcagcgggaaaaacaacccggguuagcuuagccuaccagguccccagccug gcauagaggauuaaaagggagugggauuuugccgggucccaaacccugaauguucagcaac accuugggaaguucuuucgaagguggcgcagccaagcugaagccaccagggcagugaauu uaauauuucguguagcugauugauaggguggguuucccaaaaccaucccaccccuaugggu u gaacccccuccccaauucuucccccugagccucccucgggcaccuguugcuuuuggaucc gaauaauccaauagguuccccacccuauggcugagaaauggacuguagcaagaucuguau gugugugagagagagggaaacacugugugugugagugugagagagagagagagagugaa ugagagggaaaaaguuugcugggugugaccaugguaccaaucaauaaaguugcccuguga gacucaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa 61 AW046627 uuuuuuuuuuuuuuauaaauaccaaaacauauaauuuaaauaccuguauaaaaaauaug aucuucaaacauauucacauuauugaacuuauacaaccccaccccugauacuuagucacac cagggucacagaaacacagcugcaaaaaaaaauuaagggcauugagauucugucccccaac cccagcuuucagagccagcaagcagacuguacaaggucaauaauuuuuaaccccuccccag cgcagagugcucagggugacagggucuc 62 AI848050 uuuuuuuuuuuuuuuuuuauguaacuaccggugugcuucauuuuguuuagcagaaccac ucucuugaaucacauuaacuuuuggagauuuaaaaaaaacaaaacaaaaaaaaaaaaaaaca acaaaaaaaaaaccaacccuccauagcacagcugucuuauaugcaagcaagagcacaccu acuccagcaugauuugucaucuaaagacuugaaaacaaaacaacaacaacaaaaaguuac uuauagucaauggauaagcagaguccaaauuuucacuaaucaaggacagaccuucgagggg ucacgauaaguccggaauuuucaaaccuugauucguaugaauuguacuaucugaacauaa 63 AF065441 augaggacuccacagccucauccugcucuccuuccuucuccuggcuacucaagcguucuca gaaaaggucagaaagagagccaagaacgcaccacacagcacagcggaggaggggguagag gguucagcucccucguuagggaaggcccagaauaaucagugaagcaggacaucuaaaucu cugacgcauggcaaguuugucaccaaagaccaagccacaugcagaugggcugugacgag gaggagcagggcaucagccugaagguccagugcacacaagccgaucaggaguuuucuugu guuuuugcuguugacccaacugacuucuuaaacacgacaaagaccagaucuacugguaa cagguugcccgcacgcuacgcaaacagaaaaauaucugcaggaacaccaaggagugucuagg aagaccagagugugcagaaagagauuuccagagucuaaccucaagcuggugaaccccaac gcacguggaaacacgaagcccaggaaggagaaagcagaggucuccgcaagggagcacaac aagguccaaguagcugucuccacggagccaaacagggucaaaguagacaucacacucaau ccagcugcgacccagaccauggccauuagagauccagagugucuagaggauccagaugug cucaaccagaggaagaccgcccuggaguucuguggggaaucuuggagcuccauuugcaca uucuuccucaacauacaggcacaucauaa 64 AF022992 Sequence below. cgggucgacccacgcguccgcccacgcguccggcggagcuucuggguugcgggccgaaacggcaagcggauggagggcgc ucgaacggccaggugucgugauuaaauuagucagcccucagagacagucguccuaccuccuuuauccagaccucaaaagcc ccauugugcacccgugguaucuucuucaccuucccuguuggcguccuccacuguauggcccagacaugaGGugguccccuaa aaggggccgaugggggaggagaccccaggcccggagaaccuuuuuguccuggaggagucccauccccuggggccccgcagc accggccuuguccaggccccagccuggcugaugacacugaugcaaacagcaauggcucaaguggcaaugaguccaacggac ccaaguccaggggcgcaucucaacggaguucucauagguuccucuucgGGcaauggcaaggacucagcucugcuggagacca cugagagcagcaagaguacaaacucacagagcccauccccacccagcagcuccauugccuacagccuccugagugcgagcuc agagcaggacaacccaucuaccaguggcugcagcagugaacagucagcucgagccaggacccagaaagaacucaugacugca cuucgggagcucaaacuucgucugccaccagagcgucggggcaugggccgcucugguaccuuggccacacuucauuacgcu cuggccugugucaagcagguucaggcuaaccaggaauauuaccagcaguggagucuggaggagggugagccuugugccau ggacaugucuacuuacacccuggaggaauuggagcauaucacauccgaauacacacuucgaaaccaggacaccuucucugu ggcgguuguccuuccugacaggccggauugucuauauuucggagcaggcagguguccugcuucguggcaaacgggaugugu uucgggguacccgcuucucaggagcuccuggcuccccaggauguggaugucuucuauggcucuacuacaccaucucaacug cccaccuggggcacuggcaccucugcagguucaggucucaaggacuucacccaggaaaagucugucuucugccgaaucaga ggaguuccugaccgugauccagggccucgguaccagccauuccgccuaaccccauaugugaccaugauucgggucucagau ggagccccugcacagccgugcugccuacucauuGGccaagcgcauccacucuaguuaugaagcuccccgaaucccuccugac aagaggaucuucaccacccgacacacaccaagcugccucuuccaggauguagaugaaagggcugccccacugcuggguuacc uuccccaggaucuccugggggcuccauuacuucucuuucuacauccugaggaccgaccccucauucuggccauucauaaga aaauacuGGcaGGcuggcaauccagcccuuugaccauuccccuauucggcuucugugcucaaacgggaaauaugucaccaugg acaccagcugggccgguuuugugcaccccuggagccgcaagguggcuuucguguugggucgccauaaagugcgcacggca Ccccugaaugaggacgucuucacucccccagcccccagcccagcuccgucccuggacucugauauccaggagcucucagagc aaauccaucgauugcugcugcagccugugcacagcuccagccccacgaugcucugugggaguuacccucugauauccccug guccucuacacagcccuggcuccuccagugauagcaaugggggggacgcugaggggccugggccuccugcuccagugacu uuccagcagaucuguaaggaugugcaucugguaaagcaccagggacaacagcucuucauugaaucucgggccaagccccca ccccggccccgccuccuggcuacagguacauucaauuccaaaguccuucccugccauuccccaaaccccgaacuugaggugg Ccccaguuccugaccaagccucguuagccuuggccccugaggagccagagaggaaagaaaccucuggcuguuccuaccagc agaucaacugccuggacagcauccucagguauuuggagagcugcaacauucccaguacaaccaagcguaaaugugccuccu ccuccuccuacacugccucuucagccucugaugaugucaagcaugggcagguccaguuccugugggugccaugaaagauc cgucgucagcaaugcuGGucugagagaggcaacuccucagaaggaggccagugggugggaagcacccugagcccgccacc cuggccaauaaggcagagagcgugguguccgucaccagucaguguagcuucagcuccaccaucguccaugugggagacaag aagcccccggagucggacaucaucaugauggaagaccugccuggccuggccccuggcccagcccccaguccggcccccagcc ccacagguagccccugacccaaccccaggaugcuuaucgcccaguagucuaaccaaggccguggcugucccugcacacacagaa ggaagagcaagccuuccucaaccgcuucagagaucuuggcaggcuucguggacuugacaccucuucuguggcccccucagc cccuggcugccaccauggccccauucccccuggucgccgacaccacugccgaucuaaagcaaagcguucccgccaccaccac caccauccccccggcccuaaacucccugcuauuucucccauccuucaccgggugcccucuucuggacccuggccacccccac cagccacgacccccuucccagcaaugguccagcccuacccacucccaguauucuccccucgaggaggaccccagccccuuccc ccugccccuacaucuguguccccugcuaccuucccuucucccuuagugaccccaaugguggccuuggugcucccuaacuau cuauucccuaccccaccuaguuauccauauggggagucccaggccccuuuugaggggccacccacgccugcuucccacucg cccucuccaucccugcccccaccaccucucaaccccccccaccgcccagacuccccacuguucaacucgagaugcagcucccc acuccagcucaaucugcugcagcuugaggaguccccccgcacggaggggggcgcugcugcaggaggcccaggaagcagugc ugggccccugccucccagugaggagacugcugagccauggccagauugguggagguuacugagucguccaaucaggaug cacuuucagggcuccaacgaccugcuagagcuacugcuccaagaagacucucgcucggggcacaacuccgcagccucaacu cccugggcucuggccugggcucugggucugguucaggaucccacgaagggggaagcaccucagccagcaucacccgcagca gucagagcagccauacaagcaaguacuuuggcagcaucuacucuuccgaggcugaagcuggggcugcucgggccaggacug agccugagaccaggucauuaaguaugugcuccaggaccccaucuggcugcucauggccaaugccgaccagcaugucauga ugacauaccaggugccguccagggaugcagccucugugcugaagcaagaccgggagaggcuccgggccaugcagaaacagc agccacgguucucagaggaccagaggcgggaacugggugcugugcacuccuggguccggaagggccagcugccucgggcc cuugauguggauggcgugugguggacugugggcaacaacguucaagauccuggccacucugauggacccggcucuucucaggaacu ggauggauuggggcuggagcccauggaagaggguggaggcgaggguggugggugugguguuggcggugguggggguga guggggucucauccagcccagcuuuaccugcagaagaaaacagcaccagcuagauccauuuuggggccgcuuacagcaguc uaaugagaggcuuccuuucgaccauguugggguucuuauaacucaagauacagcuggaccaaccaauaggaaacugcccca gcuucucccaacauagggggcuggacccccauuaccagcccaggcacaggagcugccucuagcuucuuagcagaguggaag uucucagccccauuuggaggauuguccacgcccgucccacuuaggagacgggcgggucuucuguuaagguugcugacaag cugcuggaaauggcuguccaaaucccaGGcugagccugaaucccagucGGcaauguuggaucugcacuuauuuauuugggag agacagcucacucucccaccucaccccaagaugggaggaggggaaccugggaucuguguaggauccagguccgugaacccc uagcugcuccagggugggggagguugguggaccauggagucccuggugcugccccucaggugggacccagguuuucucag cucuacccucuaccaaugacauuuguauuuggauauugugucuguuauuuuuuuuuuaauacaaaauggacaaaauggaaa aaccaaaaa 65 AF064088 Sequence below. gacagcggagcgcgguggcgucgacgucuagugucucagugcucccgucuguggcuaacuaagcagccagcagccaggcag cucgcgaccuggcggccaggcagccaaccauggcucaacuucggcggcuucucuccagcaaggcuucggagggggaaaauggaacu aauuucugaaaagcccagagaggggaugcaucccugggacaaagcugagcagagugacuuugaagcgguggaagcgcucau gcaugagcugcgacuggaagucucauuucaagaaauaccuugaaaacaggccugucacaccagugucugauaccuccga ggaugacagccuuccagggacgccugaccuucagacagucccagcauuuuguuuaacgccaccuuacagccccucuga cuucgaacccucccaagggucaaaucugacugcaucagcgccaucuacuggccacuucaaaucuuucuccgaugcugccaag ccuccaggcgccacuccuuucaaagaggaggaaaagaauccuuuagcugccccuccucuuccuaaggcucaagccaccagug ucauccgucacacagcugaugcccaacugugcaaccaccaguccugccccgugaaagcagcuagcauccucaacuaucagga caauucuccggagaagaacccacaaauguuggaggcuacucggaaagaacauacccugugcugcaguGGucaccaaacaga ccaagccugagcccagcacaguguccgauggugaugagaaggcgggcgcugcacuauaugacuuugcugugccuuccuca gagacaguaauuuguaggucucagccagcuccuucuuccccagugcauagucaguacugguuucuucaccuacaguaucc acugggggagugccaccccugccugucaucugccagaugguuccccuuccugccaacaacucucuuguuagcacagugguc cccagcacuccuccuagccagccaccagcugucugcucaccuguguuguucaugggcacucaggugccugagggcaccguc guguuugugguaccccagcccguugugcagagcccaaggccuccaguggugagccccaguggcaccagacugucucccauu gccccugcuccuggauucucuccuucaggcaggcaagggucacuccucagauugacucauccagaguaagaagucacaucugu agccacccaggg-uguggcaagacuuacuuuaaaaguucccaucugaaggcccacgugaggacacacacaggggaaaaaccuu ucagcugcagcuggaaaggcugugaaaggagguuugcucgcuccgaugaacuguccagacaccggcggacacacacaggug agaagaaguaugccuuucccaugugugaccgucuguuuaugaugagcgaccauuuggaccaagcaugcccgacgccaccuau cagccaagaagcugccaaacuggcaaauggaaguuagcaaguuaaaugacauugcucugccuccgaccccugcuuccgcaca gugacggccagaagauggagacgcagaauaaacuuuggucagagucaggagccagugauggugucaagugcuucugcaag gcuguggcccuccaaaagggccuaaaguagaauccuggccuuggggaggccccgccuggguuaaaugacaagaaguucuu caaccacaggcaggucacagguggacagggcucaguucuuaccacagagagagaggagaacccuuuuauuccucccuuauuu uagucuggaaaguuucggcugaggugagcgcagcacagguuuugaaucacauacacauuggggacuuuguuuuugccauu uauacuagagaccagcuuugcagugugauucuuucaaaggauugguuucaagaauauagaggcuggaaauuugguacag aaauggagcuagaaaaugaguuuaguuacacaggugaugucaucuucuccuagaguuaucuuguuucuuauuccuagucu uuccagucaaauccguggauguagcuaaguauaucuaaaacucauuuuuccacuauuguugguauuugaaguugaacagc uguacauugcugugggggagccaaaggauuggaacccucauuaagggaauugcuuggaaaugcagcuaaaauucuucuuu agcauuuugguuuugaaaguuuaggcauuuuacucuacuuuagauuuugggguugcuugcaguuuuuuguguagauuugaa aauuguauaccaauguguuuucuguaggcuuaaaauacacugcacuuuguuuagaaaaaaaucuggagaugaaaauaugua uuauaaagaagagaugucaagagggugagauaacuccuugagaaaguuggcuuuaugucaucagcaaaggacacuuaacgu caagcauacacuguggauuuuuuuguuuuuuuguuuuuuuuucaaauuagaaaguuuaaugaccguuacagauggccaca gugucuuuuuauuuauaggaguuuuucaggaugucagaguagauagguaggaaaauuguuauuagaacauucgcuucuac cuugaaaaggauguuaauguggucauguucuuagcaccacagugucugggcaucugggaaacuccgagacuuuuuuaaag ugucaugaugugaucacaccugcaguuugggcaucgaauccagguccuugcaugucuucuguaagagcucucaucgcug accuguaucccccgcaagagcaaugacuuuugcuaacaguauuucuuuucuguuguaaaguggacagaugauacacuugg ucgcaaagguaaauuauucaaaauccacagugaaaaccucaccacacuuucccauuuaaacuauuuccauaucucagagguu ucugacaugcaaacuugaacccuuuaagaagaguuacuuaaaaauuauaaaaaaucacgaguuacaauaugcacaauau uuuuuguugaacuuuauaccuugguuuacaauaaaggacuuuucuuug 66 AI787713 uugucauuugcacgacagaaacugcaggaagaugagaugcgccgggcugcggaggagcgc aggaugguaaaggcugaagaguuagcugccagacaaaggguucuagaaaaaauuuaagg gacaaagcagagagagccaagaaguauggugguaguguggguucucggucauccccacca gcaacagacccagguccuguuccuucuucucccagccaggagcccccuacuaagcgggag uaugaccagugucguauacaguuuagucugccugaugguacuucacugacccagacuuuc cgggcccgggaacagcuggcagcugugaggcucuacguggagcuucaccguggggagga g ccuguacaggaccaggacccugugcaguagcucaguggcuuccccaucuggcuuucuca gagggcugauauggaacccucugcaggguacugggacucgugccuucugcuguccucauu guggccaagaagugucccagcugaggguucuccaucccaccaucuc 67 AI853531 uuuuuuuuuuuuuuuuucacaaauaaguaauauaacuuuauuaaaaugaaaagacaauau ucaaaauaaugcaacaaaaugaauaaauccuuuguccaauacuguacacacagugcggag aucagugcauuuuucuaaagcauguuuuaaccuucauuuaguucauacuaaaguaagcuu uaaauagcucaaauaaugucauucaacaguuuaaacugaacagcuuguuaugacaugaca gcagugucccugcuagcaagcaccuucucuuuguguuuaucugcacaagauaaacaauca gaguauguaaaaacunacacaaacugauugucucacugaaucucagggcaguuaagcag ccagcgugaguuuucaaagcaggaagaugcugguaggugaccucuggcauuaaggacuuu ugcua 68 X14678 Sequence below. uucauuggaaagcacauugcucuucucaguaauuucuuuaguaucuucaugauuuuuuuccuuuugcgucuuuauuucag caauucuaucugcagaucauaaagguaguauugacagaugugauucuuuuucuuaaacauuucauuuccaggguaaggaa cucaauggcuauguuuuucucucccucuagugcauccuucuccuuuucuaccauuuucacucuauuggacuucaucaugu ucagucuggccuuugguuuucuucauagcaaucuguucaacuucacccugcuagauuuaaaaucgauuauggucuaaguca augccaugacuucuaaggagauuuccaacauuggaaacgucuggcuucuucccacggaugugguagacagaagugcuaucu cuguaggcgguucuggauacauagaaguugcuguuaggaaggacuucguaaucaucuccuuccuuaucaauuaucuuuug aaaaugaacuucuacaguacaacucugauuauccuuguguucaucauauuauguaucaguaccgauagcuuuuuugaccu uauuuuuuaugcucgauagccaaacacaaaaagcauggaaucaauaacauuagauuuuccacugccauuugguccaauaau acaggaaaagcgcuuauggaaaggucccacaaguuucucuccagcauaggacuugaaguuuugguuuacaauaugaguuau Caugagacgaggagcuccagcuucacuggccauggcuggagguggggguggagggauacuauucaaaaucuccucuaaac ucuuauccagcuccucaccuggaggcuuugcgggugcagcgcuccccucaccuacuucgccuacuacaacucccacca ccuccucucgauacaagaccgagcucugucggaccuacucagaaagcgggcguugucgcuacggggccaagugccaguuug cucacggccugggugaacuucgccaagccaaucgccaccccaaguacaaaacggaacucugccacaaguucuaccuccaggg ccgcugccccuaugacucucgaugccacuucauccacaaccccaccgaggaccuagcucucccuggccagccccaugugcug cgacaaagcaucagcuucuccggcuugccucaggccgcagaagcucgccgccaccuccaggcuuuucuggcccuucccugu ccucuuguuccuuuucgccuuccagcuccccaccgcccccuggggaucuuccacuuuccccuucugccuucucugcugccc cugggaccccugugacucgaagagacccuaaccaggccuguugccccuccugccgaaggucuacuacccccagcaccaucug ggggcccuuggguggccuggcucggagcccaucugcccacucucugggauccgauccugaugacuacgccagcagcggcag Cagccugggggggucagacucaccugucuuugaggcagggguguuugggccuccccagaccccugcacccccaaggcgucu ccccaucuucaaucguaucucugucucugauugacaagugccuaccuacccaguauggaucagcuagaucucaaagagagg acagggacugcucauugcuguggaaccugggacacuccucuaaguuaauaagucccaucuucuggacauuccaagaugca auaacccauuucccuggugcugggcuggggcaggucccuaguuugcaaauucaguguuuggguggauccguuccuagggu accuaagauguuugauggagacaguugacaguuggucuuccaggccccaugucuucuuuuguuuuugagauaggagcuuu uuaugguaccccaggcuagcuuugaacucaauauaauccugccuuagccuuuuccaagggcugggguuacagguaugcac cagccccucugcaacucuggucuccuggaaucuuaagugcugugaagagccggcucccacaauauauccuaauuuuuacu agacccugauguucaguuuccgguggucgaugccucuccugauauccuggugcucaaauuucccuccuauagcaaauagc caaagccauugccaaaucccuucucccccaaccagugggcccuuuauuuaugacgacuuuauuuauuguauuggagauuuua uaguauuuauauauauugggucgucuacuccguuuuucuuuuuguaauguuaaaacugauacuguauuaaguauaugcua uaauauauuaauauauugcu 69 AI854358 cggacgcugcagaccugaccgacgugcugugcgaguucgacgcggugcuggccgacuucg cgucgcccuuccacgagcgcacuuccacuaugaggagcaccuagagcgcaugaagcggcg cagcagcgccagcuucagcgacagcagcugcuucagcgacucggagagugcagacucauu guacagggacagcuucaccuucaaugaugagaagcugaacuccaaccaacccucucc agcucuccugcccuccgcugucacuccucggaaagccaaauuaggugacacuaaagagcu cgaagacuucauugccgaucuggacaggaccuuagcauguaugugaagcaaggaguuugg gguc 70 X67668 ccggggccaaggagaagucugcaaaacaagaggcuggaauuggccuuagcgagguaaucagu ucucuuaggagguuagggaauaagucuuucucuggaggucugagggaagcgcucgugu c agauggccagguugucauagguaaggguaaccccaucaagccgcugggcaaaauguccucu uacgccuuuuuugugcagaccugccgggaggagcacaagaagaagcaucccaauucgucg gucaacuucgccgagaucuccaagaaaugcuccaagagauggaagaccaugucugcaaag gaaaacucgaaguuugaagauuuggccaagagcgacaaagcuuguuauuacaggggagaug aagaacuauguuucucccaaaggugauaagaaaggaaagaaaaaagauccaaaugcuccg aagagaccaccgucugccuucugccuguuuugcucugaaaaucgcccaaagaucaaaauu gaauacccgugccugucuauugagauacugcgaagaaacugggugagauguggucuga g cagucugccaaagagaaacaaccguaugagcagaaagcagcuaaacuaaaggagaaguau gaaaaggauuuugcugcauaccgugucaagggcaaaagugaagcaggaaagaaggguccu gguaggccagcagGGcucaaagaagaaugacucaaaaaaugaggaagaagaagaggaagaa gaugaagagggggaagaagaggaugaagaauaaguggcuauccuaaaguguggaguauau gugcucaggcaguuauuuugcuaauaauguaaauucaagcgcagcucaacauuagcucca guaggaa 71 K02236 aucacgcuccuagaacucuucaaaccgaucucucgucgaucuucaa ccgccgccuccacucgccauggaccccaacugcuccugugccuccgguaagggggacugc ugacgggauuucugggagagcuagacaggcuuuuuggccccuccuuuaguaauuacuuu a aggguacgaccggcuaccccuuccgaaugaauucugaagcacuccugcuccuuuaaacua guccuugagauaguggcucgccuacccgggugauuugccucaccuuccuaggagaacagc guucagguacucccgggucccacucaaccgcgcucacugacugccuucuacuuuuagaug gauccugcuccugcggcuggcgccugcaaaugcaaacaaugcaaaugacuuccuggcaaga aaaguaaguuggaucuucucugccauuuccccgucacucuccuggggucccuagcccgcc gcgccucgccuucccucccgugagcguucagguggugugccucugacaagguuucucgcu cacguucaacucuucucuccccacaggcugcugcuccugcugccccgugggcugugcaaa gugcucccagggcugcaucugcaaagaggcuuccgacaagugcagcugcugugccugaag gggggcggagggguccccacaucuguguaaauagaccauguagaagccuagccuuuuug uacaacccugacucuuucuccauaacuuuuucuauaaagcauguaacugacaauaaaagc cguugacuugauu 72 X51829 Sequence below. gcucuuaguuuguggaagauuacaugcgauaucccgucgaccccucaucccuuccggccgggacagccuuugcuacag ccugugaaacauugcguccccggugccccacgccugagggcaacaugaacccgcuacuucgcggugcaguccgggacccacgga ucgcuuuuggcaaccagaaccggcgcuucagcccccggggugacgugcagcccgccgcccagacacauggccccgagcccaa gaccccagcauguccugcacuggagggacgcccacaacuucuaucuccuguccccacuuuggucuugcucagucgggccu agagccggccuaaggagcccagaagucccagaacauggcuggcaaaaacaauaacaggaggcaaaucagauagguaggcugcgg cucugcugacaccuaccccugucucugguaaccuccucccucauggggagacugaagaaaguggaucuccugaacagaguc aagcagcccagaggcucugccuuguggaagcugaaaguuccccuccugaaacuuggggacuuucaaauguugaugaguaca augcaaagccaggacaagauaaccuuagaggugaaggaaauggaacacacaacugggcaaggccacacuacaggcccgcuggccu gcaaggggcugauaagaggcuuggggaggugguggcuagagaagagggaguggcugagcccgcuuaucccacaucacagc uggagggugguccagcugagaaugaagaggauggagaaacagugaagacuuaccaagcuucugcugcuuccauagcuccg agauacaaacccaacaccccugugccuuucuuggagagggcaaaacaucaagccacggaagaaaaaggaacagaaaacaagg cugaccccuccaacucuccuucuucaggcucccacuccagagccugggaguacuacucuagagagaagccuaagcaggagg gagaagccaagguagagacacacagaacaaggcagggucacccuugucggaaugcugaagcuaaggaaggaggaccugaga caacuuuagucaguacuggaaaugccuuccugaaggccuggauguaucacccaggagaggacacagaggaagaagacaaca gcgauucggauucagcugaggaagacacagcucagaccggugccaccccccauacaagugccuuccugaaggccugggugu aucgcccaggagaagacacagaggaagaagacaacgauucagauucagcugaggaagacacagcucagaccagugccacccc ccauacaagugccuuccugaagaccugaguguaucacccaggagaggacacagaggaagaaaacagcgauuuggauucagc ugaggaagacacagcucagaccgaugccaccccccauacaagugccuuccugaaggccuggguguaucacccaggagagga cacagaggaagaaaacagcgauuugaauucagcugaggaagacacagcucagaccgaugccaccccacauacaaaucccuuc cugaagaccuagguguaucacccaagagaggacacaaaaaaugacacagaagagaaaaaggacagugagaauguggcccca ggugacucagaaacagcugacucaagccagagucccugccuucagccccagcguugucuaccaggagagaagaccaagggac guagggaagaacccccucucuuccagguggccuucuauuuacccggagagaaaccagaaucaccuugagcugcaccuaagc ugccccuucaacugcagagacggcucagauuguucaaagcccccacccgaaaucaggaccccgaaauuccucuaaaagcuc ggaagguacacuucgcugagaaagucacaguccauuuccuugcugucuaggcaggaccagcccaagcuacccgucgagguc ccuggaagcaguugcacgagaucgaagccgcuuugcucaacacauugcccaggcagaggagaagcugggucccuaccuua ccccuaauuccagggccagagcauaagcacgccuuagaaacccaucucuuccacaguccaagccucgcucuuccucugaaa ccacucccuugacccaagaugugaccacacccucuccccuucccagagaaaccccuucgcccagccuguacuugagagggag gcggggcuaagccugaguaguuuccuauuauuuauuuauuuuuuauuugaauaagaaauaaagccuuuuaauuuguagu gau 73 AW048937 uuuuuuuuuuuuuuuuuaaucaucgagaaguauuuauugagcaccagcuuugguaucgg gugugaggacucgggacaaugcaggaugcuaucccuucucaugaaacacuuacaaucuga guagagacagggagggaaccacaauacauguucuugaagugcaggcuaaagguaaacag uccagaccaggauguuacagaaacagggauguuaggagcuggagucagacccacuaagug cu uuaacacccacgauauucaacacuaagaaaagaucagccauugcucaguguccuaugagc ucccuuagcccccaagacaccaucauggccuagcuccuuguacaacuacuacuaa 74 AV139913 cccaaaacccauucagcaaaguucccaaccucgacgaacuagcaguauuuaaccaguaau agguacacuguaguauauggugaauacuguauuauguuucaguacuuucucccagauaa uuugaaaacguuccaggagaaggcagcuuccuauaugcagcgugugcuuucuuauucuu uuuuuuaauauaugacaauuauuugagaacccauuucuacuuuaaauucauuuucuug aaagucaugauucuacaccuaccauuuuccuauuaaaguacuguauucaaau 75 M32490 Sequence below. agaccgugaacgagagcgccccagagaagcgccugcaaucucugcgccuccuccaccagcaccucaagagaaggacacccgc caccucggcccucaccucaccacacuccggacgcauuuaaucccacugcucaccagcuuguugguucuguaucgccgcgc ucgccccgguuccuccugcgcgccacaaugagcuccagcaccuucaggacgcucgcugucgccgucacccuucuccacuug accaaacuggcacucuccaccugccccgccgccuaccacugcccucuggaagcacccaagugcgccccgggagucggguug guccgaaacggcuacggcugcuguaaggucugcacuaaacaacucaacaaggacuacaacaaaacucaacccugcgaccac accaagggguuggaaugcaauuucggcgccagcuccaccacucugaaaggucugcagagcucagucagaagcagaccc ugugaauauaacuccagaaucuaccaaaacggagaaagcuuccaacccaacuauaaacaccaaugcacauguauugauggcg ccgugaacugcauuccucuguauccccaagaacugucucuccccaaucugaacugucccaacccccggcugguaaaaguca gcgggcaguacugugaagaguagguuugagaugaagacagcauuaaggacucccuggacgaccaggaugaccuccucgga cucgauaccucggaggugaaguuaacgaaaaacaauaaguuaaucgcaauuggaaaaggcagcucacugaaaaggcuuccu gucuuugacaccaaaccacgaauucuuuucaacccucuacacgcccauggccagaaauacaucguucaaaccacgucuugg ucccaguacuccaagagcugcggaacuggcaucuccacacgaguaaccaaugacaacccagagugccgccuggugaaagaga cccggaucugugaagugcguccuuguggacaaccaguguacagcagccuauaaaagggcaagauaugcagcaagaccaagaa auccccagaaccaggucagauuuacuuuuggcaagauggcuccaaugucaauaauaccagcccaaauacugcacuccugcgu agauggccggugcugcacaccucugcagaccagaacuguguagaugcgguuccgaugcgaagauggagagauguuuuccaa gaaugucaugaugauccaguccugcauauguaacuacaucugcccgcaucccaacgaggcaucguuccgacuguacagccua uucaaugacauccacauguucagggacuaagugccuccaggguuccuaguuugggcuggacauggagaugucaugcauc auggagacgugggugggcggaggaugaauggugccuugcucauucuugaguagcauuaggguauuucaaaacugccaagg ggcugauguggacggacagcagcgcagccgcaguuggaguaugccaaggggcugauguggacggacagcagcgcagccgca guuggaguagacuucgcuucauaguacuggagcgugcauuauugcuccauauuggaucauguuuucggaugacguucugu uuucuguuuguauauuauuugcuaaguguauuuuuuugcuccagacccccccccccuuucuugguucuacaauuguaaua gagacauauuaagauuaguugggccaagugaaagcccugcuuguccuuugacagaaguauaugaaagcgccucucauuccu ucccgagcggagggggacucucugugaguguccuuggggcagcuaccugcacucuaauacugcaaacagauaccagguguu uuuagauugaauguuuuuuuuuuuuucaaagguguaggcuuuuagggaaggaaggaauuauauuacuggaauuauuugua aaugauuuuuauuuuauaucaguguagagaauuuauuuuuauauuuuaucauuuaauauagaauuauuuaccuaaa 76 AI121305 ccaauaccacagccgugaccacagccaagaccacagccaanagccuggccauccgcacuc ucggcagcccccuggcagugcccuccauauccugcuuguuuuucucauuaguaaacuccu cuucuaaagaaaacuggggaagcagaucuccaaccuccaggucauccucccgagcucauu ucaggccauugcuuuacauacccgaaugnagguunaauguccucaguccgcagcuccac caccuugaaccacaggaccugcaacacuaaugcacuugagaauacaaaugcuuaccugga ucuuucagggcacanauuccucuucuuguaanuacuuaguccauccauccugcguagua 77 U35374 auggagaacgaguucacauacgaagauuaugagaccacugccaaguggcuucugcaacac acuganuaucgaccucanguggcagugaucugugguuccggcuuaggagggcugacugc u cacuuaaaggaagcucagaucuuugacuacaaugagauacccaacuuuccccanagcaca gugcnaggucacgcaggccgacuggugunugganugcugaauggcagaugcugugugau g augcaaggccgguuccauauguaugaaggauacucacugucaaaggugacauucccagug agaguuuuccaucuucuggguguggaaacuuugguggucaccaaugcugcuggaggacu c aaccccauuuuugaaguuaagauauuaugcugauccgugaucacaucaaccuaccuggu uucuguggccaguacccucuccggggccccaacgaugauagguuuggaguucguuuuccu gccaugucugaugcuuaugaccgggauaugaggcagaaggcuaucagugccuggauacaa augggggaacaacuaagcuacaaaaaggcaccuacgugauguugggcagggccccaacuuu gagcuguggcagagagucgucuccuaaagaugcugggggcagaugcuguuggcaugag c acagucccaguaguuaucgucgcuaggcacuguggucuccguuucuuuggucucacuc auuacgaacaagguugucauggauuaugagaacuuggaguaggccaaucacauggauguu cuggaugccgggauagcagcugcacagacauuggaaagguuugucuccauucuuauggag agcauuccacucccggaucguggcagcuu 78 X15643 Sequence below. uuccaggacagcuggggcuccacgagagaaacccugccucccccccaaaaauggcccauaguucacugacauacucacauuu gucuauauuuagcuauguaacagcacuuacgguagcauuagauuuugauucucucucaucacaaugauaauggcuggcgc ucucucucucccucucuccccauuucauaucugcuagcacaccccuuugagauggagaGGaauuugauccauugggagaaucg agcuaaaaauaccaccauggaauugugggaaggauuaaaugcaauaaugcacaaaaggcacauagcagaaugugcccuaaau gucagccauuguuaugguauauguaaucuacaaaguauguuugcuuacuccgugugaaagacuuucagcuaucaaaca uaauacaugugaaaucaaaccuugaaaauuaauuuuuucccaacagucaagacauuugccagcugcagagauuagcauuu caugaaucuuagucuugucugauuuuuuuaaugggaaggaacaacuauccucaacuauccuuuuuuuuuuucuguaguuu uaaaaugaacuccacaaaacaugugguaauauaggauuauaugaaauuguggggugggcagcgaggaaagcagaa auagcccaaugguggcacauucacugacacagccuaaaagauuagcaaauacccauccaacacauacaauuaauacaauua auauuuuauaguuaaaacagaguuacuaaagaaauuguugaaaagaaaauuaugaagacuggaaagacggcucagugcu uaagagcuuuggcuagucuuccagagaaccagggucauccagcacucacaaggcagcuugugagcugauacuaucuguaua uucaguccuagguaaucugaugcuggguccugaccuccaaaacaggcacaaauguggugcacaggcaaauguauagauaag acucccaugcacagaacauaaauaacguagguuuaauuuuaaauuguaaaacugaaaaugguugcacuuacauuuuuauu ucagcacauccccagauauccgccauauaacaagaaaaugaugccacacucccaagaauuaagagggacaccucccaacccu acccaaauuuguauacucuaggucuaaagaaaugcaaaggaugaaguuacugccuugugaguucucaaggagggaggau accaaaaaaauauuuuuucacaaaguggugcuggagaaacucuguaggcuguuggagucaucuccugugcucuugccaaauaac ugaaaggggauacacuggaugucugugaauggggugucacuuaugagugcuagaagcggguaccuggauguggacacggu gucugagugguccgcacuccauucuccacaggaucgcuuauuguguuucuuuccuccugcuucugguuguuccuggu uuuguuuacagccaccucucuguuggaccagggagacaacugucgucuccagaauaagcgggcacagguguGGucucggugg cuguggcugugguucggcauaagucugagcauguccuggucgucagggugcguuugugcugugugugcguguccgggug agcuugcucuuucuguuccuaaaagaaaaugcacccugcgcuaccggcguccagagacucucagcccgcagaggugaccug aacggacagguaacaccuccagacaacgccuggguuggcggguugcacagcaGGccccagauuucucucucugggugccccagc uaggguagcuggaagggagcgguggccuggccuccggggagccgcugggccccgccgggcuaacccaggaggaggccggc uaggcugggaggguuagcccuuggugcccuacgccugcccgggccagucgcgccgccggccauuggcccaaagaauugu ugcacgucacuggcaauccccuauaagucuuugcacauaacggucaggacacugcaaggcuucuucucccgcauuuag gcugcggcugcaggcaccgcgagcccggagcacccacgagcuuagugugcaggacgcaccccagcacagccaccuacggccg ugaaugaagcuuccaguguccgcccccggccgucgccccgucguggugcacccgcugagagcgccuggaccgaaaggc cgguucgcucaccugcuaaccugccagccauggggccacacgggaacgacagcgacuucuugcuggcacccauggaagcc gagcgccacaccacaacgucacucaaaacgggacggaaggcgugagugugacauggccauccucaugucauuaucgucc uaaucuccuuggcgugugcugaucuauucaugggccuagcguuggugccguuuggggccagucacaccucuaugaaaaug uaauuuuggcaacuucugguggcgaguucuggacuuccauugauauuguacgucacagccagcaucggagacccugugg cgugauugcaguggaucgcuauguugcuaucacaucgcccuucaaguaccagagccugcugaccaagaauaaggcccgagu ggucauccugaugguauggauuguaucuugccgaccuccuugggccuauccagaugcacugguaccuugccacccacaa gaaagcuaucggauuguuacaccgaggaGGacuugcuggugacuucuucacgaaccaagccuacgccaucgcauccucggauugu gucuuucuacgugccccugguggugauggucuuugucuauucccgggucuuccagguggccaaaaggcagcugcagaaga uagacaaaucugaggaagauuccacgcccaaaaccucagccagguggagcaggaugggcggacgggccacggacuccgaa gguccuccaagguucuggcuugaaagaggcacaaaucccucaaugacuuuagggcaucaucaugggcacauucacccucuggcugg cugcccuucuucauugucaauaucgugcacguuaucagggacaaccucaucccuaaggaaguuuacauucuccuuaacuggu ugggcuacgucaacucugccuucaauccucuuaucuacugucggaguccagauuucaggauugccuuucaagagcuucug ugccuucgcaggucuuccuucgaaaccuaugguaacggcuacucuagcaauagcauggcagauggacuacacaguggag ccaaacacuugucagcuggggcaggagagagaacaggaacugcugugugaggaucccccaggcauggaaggcuuugugaac ugucaagguacugugccuagccuuagcguugacucccaaggaaggaacuguaguacaaaugacucgccacuguaauacagg cuuucuacucucuaagaccccuccuugacaggacacuaaccagacuauuuaacuugaguguaauaacugagaagaaauu gguauagaaaggguacagaagggggacacauccuucucgccuguuuuaauuuauguauuuuaggcugcaaacaaaa gagagaacuguauuugagugcuuauuguucuuguauaguucaguuccucuuguauggaacuuaaagguuucugucugaa gaguguuuguucugaggacugagucugucugucugucugucugucuuucugucuggaugauguuuucauguaucuaccu cacuggucaaguauuaagaaugauauauauugcuacugggaaauccauaucuaaaggagaaaguuuucuuccuguacccuu ggacuugaaauauccugugucuuggaccuuucugcugugacaaugggcccuuucucucucacuccacuuauuuacucaaa uggauucgagggcaaggauuugaggagacaacacuaguuguuuuguuuuuguuuuuguuuuuguguuugguucguu aaaguuuacaguaaauaaauuguuuaaccaugacuucauugcacccguuucuucaaaaccucuugacucuggaguguccuu gucucucccacuggaaaccacagguaaacuaugugucgugaccgaugaguugcuuaauguguaagaguaccagaauggcau gcuugcaugcaccgugccuagcccuuccgugugugucuucagagcuccagaugcaaaccugugccuucccuaacuucacuc gugucccaaagcaguccugccuguucacagcauaacccaguauguccuacaguugcucuucugugcugucacuccagaaac ccugacucacggaaacagaguuauggacauauguuuuuguccccauaugcucugacaccaccuucagccuuacuucuuaa uaacuguguauauggacaucacugcgucucuuacaguagugccuuuguacugcaucagggcuugguauguucaggaugag gaagauguucuguguaauagcuguucaagcaucuagaaauucugagggaaaucaaaggccucggucagagagagagagaga gagcaaagcuuuaaaaaacauagcuggugaaugcuucacgcccuucagccucuccucgcuccgucugcugucccgugucuu cuguucccaauucucugcacuucuguguaaaccaggcuucccaugucuggcauuccgugcauuauaugauauuuggcggc acgucuguaccaguaaauucugguagcacccccuaguuacaauaauugcagacacucagcgcguacgacccccuaguuacau augcagacacu 79 AI849109 uuuuuuuuuuuuuuuuuaagcguccaggcuguacuuuauuuuacacaagugguggcccc agaaccacagggacaugaccuggagaguaggcacagugccugaggcugcaagagccaaaua cagggauucaugccuucuccuugguccccaugaccaaauuaaaaaaaaaaaaaacaacaa aucacacagcacacaucgccacacccauccccuccuuccuuucagcaacagccaauucag cuuucuagccaaagacaguggcuacaacugaauuuacagagaaccaugcagccaagaaac cagagccacguaggguagaggcuugcguugacuucccacaugugcugucccauagcagcu gagugaccccacca 80 U70132 agaaagauaagggccagcaaggaaagaaugaggaugugggcgccgacgacccauccaaga agaagcggcaacgccggcagaggacucauuucacuagccagcagcugcaggagcuggaag ccacuuuccagagaaaccgcuacccagacauguccacucgcgaagaaa:ucgccgugugga ccaaccunuacggaaccccgaguccggguuugguucaagaaucgccggaccaaauggagaa agcgggaacgcaaccagcaggccgagcugugcaagaauggcuuugggccgcaguucaacg ggcucaugcagcccuacgaugacauguaccccggcuauucguacaacaauugggcugcca agggccucacaucagcgucucuguccaccaagagcuuccccuucuucaacuccaugang ucaauccccuuuccucucagaguauguuuuccccgcccaacuccaucucaucuaugagua ugucguccagcauggugcccuccgcggugaccggcgucccgggcuccagccucaauagcc ugaauaacuugaacaaccugagcagcccgucgcugaauuccgcggugcccacgcccgccu guccuuacgcgccgccgacuccuccguacguuuauagggacacauguaacucgagccugg ccagccugagacugaaagcaaagcagcacuccagcuucggcuacgccagcgugcagaacc cggccuccaaccugagugcuugccaguaugcagucgaccggccggugugaaccgcgccca gggcgcgcggauccgaggacugucggagugggcaacucugccccagaaagacugagaauu gugcuagaaguucgugcgcacuaugggaaggaagaggggggaaaaaagaucagaggaaaa gaaaccacugaauucaaagagagagcgccuuugauuucaaaggaauguccccaagugucu acgucuuucgcuaagaguauucccaacaguuggaggacgcguacgcccacaaauguuuca cuggauaugacauuuuaacauuacuauaagcuuguuauuuuuuaaguuuagcauuguua a cauuaaaaugacugaaaggauguauauauaucgaaaugucaaauuaauuuuauaaaagca guuguuaguacuaucacuacaguguuuuuaaaggcuaggcuuuaaaauaaagcauguuau acagaaucaguuaggauuuuucgcuugcgagcaaaggaauguauauacuaaaugccacac uguaucuucuaacauauuauuauu 81 M13805 cugagaggccaggugggcggcgaaaucaacguggagauggaugccgcucccgguguggac cugacccacauccugucagagaugcgugaucagacgagaagaucacggagaagaaccgc aaggaugccgaagacugguucuucagcaagaccgaggagcugaaccgcgagguggccacc aacagcgagcuggugcagagcggcaagagcgagaucuccgagcucaggcgcaccaugcag gcccuggagauugagcugcagucccugcucagcaugaaaccaucucuggagggcagccug gcagagacagagaaccgcuacugcgugcagcugucucagauccaggggcugaucggcagu guggaggagcagcuggcucagcugcgcugcgagauggagcagcagaaccaggaguacaag auccugcuggaugugaagacaaggcuggagcaggagaucgccaccuaccgccgucugcug gagggagaggaugcccaccugacucaguacaagccaaaagaaccugugaccacccgccag gugcgcaccauuguggaagaaguucaggauggcaaggucaucucaucccgggaacaggug caccagaccacccguuaaggacucagcuccuuccgcccaguuccccgaggcugcagagag gcagcuucccucuccgcuccggcaucacccuccugcuacagccucuccccagcauuccua ugcuugagaccauuaaagcuugcugaccugaagugaacuguggccuuuguucugaacacu gaaauaaaugaccauggugac 82 AV138783  ccccaggggugaaaugaggauucccccacccugcggaacagugaaauguguauaauuaag aggagggcgacgacccuugccgcgggacccgggacucgagcccgggacuucgcagcuaca gcaaaucuauuuuuaauauugugcugagcaagacagaucgcuugcauauuuuuaaaaauu uuuacuacagagacauuccaauaaauucguuaagcc 83 K02927 Sequence below. cugacagucgucucucucccuucuucaccucgcagcugcuaacuggucucaaaccucucagcacuucagcuucuagccacg augcaugugaucaagcgagauggccgccaagagcgaguuauguuugacaaaauuacaucacgaauccagaaacucuguuau ggacucaacauggacuuuguugauccugcucagaucaccaugaaaguaauccaaggccuauauaguggggucaccacagug gaacuggacacccuggcugcuaagacagccgcgaccuugaccacaaaacacccugacuaugccauccuggcagcaaggaauag ccgucucuaacuugcacaaagaaacaaagaaaguguucagugaugugauggaggaucucuacaacuacauaaauccgcacaa cggcagacacucucccaugguggccagcucaacacucgacauuguuauggccaauaaggaucgccugaauucugccauuau cuaugaccgauauuucucuuauaacuacuuuggcuuuaauacacuggaacggucauauuuguugaagaucaauguuaaag uacaaccuacuuucugagaagugguucacucaugccccuccuacucucuucaaugcugggaccaaccgcccacagcugucu agcuguuuccucuugaguaugaaagauuacagcuuugaaugaauuuaugauacucugaagcaguugccuugauuucuaa auccgcuaggggaauggauguugcugugaguugguaggcgggccacuggguagcuacaucgcuaggacuaauggcaauucu aauggccuugugccaaugcugagaguauauaacaacacagcucgcuauguggaucaagguggaaacaagcgcccaggcgcg uuugcugggguaccuggagccuuggcacuuagacaucuuugaguuccuugacuugaagaagaacacagucaaggaagaacag cgagcacgcgaucucuucuuugcacuuuggaucccaggaucucuucauaaaacgaguggagacuaaccagucuggucauug augugucccaaugaguguccuggucuggacgaggucuggggagaggaguuugagaaguuauaugaaaguuacgagaagca gguucguuuccgaaaaguuguaaaagcucagcagcuuugguaugccaucauugagucccauacggagaccgguaccccaua caugcucuacaaagauuccuguaaccguaaagcaaccagcagaaccugguaccaucaaaugcagcaaccuguguacaaaa auaguagaguacaccaguaaagaugagguugcaguuuguaacuuggcuucucuggcucugaauauguaugucacaccgga acauacguaugacuuugagaaacuggcagaagucacuaaagucauuguccgaaaucugaauaaaauaauugauauaaacua cuacccuauuccagaggcacacuuaucaaacaaacaccaucggcccauuggaauuaggguacaagguuuagcagaugcuuu cauccugaugagauaccccuuugagagcccagaagcccaguuauuaaauaagcagaucuuugaaaccauuuacuauggagc ccuggaagccagcugugaacuagccaaggaguauggccccuaugaaacguaugagggaucuccagucagcaaggguauucu ucaguaugacauguggaauguugcuccuacauccuguuggacuggaagccucucaaguagaagauugcauaguauggua uaaggaacaguuuacuuauugccccaaugccuacugcuucaacugcccagauucuggggaauaaugaguccauugagccuu auaccaguaacaucuacacucgaagagucuugucaggggaauuucagauugugaauccucacuuacugaaagaucuuacug agcggggcuuguguaugagagaugaaaaaucagauuauugcaugcaauggcuccauucagagcauaccagaaauuccuga ugaccuguagcaacucuauaagaccgugugaaaaucucucagaaggacuguucucaagauggcagccgagagaggugcuuu caucgaucagagccagucuuuaaacauccauauugcugagcccaacuauggcaaacucacuaguaugcacuucuacgguug gaagcaggguuuaaagacuggaauuuauuacuuaaggacgaugccugccgcuaauccaauccaguucacucugaacaagga aaaacuaaaagauaaggaaaaggcacugaaggaaaggaggagaaggaaaggaacacagcagccaugguguacucuuugga gaacagagaggagugccugauguguggauccugagaaaagcggggccugggagacgcagcgggcucuccuuccgagagg cagacgauuugagcauagauaggauauuggguuugcuuuuguuaucagcagcucugcuuggacgugccugccaggacaggg aaccacaacuuacaguacuauuucuacacaguguaaauaucauuuuaacaaacagaaaaccaaagccagcuuugauauuag gaaucaagguagaggcuuugggaauacuaaagagccuuccugcaaauagugaggagacuuaggaagucucgucucuccagc uuucccugccuggccauucucaguuugggcaaagagauuuaguuugauuugacugauugccuagaaguaaaaucaagcaa uuacucaucaggcuaaaaaccuuuggucuagacaaacuucuauaagucauuuugaaauaaacauuucuaagugau 84 X07699 Sequence below. guguggcuuccgcugagcucuuccgagcugcucgcucuccacacgcgccgccgccguaauccgccaccauggugaagcucg cauagguaagaggccuuugcgcgccgacgagacgacuagucccugcuuucggagggacgcgcgcgcgcccgcccguccg ucgcggaagggaagagacucgcgcaaucccgggcgcguucgagggcaccaugcugggaggaaaggucucgcgcgacu agcgggaggucucgcggugcuugcccucugacuuagggggaugagaagagcggaggcagguuuccgggagggcgauaucg aggguucggauguaugggcgggaggggacguugugaggagagaucggaggagcugagagcggauaggggcacugcgug agaagaggagggccaaccuuaggcggcggagcagucccaggccccgccuccccgcggcacgugcucuagugcgcgcccgccac gugcucugcggagccccgcacgugucgcgcgacccggggcagugggggagugucuguaguaccccggaaagggggacggc agcguggggauggauggguggcccggcgaucugcugucucugccggugaccgggauggacacgugguggaccccugagg ucggcgugguggacuccacauggugggggcuaaaacgagaggaaaguggaaaacaguuggguuacgugguggcugcuuua agaggugauuucgagauacccccuuccccagcaaauaacuuaaagggaucccuuuaacuggguuuuuuuuuuuuuuuuuu uuuuuggguuguggaagaugccagaaaauagauggccaggauuaggagacuuuauaaccuguggcuguuucuuggugu agaguucugucugcucaguuaucugugagaaguaaaaaaaaauuaugcgcgguucgcagaaaaaacuuccaggagaaugcc augccuggccaagaagaagucuuuaugcuuguguccuuuaguaagaaaaaggugguggccaaaggcaaagugacugaaaau gcgugcaauuuuugugugcguuuguaggcuggcaaaacccacggugaggccaagaaaauggcuccuccuccaaaggaggu ggaagaggauagugaagaugaauaaaugucagaagaugaagaugacagcauuggauaagaggagguaagaagcuauuuca acgaauuaaaccggugggaauugaaugucuggaagucuuaaaaauacaagauauguaguaaaugguugaauacaagcccc uuccucccucccucccucccucccucccucccucccucccucccuuccuuccuuccuuccuuccuuccuuccuuccuucugc aagacagucgucaaaacaggggacagaaacaggcagaauuuugaguuccaggcaagcagguaguaguacauagugaaaccu ugucucaagaccauuguuauggucauggcucaaucagauuucuuagaaaagcucaagugcugaguccagagguuugggguuu uaaaguauugaaagccaugucuccuuauuucaggguuuaauguuuaucuuugugugugcgcgcacccauuaagcaugcuu gguacccucauacuagaauguacuuggauccccuggaacuugaguuaaagccacaugugaauguuacauguuacaagagua acacaugugcuuaacuuuugagucaucucuccaguucuugguuauuguuuuuuuugguuuuaagccuaucuaaugucca uuuucuugugcucaaaguuagucucuuaauguagcauuggguauaaaggaaugcuuaugauuuguuugcuuucaagguu gucaucccucagaaaaaaggcaaaaaggcuaccacaaccccagcaaagaaggugguuguuucacaaacaaaaaaggcugcag uucccacaccagcuaagaaagcagcugugaccccaggcaaaaaggcagguagccacaccagcuaaaaaaaacauuacaccagcc aaagucauuccaacaccggguaagaagggagcugcacaagcaaaagcguugguaccaacuccugguaaaaagggagcugcca cuccagcuaagggggcuaagaacgguaagaaugccaagaaggaagacagugaugaggaugaagaugaagaggaugaagaug auagcgaugaggaugaagaugaugaggaagaugaugaguuggagccaccaauaguaaaaggagugaagccagcaaaagcag cuccugcugcuccugccucagaggaugaggaagaugaugaggaugaagaugaugaggaagaugaugaugaagaggaggaa gauggugaguuagaucuuaggauauuuaggguacugcauguacauucccucacuguuucauuagauuaaaaacucauuuu gugcucuuaguucuuuccauaacuuaauagguuuucauuugcuaaguaguuuuuguuuuuuuuaaguauuuguagcauu uaucuuaucuaauuaguaagagcaaauacauuugccuggauuuggccaucuuucuuccagacucugaaaagaaguuaug gagaucacaacagccaaaggaaagaaaacuccugcaaaaguuguuccuaugaaagccaagaguguggcugaggaggaggau gaugaggaagaggaugaagauuacgaggaugaggauuaugaggaagaggauuacgaagaugaugaugaugaagaagagua ggaaggguaaccauauuaacuuuuaaaguaugcugaccuaagguaaggcuuacuggcuaugcuaaagugucuacuuacucau gaauggcauuuuaaaacaucuagaaccuguuaaagcagcaccuggaaaacggaagaaggagaugaccaagcagaaagaagcc ccugaagccaagaaacagaaaguauaauguaagccugcaaaacuggguaaacagaucagaguagcacuagcacaauugauua guggacaaagggacuuaauacuaaaccauggaggugaaaugaaauaugcugauggugcuuuauaguuuaugaugaaauuugu aaaccuuaauccaaacaagucuguuaaugaauuaaaauuugccaucagugaacuuuuugcuaaaaaugaucuugcuguugu ggaugucagaacugguacaaauagguaaauuuuaauuuauguuacauuguaucagcuagaauuggggaguuuccaguua acaguuaaggagcugcaguaagaaagacuauaguauugaacuaaaugaucgagucauagggccugcaauuugaaguuccug uguuugacuugauaaagauaaaauaaaauuuggagaagaaaagauauugacacauaaaauuuugugcaguaucuacaacu auggaucugcauagucauaugcuuuuagcuaaaaguauucucuguacuuuuagcgggguccaugcuagcuacugcuguua guuacaauauacugaaugaagaaaucgaggugaauuuguuguaaugucuugguacauggacuuguuuuguuuuuuguuu uuuuuucuuuaagauuuguuuauguauauuagcacacuguaucuguccagaugguuugguagccuucauuugguuguugg aaauugaaugggguaggaucucaacucgcucugcucucagguccuugcuugcucuggcccaaagauuuauuuguuauuauac auaaguacacuguagcugacuuaagaugcaucagaagagggcauuaggucucauuaugggugguggugagccaccaugug guugcugugauuugaacucaggaccuucagaagagcagucaaugugcuuacccgcugagccaucucuccagccuuuggacu ugguuuggauggaaggauaagggugaucuagguuuuauuuuuguuaguacuguagaugcucuguggugugugccacaugguau aagugcagaucaccuucucauaccuguaaucuuguugggguccaucuucaaggaaauuugguuauguggacugagucug cugaagaccuagaaaaggccuugggagcucacuguuaaaaguguuuggcaauaaaauuaaacuagaaaaaccaaaaggaa gagauaguaagaaagguauguaagggggucugggugacuggauacuuaacagacuuaggcagucuggugccucuuccuuag ucauccucauugugaaccaaugagaugucauaggucaugugcuuggacaggggugauuccugggauauauaauguc agggcugacaggaggaauagcuuagugaguaaagaugcuugcugcaaaaugggugaucucuauaagccacaugaagagaga agaaccuuuaaucccagcauuugggagacagaggcaggcagauuucagaguucgaggccagccuggucuacagaguugaguu ccaggacauccagggcuacacagagaaacccugucucggaaaaaaaguuuuagcuuauccucugaccacauguguaucgug acaugcuugaagcuuaccuaucucaaauuaauucuugaucccuauaugguaguuucagaauuuggauaggaaguguu uguuucuuaauugugcugaaaauugaacgugggcuuuucacauacuaggcaaauuuguuggguuuuuuuguuuguuuuu uggcucaagacaggguuuuucuguguagcccuggcuguccuggagaccaagcuagccuugaacucagaaaucugccugccuc ccaagugcugggauuaaaggcgugagucaccacugcccugcuaggcaaucacucuuaaaacugcuacauauccucuguccc cuuggugcucauuuuacaagguugcuguguacucaaucuggcacuaugauauacuuacuagaucuagggcuuuugaua uagaaugaaccauaugagugaugagguaucuuagagauggaaacuaagucuaaauagacuuguuccauauacaacuuaua cauauggucuaaggaacaugauauacauguaaacaaguaggaaggagauaagucugguguccagggaagccaggagauccu caucugaaacuaacaggguugugagucaucaggugacaauugaacauggguacucuucauGGcaaauaguuaauaacc au-ugagccaccucuccaucccuuuauaccauuuuuuuuuuuagcauauauccuuguacuuuauaggaauuauuugcuuua aucucuugugacuuguaaauugauguacuuaauuaaaucuuuccaacauaguucgagcugcaagaacacuucuagccaa aaaccucucuggucaacaucacuggaggaugaauuaaaggaaguguuugaagacgccauagagaucagauuagucaggccagga ugggaaaaguaaaggguaguuuugugucuuugaguguuaaaguuuuauuaaguuuagugucuucuuuccccucuccuugu ccuugacagucucuagucugcugcuucaaacaacuucauaaccagaaaauugaauaucugguccucuggccucuaccuc ccauuuucuuacauuaaaaaugcucaacuuaugguuuuagaaggugugaucaauuuuacaggcucaauccaaagggcauc uuuugccacaauacuauccuucccuauuuuaugagagaaaugugauucuaggcaguuuucagucuuauuguguuggcucuuu uuccuccucaccaguuuaaaggaugaagaugagcuaauacauaguaaaagaacaguaaaagcacaugugacuaaguccuuca ugucugauucuugaguaauuuuucucuauguaguaacugaauugucuuguacucucaggauugcuuauauugaauu uaagucugaagcugauacagagaaaaauuuggaagaaaagcaagggcagaaauugauagacgaucuguuucacucuacua gugggaacaggaaucauuuguaucuuuguaugggaaguaauugggggaccuacaauuaguucaccuuuguucauauagcug auguuuagucuucaugaggugaaagcuauuugaaaucauuuccuuuggaguauaguaggcaaauaaagcuuuuuguuagu auguuuuguacuuuaaauggcuuaaacuauuuuagaaaauaguguaagacaacaaagaacaguuaucuaauuagaaugaaa augaaaggaucaguaaggcauuacuguauauaauggauauacacugguggggcuagaauuaugguauaugguacauggu ugaaguaccauugguuucaguuaacauuccaguaaccuuguGGgauggagguuagagacaugcuuuauagguggacccacuuac ugaguguuuaaauauacacagacauacucuaacauaccuuugcuaauguguuaucuuuguauuugcaggugaaucaaagacuu uugguuuuaaguaaccuuuccuacagugcaacaaaagaaacucuugaggaaguauuugagaaagcaacuuuuaucaaagug ccccaggaacccacaugacaaaccuaaaggguaaaauaauuuuuacguuagauaugggcuggacauacauacucuuacguau aagaguuaagacuguccuguuagcuuaaaaaaaaacuaaaguuuuagcuauacaaagggcaguaaauauugauaguaaauua caugcugaugccaagugggucuaagcuuuauucugagaacugacuuucaaccuucagguaugcauuuauagaauuugcuu cauuuuaagaugcuaaauaaucuuuaaauuccuguaauaaaauggaaauggagggcauaacaaucaggcuggaggggcaag gauccaauucgagaagucguaaguccuuugacaugauaugacuuugguugggugauuuuuuuuuuuauuuuuaugugccu auaugcucauuuggggcugucuuuauguuguugcugagaaaaugacaacuggauaugaugacugauuaccugagaaauaa uuuaugaaaucucaagaaaauuccucuagauauucaaguucugauccagcuaugucaacucaaagcagcaaccugguugc ccucugaguacgcuuuugguuuugauccaguGGuagucuuugguuuuuuuaaccuuaauuucuuguguuaauuacuuuuucu gguaaaagggggaaaaaagacauaacaaaaucaguguaagggaaggcucagugguugagcacugagaggaccuggguuca aaucccagcacucacauggcaccuaucgaguaggauuucucuuuguauuccugccugucguggaacucacucuguagacc aggcuggccucaaacucagaaaucugccugccucugccuccuaggugcugggauuaaagggugugcaccaccacugcccaac ccugucuguaacucuuaagaucugacauagauugcagacaaaacacuaaugcacauaaaaaaauuuuuuuuuuuaaaaaag gaaucuacuucagcugaaugugggcagguaugggcaauauucaccaagauaucauaaugaaacagggaauuuuucucuuccagaa ccauccaaaacucuguuugucaaaggucugucugaggauaccacugaagagaccuuaaaagaaucauuugagggcucuguu cgugcaagaauagucacugaucgggaaacugguucuuccaaaggguaagaaggcguaguaguguugcugcuuuuuaguga auucuucauggaguacuugguucugcauuaucuucucauugagcuccuuucuguccaucagugauagauuauggauucgc acgagaagaagagagaauucacagaacuggcacuuaucuucuguuuuugcagaaguauauuuggcuguugugugagacau uaugagauacuggcgauuuucucgaccugaagaguacuuuggucacucuacuugggugacuugguacuuauuguguuacu uuaaaauuuguuuacuuaaugggugagguuuuuuuguuuuucuuuucuuuuuuagguuuguuuuuguagacuuuaaua augagggaagauggccaaagcugccaaagagggccauggaagauggagaaauuaacggaaacaaaguuaccuugggacuaggcca aaccuaagggugaagguggcuuugguggucgagguggaggcagaggagguuucggaggcagagguggaggcagaggugg aagagguggauuuggaggaagaggccggguaggcuuuggagguaagguagggaaagguacuggaaacggauuccuaaacc uguguccuaaccaaccaccuuaaaugggggaaagucaguccuaauugguaucacccuuugauguuuuuccuuccuauagguaga ggaggcuuccgaugcggcagaggaggaugggcagacuucaagccacaaggaaagaagacgaaguuugaauag 85 X57800 Sequence below. uuagacgguuggcgcgcgcagaggguugguaauugucgcugguaggccuucgcugccgcuucuggcaucguggaaucgggaga ccuuggcagccagaccucguuccucuuagaguagcucucaucuagucgccacaacuccgccaccauguuugaggcacgccu gauccagggcuccauccugaagaaggugcuggaggcucucaaagaccucaucaaugaggccugcugggacgucagcucggg cggcgugaaccugcagagcauggacucgucucacgucuccuugguacagcuuacucugcgcuccgaaggcuucgacacaua ccgcugcgaccgcaaccuagccaugggcgugaaccucaccaggugagcggguggcgggagcggggccccacucuucccgcu uccgcucuuggcggggcugugacucugcacgcucauuggcuggcuuggccauccgcgcuuucugauuggucuauggugu cgggggcagcccucaccaaagcgcgcgguuccgaaaagcccgucuggcauuggcuccacucuguuuccgcgccaaagcc acaaagcaggagguccacggggaaaauaaguggcuccggagcugugcucauuaaaugccuacagcuuugaguagcuaucuua gcgccuaauaaacgagucuuagugcaaauguaaugucgacuuagagugacaauagaccuuuucuugacuuccagagucuca cugcgcaucauggauuugaguggaaaucugucaguuuuagcuuuuaacuuugcuacagcuaccuagguuagugccuccug uauacguauucaagaacaguguaugacuuauuuuaguacagauacauggauuaguGGccacuuguauacauuuuaaaagau uuacgaaaaggccagacgugauggggcacauucuccaguacacuagaaaccaaggacaccccgcucaaaaagaugcuuucuc gaauguuggcuuuuagugcauuuuacuaauucgguuuuaagaaucacauauacccgguaauuugcuucaccccugagaga auuuggaggacccuuaggccccuuuaacaguucuccaaccggugagugugaaauaguacaacuuauaauugcuuuuuaaaau auagauguggauuacauguugauaaagccugucuuuuuuuuuuugggggguagcauguccaaaauucuaaaaugugcug guaaugaagacaucauuacauuaagggcugaagauaaugcagacaccuuagcacuaguauucgaagcaccaaguaaguuaa acaccuuuaaaacucggaguuacguguuguuucuguuucucaaaaccaaaaaaaauauuaacaauauuguaaauuccauca uagauaggaccguguggugugcuugguaacauuuuccuucuuuugguagaucaagagaaaguuucagacuaugaaaugaa guuaauggacuuagauguggagcaacuuggaaucccagugaguuaccuuguuucugauuguguguuacccugcugugaua ccagcugaugcguuuucuuaguguaguguugguauuggggaugaauguacacugccauuucacuaaaccacagcagucu aaaguugauugaguuuuaaagaaaccagaagucuugcauucugaguucugguuaagaugcuaaaucuugagaacaugaag cugagccuucccccuuuucuagacugaccuuuaacuuguggguuuacaggaacaggaguacagcuguguaauaaagaugcc gucgugugaauuggucacguauauuccuagaccuuagccacauuggagaugcuguugugauauccuuugcaaagaaugggg ugaaguuuucuacaaguaagagcuuggcaauagaacauuaaguugucacaaacaaguaauguaauaaagaagagGGag gcggugaguaguaagggggcguccaguuaggugucugaagcagggauggagccucggcuuuuguuuuuauuuauucauu cauuuugagaugagucuugaguagaccaagcuaucuuagagcucagaucuacuccauaagcuuuuacagguagcauuu ggaaagcuaagguguacaggccuuuugcuuccuggaaauacucuuagcaaauaagugaagguugggcaagugagcaaaagaaaa ugguuggggguguauguagcuuuauguguugcagguucaagaguauuugcagucccaagggaaauaagaaagacuucaca aaauguggaaagaguuguauuaaaugcucuugacaguuacauccauagagaaagcugggcaugaugucucaaacccacaac ugauguacucaaagcuacagcagaaaaauucucagcuuaaagucaaccuggcagaaaaucuagcucaaaaagaauguagaag aaauugggaaggcaaaggaagauguucuccgaguccuccucauucaaguagaacauacuaggccucuuuaauuucuaagua ucccugaaucggaggcuuuuucucaggaauccaauguauauuucauggcuacacuuuuuuuuuucuuuuuuaaauuuugcu agcuagccugagcaucagaauuacacacagaagucugaacuaaauaggauuuuuaggguuuaguauagugaaauucagagu gcuucugcaaguauuuaagguaaauauaagguguuacuuggccucugcaugaaggggaaaguaaaugaaaguguaagaauu cgaacauagauaaacacacaacccaagaacuaguucuuaaccuuaaucugcugaauuauuucuacuuccauaucaacuucag cuccucaguucucaaauacugacauguaauucaucaguauuugucugaugugcaagcauuuccacaacaaaagaaauuaag gaauuuuucaguauccacauguucaaggauugggaauugaauaaaauugauaaucauacaaugaagacugguuuacugucc cuuagcuugcauucaucuguugguucuuguuuuuggaagugguuauuuguuaucuuccucucuucaugcauucuaugca agagaaguauggggcaaucuggaauaggaacaacuuucuccuuuauuuugauugcuuggggguguggcucuacaggaugggca agcuagacuuggggucuucuuuagucaagguuuucaucaacccuuccaaaaugauaacuauuuguuuugcuuugugguaua auaccgugaucuaauagugugauuuucugaugucuacagugaucuguauucuccucuagguaaccauaugaugaauga accuguucaccuaacauuugcucuggagguaccugaacuuuuucacaaaaggccacuccacuaucuccuacaguaacacucaa uaugucugcagaugugccccuugguaagaugauaaguuugaacauuguuuuguaaugugguauuuauaguauucggugg uuggauuuauccugucuuucaguuguauaguauaaaauagcugacaugggacacuuaaauuauuauuuggcucccaagau ugaagauaaggaagcaucuuaggcauugcuaggaaauugagaaaacuaaaccuuugaagauugcuccugaaaugccagcggug uccugaggucuuuucugucaccaaguuuguaccugaguauucuuaaauauuaaaauaaaauauguagauaucuucuguaa auaaccuacuuucuuuucucuccauucuccauaauuugcuuaaagaauaagcuccaaaguaaaaacuaguuuuguuaacau aaauguuucugcuuggcaaauacuagugauuuuccaucaaugaucuugacgcuaaaugcaguuuuaagaaauauuguuca auuuaaauaaaguuaacaauuugaaaaguca 86 M35247  Sequence below. ggugcaggauguaggccugcagaauugucagacccaguggcggcuuuugccacuggaagaauuuccaacauaaaacaga ugaucauuuugggacaaucgauucugcgaccagagguauugucauuuguuuacuauuaaaauucauauugucuggug uuuuccaaucacucgcgacugguaauuugaaguuagguucugaggauaauacaaucgcuggucgcucuaguuuauaaaacu guccaagaucugcccagucccagauguccuggguccucagggccgcuguggucugccaacuucugcagcuggaugcca gaccauccuggacucggaucccuauggguauuucuacaccgcugugucccguccuggccuaggugagcccugguucau aaucgucgacuauguggacgacaugcagguccuacgcuucagcagcaagggaggagacuccgaggauagcacccugGGcu ggagcaggaggaagcaggugacugggagcagcagacucguauagucacaauucaaggacagcugucugaaaggaaucu gaugacccuuguacauuuuuacaacaagaucauggacgacucucacacacuacauuggcugcaaggcugcgauguggag ccaggaucggcaccugugucucugguacaaccagcucaccuaugauaacgaggaucuccccacccugaacaaaaacccaag uuccuguacagugggaaacagcacuguaccucacaucucucaggaccugaagagccacugcucagaucugcugcagaaa uaccuguaaaaagggaaggagaggcuucugcguucagacccuccaaaggcacaugugacccgucaccccagaccugaag guggaugucacccugauguugacccugacuucuacccugcugacaucacccugaccugggcaguugaaugagaggg agcugacccaggacauggagcuuguggagaccaggccugcaggggauggaaccuuccagaagugggcagcuguggugg ugccucuugggaaagagcagaguuacacaugccauguguaccaugaggggcugccugagccccucauccugagauggg agccugcaugguaccaaaagccuuggauauggauuguugccaugguuuacauuuuguacaucauugguucucugugug guuugcauaugcaugaagaagaaugcaggugggagaggaaggcgugacacccaagaagcaggcagagacaguccccaag acucuagcaagacuguuguggaugaugaggagauggggguuugcuuuuggaagauuaaguccuguaaaacuugucua ggccacuccccaggaacuucaguuggcgagucuuuacugucaccuugacuggauuuaggaucaucugugagaugcccc uuugaguggcugggcugugaggacagcaaccaguucuugccacccugggacagaaacacaucucaccuuucuggcuca aggaucugaacaccugucucuugccuacucggcuucuagucaggcauuuugucaccuugucaagggucccagggacac aaagcucccuccucucacccacagcacucuugguccuacccucagugcuucagggacauauaaucaggucaaauuggga ucaaugggcuuuggaugcagaaaagaacuguggacuaauagagauaggguuuaauuaaaaaauauaucuuuuuaauuuu 87 AI553024 cuggcacagacauggcugucuucugucugcugugugggaaacgcuuucaggcacaaagcg cacuccagcagcacauggagguccacgcaggcgugcgcagcuauauuugcagugagugca accgcaccuuccccagccacacggcucucaagcgccaccuucgcucacauacagguuuuu uucuccaugugucaccaagugaaguuugugccuucuauagcaaagagaauauugggguaca uccuacuaacaguagauuuuuuguagugaacauuuuuuguauuuuuauuuauaagucuc auaagaaaaauagcgauguucaguuguauaccuugaaucugcaguuagaagagauuaaag uuaacuc 88 X16995 Sequence below. ggagccccagugcaggaggcugcgaaaguugggggagugugcuagaaggacugcggagcggagcgcacgcgggaccaggc ugcgacugggucgcuggucccggccacagggagugggagccggcuggguagguaccccgcagggagcguguuucuguuuc uagggacagugcaugaaagagaugagguguacgcgcaggcgaaaaggaaagguguuuucggaucggcuuacgaggaggg guguguagggugcauuuuugguauuaaaggauagcucuuggaguagggugagccagggcuugaaguuuaggaagcgggc gaagggucugcaaggugcuugguuuugguagguagugggcgcuuguuuaggagguuuccccgcuaggaucuccagugug aggcacucuguacucugaguuuggauguugauugccggguaggagguugucugagcauggacuggaaaaagguacucag agcuucggcguugcuggggauccauccaaguacaaguaagauuggauuuccacgggucuccucccggcucucagcccccu uucccaguguuacuuaauacuucauaggcuguacuuagauuuucugauucccuuaccgaacuuucuuucugaaccgugc uggaagaccuagggguuacugaaggaaauggccagcuagguuggcuagguaaugguuguguuagacuaaguugucagag uaucuagaaaccuaggagcuguagccuggugcagcuacugaaagccgcacguggagccuggguggaaguugcucacgaua gagucucgauguaguacugacuaggggggagaccccuucugucaucagacagacuuguauaccccaguggucuuuugaau cuguuagguaggguacaaccugcgagcuuagucaccuaacagguguugccaggaccugccccaagccggauucucccacuc ccucuuucaaccccgccucuuccuccuccuugagacacccccacccccucaggaggcuagaugcagaucuguaucuugugu 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cccgcuuccuugucuaggccugccaccuggcuccccccaccccccuccccggccuaccaaguuucuugcuucccuuacugac cccuccuccucccuccuuugugucuccucccucuccagagaugcccuguaggcaagcucaauauggaacaccagcaacgagc ccaugaccgcgugaccaccugaccggugauccccuggcccuugaguucggcaagccuaccauggaccuggccauccccuag acagcaccugccgcaccugcuacacugcccagcuucagcaccuucauggacggguacaccggagaguuugacaccuuccucu accagcugccgggggacgacccagccgugcuccucagcuuguuccucugccuccuccacgucuucuuccucauccucggcca ccucccccucuucggcguccuucaauuggugaggacuuccauguguuggcugcuacccgggcacccuuagcggcccaggag augagacccuauccuccagcagcucugaguacuauagcagucccuacucagcccccucgccaucuacacccaacuuccagcc gucccagcuuucucccugggacggcucauuuggccacuucuccccgagccagacuuauuaggccucugggcauggacaga gcaguugccuaaggcuucuucauggccuccgccaccuccaaccuucuucuccuucaguccucccacuggccccagccccagc cuggcccagaguucucuaaaauuguucccaccaccaggccacccaccagcuugggggagggaagagcuauuccaugccagca gcuuuccccggcuuggcacccaccucuccgaaccgugacacuuccggcauucuggacgcacccgugaccuccaccaaguccc ggagaugggcuucagguggcagcgagggccgcugugcagucuguggugacaaugcuucgugucagcacuaugggguccuc 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acagcgcugccugcuccaucgguagcgcucgagccucgguuucucuauuuggccccgacu cgccgcaacaagaugaucgccucgcauaugaucgccugcuuauucacggagcucaaccaa aaccaagugcaga 91 U40930 Sequence below. cccaacuguuucguccauaccuagaccgcgguuauggcgucgcccgcacgaugauggccuaucuucugggcaaggaagag g cgacccgcgagauccaccacuucagcuucugcuucagcccggagccggaggcggaagcccaagccuggccggcccggg g cccugcgagaggcugcugagccgaguggcuguacuguuccccacgcugaggccuggcggcuuccaggcgcacuaccgc g augaggauggggacuuauugccuuuuccagugaugaggaacugacaaugacuauguccuaugugaaaaaugacaucu uccacaucuacauuaaagagaugaaggagugccgacgggaacaucgcccaccaugugcucaggaggcaccccgauacau ggugcaccccaaugugaucugugaugguugcaacgggccuguggugggaacucgcuauaagugcagugugugcccaga cuacgaccugugcagcgugugcgaggggaagggccuacacaaggaacacagcaagcucaucuuucccaaccccuuuggc caccucucugauagcuucucucauagccacuggcuucggaugcugaaacauggacacuuuggcuggccuggcugggag augggcccaccggggaacuggagcccacguccuccucgugcaggggauggccgcccuugcccuacagcugagucagcuu cugcuccaccagaagaucccaaugucaauuuccugaagaauaugggggagaauguggcagcugcccucagcccucuaga cauugagguuaacauugaugugaaacauagagaaaagaguagccgccuaacacccacuaccccagaauguuccaacaca ggcacagaagacaagaguaacacucagccaagcagcugcucuucggaagucagcaaaccugacggggcuggggagggcc cugcucagucucugacagaacaaaugaaaaagauagccuuggagucgguaggacagccagaagaacagaugaagucgg gaaacugcucaggaggaaacaaugacuaaacacauuuaucuucaaaagaaguggacccaucuacaggugaacuccaguc cuauacccacaucucccaccagaggcuaauccccggcugauugaaucccucucccagauacuguccauggguuucucgg augauggcagcuaacucaccaagcuccuacagaccaagaauuacaacaucggggcugcucugaacacgauccaauauuc gaugcacccuccaccauugugauagugcuguggccaagccccacccccuuugucuuguaguugcaucacguagagcagc agggcuucuauagauaggcccagugucuuggcauucuuguagaaucuucaggugggaaugugugaugccuuuucagg caauagguaugugcaugaggaaaguuuugaaugugcauaugcugacgccugagaucagacccagguacccauggcuaa gcugagcuuccucugcuuccccuaggccuggccucuacagggaacugcagcacacacugcacucccaccuacucuugcc gccagcauugcaccagcaguccagaauuccugccugacaacccguguuuccuuuauuaaaagugauuaguacaacugcu aauuauuuucaacaaauaaagccauuauguuaaaaggaaacuguccauagugaguguaagguggcagacaagggccua cagcuccuagaguauggaguauucauguguagccgaaugaaggaucuuaucuuauacugucccccuuucuaauggccac ucuuuaguguuugugucuaauguuaaugcuuaaagcacaggacccccauguagcuuccucugacuugguuuguaagua accugaauaaaaugccauaugcacuuuaacca 92 D26090 aaggggaauugcagaccccgucugggggaaacucccgccgccccgggguggcucagcucucugucucccuuaacccaggu a cagucauuucggucuucgacgacccgggcauuuucuacagcgacagcuucgguggcgaccccggugcggaagagggcc a ggcccgcaagucgcaacugcagaggcgauucaaggaguuccugagacaguaccga a ccuucaaguacagaggaugaacucaagcggcauuacaaccugaugaauacuggaucggagguaagauggaggaccuau cc auuuugacgaggaacuggcugaccacuugcauaaacagccggccgagcacuuacagcugcuugaggaagcugccaagg a gguggcagaugaggugacccggccccggccagcuggagaugagcugcuccaauacauccaggucaugcucaa g ccagcccgucgagcauucggauucugaagucagacaugaugucacaccuggugaagaucccuggcaucaucauuucagc c ucugcaguccgugccaaggcuacucguaucuccauucagugccgcagcugccacaacacccucaccaauauc caggccuagagggcuaugccuucccaggaagugcaauagaucagucuggucgcccaaagugcccacuggauccauac uucaucauaccugacaagugcaaggugugugggacuuccagacucugaaacugcaggagcugccugauacagucccucau 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aggugagaucgaccuggccaagauaaaaaaguucauugccuacuaccaagcgagauguggaccucgggcuaucagcaga ggcagcagagaagcugaagaaccgcuacaucaucaugcggaguggggcucgucagcaugagagggacagugaccggcg uuccagcauccccaucacugugcggcagcuggaugcuauugugcgcauugcugaggcccucauuaagaugaaacuuca acccuuuaccacugagggcugauguagagggaggcauuggagacuguuccagguauccacacuggauacugcuuugucugg caaucugucggggguggagggcuucacuacccaggaggaccaggagaugcugagccgcauugagaagcaacucaagcgc cguuuugccauuggcucucaugugucugaacacagcauuguccaggacuucaccaaacagaaauauccagagcacgcua uccgaaagguacugcaggcucaugcuacgcaggggugagauccaacaccguauacaacgcaaggugcucuaucaccucaa gugagcccauugcccaucaacccucaagccugaaaugcugccaccacccuaucucccagucagugcuccaaaccuccuuu ugcccugccucuccaccucagacugcugucugcagcacaucugcagccccuggaaauguacuuuguucuguuggcuca uacuguguuugaguaucuggaggacucucuacucuggguggucuauccccugucaugccuucucaacaagaugagucugg agcaggaacaggcccuggaauguagaugggucuguauauuggcucccgggccacucacugccaagcuucuuuguaugu acacgguaauaaagcaauuggucccuggcugcuaaggucaguagacccagu 93 A1787627 ggaugcagccgggaaggugcagcggugcguacgguuuggugauucgcuguggugcgcuccgcau gugcagccgcgugggccauggggcggcgggcgcggggccggcgguuccagcagccgccgc agccuuagggcgaugaagacgccagcgacggcggcagaaaucgaggccagucgggcuggg aagguagcuaucccggagaucguaaaggagaacaagcucuucgaacacuacuaucaggaac ucaagaucgugccagagggagaaugggaccaauucauggagucacuccgagaaccucucc cagccacacugagaaucacuggguacaaaagccaugccaaauagauucuccauugcuuga agaacaaguacuuuaaggagguuggaaganccuaaaauagauggacagaaaguugaguucc acaaccacuaagcugguacccugaagaacu 94 M33988 gagcucaaauucuggcuuucuauugaggacgauauauuaaccaaugggagaaacacaaac agaauaccuccaguuaguauaaaugcuugcuguucaguugcagaauuuacuauauauucu uuuccuuucucugcuuugccuuuacugauacuuaaacgcauacaugucuggacgcggaaa gcaagggugcaaggcccgcgcuaaggccaagacccgcuccucccgggccggccugcaguu ccccgugggccgcgugcaccggcugcuccgcaagggcaacuacucggagcgcgugggcgc cggcgccccgguguaccuggcggcugugcuggaguaccugacggccgagauccuggagcu ggcggggcaauggcggcccgcgacaacaagaagacgcggcaucaucccgcaccaccugcagcu ggccauccgcaacgacgaggagcucaacaagcugcugggccgcgugaccaucgcgcaggg cggcguccugcccaacauccaggccgugcugcugcccaagaagaccgagagccaccacaa ggccaaggggaaguaaucuggcgauugucuguacugcccaguugaaaguuaaccaaaaca aaggcucuuuucagagccacccacaucuuuccauaaaaugagcugccaccucgugaaacg uucuuccacuacaguuuuuauacuacauaugaaaaaguuacgaaguagcuuucaaucuua guaaauugauuuuaauacuguuagucccugcgauaaaucuuacgaccuuccuuaguuuga gucaaaagugugguaaaagaugaaaccuuuagaacauacuauaaauuuggaauagaaauuu ggcacccagguuugucauucacgucacgauugucuagagcauaaugguaguaagggcuaa gggccauuaaaucccacuuccauaguuuc 95 A1845182 uuuuuuuuguuugguuggaaaugaagguaauuuauugaaacugguuuugggacaggcga guggacaacuguugaaaggagcuagcgcacagccgggugggagcggguucuuagccacag auccuaucuaaggcccaacuuuuucuuuuccuucugcuucuuacgggaccacauccagguu ccgguccuuccacaugcuuuugcgaagcuugauggggcgugagcccacauacuucccauu caucucucgcauggcgcgcacauagucacuggggucuuuuuuaagcugacaaagccauagcc cuuggguuuugccugugcggcuuguca 96 AA619207 uucugauccuugccaauauauguaucccauuuggaauugugaucuuaaaaugugaguuca uggcauacuaucuuauuuaagauacuugcaccccacccacucccaucucccaaaacugggaa cacugccaacuagguccuuaagaaucacgcaauuaacacaagguugggugcugcuaauuc uucaugaaaauccaaacacguuaagguaccagggauaugccacugccccccugaauuuuc aucaaaaauagacacguuuauguaaacagaacuauuuccauauucauaggugacuuuuua aguauuugagccuaaagauuuugaucuccauuuuuauaacuauuuaaauuguucacaauu auuacau 97 AW125783 cggccgccgccgcccccacacugccccgcguugacgagcgccgcgacggcaaggacagcg ccucgcuuuucuugguggcucugauccuagagaccucaaccagcaggcgccggcgcccg cccccgcggaacgcagagaagggggccacugcgcggcaaggcgagggacccccuggccaccugc cgccugcgcccccugcgccgccacccggcccagagcccgccuccccgggacaagcaggcg cgccggccgcgccccccagccccgcuuggaugagccggaggcgucauuggaucaggagc ccggccccgcaggaggcggcgagccuagccucagacaaagagucaggaauccggaggcc gcgcggaccucgaguccccgcagaggaagcacaagugccacuacgcgggcugcgagaa 98 J04103 Sequence below. cgucagucccuccaccuccccggccccgcgcgcccggaucggcccuacggccucgucucgcccugccuugcgcgccgguac cgccgcgaucuccucuccccgccgcccuccggcuggcccugccugcugcggcgcgaugaaugacuuuggaaucaagaacau ggaccaaguggccccugucgccaacaguuuucgugggacacucaagcgccagccagccuuugacaccuucgauggcucucu guuugcugugcucccuucucucagugaagaucagacacuccaagaagugcccauggccuggauucugucucccauuacuc ggccagcuacgagcuGGccuuugcucacucccugcagcaagggcaggugauaagccaagccuuaaaagccaccuucaguggcuu ccaaaaggagcaacgacgucuuggcauccccaaaaaccccuggcuguggagcgagcagcaggugugccaguggcuucucug ggccaccaacgaguucagccuggugaaugugaaccugcaccaguuuggcugaacggccagaugcuguguaaccucggcaa ggagcGGcuuccuauagcuggcaccugacuuuguaggugacauccucuaugaacaucuagaacaaaugaucaaagaaaacca agaaaagacagaagaccaauaugaggaaaacucucaccucaacgcgguuccucauuggaucaacagcaauacauuaggcuuc agcauggaacaggcuccauauggaaugcaggcaccaaacuaccccaaagacaaucuccuggacagcaugugcccgccaucgg ccacgccugcagcucuaggcucugagcuccagauguugcccaaGGucucggcucaacaccgucaaugucaauuacuguucca ucagccaggacuuccccagcagcaacgugaauuugcucaacaacaauucuggaaaacccaaggaccacgacucuccagagaa cgguggggacagcuucgagagcuccgacucgcugcugagguccuggaacagccagucgucccuacuggauguacagcggg uaccuuccuucaugagcuuugaaaggacugguagccagucucuguaccucaguaagcuaaccauguccuucaaagacuaca uccaagagaggagcgacccagucgagcaaggcaaaccaguuauuccugcagcaguacuggcuggcuucacuggaagcggac caauccaguuguggcaguuucuucuggagcuacucucugacaaguccugucaaucuuucaucagcuggacgggggaugga ugugaguucaagcuugcugaccccgaugagguugccuccggugggguaagaggaaaaauaaaccaaagaugaacuacgag aagcugagccggggcuuacguuacuacuacgacaagaacaucauccacaagacuucgggcaagcgcuacguguaccguuuc guaugugaccugcagaacuugcugggcuucacuccggaggaacugcaugccauccugggcguccagccugauacagaagac ugagggccuca 99 D90146 Sequence below. auggcucuaacaacggcugcucuuggugguagcgggccggcccugacccugaucggagacccgcgcgauugaggugcgaugucggg gagggaaacagccccugugccgcguccccgcuucgcccaccggaccuccgccccuucuccacccgagccccgagcccugcuc cacucccggcccgcguacccuaccggggucccgggaggaggucugggucucaccgcgcgccgcccccaggcccacacucgc ugcggguauuuccacaccgcugugucccagcccuacucgggggagccccgguucaucaucgucggcuacguggacgacacgc aguucgugcgcuucgacagagacgcggaaaauccgaggauggagccgcgggcgcgguggauggagcaggaggggccggag uauugggagcgggagacacagaucgccaagggccaugagcagaguuuccaagggagccugaggacugcacagagcuacuac aaccagaacaagggcggugagugaccccgggucggaauucacuaccucuccacgucccgaaacaggaggccuugaggguccc gggugcaaaguccgagguucaggagcagaacugacccaggacuggauucccuuucaguuuggaggaguccgcgguggggg ggugggggggggcggaggagggacugaccacugggucccgcaggcucucacacacuccaguggauguauggcugugaca ugggguccuauggcgccuccuccgcgguuaccugcaguucgccuaugaaggccgcgauuacaucgcccugaacgaagacc ugaaaacguggacggcggcggacauauaggcacagaucacccgacggcaaguggaugcaggcugguauugcagagaggagacc gggccuaccuggaggucgcgugaggcuccgcagauaccugcagcucgggaaggagacgcugcugcgcacaggugcagggg ccgcggucagcuccucccucuucccucaggcuggggcucaguccuggggaagaagaaacccucagcugggguguugccccu ggcucagaagggaaagagugacccuggggucuccugaucccucaucacaaugacugcacugacucucccagaucucagccuu cucccuggacagugcccaggcugucucaggagggaaggagagaauuucccugagguaacaacagcugcucccuucaguucc ccuguagccucugucagccauggccucucccaggccaggguucucagccuacacccacugucuguauacacugacuccugu ccugcugaaugugucagcccuuacaccucauaaccugaagucuccuuuacccgaugggagacauggacaucuacacuaauc ugguucccccaguuucuagaacuuuccaaagaauacagucuaccagauccuucccugucugugggguuugcauccuuugac acccaauucuaucuauuccugcaauggugaauagucacaugagccauuauggguuacccuaaacaaauacuuuucuugugu uuuuccccucucguuuucuuuuuaucuuuacuuuuuuuuuaaggGGuauuauguuacuuauaaucaggguggucuucggca cuggaaugauauugcucucucuccccaccauacccccacccccgccuauaucauuuguaucaguagcccuggcugucgugg aacucacucuguagaccaggcuggccuugaacucagaaaucagccugccucugucucugccucugccucccaagugcuggg auuggaggcuuggaccaccaccacugagcagaagaaagguuccugugagcuuaaaauguuuucuggcagaauuaaccaucc agaucacuccugauaucccugugccccaccaaguuacagugcucccccuggugaaucagaacuuggacucugagagacagg guuucugcaauccaggccugagugagagggaagaccacacacccuggagcccacuguguuccagugagugcugcacugg gguccacagcacauuccagggauccugugugacacaucuguaccuugucccccagagucaggugcugggagucauuuucuc ucagcaagaugaccacagugguuuagucucaauggugucacucuuccaguagcauaugguccugauuucuaauuuagaua cgaacucaaacacauaugaaauuucuuauuuuccauuccaucuuccauuauauagcuaccuaucucgugcuauugaacauc acauaaggaugaccauguugacccacuagcucauguggauucccucuuagcuucugaauccccucaggaaaaugugcaguc cugugcugagggggccagcucugccugaggucacuagugccaugacaguuaaaguguucauacagacacauaguucauu guaauuacugauuuagcguugucuugucauuuuucaguuugcaugcauuuauuuauuuauuuauuuauuugguugguua uuggaugcauggaaauacacuguugcuguacugaugguuggggugccuuugugugguuguugggaaauugaauuuuuuuu uuuaggaccucucuuugcucuggucgacccugcucacuccggucaacuccuaugggucaacucugcucauucagucccugc uuuuucuggcccaaauauuuauuugguuauuuauuauacauaaauacacuguagcugacuucagaugcaccagaugagggcg ucagaucucauuacaaaugguugugagccaccaugugguugcugaaguuugaacucaggaccuucaaaaaagcagucagu gcucuuacccucugagccaucuccccaguccucaguuugucuucuuaauugugcgauuucuugaaucuuccaaacagaucc cccaaagacacaugugacccaucaccccauaucuuaugaugcugucacccugaggugcugggcccugggcuucuacccugu ugacaucacccugacuuggcaguugaauggggaggagcuaacccaggacacggagcuuguggagaccaggccugcaggga auggaaccuuccagaagugggcagcugugauggugccuuuuggggaggagcagaauuacacaugccaugugcaccaugag gggcugccugagccccucacccugagaugggguaaggagggugugggugcagagcuguggucagggaaagcuggagcauu cugcagacucugagcuggucagggcugaugcugggaucaugacccucaccuucauuuccuuuaccuguccuucccagagc cuccuccauacacugucuccaacauggcgaccauugcuauugugguugaccuuggagcuguggccaucauuggagcugug guggcuuuugugaugaauaggaggugaaacacagguaggaaagggcagggucugaguucucucucagucuccuuuagaag ugugcucuaaucauuaaugggaaacccaucuacaccccacauugcuaccuucuccaacuggguccucugucaguucuggga acuuccaagaucuuccuugaacucucacagcuuuccuucucacaaguggacaaggaggggacuaugcuccagcuccagguu agguggggacaggauuguccuguggacauugcagugaagcuggagauguuggggagcucugggaacccauaguauucu uccagagaaaucuuccagggccgcaguuguccaauaugaauacauauauguacauaugcauauacauuuuuuacccuuggc aaggacagcuccuagagcucuaauagaucucucccaagugguaaaggugacacucugggaccugauuggggaggggcaau guggauaugauuggguuucagggacuccacgaauccccucugagugagugguggguuguuggaauguugucuucacagu gaugggucuugucccuc 100 AI563854 uuaaaucuggagggauuuuuucacacagccuaucuuuuuaggugugccuuucccauauuuu auuuuuacucgaguuguuguuuuaaaaaaacagcagcauuaucaaagacacaucuguacaa acauuuuuacaaaagagaacucucuaggaucagcuacaucaaguacaaucagnaaaauaua ugcaguccaacaaagacauuuuuaaaaugacuu 101 AF017128 Sequence below. ggucgcuuucugucuguagaggcggcuugccacccgagcagagggucgugaaguuccgaccggaccgguccacagaggu ucaucugaagagguggguccccuccgaggugaaaggcgccgcugagaaacgcccccaccccccgugguucaaguauauca gcccaagaacuuuucauucauaaaaaagaccagacuccgagaggcgcgagugagucagaaccgcagccgccaacgcggacc cuaccgaacauccagcccagggcauguaccgagacuacggggaaccgggaccgagcuccggggcuggcagcccguacggu cgccccgcgcagcccccgcaagcucaggcacagaccgcccagcagcagguaagacuggccaaaucgucgggggagggggg accugaguuuggacagcaucagggaugcugggauuagucuaguuugcuccgggauuuggacuggggccccgagcagcau cugacucugguggucgcgaccgaggauccugcacguucuguguggucggggaaccuauguacccgguggccaaggggac gagcgcagcgggaagacgauuaucuucgauuuccccuucucgcucgcccguaucucccuagcuuacugucuuucuuccc cuccgucuccguuugcuuacauuuccuccuaucugccccuaauacgcugucccucuaaauaccugccccaucccugc cuggacaauaucagagguguucuccaucuccaguuaauaacugggaccuggggucugggcacauagaggacaggguccau cagaacucagccgggacagagaauucuuagcagccuguccgaggcuguccguguguugcucugguuguuccgugucccuu uauccggucaaguccucaucucuuugugcgcaguauagagcccaugggccccaggcagugguuccgagggguuccugga gaccacgauguguugugaugugcgcggggucaccuucccggccacacucgcgcuccacauucucggcacccgacgucucu cacugcuggauaggggcacuugagagguugcagguguccauuuccugucgaggggccgcgagcacgugucgccagggga gggaaggagcugcguccguuucgccgagucacagcgggccgagucacugaggcugagucacccuggggccccucccuu ccuggccccaaacggccccuaaguaccgacgaccugggagcgagagaugccccuggcauugcuucuagcccagaucggug aucacuGGagaugcuaggucccccaguauugggcuggggacauaggcuguccagacuugccuaagcauaugaauugcuucc uggacuggagggcccccacauccuuagcucacagagcuugaacccaguuuucucucccagaacgcugagcccccaccccca ccgacacucaaucccaacacaugccuucagauuucugcaagaaaaggaaguaaaggaugccagaccccuuauaggaggcuuu uacucucuucacuuuauuucauggacuuaaaaaaccccaucaauuuaaacuuucaaguuuuuaaucgacagcuaggca ugcauuuaaucccagcauucaggaggcagaggcaggcagaucucugggaguuugaagccaauuuggucuacaaagugac uuccaggucagcuagagcuacauaauagagauccugucucaaaacuuaaaaaauaaaaaacaaaaacaaaagccgauuaaa acucugauuucugaacuaugaggagcuggcuucucaacagcaaugaaacguuggaaugaugguuaauaacagggaaacugag acuaaauaacaugccccagucucaaagcccaucaauggccaagcuccaagcugaugcuggacucccaagcucuggugcuac augucuauagucuuggugccugugagguagaggcagaggaaucgugaguuuaggucuagccugagcuaugugagaucc caccccacccccgggcccccaaacaacaaauucucauccuaauucucagaauugccuuaggaggcuagaagcuggaaagu augcccaucuugugaggacugggucucaaaucuuuaguuucuacuuacuuagcuguggguucuaugggcaacugcucuuccugu cugaaaacaggauuauggcagcugugugagucacuauuuguuaaauaguuggaacaguguuacgcaguccauacuugau uuaaaacaaaaaaccaaacuaucuucuggaggguaaacagacauacgaagagagacauuuugugaccugcccaaaaucacac agcuccugaacaaguaaguuucugguugccaaauguugcuuccuugugguucucccaaaacugguaucuuacacuugagguuga agggagacagaaguccagccucuguccccgggaagccccucaguccacacagaccuuaucauuucccuucuuaucucuca gaaguuuccaccuugugccaagcaucgacagcagcagccaggaacugcacuggauggugcagccucauuuccugguaccca cuggcuauccccgaccucugGGccuauccccaauacagucccccucagccccggccaauagucauacggagcccuaggggccac cuccgggggugcgucgcaggcccugcgagcagguaagaaacagcgauguuucacuuuccauagcccguagggguccuac uagacagggacaggaucuucuacgauggaauaucuuauucagcauugaaguuccuuagaggccaagaaggagguaaaa ggucaccuuugaggucaaggaagggcauccugggagaaggcuacacguaaccuaaaccacgggauaggauuugcauauauaa gcugaaaagaaucuucugggaggaggguuggaggcacagauugaggugaaggggacagaguguuaagugagcaugucu ccacugucuuacgugcacaggguugaaggaagccugaugcuugcuuuguaccucggggugacucuucuuuucaacaguc acggaaucucagccuauuucuuuuaauuaucacaaaaagagugggcaguggguggcucacaccuuaaauuucagcacug gggaggcagaggcagguggaucuucuggguucaaggccagccugguguuacagagugaguuccaggacagccaaggcuaca gagaaacccugucucaagaaagggaaaaaaaaagugaaugggaauguauuucauuuuuccaucuuccaucagaggaag ugaagcauagaaggguacucacuuguccagauucauacaaauguggaguaaugagacaauacugguccugggccugaggguc uacucaacucccaaagucagagcuuaaugagccacugucucaaugggagcucacagaagccugcagagggagugagcuga gaacuuuugccucccugaugccuuucuaaaauaaagaaggguguguuuugguugguuuguagaguuuggggucuugag agccuccugccuucccauuugcuaggaguauagguguauucuagauacccgacagggaugacggaucuuuuaggccaua gcacuuucuuuccuucucccugaaguacugagacugagucuagugcagggaggccuccauacuaaaaagcuggguguaccc guaaucccagaacucggaaaaucaagacaggaggagccauucaagucacgcucagaaacauggagaguuuaaggucagcc ugugauauauaaacccuaucuccuauaaccaaacaacaaucaaagcaaaccugacuuaauuguuaaguaggaaauaauaug cuguaaggucaucagccuggcugggggacuaaccgccucugaaugacugaagaaccugcuucaaggcccggagcccugcacu caaccccuaguggaugcacacacagauccuugccaugauggcucgaagagggauggcaagacccugggagauaugugaga uuugccagagaagagccagcaacagucuucccagcaagggaacagcuuaccucugugaucagcuggggcgugagcaagag acaagcccaggGGugaauccuuccuuuagcccuauccugaauagacaccuuuugaccacggguacuagaggguuggaggcu gugagcuguggguagguggcuuccccucggugugcucuggaacuugaacaaaucacucauccuuccugagcuuccucac augugaaugugcagagaucuggaugggugacucagcagcaucucuggcugcuccuuagaggauccagguuccaaucuca gcacccacguggcaacuucacuguccacaacgucccccaaagguucugaugcccucuucuggccuccaccagcacugaaugc acaaggugcucauacaaacacacaggcaaaauacucagagguaaauuuguucuuuuuuucuuuugagacaggguuucu cuguauagcccuggcuguccuauaacucacucuacagaccaggcuugccucaaacucacagaggcaucugccugccuccc aaguguugggaccaaagauguaugccaucacuauaagccuuuuuuuuuuuuguaaauuuuauuuaugaaugagugcuuc cauguauaccuucaugccaggagagggcaucagauccuauuauaggugguugugagccaccguguguggcugggauuug auucaggaccucugaaauaggagcucuuaacugcuaaaacaucucucuagccccagucuacauuuuuaaaucuuuuuu uaagauuaauuuauuuauuauacauaaguacauuguagcugucuucaaacacuccagaagagggcgucagaucuuguua uggaugauugugagccaccaugugguugcugggauuugaacucaggaccuuuggaagaguagucaaugcucuuacccgc ugagccaucucaccauccccuuuuuuaucuauaaaaaaaaagggguggggccuggagauauggcucagccguuaauag cacugaaugcuuuuccagaauuccugaauucaauucccaacaaccacaugguaacucacaaccaucuguaauggggaucca augcccucuucugguguaucugaagacagcaagggucuacucacauauguuaaauaaauaaauaaaaauuuaaaagccag guuguguugguucagacagcagaucucuguuuaaggccagccuggucugaucuacaaaccaaguuccaggacagccagg acuacacagagaaacccucuaaaaaaccaaucuauguaggggguggcuggugaaaugggcuccgugaguaaaggguacuugcu gcgaaauuaaugaccugaguucaauccuugaaauccacacaguagaaggagagaaccaaccuccaagggugcuaugacaca cacacacacacacacacacacacacacacacacacacacacacacacgacuauauauaugaauauaugcucuagccaggca uaguggcacaugccuuuaaucacagguacuugggaggcagaagcaggugaaguuugaauccagccuacagaguaaauu ccaugacagcuagaacuaugaagaugaacccugucuuuaaaaacaacagcaacauaaagaaucuauguagggaagcuggaa gggaugcugauacagucugcaauccuauuacucuagagguggaagccaaagaaucaggggguuucaggccggucuugccu uacacugagcuuaggccagccugggacacaugagacuuugucucuuuuuaaagacaaaacaaggggguugguuagau ggcucaguggguaagagcacccaacugcucuucugcagguccgaaguucaaaucccagcaaccacaugguggcucacaac caucuguaacgaaaucugagucccucuucuuugagugucugaaaacaacuacaguguacuuacauauaauaaaaauaaaua aaucuuaaaaaaaaaaaaaaaagacaaaacaagccagaugaggucugugaguuccaggccagccuugucuauaaaucaagu ucaaagccagggcaggggcuacucaggagauucuaucuaaaauacaaagaaacaaaacuacaaaaagcaggaaaaaggaaucuac gaaagggcuggugaagggguguaacucagugguagagcauuuccgaguagcauguaccaagccauggguuugauccc uagcacuaagcaaaagaaaaguccuacaaagggcuauguuggcauauuagauugauucccaguaucuuuuggcacucaag aacaccuucuacaauucacaggcuccuggaugaagaaaucccaucuuccacaaaugaggaagcuggagaguccugugaaaag agauaaucaugucucauacacucaggagagaaggcuacuucugccugagaaaugaaaaggcuuccuggggucccaacauc uuaguccaguccuaagaugcggaagggaggaagaucaaauuuacauagagggauucauucaggaaauaaaccaucag uaaagcuagguguaugugagcuauaaaugucaccaauggagaugacaagcgguccaguacaggagaagcaacuguauaguggu cauugucucccuucuucuaucccaaccuagaucagcccagaggggaagagcgccgcagggugagacgcgagcggaacaa gcuagcagcugcuaagugcagaaaccaaaaaaaggagcuaacagacuuccuacaagcgggugagcaucauccccaggccca gacccacagagccccaagaggggucucggcucccaagaacacaaaagacccaaauuuacuuccuucaggacucugucauccuc ccugccugugguugaaguccuggaaaaaggauaagggaaaguggcuuaaauauuguuugucgaucuucgaguucagagucg aagaugguaggcagcaauucuccuaagaugccccuucugaugggagucauggccauuuucucccagaggcucacggga gggagugcaguccagacuuguuggggaugacaggcacaguucccuacuccagccugaggcuuggggaucuuuagccuuc auuuuccuaucuuucugcuaauccuguaaagugaccgacaaauuggaggaugagaaaucggggcucagcgagagauu gaagagcugcagaagcagaaggaauccuugagcugguucuguaaucccaucgccccaucugcaaaaucccagaaggaua caagaaggacccaagugguucuggcaggcaccagcauugcuagcagcccaccaGGcccccggccgcccaguggccuugcaucu cccuuucuccaggacccguacuugaaccggaagcacugcauacccccacgcucaugaccacacccucucugacuccuuua cuccgagucugguuucaccuauccuagcacaccauaaccuugcuccuccucucaccgaaagaguagcagcagcaguguc aaccccuccuccgacccccuggGGcucuccuacacuccuggcuuugugaggcacccagccacaucccuugcugguggcuacu ccaagccauccccuuucucccauugauccagcaggccuggaccauacccuugccccaaaccagcagaucuuuuaucucuuc caacuagaacaaacacauuaugcuuugaugguagagccaggcuugaaggauauccccaaaggcugcucacugguuuuucuaggug cuggccuaucauaauugcacaaaauuagaggaaaauauguucccucugccagagaacgccuggcagcccagacuuugua gauccccagggguccuuugacacccuuaccccuugcagaccacuuucccacaccacgucacuuucuucauguuauccagc cuacucuacaccuagacagaaggugcccuuugacuagccuagaacacuaacucacacagcaucaacagccagcagcaccgg acauccugcaggcuccuccugaauggcacaacgcaggaggcgccaggggcuucugugaggagcggagcugcacucccuag cucugagaagcgcuuagcuucaggguauccgagccuccaccgcaagggcagcugcuauuuauuuuccuaaagagacuauuuuau acaaaccuuccaaaauggaauaaaaggcuug 102 X67644 Sequence below. ccauggguuccuaauggugcuauuaacangggcacaaagucucauaauuuuagaaacuucacuuauuuugugacccaccu aguauggggcaaaggcaggagcuucggacuuccugucuucccuuaucccuuugaauagcgucucgggagugucccuaag uaaccauugcaguuuuguguccguuugcucuguunaaucucugugauguguguaugguuuucacgugaacggaggcag acagagcccggucuguggGGuucuagugugguucuuuaucuucuuggaaguuugugcaauaacuucccuccugguuuccugc gcauaccuccaaguaaguacgugaauguguuuucuguggucccuugaucuugcuggacuucacuaaggaggguggcugga ccaucugcuacgugucugagagccccucucuagcuaccucauguccggacgugagcuuacucccaauguuuuacccacaa acauucacuacucccaauaaagaacaugcacuauggcaccuaGGugaauaaccaaucaacgcuccgccuacauuugcuuccu ccuuggaauuuccagccccuugcagccaacugcuccccagcugcgaagggcggaguuccccccggcccggccccuucuuug gcucuauaaguagcucugcuuugcgggggauuugcacuccucuacacucucugcacaacgucuaaauuaugugccacucgc gcaaccaucuccacaccaugacuggccugagggccccuucuccagcucccuccaccggcccggaacuccggcggggcucugg ucccgaaauuuucaccuucgacccucucccggagcgggccgugguguccaccgcgcguuugaacacuucucgcgggcaccg aaaacgcagccgaagggugcucuacccucgaguggugaguaucgcccgagugggcaucaggaggucgcgucgcccuggaac uuguagguaacaacuaggagcagggaccuucgaucugacguuucccucuuuuaucugcucagguccggcgccagcuaccaa ccgaggaacccaacauugccaagaggguccucuuucuccuguucgccaucaucuucugccaaauuuugauagcugguaggugg gugugucgcagccccuggcuccggaggaugcuaccagcgccgugacaccugagcccauuucugcgcccauuacugcgcccc cgguccucgagccuuugaaccugaccucggaguccucggacuaugcgcuggaucuuaaagcuuuucucuagcaacauccgg cagccuucuaaacggcgaugggucacaguccgguagguaacaaaggcaccauagauauguaccuagugcaagagaacguauccc aaacugggauuucuaaggcaacgcuaacucagaacacuaccgccaagagacaccgcggguccuggcuaggcccacuggggac ggacagagacuuucuccgugucuaauuaauauuuauguauuuauguauauccuccuaggugaaggagggguguauguaau auuuuucuaacuuauacagggguggcgaaauaugccucccugcugguaacacaggauauuuauuacgauuuauagggucggu aagacagaguugugggagggaggacccgggugguaggacucccagcuuggggauuagucugggggggguguaauaagau uagguguaacacuccgucuuccagcacuucaacucuguagucuguuguaaggcuuugaagacccuugggaauccggccu uuggaugucuucugguugcuucucaggggcagcugcaggagucuuggguccauggauugucagagggcggcuaucuaugg ucgccuaguauguauguucugugaacacgaauaaacuugauuugccugucauuauuaucugcaguucucgaaguguauca uucag 103 AF064088 See above (same Accession Number). 104 AI843085 uuuuuuuuuuuuuuuuuaaauugccgaauuaaguucuuuuaauagauugcauauauaga u guuuagccauacucuagaucaacucuuuaagaguagaauuuuauauccaauuuacaugcu ucagauaucaccucuguuuguuacauaaggucuuguauccaaauguccacuuguacacug agagcuuuaggaacaaaaaaggacacagagagaguugccauuuuuagcagcaaugaaaca ucacuaaccccuuuuuacauaccgaauucaagucacuac 105 A1843085 cggccgccgguauuuuuungcaaguauugagaguucuguauguuuugaaaagaguaauuu uaacguuugggugccaagaaguggguuuucucagaguccauugccggcaaugggcaagcc uggcgguacuccucgugccgaau augg 106 X58609 cgcugggaacgcugcuccugcugcuggcggccgcccuguccggacccagaaccgagcu gugagugcagggucgggagggaaacagaacuuuccaaacagucugcggagaggagcggau gcggcaccggggaagccgcgugcccgcgucgcccaccagacccuccgucucuuuacccgc gucccuagccccgcgcccugcuccccuccugucccgcgcauccgccugggucccgggag aaggucagggucucaccgcgcgccgcccccaggcucacacucgaugcgguauuucgagac cgucgugucccggccgggccucggggagccccgguacgucucugucggcuacguggacga cacggaguucgugcgcuucgacagcgacgcggagaaaccgagguaugagccgcgggcgcg guggauggagcaggaggggccggaguauugggagcggaucacgcagaucgccaagggcca ugagcagugguuccgagugagccugaggaaacugcuaggcuacuacaaccagagcgcggg cggugagugaccccgggucggaggucaggccccuccacuucccgacacagggacgcugac guccugguucccaagucugagauugagaacagaacggacccgagaccgguuucccuuuc aguuuggaggaguccgcgggugggcggggcugaccgcggggucccgcagguucucacaca cuccaggagauguauggcugugaugugggaucggacgggcgccuccuccgcggguaccgg caguccgccuaugauggcugcgauuacauugcccugaacgaagaccugaaaaccuggacu gcgaaggauguggcagcgcugaucaccagacgcaagugggagcaggauggugcugcagag uauuacaaggcuuacauggagggcgagugcgugcagucgcuccgcagauaccuggagcuc gggaaggagacgcugcugcgcacag 107 M18837 Sequence below. auggcgucaacaaugcugcuucugcugguggcagucgcccagacccugaucgagauccgcgcgggugaguaccggguccg gagggaaauuggccucugaggaaaggggagggggcggcacgggggaagccugucccggcgucgcccaccugacccuccgcc ccuucuccacccuagccccgcgcccuacuccccucccggcccgcucacccgcgggggucccggaaggaguucggggucuca ccgcgcccugccuccaggcccacacuugcugaguuauuucuacaccuccgugucccggccgggccuuggggagccccgguu caucucugucgguuacguggacaacacggaguucgugcgcuucgacagcgacuggagaaucgagauaugagccgcgggc accguggauggagcaggaggggccggaguauugggagcgggaaacacagaaagccaagggcaaugagcagauuuuccgag ugaaccugaggacccugcucagcuacuacaaccagagcgcgggcggugagugaccccggaucggaggucacgaccccucca cgucccaaaacaggguccgagacgucccgggccccaaguucgagguucugagcagaacggacgcgggacugguuucccuu ucaguuuggaggagccgcgggugggcggggccggggcgugugggcggggcugaccuggggucccgcaggcucucacac uauucagaugaucucuggcugugaaguggaguccgacgggcgccuccuccuggguaccagcaguucgccuacgacggcc gcgauuacaucgcccugaacgaagaccugaaaacguggacggcggcggacauggcggcacagaucacccgacgcaaguggg agcaggcuggugcuacagagaaaagcaaggccuaccuggagggcgcgugcgugcagucccuccgcagauaccuggagcucg agaaggagacacugcugcgcacaggugcagggaccgcggacaacuccucccucuacccucgggcuggggcucaguccugg ggaagaagaaacccucagcuggggugaugccccugucucagagggagagagugacccuggucuccugaucccucaucacag ugacugcacugacucucccagggcucagccuucuccuggacagugcccaggcugucucaggagggaaggagagaauuucc cugagguaacaacagcugcucccuucaguuccccuguagccucugucagccauggccucucccaggccggauuucaaccc acugucuuguagacacugacuccuguccugcugagugugucagcccuuacaccucaggaccagaagucgccuuuaacugauc ggagacauggacuacccuacacuaggcugauugccucaguuuccugaauuuucaaaagaauacauuucccagaucccucc cugucugugagguuuuccaccccuucgacaaccuaauucucucuauuccuauaguaguggucacaucagcccuuauggggu acccuggaggaauaucaauaguggaauuucuucuucuucuucuucuucuucuucuucuucuucuucuucuucuucuucuu cuuucuucuuuucuuucuucuucuucuuucuucuucuucuuccuucucucucucucucucucucucucucucucucucucuc ucucucucucucucucucucucucucuucuucaguuuuuugagauaggguuucucuguaugcccuagcuguccuggaacuc acuuguagaccaggauggccucgaccucagaaauccgccugccucugccucccagugcugggauuuaaggcguguggccac cuugcccagccuuucuuuuuucuuuacuuuuuuuuuuuuuuuuuggagguauaauuuguuucuagucaucuuuguc uuuugucugcacuggagugauccuguuucucccugcccuuauauuaucauguguaucagucuccacaggugccagggaag uuaagacaaguuaaaucaggguucucuuuaaaggagagauuccugugaacuuagacuguuuccugucagaacuaaacaucc agaagccuccugucuuccucugucccacauguuacagugcuccccccccccccccagugaaucuggacuuggacucugau gacagggucuucugcaauccagggcuggagugagagggaagaccacacacccugugagcccacuguguugcagugagugc ugcacugggguccacagcauacuccagggauccugugugacacaccuguaccuugucccccagagucaggggcuggaaguc auuuuucuggcugagugucagagguuucaccauuucugcuacacacucugugauggcugcucacuuggacuggcgguu augcuuauagcaagauaaacacaggugguuuacgucucaguuaucacacccuuccaguggcauauggcucuaauuucuacu uuugauacgaacucaaacacuuauuaaauuaguuaguuuccauuccaucuuccauucuaguccauucaugcuaaagaacau cacauuaggacugccaggaugacccacuggcucauguggauucccucuuagcuucugagucccccagaaaaauuugcauu aaggaaaccagcucuaccugcaggucaccaaugccauaacaguuggaaugucaaacagacacauuauucagugucaucaggu gauuuuacugugccuuguguagauuuagagggucuuguuuauugugguacuuuuuuuuguuuuuuguuuuuuuuuuu uuuuguuuuuauuucaugacaggauuauucuguauauccuggcuguccuggaucucacauaguggaccaguuugaccac aaacucauaaucuuccugccucuuccucccgagugcugggauuaaaggcguguaccaccaccaaccagcuaaucgugaga uuucuuucuuuuuucuuuucuuuucuucuuuuuuuuuuuuuuuuuguuguuguuguuuuguuuuuugagacaggguu cucuguguaucccuggcuguccuugaacucacuuuguagaccaggcuggccuugaacuuagaaauuugccugccucugcu ccagaguacuuaauuaaaggcauguggccacuaccaaccagcuaauuguggggauuucuuaaaucuuccacacagauccucc auaggcacaugugacaugucaccacagaucugacggugaugucacccugaggugcugggcccugggcuuuacccugcuaa caucauccugaccuggcaguugaauggggaggagcugacccaggacauggagcuuguggagaccaggccuucaggggaug gaaccuuccagaagugggcaucugugguggugccucuugggaaggagcagaauacacaugccaugugcaccuagagggg cugccugagccccucacccugagaugggguaaggagggugugggugcagagcuggggucagggaaagcuggagccuuuug cagacccugagcugcucagggcugagagcuggggucaugaccucaccuucauuuccuguaccuguccuucccagagccucc uccauccacugucuccauauggcgaacguagcuguacugguuguccuuggagcuuggccaucauugcagcugugguggc uuuugugaugaagagaaggaagacacacaaguaggaaaagggcaggaguugaauuucucucagccuccuuugaguguacu cugcucaucaauggggaacacaggcacaccccacauugcuacugucuguaacugugucugcucucaguucugggaacuucc uaguuucaagcuauuccuugaacucucacagcuuuccuuucacagguggacaaggaggggacuaugcucuggcuccagg uuaguguggagggacaaaguuauccugaagucauggagugaagcuggaguuguuaggugcucuaggaacccauaauagc uucucuguuguaauccucugguggccugugucagaucuugcuauagauauaucuuuguauauauuuuucccuaggcagg gacagcucccagagcucugauauguuuucucaagauuguaaaggugacauucuuggccuguaugcagaggguacugu ggacaugguuuuuuucauaacucccacaauccccuguggaguuuggguugguugggauauuaucuucauugugguagu uccugacccucauucucuaucaugaagacagcugccuggaguggacuuagugacagccagugugaccuugggucuucauu uuucuuuagagaacagcgccugauguucccugugagccuaugggcucaaugugaagaauuguggagcccagccuucgccu acacaccaggaccuaucucugcauuacccugugguucccuuccaccgccaaccuuccgggucugcag 108 AW124268  uuuuuuuuuuuuuuuuucagaauaauugcagacaaauuccauuuauuuuucuaaaaacc u cauuucuaaaauuuauacaggccucacauuccuaaaccaccucuggcacuuucuugaau unagucuaggcguacacagcuccgaaagaaaaauagagauccgguuccaggaagauggcc augaggacucgcagauaugucuccucggaccuggaaugugucagccaugggauccacua auccaccauccgguacacagggucacccacucucaucucccaaacuucuccaccgagaa auacaucccaaaaaguggagaugacugguauauacucuucacagaaggaucacacaggcg auagcucuucagggucuccagucgc 109 AF090738 Sequence below. cucuagaugaauacacucucaugagggccaccuucucugguaguucaggucgccucugcccauccuucccugcguccucuc ccaaagguggccuacaacccuuacccagaauacuaugaagacauugaaauuauucucacaagagguuccagcaguaaccuag gggcagaugauggcuacaugcccaugaccccuggggcagcccuuaggagugguggucccaauagcugcaagagcgaugacu acaugcccaugagccccacaagcgugucugcucccaagcagauccugcagccacgcuuggcagcggccuugcccccuuccgg agcagccgugccagcacccccuucaggguugggcaggaccuucccaguaaacggagguggcuacaaagccagcuccccagc ggagagcuccccagaagacaguggguacaugcgaaugugguguggcuccaagcugucuauggagaacccagacccuaagcu acuccccaacggggacuaccucaacaugucccccagcgaggcaggcacugcagggaccccaccugacuucucagcagcuuug cguggaggcagugaaggccucaaagucaucccgggccacuucuacagcucuuuccccgcucuuauaaggcucccuguucc ugcagcauagacaaugaccaguauguggcucaugagcuccccuaugggccggaucuuggaagaagagagacuggagccccag gccaccccaggggcuggcaccuuuggggcagcuggugguagucauacccagccucaucacucagcagugccuuccuccaug aggccgagugccaucgguggccuccugagggcuuccugggccagcgaugucgggcaguucggccuacacgccuaucucu agagggacugcagacccuucccagcauggcaagaauacccucuacccacagagcccaagagcccuggcgaguacaucaacauu gacuuuggugaggcagguacccgucugucuccgccugcccccccacuacuggcauccgcggccucaucuucuucacugcuc ucagcuaguaguccuucuucaucccuggguucaggaaccccaggcaccagcagcgacagccggcagcgcucuccacucucu aacuauaugaaccuggacuucaauucucccaagucccccaagccuagcacccggcaauggggacacaguaaucuccauggau ggccuucucucuccagaggcuucauccccauacccaccacugcccccacguccuuccacuuccccuuccuccuuacagcagc cucugccaccugccccgggagaccuauaccgccugccuccagcaucagcugccacuucccagggucccacugcuggcuccuc aauguccuccgaaccuggggauaaugguggacuauaccaagauggccuuuagugugggcugcaaccccaccacaaccuaucau ggcaccuccaaagccagaaggugcccgaguggccagucccacaucgggcuugaagcggcuaagucucauggaucagguauc ugggguggaggcuuuccuucaagucagccagcccccugacccccaccggggugcuaaggucauccgugcagacccacaggg gggacgucgucuccacaguucagagaccuuuuccucuaccaccaccgucaccccaguuuccccauccuuugcccacaauucc aagcgccacaauucggccucuguggaaaaugucucacucaggaaaagcagugaaggcagcaguacccugggaggaggugau gagccgcccacauccccaggacaggcacagcccuugguggcugugcccccagugccacaggcuaggccguggaaccccggu cagcccggagcuuugauuggcuguccuggaggcagcaguucucccaugcgcagagagaccuccuuggguuuccagaacug ccucaacuauaucgccaucgaugugaaaggcgaacaaggguccuuagcgcagucucagccgcagccaggaggacaaggaacuc cuggagccggacccguagccuuggggggcuccucggcaccgucggaggcucuggcgccagcggaguguguggggguccag gcacuguagcuuugcccucugccagcaccuaugcaagcaucgacuuccugucccaucacuugaaggaagccacagucuuga aagguggaggcccuuugaccuugaagauaugggagggaaaguauaguauugggguggcu 110 AI834950 uuuuuuuuuuuuuuucagcugugaacuauuggauuugagacaggaacagaacaaaucg acgguuccagaggaguuguggagagagcacgaguguuuuuaaauaggggaggaugggagcaug gcggugggggugggggaagaguuauuuacaagaaggcucagggggccagaggcucaucuu ggaauauuuuauaacaauauuuauaagauucugguuugcuuuuccuuuucgucucguaaa guuagagagaauugcauaguucgauucuguccaagggggcagcugcauaugguggccggg cgggucacuggucgu 111 AI1851365 uuuuuuuuauuuuuuauaaguuuucaccacuugugacauucagcauguuacuaucagcucc agccgcagcguuuuuaaggcguuauagauuaggcaggcaauacaaggaacacgauuaaga aacugacacguaccacacgagcaauuuccagaggcuccucuucugcggugcacacguaac aguuucucuuguuncauucagacaguucugaguugccacucugagauugcgccuuccuguuc ucaccuggacaaauauauuguuuaguuuuggguuugguuugguuuuaccuuacuauagcuuuu cuuucaacuacauuuugugucaugcuuguuagcuaacucaaauuuugucuuuguauauuu acuacuguaaaauuagaauaauuuacuguucaucucauccucugucacugauggaaccua gagacgccacaagagccacuggccaugacauaccucacaagcuacaucccuguccucaaaa u 112 AW047339 cggccgcagccaccggccuggcgccaagcugcuggcugcggcagccaauaccucggugaagc ccauuuucagucgcgaccugaacgaggccaagcggagggugcgcgagcucuaccgcgcuu gguaucgggagcgugccgaacaccgugcacuuaaugcagcuggauaucacggugaaacaa uacalgauaaaguccgagaaauguucaugaagaaugcccaugucacagaccccagagug gaugaucugcuggucauuaagggaaagauggagcuccaggaaaccaucaaaguauggaag cagcguacacacguuaugcgguuuuuccaugaaacagaaacaccaaggccaaaggauuuc uuauccaaguucuauaugg 113 U06834 Sequence below. gcaccugagcgcgggugccuggcgcgcccgaugggaucguugagaggcccucgacggaaagucccaaacucggaucgcauu cagccaaauugaggcggcgccauggagcuccgagcgcugcugugcugggcuucccucgccacugcuuuauaauagacccug uugaacacaauacuggaaacggcggaucugaaaugggugacuuacccucaagcagaaugccaguaugagggagcuaagcgac cuggaugaggaacagcacagcguccgcaccuaugaggugugcgacaugaagcgucca gguggccaggcucacuggcugcgcacuggcugggucccaaggcgaggugcuguccacgugguaugccacgauacgcuucac caugauauaaugccugucccugccgaaugccagucgcuccugcaagggagacauucacugucuuucuauuacgagagcggaacg ugauacggccacggcccauacgcccgccuggauggagaaccccuacaucaagguggacacaguggccgcagaacaucugacu cggaagcgcccuggagcugaagccacagggaaaguuuauaucaagacgcugcgccug aguccucucaacaaaacugggcuucuaccuaucuuuccaggaccaaagagccuacauggcucuugcucucccugcaucucuuu uacaagaagugcuccuggcugaucacgaacuugaccuacuuccccgagacggugccucgggagcucguggugccgguggca gguagcugcguggccaacgcggucccuaccgccaaccccagccccagccucuacugccgggaagauggucaaugggcugag caacaagucacaugcuggcaggcuugcgcggccaggguacggaggcugcauaaagcaacaaa guaugcagagccuguggccagggaaccuucaagccccaaauaggagacgaguccugccugccgugcccagccaacagccacu cgaauaacauugggucuccugucugccugugucgaauuggguauuaccgggcccgcucagacccccggaguucaccuugca cuaccccacccucugcuccaagaagcgugguucaccauuugaaugguuccacccugcgccuugaguugaguucuccccuug aguccggaaggccgagagaccucacuuaugcuguucgcugccgagagugccguccuggggguuccugcuugcccuguggg ggcgacaugaccuucgaccccgguccucgagaccugguugagcgcuggguggcaauccgagggcugcguccugaugucac cuauaccuuugagguugcugcuuugaaugguguuucuaccuuagccacuggaccaccuccuuuugagccugucaauguca ccacugaccaugaagugccuccugcaguaucuggacauccgaugacucagucggucacccaggcaacuuuggauccugucauagg cuauccccagagcacccaguggggccgugcuggacuacgaggucaaguaucaugagaagggcgcagagggccccagcagug uucguuuccugaagacaucagaaaaccgagcuga cacggguccgaaucugggcuuacggucccuucggccagggagcauucacagucagacucaacuagauggagaacgagaggcuggc gggagcagcuggcccugauugcaggcacugcgguugugggugugguccugguccugguggucgucaucauugcaguucucug ccucaggaagcagagcaaugguagggaaguugaguacucggauaagcauggucaguaucucaucgggcacguuaccaaggu cuacauuugauccuuuuacuuacgaagacccuaaugaagcagugagggaauuuggccaaagaggauucgauggucuccuauguucaa gauugaagagguaauuggugcaggugaguucggcgaggugugccggggucggcugaaggcaccagggaaaaaggagagcu guguggccaucaagacucugaauuggcuacaccgagcgccagaggggcugaguuccugagcgaggccuccaucaugggcc aauucggagcauucccaacaucauccaccucgagggcguggucaccaacaguGGugccgguuaugauccucacggaauucaugg agaacggagcccuggacuccuuccugcggcugaacgacgggcaguucacagucauccagcuggugggcaugcugaggggca ucgccucgggcaugcgguaccuggcugaaaugagcuauguccaccgagaccuggcugcucggaacaucuuggucaacagua accuggucuguagguguccgacuuuggccucuccagauucuuguaggagaacuccucugaucccaccuacacaaguuccc ugggaggcaagauucccauccgauggaccgccccugaagccauugccuucaggaaguucaccucugccagugaugccuggc gcuaugggaucgucaugugggaggucaugucuuuuggggaacggccauacugggacaugagcaaccaggaugugaucaau gccauugaacaggacuaccggcuuccuccuccuccagacugccccaccucccuccaccagcucaugcuggacuguuggcaga aggaccggaaugcccagccccgcuuuccccagguauucagcggcucuggacaagauaauccuaaucccgcuagccucaaaa ucguggccagggagaauggcggggccucacauccacucuuggaccaacggcagccucacuacucugcuuucgguucugug guugaguguucuucgagccaucaagaugggaagauacgaggaaaguuuugcagcggcuggauucggcuccuuugagauggu cagucagaucucugccgaggaccuucuccgaauuggaggucacucuggcaggacaccagaagaaaaucuuggccaugugca gcauaugaagugggaagcuaagccaggagccccuggugggacagggggaccagcccagcaguucagaccuccaaggacuca ccaccguggcagauucuucuuuccgggaggcagaguuggguggggacucacaagaugagccccucccccucgucacagccu ucccauuggauuucacuuugaacagagggguucguagacacauauuuugggaaccgugccauauuggaucauacaugugc ccuccaggcggggaaccccaaacucagagugagucuuucccucaagacugggcaaagaaacaucccuacgucucuaaccucc caucuucccagaggcucucuccccaagcgccuuccaccucaacgggcaugucccugcagaccaaagagaaagggugaccagc cugccaacuuuggaguggaaaaugccgucccaggaggcaggaaggugcuuucaggacccggugauguaaucauuuugguuu ugaugguccugacuugcugucaccaccaaaggcaaucauuuuucccuuguaaaugccccuccccucaucuggccuucauauua aagguucugaaguuuuacuguuuuuuauuuuguuaauuuuuuccuccuuccccccucccuccccuucuuguccagauuuu guuuguuuauggcaccugguuccacuaucuccuguugguaacaaggacccaucgauauguucuagaacagugccuuuga aaugcca 114 AA980204 ggcagcgagacgagcucacggucgaggauacgggugaagcgggacaggagcaggagccgg agccgugccaaagcagaaggugcaggucugcgccgucgguugggcaugacccauuucaagc cggacagugaggagcggaugcagacggcacgaccauggccacgauggugcuuccucgaga ggagaagcugagucaggacgagauagugcugggcaccaaggcggugauccaggguuuaga gacccugauaggguagcaucgugcccugcuagcuccccuagcuucucaugaagcaggaua gggcugagcgaucucacaggagcacugccuccuccuacgccgcucccuagagggccaucaag cuggggcuuggggaggcucaggugauccuggcauuaucaagccaucugggggcuguggag ucagauaagcagaagcugcgggcucaggugcggcccugguacaagagaacagugguuucg ugaggagcuggcagggacacagcagaagcucagcgcagugaacaggcgguggcucagcug gagaagagagcagcacaucu 115 AI843232 ggcagcaagacgagcucacggucgaauauacgauugaagcaugacaggagcaggagccgg agccgggccaaagcagaaggugcaggucggcgccggcgguugggcangacccagucaagc cggacagugaguagcggaugcagacggcacgaccauggccacgauguugcuuccucgaga ggaGaaacugagucaggacgagauaguGcuggGcaccaagGcgguaauccaagguuuaga gacccugagaggggagcaucgugcccugcuagcuccccuagcuucucaugaagcaggcga gucugagcgugcucacaggagcgcugccuccuccugcgccgcucccuggaggccaucgag cugGggcuuggggaggcucaagugauccuggcauuaucaagccaucuaugggcuguggag ucagagaagcagaagcugcgggcucaggugcggcccugguacaagagaacagugguagcg uuaggagcuugcagggacacagcauaagcucagcgcagugaacaggcgguggcucagcug gagaagagagcagcacaucu 116 U59807 Sequence below. augauguguggcgcgccaucugccacaaugccagccacggccgagacgcaggaggucgccgaccaggugaggcugggccca ggucaggccagucuuagccaggccugcggagacccgucggccucagugaccggccuucccauacuggucagguccuucagc guuuuccggggcggccacaaguguaacugggaacugagggcucugGGaucuggugggaaaauucagauccgggaacuag ggcgagucuucugccgcuugcauacaagagggccacucaccuauuagggaacuagccccgggaucgguggagggauccgg uggucccagagaauucaggaaggcaguguuauaaccuagacggcaccuuuuugacuuacacccaugccuaaacaagagaaa gccagacugggcuacugugcuugucuccucaaaagaaagaggcuaggacuguuuagcucaguggcaggaauucaacuaauac caccaccaccaucaccaacaccgccccucagggaaaaaaaaaaggaucaaaaccagaaguuguagaacaugcuagugccuag ucugaaacgaggggguggaccuugggccuggucugcccuuccuguuacuguuagcagagcagagauucaguacaagguag ggauagguucaagguauuaggcaagaaaaaaaaaauuaaacaaauccucucuucaacucuccugccacgccccaagcccagg acccuguccacuaagccuagcugaucuugggaggaguuugcucugaacugaaguggccaagaaggaagugagucagcucca ugagacccuagaaaugaggaaauguuacagacacacuggccaggcaagggaaccuuggccacgugccacaucagcacucagg aggcagagacaggcgagucucucugaauuugaagccagcccaguuucuuaguuccaugccagccauagcuacauagugag acccugucccccccccccccaaaaaaaaggagcuguguuguucuuuaucaguggggccaacaguuuaccaugucccccggaa ugaggaguauugaaggcuggcagugugugugugugggggcaccugugcaugaaucuaaguccuuccuucucacccaccau ccaGGgugaagucccagcuugaaucgaaagaaaaucagaaguuugaugucuuuaaagccauauccuucaagagacagauagu ggcuggcaccaaccucuucaucaagguggguacugauaguagcuugccaugaacuggggacauagucucagaguagagcag aguguccugcaacuuccugcagagaaccccuuaaggggacauguacauguucugagaggaugaauuugggguguuagggu ucccggccuuaaaugaguagacaaggguuaucacuggcuaaguuauuggcuggaggccuuuucuugcucaguuucuaagg cuggguuagccuggaacuggaaccuuaccuuucacucacaugucugucugucugucuuccuccagguugauguugaugg agauaaaugcgugcacuugaggguguuucaaccccucccccaugaaaacaagccuuugacccugucuuccuaucagaccaac aaauaaaggcacgaugagcucuccuacuucuga 117 AI152659 gaaaauguuaagagccaucaaauuucuggauauuuugcuaggaaaaugaaauucuacacu uauuuuuuguagacuuuuuuuaaaugcuguuuacaugaauuguauuuuggaaaaaauauu auacuuugcacccugugaugcauuaagugauuuuauguauggucugcuauguggucagag gucaccuuauuccuaugaucuggaauuguuuacuuucuacaaaguaagcuuuguggggau uuugcuuucauuuucuuuguagcugauguuauuuuaccaggugugcagcaggaauuacac cacuguguggaauuauaaauacaucccaugugca 118 AI850090 uuuuuuuuuuuuuuuuuccuggugaauauuuuuauuagaggugacaguuucccaggugac aguuuuucccaaggaagcaaaucucugcgucuauaagggaagaccacagaaccuucacuu uguaauuuaccuguguaauuuauccaagaacacagcacagcaauugcuuuaugugguacu cugaccuuaaguaacaaguuguuaacagaaaacacaucaaacaaaaggauaauucucuaa uuaucaagucagccaucagcuuuucuuaggauagagagagauaguguguguguuugugug uguguguguguguaugugucugucugucugucugucuagguaucccacuuagggccaug u gcauuuuaguuaaaugcuccaccacuuagcuguuucuuauccgcacuuuucucagauuuc agguuuguuuguuuguuuuuuguuuuuuaacuaggcaugaaaauaaacuucacuucaaa u 119 AF064638 See above sequence (AI850090). 120 AI843106 uuuuuuuuuuuuuuuuuguggaaauuacucuuuauugaaaaauaccaguaauacugacag acuucaaaaucaauuuacgguuccagaauacaaaguacuuaauacauuuuuuuccaaacc uguuuguaucucaaaguuagcauuuuuguaaaucaagauacaaauaugauaacuucacua aaauauuuuccagcuuuauucuuuaaggaccuguauaaccuucaaagucagcgucccgag gucagcagggcauggggcagaaugcaccuggcacucccuaugcagcagacugcaaccaca uu 121 AF033186 auggccaacuuucccccgaauguuuaacaagaaagagaucggugagaucacacuauaggg gaacuuucuuggcuccagcagcuccuuuugacaagaaauguggugguuugagaacuggacgguu gcuuugcuccugauuguuccuacuuuucguguucacaaggauaucgcauagugaagcuu gucccguuggucccaggugccguaagaacuuucuuuugcaugguuccaaaaauguuaccaau ucaagcugucuaaaauuggcaagacaaaacaguaaugguggucagaaaaacaagccuccu gagcacguuauauacuguggagacauagucuggagucuuuucuuuugggucuucaguucca gaaaaacaaagucguuuggcguuaauauaaaauggcaucaguuccgauuuggacaggaucagg cuacuccuugccacaggauuaaacaauggucgcaucaaaaucugggauguauauacagga aaacuccuccuuaauuugguagaccacauugaaaugguuagagauuuaacuuuugcucca gaugggagcuuacuccuuguaucagcuucaagagacaaaacucuaagagugugggaccug aaagaugauggaaacauggugaaaguauugcgggcacaucagaauuggguguacaguugu gcauucucucccgacuguucuaugcuguguucaguuggcgccaguaaagcaguuuuccuu uugaauauguauaaauacaccaugauuaggaagcuggaaggucaucaccaugauguugua gcuugugacuuuucuuccugauggagcauugcuagcuacugcauccuaugacacucaugug uaugucugggauccacacaauggagaccuucugauggaguuugggcaccuguuucccucg cccacuccaauauuugcuguaggagcaaaugaccuaugguugagagcugugucuuucagu caugauagacugcauguuaccagccuuggcuugaugauaaaauagugaaguuucuggaaaauc gaugaggauuguccgguacaaguugcaccuuugagcaauggucuuugcugugccuuuucu acugauggcaguguuuuagcuucugguacacaugauggaaguguguauuuuuugggccacu ccaaagcaagucccuaGGccuucaacauuauauggucgcaggucaauuccgaagagugaugucc acccaagaaguccaaaaacugccuguuccuuccaaaauauuggcguuucuuucuccuaccgc gguuag 122 Z50159 auggccagcuuucccccgaggguuaacgagaaagagaucgugagaucacguacuauaggg gaacucuuggcuccauucagcuccuuuugacaagaaauguggugguuuagauuggacgguu gcuuuuuggcuuccugaugguuccuacuuugcaugguucacaaagauaucggcauaguggaaggcuuu gucccguggucccagugccguaagaacuuucuuuugcaugguuccaaaaauguuaccaau ucaagcugucuaaaauuggcaagacaaaacauuaaugguguuucagaaaaacaauuccuccu gagcacgguuauagacuguauagacauagucuggagcuugcuuuugggucuuuucaguucca gaaaaacagagucguugcguuaauauagaauggcaucgguuuuccgauuuggacaggaucag cuacuccuugccacaggauuaaacaauggucgcaucaaaaucugggauguauauacagga aaacuccuccuuaauuugguagaccacauugaaaugguuagagauuuaacuuuugcucca gaugggagcuuuacuccuuguaucagcuucaagagacaaaacucuaagagugugggaccug aaagaugauggaaacauggugaaaguauugcgggcacaucagaauuggguguacaguugu gcauucucucccgacuuuuucuaugcuguguucauuuuggcgccaguaaagcaguuuuccuu uggaauauggauaaauacaccaugauuaggaagcuggaaggucaucaccaugauguugua gcuugugacuuuucuccugauggagcauugcuagcuacugcauccuaugacacucgugug uaugucugggauccacacaauggauuaccuucugauggaguuuugggcaccuguuucccucg cccacuuccaauuauuugcuggaagagcaaauggaccgaugguuugagaggcuuguggucuuucaau caugauggacugcauguugccagccuugcugaugauaaaauggugagguucuggagaauc gaugaggauuguccgguacaaguugcaccuuugauucaauggucuuuucugugccuuuucu acugauagcaguguuuuagcugcugggacacauaaugggaaauguguauuuuuuaggccacu ccaaggcaagucccuagccuucaacauauaugucgcaugucaauccgaagagugaugucc acccaagaaguccaaaaacugccuguuccuuccaaaauauuggcguuucucuccuaccgc gguuag 123 X78683 Sequence below. gaauuccguguuucaaggcgaguuucuguaagcuguuauggguagaggcuggcguugcaccccuuccugaccuucuggugccg ccgccgccgccuucgggaggaucagacauggcccagaacuugaaggacuuagcuggacgccugcccgccgggccucggggc augggcacggcgcugaagcugcugcugggggccggggcgguggccuacggcguccgcgaauccguguucaccguggaagg cggucauagagccaucuuuuuuaaucguauugguggcgugcagcaggacacgauccuggccgaauuucacuucaggaucc ccugguuccaguaccccaucaucuauaacauucgggccaaaccucggaaaaucuccucccccacagGGcuuccaaaggaccugca gauggugaacaucucccugcgugugcugucccgacccaaugcccaggagcuccccagcauguaccagcgucuagggcugga cuaugauugagcgauuugcuuuccuuuccauuuuuuaaugaggugcucaagagugugguggccaaguucaaugccucgcagcuga uucacccagcaggcucaagugucccuguuugauccgaagaggagcugacagagcacgccaaggacuucaaccucauccuggaug auguagcuaucacagagcugagcuucagccgagaguacacagcugcuguagaagccaagcaaguggcccagcaggaagccc agcgggcccaguuuuugguggagaaagcgaagcaggaacagcgacagaagauugugcaggcugagggggaggcggaggcu gccaagaugcuuggaGGuaacacuugagcaagaauccuagcuauaucaagcuccgaaagauccgggccgcccagaacaucucua aaacgaucgccacaucacagaaccgaaucuaucucacagcugacaaccuugugcugaaucuacaggaugaaaguuuuacucg gggaagugacagccucauuaaggguaagaaaugaguguggacaucaagaaccccaccaccagagaaguuggcacacuuguc cagcuuggaggaggccagcucggauucaagcacagcccacccugccccaggcaucauaugauagacuuuucuguaucuggccc ucuuggauuaggaagacugagaccagcccuuucagaggcuuuccuccuuccuguguuggcugggaagcgggguggacaa ugugauuucuccgugauuuccuacagccuugagccucucccagagugggggagauaaccaccaugccaggaauuc 124 X68193 acccaccggcuuucagaccauggccaaccucaagcguaccuucauugccaucaagccagga uggcgugcagcgcggccuggugggcgagaucaucaaacgguucgagcagaagggguuccg ccugguggccaugaaguuccuucgggccucugaagaacaccugaagcagcauuacaucga ccugaaagaccgccuuucuuucccggggcugglugaaguacaugaacucggalcccgualu ggccauggucugggaggggcucaauguggugaaaacgggccgagugaugcugggggaga c caauccagcuuuucaaaaccaggcaccauccguggggauuucugcauucaaguuggcag gaacaucauucauggcagugauucaguggagagugcugagaaagagauccaucugugguu uaagcccgaagaacugaucgacuacaagucuugugcccaugacuggguguacgaguagac augaauuaaaccagaauccuuuucagcacuacugaugguuuucuggacauuagcucuucauc ccacugacaggauggaucaucuuuucuaaaacaauaaagacuuuggaacugaaaaaaaaa aaaaaaaaaaaa 125 AA062013 uuuugcuuucaacaugacagaugccgcuguguccuucgccaaggacuucuuggccggugg aguggccgcagcaucuccaagacagcggucacaccaucgagagggucaagcugcugcugc aggugcacaugccagcaagcaaaucacggcagauaagcaauacaagguucaucauagacug cgugguucauauccccaaggaacagauaguggcuucugguuccuuuaggcggugggaaccgggc caaugucaucagauacuuccccaccaaggcucucaacuuggccuucaaaguuaauuccaa gcagaucuuucugggugguguugacaagaggacccaguucuggcgcuacuuuugcaggga accugggcaucaagugguuaccacugggggcuacauccuuugaucuuuauguacccucuugau uuuugccgguaccgucuagcagcugaugugggcaagcuggagcuaaagggaauucaaggg ccuugggacugccugguaagacuucaaucugaugggauaagggcuguac 126 A1465965 auccgggacccccacggccccuuugcagcuugccacaagguucugagccccuuggaauac uuccgccaauguguguaugacauguuuugcccauaagggugacaaagccuaucucugccgu agccuggcugcuuauacugcaggccuucaggcagcuggggcagcaguaaaacccuggagg acagacagcgucugcccucuccaguguccuuccacagccacuacuccaucugcacccgc uccugccagggcuuccugugcugcucucucuggccucacuggcugcaccac 127 U50413 Sequence below. ggcacgagccgaguuggaggaugcagcggcagcguucagcggcagcgguagcuugugauugacggcugugcagccaaggaucc gggacagcgaagcgacggcaggucgcagcuggaucgcaggagccugggagcugggagcuucagaggccgcuguagcccag gcugggcagaggaaggaugcgagccuucccuugaggugaugcugagaguggagcguggcaguaaaaucagacgacagaugga cagugugacaggaucgucagagaggauugggccucgcuuucgagagucagccuggagucaagguuuuugacauguugcugag aaggacacguaugagggacaguggcgcgcggagggaaagcccugucuucagucaccccguuugauggaggacagauggacag cagccggacggccagucuccucucuuuaaccuuuggauagugguccuuugugcucugcuggacaccuguuggggauuuua gcccauucucugaacucacuuucucuuaaaacguaaacucggacggcagugugcuuagccagcuccucuguggcauuggcacu aaagcugcagacaugaguacaaaggggcuuaccaguacagagcacuguacgacuacaagaaggagcaagaggaagacauugac cuacaccugggggacauacugacugugaauaaaggcuccuuaguggcacuuggauucagugauggccaggaagcccggccu gaagauauuggcugguuuaauggcuacaaugauaccacuggggagaggggagacuuuccaggaacuuacguugaauacau uuuaaauaaaaaaauuucacccccuacucccaagccucaucccccuucaaccgcuuccuguuggcuuccgggguucuucaaaaacu gaagcugacacggagcagcaagcguugccccuuccugaccuggccgagcaguuugccccuccugauguugccccgccucuc cuuuuauagcuccuggaagccauugagaagauaggacuggaauguucgacucuauacauacacauagcuccagcaucccug cagaauuuacgacagcuucuuggauuuguaaugccggcgucaguagacuuggagauggauucgacguacacucuuagcaggauugcu cuacagagcccugaagacugcauccagcuguugaagaugcucauuagauugccuaauauaccucaucaguguuggcuuug cuucaguauuugcucaugcauuuuuucaagcucucucaugccuccagcauaaaccuuuugaaugcuagaguccucucugag auuuucagccccgugcuuuucagauuuccagccgccagcucugauaauacugaacaccucauaaaagcgauagagauuuuu aucucaucggaauggaaugagagacagccagcaccagcacugccccccaaaccucccaagcccacuacuguagccaucaucag caugaacaucauuauguccuugcaguuaugcugaaugguacuggggagacaucucaagggauguagugaaugaaaaacuccg agacacuugcugaugggaccuuuuuugguacaagacgcaucuacuaaaaugcacagcgauuuacacuucuuacaccuaggaauau aggaauuaacauauuauucaaaaucuuucaccgugauggaaaauauggcuucucugauccauuuaccuucaucucuguggu ugaguuuauaaaccacuaccggaauuuugucuuuugcucaguacaaccccaugcuggaugugauguugcucuacccaguguc caaauaccaggcagggaucaaguuugucaaagaagauuauuauugaagcuguaaugaaaaaauuacaugguauauuaauacucaauu ucaagaaaauagucgggaauaugauagauuauaugaggaguacacccguacuucccaggaaauccaaaugaaaagaacggcu aucgaagcauuuuaugauaccauauaaauauuugaagaacaaugccauacccaggagcuuguacagcaaagaauacauagaga aguuuaaacggcgaaggcaacgagaaagguaauuucaaaggauuaugcauuaccaugauuagcugagucggcguaucagugaga ucauugacaguaggaggagguuggaagaagacuuguagaagcaggcagcugaguaccgagagaucgacaaacgcaugaaca guauuuagccggaccucauccaguugagaaagacaagagaccauuacuugauguggcugacgcagaaaggugugcggcaga agaagcugaucuuaguggcugguugaaugauauuaccgaagaucuauucucccugguagaagaugaugaggauuugccccacc augacgagaagacguggaaugucgggagcagcaaccgaaacaaagcggagaaccuauugcgagggaagcgagacggcacuu aucaagacugccaccggcuauggcuuugccgagcccuacaaccuuuuacagcucccugaauugagcuggugcuacauuuucaa cacaccucccucgugcagcacaaugacucccucaaugucacacuagcauacccaguauaugcacaacagaggcgauguagcg cugcccucggauccaguuccucaccuucaugccacccauggccucugaguagcauagggcuccucuccagcccgaccuguga acugagcugcagauaugaugccggcugucugcacaugggacuagagcuuucuuggacaaaaagaagucguuggaugacacgc aaccucuacuauuggaugaccagacguucuaaccuuuauccucuuucuuucuuuucuuucuuuucuuuucuuucuuucuuuc uuucuuucuuucuuucuuucuuucuuucuaauuuauagccacaucacacaaccaucacacagagagauagauaugcaaauau cucuccgugcagggacaaagauugccuuuuaccauguugcuuguuuacgcuuucuguagcuuuuccagcuacaaguugguuac uuuuagagaccagauggguagacagggccgaagagccugcaccuggggccgcuugguccagccugguauagccuaugugucg cuggguguggugaacccagacacaucacacuguggauuauuuccuuuuuaaaagagcgaaugauauguaucagagagccgc gucugcucucgcaggacacuuugagaguacauugauuucagucuguucggaggauauaugaucuccagaauacguuuuugu uuauacuuaucaaggucaacaaccaacaacccaccaacagaaaaaaaaaaaaaa 128 AW120502 uuuuuuuuuuuuguuuuanuuuggcuccaaugaucgcauucucaaacuccuuugggagg g cauuagaugacccaguauccuuacuuacuuagauucacacuuuguuuuucuccucugagcucu uuucuccaggcucacngucuuuguuuuucaaggcuuucuugauccuuugaacaauuuucuu ccuuugaagauucuccugg 129 X62940 Sequence below. agccgaguaggaccgagcugcugcagacgcucgggucacucgagccagcaccaccuucucacgcccugagcugcagaca gcuaggcgguuuuaucuaguuugaaccaggcugcuggagcuugcucccucccgcccucucucuuuuuuuuccacggggcu guuuuuuuuauuuggcugcuauugcaugauaucccaaugguguagaccaguggcgauggaucuaggaguuuaccaacuga gacauuuuuccauuucuuucuugucgucuuugcugggaaccgaaaacgcuuccgugagacuugacaauagcucuggugca agugugguaacuaucgacaacaaaauagagcaagcuauggaucugguaaaaaaccauuuaauguaugcggugagggagga aguggaaguucugaggagcagaucaaagaucuuauagagaaaaacucccagcuggagcaggagaucaaucugcugaagac gcuggccaguccggagcagcucgcccaguuucaggcccagcugcagacuggcuccccuccggccaccacgcagccacaggg aaccacacaggcccccugcacagccaacaucccaaggcucaauaucaaccacauagccuccuaggccccaacagaacuagcugg cugcugcugcugucugaacugaacagaccgaagagaugugcuagagagaagccgccuccacagucacccauuucauugcug ucuacgaaagagacgugagacucacacgcuguucucgcuuucuccccaguauuaagcacucauaagcuuuuggcuugaaga aauguacuagguugaaugaauuaauaguuaaucagagaguaagcagauauguacccuguggcaacgguggcagaugucuaagg aaugguuuaauugaccccgaggagcucugugccuuuucaacccuccccagccgcccacccugcuucugagagcucugcu cucgccuucguggggcucgccugcgugggguucgaaagugggcugcuccuggauucugcgcucucuucuccuucccuuca aaaaacucggaggaggccagaaacaaaacugcaauauggggcgggggggagggaugaugcaguccuuauacaaaaccaacaac ugucaccaaagcuuuuaaaacacgauaguacugucccucuuuucugaaccaucagaagacacaaaacuguuagugacacaac ggugacagguagcugggaccuaggcuaucuuauuaugaagguuguuuugcuuguuguauauuuguguauguaguguaac gaauuuguaccauagaggacuguccguaacuacuguuuagcuucuacacauugaaauguagauguuucauuggcugucug aaaauuguggcuuguccuuccuagagagaucuacuuuaaaacugcuuuguggcaaaaaccacaccugaagaaauuuuaug auuuuggcccaguuagucacucuguguaaucccggauucuagcugcugaagucuugcgaaguaaacuccccgugaccgaug ucaguuaagcuggugauaccuuugagaaguggucaguugcuaaggaaguuugauuucccagguagguuguuucugcaccucacc uguauaaucguucugcgcaugucccccacacaguccccaccuguauuuaccuguucuacuuaucaccuuucauuauagcau aucauauguugau 130 U60020 Sequence below. auggcugcgcacgucuggcuggcggccgcccugcuccuucugguggacuggcugcugcugcggcccaugcucccguugaau cuucucccuguuauucccgagguggccggcugcuccgggucuggguagugggccuaagucgcuaggccauccuaggacuag ggguccgcugguccucggggucaccgcaggagcccauggcuggcuggcugcuuugcagccgcugguggccgcacugagu uuggcccugccuggacuugccuuguuccgagagcuggccgccuggggaacacuccgggagggugacagcgcuggauuucu guacuauaacaaucguccagaugccuucacuaucaguuauguggcagcauugcccgcagccgcccugugggcacaaguuggg ggagccucugggcgcccagcucaacagggacgcuggagacaugcugugucggaugcugggcuuccugggcccuaagaag agacgucucuuccugguucugguucucuugauucucucuuggcuuggggaaauggccauucccuucuucacgggccgcau cacugacuggauucuucaggauaagacaguuccuagcuucacccgcaacauauggcucauguccauucucaccauagccag cacagcgcuggaguaugcaagugauggaaucuacaacaucaccaugggacacaugcacggccgugugcacagagagguguu ucgggccguccuucgccaggagacaggguuuuuccugaugaacccagcagguuccaucacaucucgggugacugaggauc agccaacgugugcgaguccauuaguuuacacgcugagccugcugcuuuugguaccuggggcgagcccugugucucuuggugu ucauguuuuaggggucaccguaccucacucuggucacccugaucaaucugccccugcuuuuucuuuugccuaaggaaggcug ggaaaagugcaccagucacuggcagugaaggugcaggagucucuagcaaaguccacgcagguggcccuugaggccuuuucg gcgaugccuaccgugcggagcuuugccaacgaggagggugaggcccagaaguucaggcagaaguuggaagaaaugaagacg cuaaacaagaaggaggccuuggcuuugucgcugaagucuggaccacgagugucucgggaaugcugcugaaggugggaau uucuguaccugggcaggcagcuggugaucagagauacugucagcauggcaaccuuggucuucauucguucucuaccaacuuc agaucacccaggcuguuuucaggaccagcucucccuuaccccuccaugcagaaggcugugggcuccucagagaaaauaaucg aauacuuggaccggacuccuugcucuccacucaguggcucguuggcacccucaaacaugaaaggccuaguggaguuccaag augucucuuuugccuacccaaaccauccaaaguccagguuucuucaggggcugacuuuucacccugcauccuggaacgguga cagcguuuuggagggacccaauggaucagggaagagcaccguggcugcccugcugcagaaccuguaccagcccaccgggggcc agcugcugcuggauggccagcgccugguccaguaugaucaccauuaccugcacacucagguggccgcagugggacaagagc cgcugcuauauggaagaaguuuucgagaaaauauagauuaugucugaaccggacuccaaccauguuaggaaaucacagcug uggccguuuagucuggaacccacgauuucaucucuugauuucccucaggggcuaugacacaaagguagguggagacuugauaac cagcugucaggaggucagcgacaggcaguggccuuggcccgagccuugauccggaagccacuccugcuuaucuuggauga ugccaccaguuucccuggaugcuggcaaccagcuaugguccagcggcuccuguaugauuagcccaaugggcuucucggac aguuucaucuuauucacccagcagcucagccuggcagagcaggcccaccacauccucuuuucucagaggaaaucucuguucggc ggagcagggcacccaccugcagcucaugaagagaggagggugcuaccgggccaugguagaggcucuugcggcauccugcagacug a 131 L32752 gaauuccggggccgcucucuccggcaggaucgccgcgauggccgcccagggagagccgca gguccaguucaaggucguccuggugggcgacggcggcaccggaaagacgacauucaugaa gcgccacuugaccggagauuugagaaggauuauguagccacccugguucguguuagguuuca cacauuagucuuccauuaccaacaaaggaccuaucaaguaucaauguuguaugacacagccu ucaggagaaguucggggggcugcgcgauggcuacuacauccaagcccagugugccauuau aauguuugacgguaacaucaagaguuuacuuacaagaaugugccuagcuggcauaaagaucu agugcauguuguggugaaaacauccccauuuguauaugguguggcaacaaagguggauauuaaagga caugaaagugaaggcaaaaccuaaucucuuccaccgaaagaagaaucuucaguacuuuauga cauuucugccagaaguaacuacaacuuugaaaagccuuucuucuggcuugccagaaagcu cauuauagauccuaacuuggagguacguugccauuggccuacuucuugccccaccuaagguagu cauggacccagcuuauggcagcacaguacgagcaugauauagagguugcacagacgacugc ucucccagaugaggaagaugaccugugagaaagugaagcuggagcccugcgucagaaguc uauuuuaggcaacuuguccuggugauggccagccaacgguacauguuguggugccaccuuauuuu agcaaaaggagaucgagcaauucauugggaugcugaaggagaugaaugggcuucggagug aauguggcaguuuaaaauacaccuucauuuuuuuggacuugcguauuuagcccccuggaac agaguuuguucuggauuucaaagauaauuacugcuaccguagcaucacaauagucaguggug accggaauuc 132 AI8400413 uuuuuuuuuuuuuuuuuuugauuuuaugaaaaguuuuuauuuuuaucaguacuuguaaaaaauucuc aucauaaaugcuacguuuaaucaaggaaaaggcacagagaagcaugugucguuugaguccu cgauacuggaccucccagcccaugcucccuaugaggaucuagcugcuguggaggucuuc acagcauugguuuucuggagacuuaauucucaugauugcguucaugcacuccucugacagcc accuagcaugcagaguaguuugcacucaucagcgaugacugcguagagcuuuuacuaucucau uuuuaucugauuaacucuuuuggaaauuucucauugggauugcugagagcuucgcauau 133 AB020424 ucgggaaucgauugagagaccgcgaaccuguaaacggaugauaccgagucgggcaggcgu uaugccagcccaacucgggaccucgcaucauguccgcggcuaccuuagaguuuucggga augauuuuucgguuugaugaacgaaaccccgguacguccugugccaaggagcauaugucagg acggacgcucauuaaugccucagugguggggcaacguucgcucucuaucuauacgacucu cgacaauggauaucucggcucucgcaucgaugaagaacguagcgaaaugcgauacuuggu gugaauugcauauccugugaaccaucgagucuuugaacgcaaguugcgcccgaggccuu ucgguugagggcacgccugccuggacgucacgccuuuguuuugcucuugugcccgugcucuu ucgggggcggucauggaugcggagauuggcccuccgugccucgugugcggcgggcuuaag cgcggggugucggcgucgggaagggcacgacgagugguggacggagcaccagcaggaugu uuuuggucccccuuucaccuuaaggggcucaagagacccggacuagguagccgcgcuucgu aagaggagggcgagcugucucgcaau 134 AI848453 uuuuuuuuuuuuuuuuuuuugaaguugcuggccccuuuauuagugacccgggcaaguuuuaagga gaacaacauuaaagcacacaaaguguauccaugucaccagcucaaccaggaggagugagg gucacggcaggguucucccaugguguaagaaaucaacgcaauuucaucacaccccguuac uuuuccaaguuaacgaaccgauaagaaaagauuucucccuuaaacugacaaguacaauguac auguacaugauuuuggaauaauuuaauacuuuaaccucaagauacaacuauauucuaaga ccauuauuuuaaaggaacggauccuuacaaaaccaaaauaacccauauagcacgagguug guuuagccuuucuucuucuuucaacaaacgugcaccacauguuucaguagcaaggccgau gccauggauaugagagcugugauuugcagggaccaaccacaucuagaaccggggaggcca aucauacgguggguu 135 AU040563 cccuuggaggauaguuuuauugacaagucgaguuagguuuuagaguaaacuuuuaucacc ccagucaggccccuucccaggggaggcucgcugguagcucagauggccuugguggugggc agauuguuguaguugucuuccuguucccuccagcaggcuucgggagguggcuaucuccuu uccagccuggacuugauguccaguagcugcuuauacuccggguucuggcgcucuaugugc ggcacgcaggugcngcg 136 X89749 Sequence below. agacugacuuccuugagcagauuaccucuccuccuucucaugccagagacugcugaugaggaaagguccaggggacugucc augcugucuucauccucagagucacugccugaugcugcaacaagacccuucuuguuuagcaauagugguuggaacacucuc uuguaaguuaccggagcacuaguauaggaggaggaucaucgacuacccucccgccacuccacggcugcuggcuccuagaaa ccccagcuucaccucucacugggacucgaguuccagaaugaaaagcaagaagggucuuuguugcagcaucaggcagugacuc ugaggaugaagacagcauggacaguccccuggaccuuuccucaucagcagccucuggcaugagaaggaggagaggcaaucu gcccaaggagucaguccagauucugcgagacuggcuguaugaacacagauacaacgccuaucccucagagcaagagaaagca cuugcugucccagcagacacaccuauccacacuacaggucuuguaacugguucaucaacgcccgccgcaggcuccuuccugaca ugcugagaaaggauggcaaagauccaaaucaguucacgauuucccgccguggggccaagauuucagaagcuagcucuauug aagcugcaauggguaucaaaaacuucaugccaacucuagaagagagcccauuucauuccugcguaguuggacccaacccaac ccuagguuagaccagugucucccaaaccucccuccccaggauccauuuuggcucgcccuuucagugaucugccauaccacuuuu gacugcauugaaggaugggccuuuucucucuucugucagccgauuggugugggacagaguacagauguaccgcaaauuagcac ccagcaacuuuacagacaccucucucguguacccagaggacacuugcaaaucuggacccaguccaaacccucagaguggucu uuucaacacuccucccccuacuccaccagaccucaaccaggauuuuauuuggauuccagcuucuaguguuauguugcacucaa acgagcggcagagauggagcuucaggccaaacucacagcuuuaaccguuuuuucaaacaaaacaguucuccaaaauacggucc ugauugccgggggugauggcaagagaugcauuuuuuauauauuuuuuc 137 AW125390 uuuuuuuuuuuuuuuuuggugguuaucaagugcacuuuauuaaauccacuguggauaggau aaaugaguguuacaccugcguguagggaggggcaaggagggacgcagcugcggaggguga agcacuucaggaccggaagucggaauccucuauuaagugugaagguuuugagcguuaaga acaaugaugaugacacuaacaaugggugauaacaaccaucaggaugcugaauaccaaggugg cugauguucaggcacuuagcaguggaggcguaggccugggcuccagucacaucacccacc aucuuccgaucccuagacuucacggaguaggcauaggcuaugaagcccaggcagcagaag uucaugaagaguguauugaacagggaccagaccacauggucaggcaccgacaccucucug ggcauguugaucacaguaguucugacagaagccga 138 X0582 Sequence below. aagcuucaggauacagugcacacucgguaaauaaaaacuacaggcugcugcgaauuauauuucaacuuuaccggagaggcaaa accugacuguccauuaacccuuaacuuccaaacgcaaacuacuuacuggcaucuuuuggcauuuuaccuuaugccuuguuag guucaaggcaagagaagcgucaucaauaaccacgcaugugcaacagcuuuuccagaggaaagguguggguggcucuuaaaa gagccuuugagauaggauuugugaguuaaacgagcucacuuggagcugguguacuuggugacugccuuggugcccuccgac accgcaugcuuggccaggcuccccgggcagcaggcagggcgcacggccgucuggaucucccgggacgugauggucgaacgcuu guuguaaugcgccaggcgggaagccucgcucgcgaugcgcucgaagaugucgaucacgaacgaguacaugaugcccaugg ccuuggaggagaugccggugucggggugcacuugcuucagcaccuuguacacguacaccgaguagcucuccuugcggcug cgcuugcacuucuugccguccuucuucugggccuuggugacggccuucuuauagcccuucuucggaucgggagcggacu uggcgggcacaggcauacugagaggaugaagugaacuaaguagaaaaaggauaacuaaaaguuaaugacuguucuggcug caauuuuaaacaaacuuacggcuauggcaaccugaaucaccauacgucauguacuaacaguccaaucaaaacaagggauuuu caaaccagggcgccauuaguaaccaauguguaaccaaugaaaucucuccguuuucgcguccaaccuugacuauauauacua ugcguauacgauuuugcuucauacugcgguggauaucaacagcugaguuaugucuggacguggcaagcaaggacguggca agcaaggaggcaaggcccgcgccaaggccaagacgcgcuccucccgggccggccugcaguuccccgugggccgcgugcacc ggcugcuccgcaagggcaucuacucggagcgcgugggcgccggcgccccgguguaccuggcggccgugcuggaguaccug acggccgagauccuggagcuggcgggcaacgcggcccgcgacaacaagaagacgcgcaucaucccgcgccaccagcagcugg ccauccgcaacgacgaggagcucaacaagcugcugggccgcgugaccaucgcgcagggcggcguccugcccaacauccaggc cgugcugcugcccaagaagaccgagagccaccacaaggccaaggggaagugaaaccaaacauuacgaaucaccaaggcucuu uucagagccacucacuuucucaaagagaccuaacacuacugggauaaugcauuguaugaaauacguauauuaaccuuccuc cuauuuucccugcuugugguuaguucaaccccuaagccuuaggcuaagaguauauugguuuuggaaggcaggcacccaa ccucggaccuagguacauaaaacagacacaucuugaacuccaggccagccuacucugcaggacgaguuccaggacagaccgga cugcacaaaaaauugucuugaaauguuccuuuaucagcacauaugcugauaaacaacuaaucacuguacaaucaauccucac uuugaauccuguuuauguggcaugauugacaaguccugccauauggcaaagucaaaaucagcaaaggaugauaaagcauua ggugguaucacagcuaaaac 139 AW046181 uuuuuuuuuuuuuuuauggcaaauaguuuucaagauuuuuauugcaaaccaaaauugguuu a ucgcacacaaaaaaaguugugugguaaggaggaggaauuguacaggauuauaacccaugu uaauuacagguacauuaaaauggaugguuuacaaauaagccugguaaguuuaaauaucuaggug uuauaacccaauguacagacuuccuuuacacgauacauacaauaaucaggaaugcaaaag aauaugaacaaagggaaaaaaaacauaaauaaugcccguuuuauaggugacauuuauuaaac aauugaaaacaccaaccagcuuugacugacaacuagggcauuggguccauaaaaacccuuu cuaaaaauagaaauau 140 U10118 Sequence below. gaggcugcucaagagcugcgguugggucaccgcuucauguuucucugccgauucuggggaaagauggcaacgaaugaugc uguucugaagaggcuggagcagaagggugcagaggcggaucagaucaucgaauaucucaagcagcagguugcacuucuua aggagaaagcaauuuugcaggcaacaaugagagaagaaaagaaacuucgaguugaaaaugcuaaacugaaaaaagaaauaga aaagcuaaagcaagaggcuugauccuggcagaaauucauaacggaguggagcaagugcguauucggauuugaguacuuccacuugca gacgaacuguacugcuucugaaaguguggugcagucuccaucaguagcaaccaccgccucuccugcuacaaaagagcagau caaagcgggagaagaaaagaaggugaaagagaagacugaaaagaaaggagagaaaaaggagaagcagcagucggcagcagca aguacugacuccaagccuaucgacgcaucgcgucuuugaucuucgaauugguuuuauuuuuacugccaagaagcacccugau gcagauucacuguauguggaggaaguagaugugggagaagcagccccgcgcacgguuucgucagcgggcuggugaaucaugu uccucuagaacagaugcaaaaucguauggugguuuacucuuuuuaaucuuuagccugcaaagauuucggguuguucugucuc aagccauggugauguguuuccaguucaccagagaaaguggagauucuggccccucccaacguuguccguuccuggggacagaa uuacuuuugaugcuuuccuugggagagccugacaaggagcuuaaacccuaagaagaagaucugggaacaaauuccagccugacc ugcacaccaaugcugaguguguggccacauacaaaggagcucccuuugaggugaaggggaagggaguuuugcagagcccaaa ccauggccaauaguggaauuaaauaagugcucuguaacugaaauuacauuguucgaaaacuuuuaacaauaaagagaagugu gguuaucacuuacauau 141 AW212775 ggccuuguuuuugguuugcaauaaagaguauuucuuuaaaaggcacauuuuguuaaauag gcaguuccccuccugccucuuccuuuguagcaguguacugcauccuagaaacauuuagca aagcagcccuuagccuccccgacccccuuucccucccucccagca 142 AI846302 uuuuuuuuuuuuuuuuuaaacaauaacaccgucuauuuaaaauguuuacucccaaaaauua uagauauaaaaaaaaaaauaagacaauuaacagcacuaaaccaggcaccuucaaccgaau cccaccauccucguuaacucccuuccuguuacccuuuguagaugaccagaagauuucagg   agccccuggacagccagagugguuccugcccagggcuucccgccuuccuccuuuccuaga gcuucccgugggaaagcuugggugagaauuuuuagccuaaagggagggggcuguggccgg g cacuugcgcucauccacucuagg 143 M22998 Sequence below. acaggguacaguugugcgucagggcguggaggucuggcgggagacgcauaguuuuacagcgcguccguucuuuccgucucgcag ccggcacagcuagagcuucgagcgcagcgcggccauggaucccagcagcaagaagguuuauggccgccucauguuugcuuuu aggagggagcaguacuucggaucacuugcaguucggcuauaacacuggucaucaacgccccccagaagguuauuuggaggagu cuacaaucaaacauggaaccaccgcuacggagagcccaucccauccaccacacucaccacgcuuuggucucucuccguggc caucuucucugucgggggcaugauugguuccuucucugucggccucuuuguuaaucgcuuuggcaggcggaacuccaugc ugauggauugaaccuugucggccuuuugguggcuacuuguacuuaugggcuuucuccaaacugggcaaauccuuuugagauacuu gauccugggccgcuucaucaucgguguguacugcggccugacuacuggcuuugugcccauguaugugggagagguuugucaccuac agcucuacguggagcccuaggcacacugcaccagcugggaaucgucguuggcauccuuauugcccagguguuuggcuuag acuccaucaugggcaaugcagacuuguggccucugcugcucagugucaucuucaucccagcccugcuacaguguauccugu uugcccuccugccccgagagcccccgccuccugcucaucaaucguaacgagggagaaccgggccaagaguuguggcuugaagaagc uucgagggacagccgaugugacccgagaccugcaggagaugaaagaagaguuucguucagaugaugcgggagaagaagguca Ccaucuuggagcuguuccgcucacccgccuaccgccagcccauccucaucgcuguggcgcugcagcugucccagcagcuuu cagguaucaauugcuguguucuuacuacucaacgagcaucuucgagaaggcagguaugcagcagccuugugguacgccaccaucg gcuccgguaucgucaacacguuccuucacuguggugucgcuguuuguuguagagcgagcuggacgacggacccugcaccuc uuggccuggcuggcauggcaggcugugcugugcucaugaccaucgcccuuugccuugcuggaacguucugccuuggauuuuc cuauucugaacaucguauccaucuuuuggccuuuguggccuucucugaaguaggcccuaguccuauuccaugucauugugg gccgagcuguucagccaggggccccguccugcugcuauugcuguggcuggcuucuuuccaacuggaccucaaacuucauugu gggcauguuuccuccaguauguggagcaacugugcggccccuacgucuucaucaucuucacgguuucuccucgugcucuucu uucaucuccaccuacuuucaaagucccugaggaccaaaauccaaaccuucgaugagauucgcuuccggcuuccagcagggggaug ccagccaaagugacaagacacccgaggagcucuuccacccucugggggcggacuuucccaagugugaggagccccacacccagc ccggccugcucccugcagcccaaggaucucucuggagcacaggcagcuagaugagaccucuuccgaaccgacagaucucgg gcaagccgggccuuggggcgccuuuccucaaccagcaguggaagguccaggaggauauucaauacuuugauggcuccagaauuuu uuuuuuuuuuaucagccacucuccuaucuccacacuguagucuucaccuugauuggcccagugccugaggguggggacc acgcccuuguccagacacuugccuucuuugccaagcuaaucuguagggcuggaccuauggccaauugacacacuaauuaccgaa cucugagcuaggaggcuuuacgcuggaggcgguagcugccacccacuuccgcaggccuggaccucggcaccauaggggucc ggacuccauuuuaggauucgcccauuccugucucuuccuacccaaccacucaauuaaucuuuccuugccugagaccaguug gaagcacuggagugcagggaggagagguagggccaguucugguucugccagguucuagucuccugugcacugagggccaca caauaccaugaggaaagaccucggaagcuggagaacuuaacuugcugaagacacggacacuccugcccugcuguguauagauug gaagauauuuauauauuuuugguugucaauauuaaauacagacacuaaguuauuaguauaucuggacaaacccacuuguaa auuacaccaacaaacuccuuuuuaacuuuaccuaagcagauuauaaau ggcuggguuuuuuag 144 X64837 Sequence below. gcuuucuaaacuagcaagcaucguguggguuuccuucaggagugggagugcagacagaccugacagcguccgcuaagcgacac agaguccacaccucaguucgccucuggccacggucuuguugccacaaagaagacagagcaaggcccaccauccuccggaguacauuu uugaacgggaaucuaaauauggugcacacaauuuaccauccuuugccuguagcccuggagagaggaaaaggcauuuauaugu gggauguggaaggcaggcaguacuucgauuuccugagugcuuauggugcugucagccaaggacacugccacccaaagauca uuagaugccaugaagagucauuguggacaagcugacauuaacaucucgggcuuucuauuacaauguccuugguuauuugagg aguacaucaccaagcuuuucaacuacaacaaaguucuccuuaugaauacaggaguggaggcuggagagacugcauguaagc ucgcucgucguuggggcuacaccgugaaaggcauccagaaauacaaagcaaagauuguuuuugcugaugggaacuuuugg ggucuuaacacuauucugcaaucuccaguuccacagauccgaccaguuuaugauggcuuuuuacccuuucauugccaguucuuuua accaucccauauaacgaucuggcccgcacuagagcguugcucuucaagauccaaauguuugcugccuucauauuggagcccauc cagggugaagcaggcuuaucguuccggauccaggauaccugacaggaguucgguacucugcaccaggcaccagguccug uuuauugcugaugaaauacagacaggauuggccagaacugguagauggcuggcuguggaucaugauaugucagaccuga uuaugguucuuucuugggaagggcccuuuuucuggcgguuuauacccugugucuugcaguacuuguaugacgauaagauaaugcug accauuaaaccaggcgagcacggcuccacauacggcggaaacccacuuuaggcugccgaauugccauugcggcucuugagguu uuagaauggagaaucuuugcuugaaugcagacaagaugggcgcuuauccugaggaaggagcucauugaagcuuccucuugac guuaugaccucaggugagagggaaaggguuuggcuuaaaugccauuggucaucagagaaaccaaagacuuguaaugcuuuuaaau gugccugcgacuucgagauaugggcuucuggccaagccaacccacggugauaucaucaggcuuucccuccccuugugau caaggaggaugagauccgggaguccguguuagauucaucauaagacuaucuuguccuucugagauuuuaggaacucuggggag ccaucuuuucagacagggcucuuaugaaacucuacuuacaauggccaggaucuugucuuccugaaaggcauauauuucaauuga uugagguuugacugugugggaacuuucuaaggagaaacggacccaucugcguacagccugcagauggaggccugcaguca uuuauugcgucuuuacaguuuccuugcuuuguuaugguuuguauuuagaaguuauuucugagauacuacagaacagu uaaaucauuauaaucaaugaauguuaaguugauugaagguuaagcauauguaaaauacuaguuuuaaaguaaacuuuuucauu ggccaacaccagaauguauuauauagauucugagaauucauuacuaaauuacacuuugcuugauugcaauuuguaaaacau uuauuuuucaguauuucuuuuauaaagcuuaauguuucuuuuuuacgccaacauguauuauuuuuauuuccauuuugguaau aaucaauguauuuuuucauccugaugacuggcauuuucaucaccuauuugagaucacuugggguguguuucagggccuuuuuauuc uaaauaaagcuaugaccaguuucugucugu 145 AI843119 uuuuuuuuuuuucuuuuccgacgcccacaagaggaauuagagauuuaaugauagauagua uggggaaaucacaguuuucagacaugaguaaucaaaaacuugacauuuuucuugauaucc aaaucuagaugucuguaucaaaccagaggugauggccuuggggauggcagugaagacugu uaggaccauuagaucagau 146 AI837786 uuuuuuuuuuuuuuuucaguuuuuaaucaauucucagucuuucucgggcugaugcaau u gcaagaacguauugguauugguauauuucagcuacauacaagguuuaugauuagcaaugg agauaaauuaguuauuuuaauauugacuucauauagagauagugcaauguuguuuguuuuu cauaucacuugcuugacagguuuguggggguuuucuucccuaucauuuuuaacaaucaagaua acauggacucaagacagaauuuuucgggaaccucacucaguccucacacagcagugacuu gggaaucuacguguguuccaccgcaguugugaaacacacuacuccguguccaggacucau uucucagaguaguaucauuucgaguuccauccacaccuggggucgggacaca 147 U41465 Sequence below. ccgggcucgauuucucuagacucgaguuuagaguauucgagcucucccaguuuuuaugcaauauuuuggacugugaugcaa ggcacuuuggcauacacuacauggccuccccggcugacagcuguauccaguuuucccggcacgcuagugauguucuucucaa ccuuuaucgccuccggagucaugacaucuugacggacgguugucaucguggugagccgugagcaguuuagaacccauaaaa cagugcucauggccugcagcggccuguucuacaguaucuucacugaccaguugauaugcuaccuuaguguaaucaaucuag auccugauaucagcccugagguuguuuugcauccuccuggacuucauguacacaucuaggcucauccugagggaaggcauua ucaugggcgguggaugaccacagccauguaccuacaaaugaagcauguugucggacacaugcaggaaguucaucaaggccaug aagcagauauggccccugcacuuuaaccuccccguuagaguuccugaucagccggaugcugaugccccaugacaucauggc cuaccgaggucgugaggucguggagaucauuaugccacugagauauacucccggguuuugagagcagagcuuuugcuccucc ucuguacaauggccugucaucaccaccaggccucuuaucccauguacagccaucucccgcucagcaccuuccucuucucugau gaggagcuccgagaugccccccgaaugccuguggccaacccuuuucccaaggagcgugcccuccccugcgacagugccagg cuagucccuaaugauuuuuagcaggccagccauggaggugucccccaguuugugucacagcaucaucuacucgcccaauugag gcagucccagaggaggcucggagugacauacacuacaguguaccugaaugccccauaccugcuaucccuucugcucggaau gcuccauacuuccccugugacaaagccagcuagaagaagagagaccuucuucggaggaugagauugcccugcauuucgag ccccccaaugcacccuugauccggaagggucugguuuguccccagaguccccagaaauccgacugccagcccaucucaccca cagaguccugcagcagcaagaucgccugcauccuucaggccucuggcucuccgccaucaaugccccucugacccgauagc cugcaucuggaagaaguauaaguucaucguucucaucagccucaaucagaaugccauacccgagggcucugagcaggcaga gcugggucgccucuccccucgagccuacccugcaccgcccgcuugccagccgccuauggagcccgcgaaccuugaucucca guccccgaccuagcucagugccaguuugggauugacucuaccaucccccaugccagccggcucaauauucucgugaucaggucc cuggggaggcuccccccgaugcagcagugagaggucacucaccacucuacaugcaccccccaaaggugcacauccugcauaucuuc aguccccacagcauacagagaugugccuccauacugcugggcccacguucccggaggagaugggggauacccagucagagu auucguuauucuauucuguugaauguugaccuucuucugcuacgaaugugacugccguuucucugaggauugccucgcucaag aggcacacgcugcaggacggcacaggugacauaccauacauauguggaucgcugccaggccuccuuccgcuacaagggcauccucg ccagccacaagacuguccacacgggugagaaacccuaucgcuguaacauuuguggagcgcaguucauucggccagccaaccu gaagacccacucucgauuucacucuggagaauagcccuacauaugugauaccuguggguuccagguuuguucagguuugccca ccuccaugcccacguacucauccacacugggagagaagccguaccccuggugauaucugugggcacucacuuccgggcaccuuca gacucugaagagccaucugcgcauccacacaggagagaauccuuaccauugugagaaguguaaccugcacuuucgucacaaa agccaacugcgacuucauuugcgccaguagcacggcgccaucaccaacaccaaggugcauuaccgcgugucggccgcugacc ugccuccggaacuccccaaaaccugcuaaaugaugcauggaguguuccucgcccuuuccucuccagccccuucucagauuc uucccauaggaugcuguaacacuuuauacaaaggucaucccaugauguagugccucucucauccacuagugcaaaucauag uugggguggggguggg 148 U70494 ucgcgauccgacggaggaguaggcacuggaaucucgcugagcguccgccuggccucuacuu cuuccucgcucgucggagcuucagcacgguccgagauggcuggcgguaaggcuggaaagg acuccggaaaggccaugacauaggcgguuucccgcucgcagcgagccguucuugcauuuucc cugugggccguauucaucgacaccuaaaaucuaggacaaccagccacggacguguaggcg cgaccgccgcuguguacagcgcagccauccuggaguaccucaccgcagagguacuugagu uggcaggaaaugcuucaaaagacuuaaagguaaagcguaucaccccucuuucacuugcagc uuacuauacguggagaugaagaauuggauucucugaucaaagcuaccauugcugauggug gugucaucccacacauccacaaaucgcugaucgggaagaaaggacaacagaagacuguuu aaggaugccuggauuccuuauuaucucaggacucuaaauauuccuaacagcuguccagug uuggugauuccaguggacuguaucucugugaaaaacacaauuuugccuuuuuguaauucu auuugagcaaguuggaggcuuaauuagccuuccaaccaaccaaauuucugcauucgaguc uuaaccauauuuaaguguuacuguggcuucaaagaagcuauugauucugaaguagugggu uuugauugaguugacuguuuuuaaaaaacuguuuggauuuuaauugugaugcagaaguu a uaguaacaagcauuugguuuuguacagacauuguuuccacucugguggauaagcucaaua aaggucauaucccaaacuagcuuuaaacuugcuuaauaaucgggucuuaccuuagaucuc acucagcaacaaguacauucucugcuuacuaauuaaacagugcaucuguagucauaaaaa aaaaaaaaaaaaaaaaaaaaaaaaaaaaa 149 D17666 Sequence below. caccaccgugcacgcagcuccgagcccgugagguguuaguucuugcccucguaacccccucuguccagccaccaugauaaa cgccagcagagccgcggccgcgcgucucgugggcaccgcugcgucccggagccccgcagccgcccguccccaggugagaag cugccaugccuuccggugggggcuccaggcccggacucgagugaggcaggccuugccuucgggucagacucuaggaaaaa uccggaugaagggauguaacggaccuucugugggcauuguuggccuucuugcagggcuuuagcuucgaacugugcugag ucacaauccuuggcguuccuaagucuuuaccccgcuaauugagacgucuguccccccucuaaccugugcgcuuugaaugug ccuggacuuaggcaguggacguaguuuacuggaaauuuuuuuuuuuuuuuuuuuuuuuuuuuauuuuuuauuuuuuuu uauuuuauauuuuaauuuuuauuuuuuauuuuuuauuuuuuauuuauuauuuuuuauuuuuacauacuaaggacuaaa gcuugcauguguuccucagaauaugaaaagcccaaguucuuguguaguugaugacugaugcaacuuuuuuccccccagga gagaaaaaaaaaaaacacuuauugaaccucaaagcuuggauggguugggugcguuauacauuuguacuuguaguuuauuc aauaugccacugguaacaccaacauaaaacacaguucuucguauuggagaccacuguucagaugaccauggaauuucauuu cuuacagaucagaagcaaucaagggugcagugguugguauugauuuggguacuacuaacuccuguguggcuguuauggag ggcaaacaagcaaaggugagcaugauuggaaaccugaggucacuuagauacccagucuggcauuaauuuacauaggaaugcu gagucgaagcccagguuagugaugggcacuuuaauccuaguaaagacaaagggaucucugaguucaggaccagccuagag uauuuauuuuuuuuuuuuuuuuuuuauuuauuuauuuuacuuuaaucagugucuuugggaauuuuagguccuggagaaugcu gaagguaccagaacuaccccuucugugguugccuuuacagcagauggagaacgacuuguugguauaccagcaaaacggcaa gcugucaccaauccaaacaauaccuucuaugcuacuaagcgucuuauuggacgacgauaugaugacccugaaguacagaaa gacacgugaguaauaggaaaaucaguccagaagacuggugcuuugaucaaaguucuguggauaccuugaguucuguggau caccuugguucacuuuuaucauuauuucugcuugggaagaaaucacaccaccaucauggcauauauuguauuuuuuuauguu auuucuuuguuguuguuguuuuccuauuuauuuguuuguuuguuuggggggggguuucuuuguguauuuuccuggaac ucauucuguagaccaggcugguuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuauuuauuuuuuuuu uuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuucaugugauauaugaugaacuuagagugguuaag uuucacagggauaguuucuuacauaaucuuucugucuuuaaguaagaauguuccuuuuaaaauuguccgugccuccaau ggugaugcuuggguugaggcucauggaaaacucuauucuccaagucagauuggagcauuuguguugaugaagaugaaaga gacugcagguaaguggauuuauuucacauuuaggaaaauuggaaugugcuguuuauuucucugcauuaauacugauuaac uuucauauuucuguagauaaugaagucugaagcuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuu uccugggugcuaaguugcaaggugauagcucagguacucacucuagugucuuucuuggggugcucuuuuccaaggccucu cuacauauuaagccacaaaguuagucuguugccccucaagauugaugagauguggaauauuauugcuacaguuuuuuuugccuu augcugugaucacagucccugcuuauuucaaugauucacagcgacagguaaaauuagaucucuuguuugcugggagugga ggugggguaccugaguuaaaggauggaaagauagauuauuucuacuuucucuauugccacuaaggaugcuggccagauau cuugggcuuaaaugugcuucgaguugaucaaug-agccuacagcugcuugcucuagcuuugguucuggacaaaucugaagauaaag uguaaguuggucagaugacguagcauuaccugcauuuacagggguuguguguguguguguguguguguaauuuuacuac aauuuuuuguggguccguguguugugguacauuuguacauuuguacauggcauguuauauggaugucaaagauuuuuuauu uuuuuuuuuuuuuuuauuuuuuauuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuu uuuuuuauuuuuuuuuuaaaccaguaguugguguguuacuaauuuuacuuguuucuguaugacaugcuuauaugauacg uuaacaggcaugccacuuaguuuugauaacuacauucaguuauuaaguauuucaggaaauaucauaguuaauaauuaaacuu uuggucuuuuuaauucguuccuuuguuuuuguuccuuggaacuuaacuuacuuauuuauuuuuuuagcauucuguguauga uuuaggugguggaaccuuugacauuucuauccuggaaauucagaaaggaguguuugaggugaaaucuaccaauggggaca cuuucuuaggaggggaagacuuugaccaagcuuuguugcggcacauugucaaggaguucaagagagagguuaguuaccac ugcuuagucaccacugguuaagguuguaggcguuggguuguuugagaauuuuuuguuuuguuugcauugcuuuuuagcuuugu uaauagcuuuuuuauacuaagguaacuaacuauacuucagauucauggguaaacuaaaccaguuuaguuauauaaucuuag auuugggaacaaaagaccaagugacaguguuauaguagggagaaguuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuu uuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuacuacucucucg cagucuauauaugucuccuaauccuauuuauagacagggguugauuugaccaaagacaacauggcgcuucagaggguucg ggaagcugcugagaaggcuaaaugugaacuuuccucaucugugcaggugagggauggaaaaaucccaguacugagcauau uuugaauaguguauucuaauuuaccuaauuuucaguguagcucuuuacaguuuucuguuggcugaaaacuuggguucaugagc aaaggaacaacuugaugaucaguucuuuucauuugaauugaaugauuagauuauggauguguguauucuuuuugccugcau gugugucuguacuacauuugugcuugguuucuguggcggccagaagaggguaucagaacugacaugucaguguugggga uuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuu uuuuuuuuuuuauuuuuuuuuuuucacacugaaucuaaauucugaucaugucuuucagucguguuauguuacuuuugagu gaguaucaaagaucacgucucccaucugacgugugguccugugcagacugacaucaacuugccauaccuuaccauggaugc uucuggaccaaagcauuugaauaugaagcugacucgagcucaguuugaaggcauugucacagaucuaaucaagagaacuau uugcuccguugucagaaagcuaugcaggauugcagaagucaacaagagugacauaggagaaguugauucugguuugguggcauga caaggaugcccaagguauggacucaugguauuucuccuagaggaaaaaaauaacaaugcauucuugaggcaaauggcugu guuguguguggaaacaaaugugauccauucuucuaguguucuuuaaagaguggugagaccagacucaccaaaaagugcuu Uuagucaccugugauggcucauguaagaggauggccuugaguucuugauaagaugcaacuuacagaauucuaccuuugcaca cacacuuaaacccagucugguaaagagaaguuguuaagcuuuuuauuuuuuuuuuuuuuauuuuuuuuuuuuuuuuuuu uauuuuuuuuuuuuuuuuuuuuuuauuuuuuuuuuuuuuuuuuuuuuauuuauuuuuuuuuuuuuuuuucagauguaaaauuga uaauacuucuuccuaagauugguucgauuguguagaauaugagaacuguauuuuuauaaccccuugucaugugccuucuauu ucaaaugauauccucugggaagcuagauaauuaaauucuucucucauuuaaguggacaguggaugagaugcucugaaguu guaaauacaaacaagucugcagucuuggauaugaaucucucugacuugcugucuggcaggcguauucuguuuggcucca ucagucgcccuggguguuggcuaacaguuuucuuucucccugaugcuuagguucagcagacuguacaagaucuuuuuggca aagccccgaguaaagcuuguuaauccugaugaggcuguagccaucggagcugccauccagagagguguguuugacuggugac guuacagacgugcugcuccuggaugucacuccccucucucuggguauugagacucugggaggcgucuuuaccaaacuuau uaauaggaacaccacuauuccaaccaaaaagagccagguaagagccauucuuuuuuccugccuauuaacagucccaaguugu acaauagcuguuuuacaaucacuuuaugaacucuuuaaaacuuuguuucuaagacuauacuaacuggacuagguguuuuuu uuuuuuuuuuuuuuuauuuauuuauuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuu uuuuuuuuuuuuuuuuuuccuagguauuuucuacugcugcuaauggacaaacucaaguaaagauuaaaggugugucaggg ggaacgagagauggcuggagacaacaaacuucuaggacaguucacuuugguaaguguuuuugagucugaguaucaugcuu uuggggucuauagcuugcaaagcuccauacugcugacauuucaggcauauuguguuauuuuuuaaaaagaacguuaugua caugaguuaugauacccaugauuuuuguuuuuaccuaaagugcuuuguguuuucagaauuugauauuuucaaaucugg gaaauguucagacucagaagcaaugcuaacucagaaguuaguuuuauccugauuacucauuuuaaaaaacuuaauagcuac ugguucuggucagcauugcuacaguagagaaguuuauuugcuguaaauucugggcacauauauccaucaugguuuuuaac uucuuguagcccaguuuauuucauuaaagcacuaauacuaccaccaucacuuauauucucaugguuuugaucauucagugaaga uacuuguuuuaggaaacaaguauuaguuggccugauuuggaaaugagaauacauaugccuuucaaaggagcucacucua gauauuuuuuuagauuggauuucccccagccccucguggagugccccagauugaaguuacauuugacauugaugccaau gggauugugcacguuucugccaaagauaaaggcacuggucgugagcaacaga 150 X14897 Sequence below. auuuaaaucacugagaacuagagagaaauacuaucgcaaacuguaauagacauuacauccauaaaaguuuccccaguccuua ccacaagaguaaaacuguucaacaguuaauaguucaaacuaagccauugaaucuaucauuaggaucguuaaaaugaaucuu ccuacaccuugcaguguaugauuuaacuuuuacagaacacaagccaaguuuaaaaucagcaguagagauauuaaaaugaaaa gguuugcuaauagaguuacauuaaauacccugauggaaaaaaaaccuaaauaucaaaauaacugauuaaaauucacuugcaa auuugcacacgaauaugcaacuuguuaaaucaugcaguguuuuauuuaagaaaacauauaucaauacuauuaauauaguuuu agaggggguaaaauccagguccucugccaggaugcuaaaauuagacuucaggggaauuuugaagucuucaauuuugaaacc aacauguaggcugcuaccaucacagucauuuuaucaaguucugcucagucaugaacuuauuacaugagagcacgccuauug cagcaaacacaacuugcugggccacuuuccucccugucgugacacaaucaauccguguacuugguguaucuaaagcgcacg cugcaccgcggcacugcccggcggguuucugggcggggagcgauccccgcgucgccccccgugaaaccgacagagccugga cuuucauugagguacagcggcggucuguaggggaucugguuaucuugcagagggaacuugcaucuuaaacuugggcaguucuc caaaccagagacuaagcuuccccgagcagcgcacuuuggagacguguccggucuacuccggacucgcaucucauuccacuc ggccauagccuuggcuucccggcgaccucagcguggucacaggggccccccugugcccagggaaauguuucaagcuuuucc cggagacuacgacuccggcucccguuuguagcucaucacccuccgccgagucucaguaccugucuucuuguggacuccuucgg caguccacccaccgccgucaccucccaagaguacgccuucucggggaaaugcccggcuccuucgugccaacagucaccgca aucacaaccagccaggaucuucaguggcucgugcaacccacccucaucucuuccauggcccagucccaggggcagccacugg ccucccagccuccagcuguugacccuuaugacaugccaguaccagcuacucaaccccaggccugagugccuacagcacugg cagggcaaauggaaguagugggccuucaaccagcacaaccaccaauggaccugugucugcccguccagccaaagccaggcc uagaagaccccgagaagagacacuuaccccagaagaagaagaaaagcgaaggguucgcagagagcggaacaagcuggcugca gcuaagugcaggauccgucggagggagcugacagaucgacuucaggcggauacugaucagcuugaagaggaaaaggcagag cuggagucggagaucgccgagcugcaaaaauuagaaggaacgccuggaguuuguccugguggcccacaaaccgggcugcaag auccccuacgaagaggggccggggccaggcccgcuggccgaggugagagauuugccagggucaacauccgcuaaggaagac ggcuucggcuggcugcugccgcccccuccaccacccccccugcccuuccagagcagccgagacgcaccccccaaccugacgg cuucucucuuuacacacaguuuaaguucaaguccucggcgaccccuucccuuuguuugcccuucguacacuuccucguuug uccucaccugcccggaggucuccgcauucgccgggcgcccaacgcaccaauggcagcgaacagccguccgacccgcuaaacuc gcccucccuucuugcucuguaaacucuuuagacaaacaaaacaaacaaacccgcaaggaacaaggaggaggaagaugaggag gagaguuggaguuaagcaguccgggguuuguguguguggacccuuugacucuucugucugaccaccugccgccucugccaucg aucaugacggaaagaccuccuuuguguuuugugcuccgucucugguuuucuaugccccggcaugaccggaggagcugguga cuuuggggacaggggguggggcggggauggacaccccuccugcauaucuuuguccuguuacuucaacccaacuucugggg auagauggcuggcuggguggguaggguggggugcaacgcccaccuuuggcgucuugcgugaggcuggaggggaaagggu gcugaguguggggugcagggugggguugaggucaagcuggcaugcaccuccagagagacccaacgaggaaaugacagcacc guccuguccuucuuuucccccacccacccauccacccucaagggugcagggugaccaagauagcucuguuuugcucccucg ggccuuagcugauuaacuuaacauuuccaagagguuacaaccuccuccuggacgaauugagcccccgacugagggaagucg augcccccuuugggauuucugcuaaccccacuuccucugauuccaaaaugugaaccccuaucuuuacugcucagucuuuccc ugugcaguauuaugcuaugucccucucacccucacccccaccccaggcgcccuuggccguccucguugggccuuacugguu uugggcagcagggggcgcugcgacgcccaucuugcuggagcgcuuuauacugugaaugaguggucguuauugcugggugc accggauaggauugacccccagcccuccaaaacuuucccugggccuccccuucuuccacuugcuuccucccuccccuugaca gggaguuagacucgaaaggaugaccacgacgcaucccgguggccuucuugcucaggccccagacuuuuucucuuuaagucc uucgccuuccccagccuaggacgccaacuucuccccacccugggagccccgcauccucucacagaggucgaggcaauuuuca aagaaguuuucagggcugaagcuuuggcuccccuauccucgauauuugaauccccaaauauuuuuggacuagcauacuua agagggggcugaguucccacuaucccacuccauccaauuccuucagucccaaagacgaguucugucccuucccuccagcuu ucaccucgugagaaucccacgagucagauuucuauuuuuuaauauuggggagaugggcccuaccgcccgucccccgugcug cauggaacauuccauacccuauccugggcccuagguuccaaaccuaaucccaaaccccacccccagcuauuuaucccuuucc ugguucccaaaaagcacuuauaucuauuauguauaaauaaauauauuauauaugagugugcgugugugugcgugugcgug cgugcgugcgugcgugcgagcuuccuuguuuucaagugugcuguggaguucaaaaucgcuucuggggauuugagucaga cuuucuggcugucccuuuuugucaccuuuuuguuauugucucaucuccucuggcuguuggagacagucccggccucuccc uuuauccuuucucaagucugucucgcucagaccacuuccaacaugucuccacucucaaugacucugaucuccgguuugucu guuaauucuggauuugucggggacaugcaauuuuacuucuguaaguaagugugacugggugguagauuuuuuacauucu auaucguugagaauuc 151 AJ006289 Sequence below. caccugauucccgaaggcccgagcccuuagucuaggcaugguggcgcaugccggaaggacgccaucccuccuaggccau ggaggcucccgcaccgucccucacggaggaggauuugacugaagugaagaaggacgcuuuagagaauuuacguguuuacc ugagugagaaaancanagcugagauuacauuuugaucaucuacgugcaaaaaaaauacuaguagagaagacacugaagaaa uuucuugccgaacuucaaauagaaaacgggcugggaaguuguuagacuacuuacaggagaaccccagaugccuggacaccc ugguggaauccauccgcagggagaaaacacagagcuuccugauucagaagauaacggaugaggugcuaaagcuucggaaua uaaaacuggagcaccucaaaggccugaagugcagcagcugugagcccuuugcagccggagccaccaacaaccucucuaggu gcaauuccgauaagagcaaucucucugagaaacagagagcauccacugucauguaccacccagagauagaguccagcacgg cucccuucuucucuauggcgucgucccugaacuugccaguccuggaaguuggcaggacugaaaacagcagcuucucuucag ccacucuuccucgaccuggggacccuggggcucccccuuugcccccagaccuucgguuggaagaggggggaaguugagga aacucaagugagauguuucuccccuuacggucacgggcucuuucacgccaaugauacaucaccgccuaguuguuuuacuag ugaugcaaaaugcugugaaggaggccaucuuucuauacaaaccacggugacaggucacucacauucgaugcgugccuuua aaucaguguacacauucucuguaaauaggauuuguuaggguaaagaagcgcucuggggcggcgugguguaaucauggugg ucgugacuuuuccauaauguccuuucuuuuuuauuauuuunagguguuugcguauuuunacuuuucauaagauuaauu uuaucggaauauuucucaauuugagaaaacaacuuguggauugggaauaauguunuuagcacauuuaugcuacaaanuuu cagucugauuguuuuucccacugaucuggcaguauuuuuagcaguaagcuguugugugucaggaaagcuggacacggga aagcugccgacacacucagcagugucccacuccunaguucugagaagccgucggguucugaggagacaccugguggcacug agccuggugaccucaguaggccaaaauuuguuuuuacucacccugccaacgugagugucuuacuuucacaagccuugug uccucagucuuaucuuaaaggauguuaucuuggcagggcaucacuuguaauuaauggaugauacuuguanuugacuaaag uccucgcucugagccguuuguucuggcuccgagagcgcugacaugugaagcauggugagcagcgagggaacugacaggau auggccguauccaguguagcuuuaguauuugcaucaggcagccaccagcuccauccguguucuuacugcuuuacaaaguu ugacuaacuuuacacauuuuaaaaaugcugauugucuucguuuaaanuauaauuuuaccuauuucuugacaucuaacuccu auuuauuucuauuauuuaaaaauuaagaaaugaaaauuugcuauuaacaauaaaguuuuuuuaaugu 152 X12944 Sequence below. gguugggggguuggucagcgccgacguccccugccgccaccaugcccaaaagaaaggcugaaggggaugcuaaaggagacaaa accaaggugaaggacgagccacagagaagaucugcaagguugucugcuaaaccugcuccuccaaagccagagcccaaaccua aaaaggccccugcgaagaagggagagaagguacccaaggggaagaaggggaaagcugacgccgggaaggaugcgaauaauc cugcagaaaauggagaugccaaaacagaccaggcacagaaagcugaaggugcuggagaugccaagugaugugugugcauuu uugauaacuguguacuucuagugacuguacaguuugaaauacuauuuuuuaucaaguuuuauaaaaaugcagaauuucgu uuuacuuuuuuuuuuuuaagcuauauuguuagcacacagaacacuucaunacugggugggggaaggaucauguguca guaacaaaaucucucccaagcuggauugaggacagaaaaccucuuucccugauaauuuuggaaggcuccuguuggcuccca agagagaaauccugaucuuaaccuagguggccaccaaggcacaacaaugccuuguggucugggaaaacuauaaauucacuu uuauauccucuucccccuguacuaucaacauagacuuaauucccuuaaaaaccagagaccuguuggaaccuggcccccaaaa uugguuucccaguccauugagugauggggacuuugcagugacuucauugaguguucucaaaagagcacugguuccuuuua uaaaaaauuguggaucuucagauugauaauucugccuaaaagucagggucggcuugugaaaaguugunaaaacaacauccu uaaugugaaaugucaacccucacucuaagcuacuucccccuuuucaaagcauugaaugaagacuucauuggguuuuauagu ggcuuucugauuuugguagucauaucagaagggaauuuggaaguucuuguauauuguugcauugucugcccauguccug ccugaauaccaugauuguuuaugaaagaaucuuaauaaagcuaguuacaguuagacuggaaaa 153 AW061302 uuuuuuuuuuuuuuuggaaguccauaaguaguuuauugucuucaagacuacagugugg auuccucucccagagaagggucuuucagaggcaggggacuuuucacccaggugcaggccgu cuacuugucauuuucauacauaucuggauucuuccuuuucgacugcucaaacuccuauuu gccccauguguagaucagguagaccacuacaaacggcggcgccacgcgcaggaugcgcuc gcgagugcggcgcaacacuuuuggggaugccuuugcugaaauagcuugggaaggcgcgcug cucaaagggcgacaagcugua 154 U67328 Sequence below. caugaagccagagauguggaagaugugucuagacugcaucaaugaacugauggauacguuggaugcacauuccaacaucuc ugucggagagaacauuuuggcagagagugagaacuuacacaacuuugaucaguucacuccguguacgacgcugcauccuaa cuuugguggagcgaauauaugaagaauuuaccaaaauaaugcaaaauacugauccucacucccaaaaguauguggagcacc ugaaggaugaggcacaagugugugcaucauugagcgagugcagcgcuaccuggaggagaaagguaccacugaggagaucu gccagaucuacuuaaggcgcauccugcacacguacuacaaguuugacuacaaggcccaucagcggcacguuacuccuccuuua aggauccucaaagucugagcaagaccaggcagaaaaugagggugaggacucagcugugcuaauggaaagacugugcaagua caucuaugccaaggaccguacagaccggauccguaccugugccauccucugccauaucuaccaucaugcgcuccacucccgc ugguaucaggcccgugaccucaugcucaugagccaccuacaggacaacauucagcacgcagacccgccggugcagauccug uauaaccguacuaugguacaacugggcaucugugcuuuccgccaaggccugacaaaggaugcacacaauggcacuucugga auucagucaagugguggugccaaggagcuucuaggucaggguuugcugcugcgcgcuugcaggagcgaaaucaggaaca ggaaaagguagagcgacgccggcaggugcccunucaccugcacaucaaccuggagcugcuggagugugucuaucuggugu caacuaugcuccuggagauccccuacauggcuacccaugagagcgaugcccgccgacgcaunaucagcaagcaguuccacca ccaacugcgggugggcgagcggcacgcccugcuagguccucccgagucaaugagggagcaugugg-ucgcugccuccaaggc caugaagaugggcgacuggaagaccugccacaguuucaucauuaaugaaaagaugaaugggaaagugugggaccuuuuccc ugaggcugacaaaguucgcaccaugcuaguucggaagauccaggaagagucucugaggaccuaccuuuuuaccuacagcag ugucuaugacucaaucaguauggagacacuaucagauauguuugagcuggaucuacccacuguucacuccaucaucagcaa gaugaucauuaacgaagaauugauggcuucccuggaccagccgacacagacuguggugaugcaccguacugagcccucugc ccagcaagaaacuuggcucugcaagcuggcungaaaacuuggcacccuaguggagaauaauggaugguguuugaccaaa aacagggaaccuaugguggcua-uuuccgagaccccaaggguggcuaccggaaaaauggaggcuaaaugccccgugguggcu acccccagcaacagucucagacaaccuccugaguuccccacuucagucacccuguggacagaccaucuaaccuuuuucuccu aacucaccccaaucauuaaagaucuuuugaggaauuaaaaaaaaagaaagaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa aaaaaaaaaaaaaaa 155 AI604314 uuauuaauuaaaaaacaauuuauugaaaaagaguagugcuuuguacaaauucccauugca gcccccagauaucaacugaucucuuuccagcuuugguaguaggguauaaaaauaucaaaa cuagguaaguucugauguaagauuucuaugagauuauuauagaauauauagauuugugua guuuggcaaguaucauuucuaugcauuuacauuacauauuaagcacagauucuguggcaa aacaucuuugcauganuacuuuacacacacaaauauaguaaancuuacauaguacaaauu cacauaagacuccauucugucuauaaucauccaugugguuuuaccaugaauuaana cuuaaccucuccuauaacucagcuuccauuuaauuuugaaaguaucacuucacaaaga gacuucauuugcuuuuauuauacauagacu 156 AI845121 cggccgccaagaaguauaacaugcgaguggaagacuacgagccauaccccgaugauggca uggggunggcgacuacccgaugcuccccaaccgaucacagcaugagagggauccguggu aucagugggaccacucagaacucaggaugaacuggggngaaccgauacacugagaccuag acauguacaucaggaaucguguggacacgucaccaccccuguguccugngaugucaugu guaaacaucucuucggcnnuguggcnuucaugguuuucauguucuggguagggcacgugu ucccuuccuaccugccugugaguccgaagcaguacccuuacaaaaaucuguaccuggagc g 157 AW047756 uuauuuunuuauuunuugaugcaaaugucuuuaunuuccacuuaaacaaguuucccuuuu gcacuggccuguggcacaaaacagauggcuggguggugacauuaacugucaaguuaguga gaugcagagauggugagacacugcauuugagugcauaauacuuuuauuccagaggaacgc caugcagcccaguuacaccuuuagaucagaaaggcugaugcaugaccagccucuauugcc ucccuugguaagaaggacccacaagugcagaguccaacagaugcuggcucugagcugaac ucagggcauuccaauuaccacuuucuucuucaccuacacagggccugcucagauguccuu uuuacaacuccauaagcccuuggccaaagucccugcaguguuuggggaggaccuuccca cccuucaccagucagugucugaucugguggag 158 AI838021 uuuuuuuuuuuuuuuuuaauaucuguaauaguuuanuucaaagauuugacauuuacaag agaggcaccacaugcuaucugacaguaaaauacugcagggacugaaggccaaggagagag auccacagaagacaggccuguagugcaggcauugcaucgaccuugcccacagugcnuugu ucccaacucaggacaguacuuuagugcnugcuucauuacuggaaaaguucacuggacau aguunccacuuncccccacagcuuccagcucagcaaacuuaagcuacuacuccucgau gcucucauagaggcucuugauuugugucuggaagaacuuggcaagcucuacucguuuggc uuucagugucggugucagnaguccguuacaa 159 AW122893 uuuuuuuuuuuuuuuucugaggnauuaaaauaucuagacugaauuuugccaaauguaag agggagaaagnaccugaagacucugacuacuugcuuanuuuugauugaccuucuugcuu augucauuacugccucacaacgngunugauguccuuuaaugauacaaagugagccgugc cuucauuuucuugcccauuuugguaccccucaugccg 160 M59821 Sequence below. gcgcccgaacgucuagcagaguaccuacugcuguaagcnugucgucugggcugcaccgcccgucuuaacccauucucgacu uaacuacucucgucgaacaagcauggaaguacagaaagaagcgcagcgcaucaugacucugucgguauggaagauguacca cucucgcaugcagcgagguggcuugcgacuccaccggagucugcngcuaucccucguuaugcgcagcgcucgagagcucua ccucucagccaagguagaagcccaccagcccgaguucccgccaucccgcagggcucuugacccucgccugcacccgccgcag gaagccgaaguugcaguggaaguagcgucccccgaagccgugcagccuccggagcccauggauacgcaagaggaagugcug cgaguccaggagaccccugcgcucugugacccgccccccgcuagagucagccuaagcgccggagcagcagcguuuugagc gacaguagugaugccggacugguaccaagcaagaaggcccgucuagaagagguggagggggaggcgacgucggagguucc caaucgccugcagcuuccuccggcacaaagcgaaagugccuucccuaaccucgcccgcguccuccaaaggcgcuucuccaau cuccugaacuguggacccgccgugcccccgccgacgccccccacgugcgaggccaagccagccugccgcccggccgacaaua ugcucaacgugcuggugcgagcugugguggccuucugagagcucugguggcuucuuucgagcggcgccaccggagcggag aacuucacacccgaggcgaagucggcgggggccgugaagaagagccgaugcccgagcuucgagaggccagggcaaggacu gaggagcgaggggcgcgggcgccuucucccagacgugcguccauaggugcuauuaaaggacugucccuuccuuggcuugg agaagggacaccuagaucuugaaucucagggucgaacucucuaggggccaggcugcccuuucaaggccguuucacuaccau ucgcguuucggccccuacaagugggcacgcuugugcaagcggucagaguugcgucaugggacagacgcgggugcuuccug uugccucugcguggguguggggccuaggaagaggccaggguguggacccgcccuagggacugggaagugacuugagucac cucgcccccacaggcugcugugggugagccugaacugaaccaaucaaaucugcgcagaguugaaguggcuggagaccccgg gacuguuucaaccuagaugaucgccuggcguggaccaccgauggacgggcuuggccgcuggucguaguuuugccguagaca caacuucuucaggcaggaaagaaaauuuuuuucuaccagcguguuuaagaaagucuguuuacuuuucccacgguauguu guuuaauuagcaacuaccuggaguucuacaaugucagcuaggaaaauaaagaccaucggugu 161 M13805 See above (same Accession Number). 162 A1845886 uuuuuuuuuuuuuuuuugguuccacuuaaguugcauguuuuauuucucccaaucccagc a auagcacagaagcccaucauguccaucccagacugguuucuaguaggcugagaugacagg gagccucaguaacgcuaauggcacagagggcucccaaaugccaggcacaacugugccucc acacuggugacugcccagagugcccuugccccaguguguuggcacucagucugacuuac aacgcaaccugcaccuuugaaagggacagucugggaguggggagugugagggagugaagc ucaaacugccuccugucagcucacccuuucaacauuaaacagagaccaagagagaaacag uuccaauauuucacauauauuucuucuugugcagucuaaucgagaaugccauguaaaug gucacuguucgaaaugcagcaauuuagu 163 X53157 gucucggugagauguuucaagguuacuucgcggagugggcuuuuggcgugcaggcc cugaggcgcacggcccguggcgcggccgugacccgcuccauggcuucuggaggugguguc    cccacugaugaggagcaggcuacugggcuggagagggagaucaugauagcagcacagaag ggacuggacccauacaauaugcuaccuccaaaggcagcuucaggcaccaaggaagacccu aaucuagucccguccaucagcaacaagagaauagugggcugcaucugugaagaggacaac uguacugucaucugguuuuggcugcacaaaggcgagagucagcgaugccccaacugugga acccauuacaagcuggugccccaccaaauggcccacugagccccuguguuaucuuuucag aauguaaagaaaaacuucucucuaauaaagacuagccauugcaccugcuccuccc 164 U19118 See above (same Accession Number). 165  AF062071 Sequence below. gcgcaccgccuggguggcgcgccagcgucgucuaggugcaucgcgggcccccgcaguuagaaaaauauggcucaggagacu aaccanccccagggcccaugcuguguaguacaggauguguuuuuaugguauccuaggacaaauggaauguguucugu uugcuacaaagaacaucuucagagacagcagaauaauggcagaauugagcccaauauggacagcuaaugguuccaacagucc uaccucagauucugcaucuguacagagagcagaugcugguuuaaacaacugugaaggugcugcuggcagcacaucugaaaa aucaagaaaugugccuguggcugccuugccuguaacucaacaaaugacagaaaugagcauuucaagagaggacaaaauaac uaccccgaaaacagaagugucagagccaguugucacucagcccaguccauucaguuucucagcccaguucuuucucaaaguga agaaaaagcuccugaguugcccaaaccaaagaagaacagauguuuuauguguagaaagaaaguuggccuuacaggguuuga cugccgauguggaaauuuguuuuguggacuucaccguuacucugacaagcacaacuguccauaugauuacaaagcagaagc ugcagcaaaaaucagaaaagaaaauccaguuguuuguguugaaaaaauccagagaauauuaaaauuacuacaugugaagagac ugaaacuuuguuuuuauuuuaauauaucguaggaaaacauuaaagagcagaugcauggccauuuuccuuugauguucucc agaguuuugcuuuauacuugucugucauauaauugaucuuuuaggauguuuggguguuuguuacaggcagaauuggaua gauacagcccuacaaauguauaugcccuccccucaguaaaauuggacaaaaauaugcacaacaaauuaaaauacacauauac uaaucaagguauaaucuuuggcuaguguuaugugccuguacuuaaaaaaaaaaaaaugguacaccagaaaaggacuggca gucuacuaccauagucaaacuucaccuuaauuucgacaugacuuuuggaagcaggaagaaugcuacaaaacugguauuugg uaccaugugugagccugguuaaauuggucuucuaaaagcugucaauuaggacauucugcgaaagguaacaucacuacuggu ucuaagucaaaccaucaagucaacagcagggugccugagauaaucuuggaagcuuauugugcuggccugcaccagaagaua ucugcauucucauucuaauauauguagcacagaacugcacuaggauuuguuuacaaguuagaaauuaaacucuuuuuugguu uucacauauagcagcucuguuaaauaacaugcaucugauuuuuauugcaaagguaucuaaacaauuaauuuuucaugu gcaucuuuuguugaauguuuugguucaagaaagaauguuuaaagcunuuuaaagacuucaguucuuaauguaacuguacc cuucuuucauggaaaaucauaaccaacauggcugcaguauuacuucuuuaguuuguauccagcaccacuugcagagggcugcuu uaucauauuguacuuggguguaggacucuaguguucuuggguguauugcauaggcuacauuaucuacaacauuguacaa uaacanuagaaaaggcgguauacuucacugaugcuugucugguaauaucacuucuguguuaaaauggaagguuuuuugu gauguaugaaacuuguguuuuuuauauauaaaugaguauaguuuuauuaguguugugguaaugccuguuuucaucugua aauaguuaaguauguacacaacaaggcacuacuucugauuuuugcaguguucaguccuaguuuuucuuuuuaaaacauu gaguuugcuucaauuuuauguaccuuaguucuaaguuagauuugcagauguguacagauaguucauauuuauguauug cacauaaucaugcuauucagcauugaugcuauauuguauuauguaaauaauaaaagcaguguacagagggaaaa 166 U10404 augacaggaugccgcuguguccuucgccaaggacuucuuauccaguggaguggccgcagcc aucuccaagacagcgguagcacccaucgagagggucaagcugcugcugcaggugcagcau gccagcaagcaaaucacguauauaagcaauacaagggcaucauagacugcuugguucgu auccccaaaganagggaauccuguccuucuggcgugggaaccuauccaaugucaucaga uacuuccccacccaggcucucaacuuugccuucaaagauaaauacaagcagaucuuucug ggugguguggacaagaggacccaguucuggcgcuacuuugcagggaaccuggcaucaggu ggugccgcuauggcuacauccuugugcuuuguguacccucuugauuugcccguacccg u cuagcagcugaugugggcaaagcuggagcugaaagggaauucaaaggccuuggugacugc cugguuaagaucuacauaucugaugggauuaugggccuguaccaaggcuuuaauguguca guacagggcauuaucaucuaccgagcugccuacuuugguaucuaugacacugcaaaggga augcucccagaucccaagaauacucacaucuucaucagcuggaugauugcacagucuguc acugcugucgcuggccugacuuccuauccuuuugacacgguucucuuucguaugaugaug cagucuggacgcaaagganugauaucauguacacaggcacgcuugacugcuggcggaag aucgcgcgcgaugaagggagcaaggcuuuuuucaagggcgcaugguccanguucucaga guuauggguggcgccuuugugcuugucuuguauguugagaucaagaaauacacauua 167  U07634 Sequence below. cguagaaguugucucugucggcgggcgggcgggcaggaguggggcaccgagaccggcgugcggacagcagggaucgcggg gagcgaggggugcngcauggagcuccgggcagucgguuucugccuggcgcugcugugguuugcgcgcuggcggccgcg acggcacagauaaggaaguuguuuuguuggacuucgcagcaauaaaaggagagcucggcuggcucacgcaccccuaugg cuaagggugggaccugaugcaganaucauggacgacaugccuaucuacauguacucggugugcangugguauccggcga ccaggacaacuggcuccgcaccaacuggguguaccgggaggaggccgagcgcaucuuuauugagcucaaguucacggugcg agacuguaacagcuucccggguggcgcccaugccugcaaagagaccuucaaccucuacuaugcagagucagauguggacua uggcaccauuccagaagcgccaguucaccaagauugacaccaucgccccugacgagaucacggucagcagugacuucgag gcucgcaacgucaagcugaacguagaggagcgcaugguggggccccuuacccggaaguucuucuaccuggccuuccaggac aucggcgccugcguuucggcugcucuccguucgcgucuacuacaugaugugucccgagaugcugcagagcuuggccuucuu ccccuugaccauugcugucgcugunuccgauacacaaccccuggccacgguggccgguaccugcguggaccaugccguggu gccuuaugggaucgagggggcucucaugcacugcacgguauauggcgaguggcuggugccauccgagugccugugccagg aaggcuacgagaaggucgaggaugccugccgagccuguucuccaggauucuucaagucugaggcaucugagagcccuuccc uggaguguccagagcauacccugccauccacagagggugccaccuccugccagugugaagaaggcuauuncagggcaccug aggacccacuguccaugucuugcacacguccacccucugccccuaacuaccucacguucaugcauggguuuccaaaguagaacu gcguuggacagcucccaaggacacugguggccgccaggacaungucuacagugucacuugugaacagugcugcgcagaguc uggcgagugugggcccugugaggccacggugcgcuanucagaaccuccucacgcccugacccgcacgagugugacagucag ugaccuggagccccacaugaacuauaccuucgcugucgangcacgcaauguucgucucaggccuggugacuagccgaagcuu ccagacugccagcgucaguauuaaccaaacagagccccccaaaguaaggcuggaggaccgaagcaccaccucccugaguguc accaggagcaucccggugucacagcagagccguguguggaaguacgaagucaccuaccgcaagaagggggangccaacagc uauaauggccgccgcacggaaggcuucuccuuugacccuggaugaccuugcuccgganaccacuuuaccuggugcaggugcag acauggacgcaggagggccaaggagccggcagcaaagugcacgaguuccagacgcuguccacggaaauaucucgcaacaug gcggugaucggcgguguggcuguagguguugunuugcuucugguacuggcaggaguuggccucuucauccaucgaagga ggaggaaccugcgggcucgccaguccucugaguuauguccguunauccaagucagaacaacuanagccccugaagaccuaug uggauccucacacuuncgaagaccccaaccaggcuguacucauuuuaccaccgaaauccacccauccuguguggcaaggca gaaggucauuggagcaggagaguuuggagaggucuauaaagggacgcugnaggcauccucggggaagaaggagauaccgg uggccaucaagacacugaaagcgugcuacacugagaagcagcggguggacuuccugagcgaggccagcaucauuggccagu uuagccaccacaauaucauccgccuagaggcgguauucucuaaauacaaacccaugauaauuaucacagaguacauggaga auggagcgcuagacaaguuccuuagggagnaggauggugaguucagcguacuucaguuggugggcaugcugagggguauc gcauccggcaugaagnaccuggccaacaugaacuacgugcacagagaccuggcugcccgcaacauccucgucaacagcaacc ugguguuucaagguuuuccgauuuuggccugucgauugugcuggaggauuuaccccgauugccaccuacaccacaaguggcguuc aagaucccuauucgauggacagccccagaggccauuuccuaccgcaaguucaccucagccagcgauguguggagcuacggc auugucaugugggaagugaugacuuauggcgaacggcccunacuggaacugucaaaccacgaggucaugaaagccaucaac gacggcuuccggcuccccacgcccauuugacugcccuucagccauuuaccagcucaugaugcagugcuggcagcaugagcgc ucccaccggcccaaguuugccgacaucguuagcauccuggacaagcucauccgacgccccgacucccucaagacgcuggcug acuucgauccccgaguguccauccggcugcccagcaccagcggcucggagggaguccccuuccguacuuguguccgaguggc uggauuagcaucaagaucgaacaguacacggancacuucauggugguggcuacacggccaucgagaagguguuuacagaug ccaacgaagacaucaaaaauaucggaangcgucuuccuggccaccagaaacgcauugccuacagccugcugggacucaagg accaggucaacacaguggggauuccuaucugaguccaunggggcugucacacaauacungaagagccacaguggucucccu gccgaucugguuucuggcccacuggaacuuuauuuauuucuguuuccucuuucuaugccucccuaggacucugcagguugcuu uuuaaaugacaccugccuaagccugauaaacuuggauugcuagucagggcucucuuuccccugaaaaauacccagcuaaga acuuagcagunugccauggccuucccagcauccccugaggcuaaaguuccaccaagagucganaucgacgagggacauuuc caaacggaccuccccaucuncanuuggccuccugagaagccacucuggagcugaggcnaagcacuaagcccaggaccauaug acuagcacuguaccgcccgccccuaguuagaagguaaguuuuauacuuggcuggguuguggucacaagcaaucucccaan gccuuuuncagaccccagucugcccucccgucgagggccagcuucuugcuuuccuagggcccucucaggaugcuuggcug ugcugagguuunuauuaaauanauauuuuauacuugcggaaagaaugaguguguggcagggacuugccagggcuggagac agaggauccccugcaucaagacauucccgguucugguuggcuuugcggaccugcaggagacuuuccgccaccaccccgucucca gccccuuuggacaaaugucgcugucaguguuncagauuucuuuuauugggauguuunuuuguuguauunuuuugaaccu uaacuuanuaunuuuuuuauanuuaunguuagaaaangacuuanuucugcucuggaauaaaguugcagaugguuca 168  X04663  Sequence below. ccaaaaaccuuuuuuncuuucuuguncgguaccuacanuggaaccaccauaaacaauuauuucauuuuaccguagccauuua aggaaaucgugcacauccaggccggacaguguucaaccagaucauugcuaaanucuaggaauucauaagcgaugaacaug gcaucgaccccaccgguaccuaccacggugacagcgaccugcagcuggaccgaaucucuguguacuauaaugnagccacagg uggcaagnaugucccucgagcuaucuugguggaucuagaaccugggacuauggacuccguucgcncagguccuuuuggcc aaaucuucagaccagacaacuucguuuucggucagucuagggcaggcaacaacugggcuaaaggccacuacacaaaggaag cugaguuggu-ugacucugucuuggauguggugcggaaggaggcggagagcugugauugccugcaaggcuuucagcugac ccacucacuggguggaggcacuggcucuggcaugggcacccugcncancagcaagauccgggaagaauauccugaccguau caugaauaccuucaguguggugcccucgcccaaagucucuuuauaccguggucgagcccuacanugccacccugucugucca caccacgccaaccuacggagaccugaaccaucucgucucggccaccaugagcggcgucaccaccugccuccguuucccgggc cagcuuaaugcugaccuucgaaagcuggcugucancauggugccnuucccacgucuccacuucuucaugccuuugcuuugcc ccucucaccaaccauggaagccaacaguaccgaucccucacugugccugaacuuacccagcaauucuucgaugccaagaaca ugauggccgccugcgacccgcgccacggccggnaccucacaguugccgccgucuuccguggacggauguccaugaaggagg uggaugagcagaugcucaacgugcagaacaagaauagcagcuacuucguggaauggauccccaacaaugucaagacagcug ucuguaacaucccaccgcguggccucaagauaucaaucaccuucauuggaaacagcacagccauccaggaacuguucaagc gcaucucugagcaguuuacggcuauguuccgccggaaggcuuuccuccacugguacacgggugagggcauggacgagaug gaguucaccgaggcuuuagagcnacaugaacgaccuuugugucugaguaccagcauuuaccaggaugccaccgcggangagna aaggauuucggaaaggaggcagaagaggaagccuaacucagugagcccugcaucagcucaggcugcuuagaucccucaac cuuucuccaacugcccuuuguccuccaguuucuuucugcugccucugucuuguauuuguuuugcuucuguuuucucauu ggggguaaauggugccuggcacauggcaggcacucaauaaauauuuguuugugg 169  X61232 Sequence below. ggcagacaaaagaggccggcagugcagcucgcgggacgcauggccgggcgcggaggacgggugcugcuggcgcugugugc cgcgcugguggccggcggguggcugcugacgcgugaagcccaggagcccggggcgccagcggcuggcaugaggcgccgcc   ggcggcuccagcaagaggacggcaucuccuucgaguaccaccgcuauccagagcngcgcgaggcgcuggugucgguauggc ugcagugcaccgccaucagcaganucuacacagugguucgccagcuucgauuggccgggagcuccuuugucnucngcugucug acaaccccgggguccaugaaccgggugaaccugaauuuaaauacaucgggaacaugcauggcaaugaggcgguuggacggg aauugcucauuuucuuggcccagnaccuguguaacgaguaccagaaaggcaaugagacaauugucaaccugauccacagca cccgaauucauaucaugcccuccuugaaccccgacggcuuugaganagccgcauggcagcccgguucagcugaagncuggu uugugggccgcagcaacgcccagggaauagaucugaaccguaacuucccagaccuggacaauaucguauauguuaaugaga aagaaggcggucccaacaaccaccugcugaagaaucugaagaaaauuguggaccaaaauucaaagcuugcccccgagaccaa ggcuuucauucacuggaucauuugacauuccauuugugcuuucugccaaucugcaugaggagaccuuguggcuanuucc cauaugauaagacacggagcauuacugcucacgaauacaauuccugcccugaugacacaauuuuccaaagcuuggcucgcg cguacucuucuuucaacccagucaugucugaccccaaucgaccucccugcugcaagaaugacgaugacagcagcuuugaug auggaacgaccaaugguggugcaugguacagcguccccgguuugaaugcaagacuucaauunccugauucagcagcaacugcu uugugaucacuguagagcuuacgugugagaaguucccaccuaaagagacucucaaaagcuacuggguaaauaacaaaaacu cccucaucaacuaccuggagcagauacaccgagguguuaaaggguuuguccgugaccuucaggguaacccgaaugccaacg caaccaucucuguggaugggauagaccaugaugucaccucggcuaaggauggggauuacuggcgaungcuugcuccugga aacuauaaacuuacagccuccgauccuggcuaccuggcaaucacaaagaaaguggcaguuccuuuuagcccugcuguuggg guggacuuugagcuugagucuuucucugaaaggaaggaggaggagaaggaagaauugauggagugguggaaaaugauguc agaaacuuugaanuuuuaagaaaggcuncuaacuaauugcuuucaucuaucuauagacuguaguaagaugcaauguggcn cuuuuucuuuuagguuguuuugcaguugauauuuancauugauuuuuuuugaucauuaaguaauaguuncuaaucacguaa auacacccggacaaaaauauaaugcuggacaucuucauucuacaucaacauucgcuuaaaucauucaaaaccucuuuuaacg naaugggugacaaugucacuugacagangcaugagagucacgauauagcugacugugacccugcacugcaaucacauaguu ccauauaaguuguccuuagucucuuguuucugauucacuguauaagcaugauccuuuguanugcacuuuggaugggaagaaa auguacgugcuuuucagaauggcucugaacagaaugguaaaccuaguucuugcguguacuuuaaaaaauggaauuguauua gucagcuguuaaugccacuucagaaguuugggguuuugucuugauuguagauugg 170 X14309 Sequence below. gccacggacgccucucugaacggggauccaguucauugauuagagcugccucacugacuacaggccgugucgugucaccguuu Cugcaggcaccaugagccaggacaccgaaguggacaugaaagauguggagcugaacgagcuagaaccggagaagcagccca ggggucauguucaccggcuuauccnauugaggagcuacugaagguagcguugcagcccuggcugguuugcgcacccgcugggc gcugcuacugcucuucuaucucgguuugacuugaucaugcuggcgaucgccguanuuaucaucguucgggcgccgcgcugc cgugagcugccuguacagaggugguggcacaagggcgcccucuaccgcaucggcgaccuucaggccuuuguaggccgua ugcguugaguucauagcuggucuguagagccaucuggauuuacuugagcacccugaaggugaagggccugguguuaggcccaa Unucacaagaaccagaaggaugaaaucaauugaaaccgaccugaaacagauuaaucccacuuuaugcucccagguaaauuuuaa agaccuucuacaaagugccaagaaaaagagcauucacaucauunuggaccucacucccaacuaccagggccagaaugcgugg nuccucccugcucaggcugacanuguagccaccaaaauguaggaagcucugaguncuuggcugcaggacgguguggaugg Uuuccaauuccaggauaugggaaagcugauugaaugcacccuuguacuuagcuguguggcaaaauaucaccaagaacuuaag ugaggacaggcuuuugauugcagggacugaguccucugaccugcagcaaauugucaacauacuugaauccaccagcgaccu gcuguugaccagcuccuaccugucaaauuccacuuncacuggggagcguacugaaucccuagucacuagguuuungaaugc cacuggcagccaauggugcagcuuggaguuguaucgcaagcaggacuuccucgcagacuuuuauaccggaccaucuuucuccgacu cuaccagcugcugcucuucacucugccagggacuccuguuuuuagcuacggggaugagcuuggccuucagggugcccuuc cuggacagccugcgaaggccccacucaugccguggaaugaguccagcaucuuucacaucccaagaccuguaagccucaacau gacagugaagggccagaaugaagacccuggcucccuccuuacccaguuccuugcggcugagugaccuucgguuguaaggagcg cucucuguugcacggugacuuccaugcacugucuuccucaccugaccucuucuccuacauacgacacugggaccagaauga gcguuaccugguggugcucaacuuccgagauucgggccggucagccaggcuaggggccuccaaccucccugcuggcauaag ccugccagccagcgcuaaacuuuugcuuaguaccgacauuugcccguucaaagccuuugaguuaggacaccucccugauuucugga aaaccugagccugaauccuuauguaugcuugcuguuacaguuccccuuuguggccugauuccuuccuaugcagaaccuacca cccuccuuuguucuccccaggccuuuuggauucuagucuuccucuccuuguuuuuaaacuuuugcagaunacauacgaau ucuuauncuggguguuuuugucuucaaauaaaaacaucaccccugccucaug 171 U42386 Sequence below. ancuuaaaccncguuuauuuugauanccuguuugacuucagunaugnccaagaugccnauuguuuuuugcccnaaauaaauuu acugaacuugggcuaaaaccaaaccuuggcacacaggugugauacaacuuaacaggaaucaucgauucauccauaaauaaua uaaggaaaaacucaagugguagccugucuuaaggcuuuugauacuugcagauuggggaaaaacaaacaacaaacgucuuga agcauauuaauggaauuaguuucuuaauuguagcaaacuguauuaaguuaaaaguucuguunuacuucacucuauccuggaua gguauuuagaaccugauaauagucuuuaaacaagccauuccagucaugaugaggugauguauggauacaugcauacauuca angcacuguucucaaaguuaaugcauguaaauacagcaauuccucuuucaauguuuaggcagaucguuaacuaugagcuag ccaaaugugggcauguunuuacagggaaaguuuaaaggucugauaacuugaaauagguuuaggagaauucaucuacuuag acuuuuuaaauugccugccauaaaaaauugaaaugguagaauggcugaccacagcaaugaccagcccucaccuaaugcucug gaugaunuuuggucuanuaacgcaugcuaguguugauguuuuuuggucaagaugggaaugaacaggaagaauuangcagc aggcuuuuuuuaaaugccgauucacauuacucuguucaagcugcguugagauuuuuaaacuggcuuacuauagacuuuuu aaaaaaaaaaaaaaccaaacaaauggcuccagaagaguaacaaacugaaaucugagaucacacagguuugguaauauguacaua acugaacaaggugucaauucugcucuacagugcaguuuagucaguuuunguugcanaggunuccauuguuuuuauagucu ggnuaugcuaaaucuggccaaagaugagcauuguccaccacuaaaaugccuaugccacuuuggaauucuggguuaauuuug uugaccagaaugcagaucaaaauguucaaucuuuuuacaguggcauaagaagauaucaaaaauuuccuaaagugcaauag auuucauguguauuugugccuuguucuaaaacuuuuauuaaguaggugcacuugacaguauugaggucauuuguuaugg ugcuauuucaauuagucuagguuuaggcccuuguacauuuggcccauaacuuuuuacaaaguacuucuuuuuugcacau uucagagaauuuuuauauauuaugucuugugugcguguccuuaaacuuccaaucuuauuuuugucucuuuggagauuguuugaacg cagcuugucuaggaaagggaugggacuagauucuaaaauuuanuugggaccaugggaaugauaguugggaagaaacuuug cacacgacagauuucuagauacuuuuugcugcuaguuuuauguaauauuuauugaacauuuugacaaauauuuauuuuug uaagccuaaaagugauucuuugaaaguuuaaagaaacuugaccaaaagacaguacaaaaacacuggcacuugaauguugaa uuaagcagacccggcauuggcguguagccauaacuuucugauguuaguaaaaacaaaauuggcgacuugaaacuaaaucau gccaagguuugauacacuugucuugagauauuaacgaaacacuuccaaacacugauacaaaguguccagauucucagaugu uuguugugugaguuuuguuuaguuguauuuuuuuuucagugaaugucuggcacauugcaauccucaaacaugugguuau cuuuguuguauuggcauauucagugacuuguacauucagcaauagcauuugagcaaguuuaucagcaagcaauauuuuc aguuuauguuuccaaauuaagaauggguuuaaacuugcugaauguaaauuauugacccucaagucacuguagcuuuaguagu ugcuuauuguauuaguuuagaugcuagcacugcaugugcugugcauauucuaguuuuauuaaauaaaaaguugaacuac acagucuccuuuguuguugucaauugugguuuacuuuuagaggugaaaauaaaguugugcucuugccucgugccaauaug uacauaacugnacaauugugucaauncuuucucuacagnuunaguuuagncauuuuuagungnauaguuuucccaunguuuuaua ungncuguuuaugcuaaaucuggccaaagaugagcauugcccaccacuaaaaugccuaugccacugggaauccuagguuan uuuggngaccagaaugaagugancaaaauguccanucuuuuuacaguggnauaggaagauggnaaaaauunccuaaagug naauagauuuccaaguguuungugccugguncuaaaacuuuunuuaaguaguugugcacunganaguauugauugncauug auuauggugcuauuuccanuuagucuagguuuagacccu 172 U51126 Sequence below. g gacuaugggcaucuggguucuuccucuucuacuuggccacgagguaaccggcuucuuguaccacgugugcucaccucuac aaucugugcggauucagacuccaagcaacuaggcuacccagugacaggcuaaaaacuacagcucuaacgucuuggaaggcg auuccauggaccaggauguggaaagcccaguggccauucaccagccaaaguugccuaagcaggccagggacgaccugccga gacacaucagccgagacaggaccaaaaggaaaauccagagguacgugaggaaggaugggaagugcaacguucaccacggcaa ugugcgggagacguaccgauaccugacggacaucuucaccacccugguuugaccugaaguggagauucaaccuguugaucuu ugucauggucuacacagugacguagcuuuucuuugggaugaucugguagcugauugcguacauccagggagauauggac cacauagaggaccccucguggacuccuugugucaccaaccucaacggguuugucucugcuuuuuauucuccauagagaca gaaaccaccaucgguuauggcuaccgggucaucacggacaaguuucccugaggggauuauucuccucuuaauccaguccgug uugagguccauugucaacgccuucaugguaggauguauguuuaugaaaauaucccaacccaagaagagggcagagacccug gucuuuuccacccacgcggugaucuccaugcgggaugggaaacugugcuugauguuccgggugggggacuugaggaauuc ucacauuguggaggcauccaucagagccaaguugaucaaguccaaacagacuucagagguuggaguuuauuccccucaacca gacugauaucaacgugggguacuacacaggggacgaccggcucuuucuggugucaccauugauuauuaaccaugaaauuaa ccaacagagucccuucugggagaucuccaaagcgcagcugccuaaagaggaacuggagauuguggucauccuggagggaau gguggaagccacagggcaguucugaaaucgaaaucaagcagaggucuauaagaacacccuggagacccccaugcugcugga ucuuggguccaugaacugcuuuuuuugcuacaaucaaaaaugcuagucgcugaucugauaggagaggaaacgagacuca gagccugaaggauaacacgcugagggcugauuucauacacucuucccggcuggaucaucccagcccccacagcguccaggc unaguuucuuccuuuguuuuaacaaucuauacuuccuccagccugggcgagcuaguauacccagaguuugguuuuguuuc uuuucagagcuguaagcccaguuccauuugaccucaucugggaggagaguuaagcaauaagaccugaaauuucuaaacucug ggguagaaaaccucugcagagacagcgucucugggaagucucuacagagacagaguagggaagucucacgaaggucagagu cuuacuuccauaccuggagaaauccgcccguccguucagugccgguuucaacuccucugccaaagacuucuuuccaagaca cugguaucagcuaucccagcaguaacuuuggcaguauauaaaucaauggcacugccccauaaaaccccguugaguaaaaccu auggucuucaacagcugaggagccuguagcccagcuccugugugaggcuaaggcuguggagaccaugccugcucaccucc ucguugaaaagcaaaacacuguaagaaaccuaacaugacuuuuuccaacauuucucaggcuggggagaagacuugguccac aaauuagcuugaggucuugaucuggaucccuagcauccauggaagaaggugggcaugaucacccacacuccucaucccauag cucugaaugagguaggcagauuccuggggcucaccagcucauccuaacagccaggucccaaugagggacugucuacaaaag aacaagagguggauccugagaagcgacacccaagcuugaccucuagccccuguacacaccuguuaagcaccugggcaucgg gacacacacucgcaanuugcaaacaaggcaaauncucacacnucagaaggcacngagagaancccauaagcncaaaaagnun ggagccaagauugaccauuaugacuuuuugaaaagacuaaaccacuagauagaauguuucauuucuaaaacaccuuac cugaaaaguauuacugcucuucuuucugcaacuggaccaugcagagauccacaaagagaugcccagagauuauuagugaug gucaunugauauncacaauguggacucuaagccaaggccccancaacucagauccagaggcugacagugugcunancuuag agauaccacagugacugccuaaucaccacguccuuaagucaggggaguuuaauuauuuccuaugaacaccgaauggggaca gcggauuaccaaugaagcaauccaaccugacaauccuaaccacccagaagaggaucgcugggggaaagcaugaauuauuuac gugucaacaugugcacacuccggccacgcagcucaacagccaggagugcuucnccacuuagcccugcccuggcauccauun augaucucgucuanuguguuuunacccagcnagcuuuuucucaaaaauaauaucucccagccauaaaccuacucaucug uguccucuuuauuucaacccacaauuacaucauucacuggcuugcucaguuucuucaacucugaaaugagaaugauaaug augaugccucnucccccaagccaccauccucccccgugaccuuccuagguacagacucaaaccagggaagauuauuuccuuc ucauaggccacagaguganaugcaauaaagaacaaagccunguagggaagcagagagaaagaccaguccucacaagagacu ccauuguuuccaggaacuuugaagcuuggacaaaaugucagaugauccccuuugaaggugcuccaaagagucaaugugaaa aauauugacugaugugugcccguccacaagccaaggugccucugcccuggucaccuaccaugaauuauaaacugaugauau uuaaaauaauaaggaacacuggagccggccagaaaggauucugcaaucccauaaauagcaacauucaucacuacaaugccug ccaacggugaccaugaauguagauuacccccaacucuucuaaggccacuaaggacagggcaaacuaccucugagaauagag gcucacuguucugcaucccacuucuaaauguuccaugaauuuuuugagacaucucccauaucccuguuagaaagauucaac cnugugcuauuaaccaaaucaunuugaanuccauaaaccucuacucuaaagnauacacuuuuucuacaanacagacaacaa auaugacuuuuuccuaugaaagaguaauaaagauacuauaucagucugcuuugacucaaaaaaaaaaaaaaaaaaaaaaaaa aaaaaaaaaaaa 173 AF093853 Sequence below. gaguunugguaggcccagguaccuccuccanaanugaccacauanuuggucacanaucaagccnccacaganacaaaaauau ugaaauuaucccaugcauccugucugaucaccacagacuaaggcugaucuucaauaacaacauaaaaauagaaaaccagguu cacugcugcggcugcgccnccnuguucucagcgncaccacugccgccaugcccggagggungcuucncgaggacgangccc ccaacuuugaggccaauaccaccaucggccgcauccgcnuccacgauuuaccuggaaganucaugggacauncucuuuuccc acccacgggacuuuaccccaaugugcaccacagaacuuggcagagcugcaaaacugacgccaaaguucgccaagaggaaug uuaaguugauugcucuuucaauagacaguguugaggaucaucuugccuggagcaaggacaucaaugcuuacaauggugaa acacccacgaaaaaanugccauuncccaucanugaugaunagggcagggaccungccauccuunugggcauanuggaucca gucgaanaagacgauaacaacaugccugugacgacccguguaguguucauuuuuggcccugacaagaaacugaagcuguc uauccucuacccugccaccacgagcaggaacuuugaugagauucucagagugguugacucucuccagcugacaggcacaaa gccgguugccaccccaguuaacuggaagaagggagaaagcgugaugguaguccccacccucuccgaagaggaagccaaaca auguuucccuaaaggagucuucaccaaagagcucccgucuggcaaaaaauaccuccguuauacaccccaaccuuaagucuuu gcggaaauuggggcugcaucugcacguccagcacuggggccugaggacgucagccggcagccguggguccuugcagcagg nccguagaaagancguggcangaucacagccgguccuguagaucgcucgcuauacuacugggucaunaaauggaaauggca ccananccuucucggaauucuuuacucugugccuucgccaacauucuaccccucugccugucacaaugcccuacuaacugg cucucuuugaaacgaauuauguauugaagauuccuuaggucucugcagggucuuugaucagcaagcaagguagugucagu gugggcucugugcuagaaugaugaaacaccuunuguagcuunccgaacggaaucuucugunacccanuunggagagcacu gacauggggagangcuuncaauucuguauuuuuaguaaananaguggggacaaccgggaanauucuuncagggaaucuau uguaaguuucuaucgaaguaggcucaanaagccuuucgccucccaaangugcgcauguaccuccuaanguuuccacaucug cucucuggugaugucugccngugaacgcaccunanaanagacaggcgaugacagugununaccacucagnguccuaguag ugaguggccauuucuaaauucuacuuuuugagauucaacaaauaaaauccugaucagaaaaaaaaaaaaauagaaagccaa cauucauguggaaacuaaacaacacuacucaaugauuccuuggucagagaugaaauaaagaaagaaauuaaaaacuuuuua gaguunaaugaaaaugaagccacaacauacccaaacuuaugggacacaaugaaggcauuucuaagaggaaaacucauaaccc agagugcauccaaaggaaaaaaaaaaaaaccuagagagaguguacacuagcagccugacugcacacauagaagcucagcaaa aaaaggaaucaaauucacccaaaaggaauagacaacaagaaauaaucaaacuuaaugcugaaaucaaccaaauggaaacaaaa agaacuauucaaagagugggccaaaccaggagcuaguucuuugagaaaaucaacaaganagauaaacccuaagccagacuca cuagagggcacagggacagcauccuaauaaacaaaaucagaacagaaaagggagacauaacaacagauccugaagaaaucca aaacaccaccagauccucuacaaaaggcuauacucaacaaaacuggaaaaccuggaugaaaggaaaagcuucuagacaga 174 Z19521 Sequence below. augagcaccgcauaucugaugcgucgcugggucaucgcccugcuccuugcugcugccggaguagcaguagaagacucagg cagcaggaacgaguuccaguguagagacggaaaaugcaucgcuagcaagugggugugcgauuucagccccgagugcccgga uggcuccgaugauuuccccaaagacaugcaugucugucaccugucaguccaaucaanucagcuguggaggccgugucagccg augcauuccuaacuccuggaaaugugauggacagguagacugugaaaaugacucancgaacaaggcuguccccccaagac gugcucccaggaugacuuccgaugccaggauggcaagugcaucuccccgcaguuugugugugauggagaccgagauugcc uagauggcucugaugaggcccacugcccagccaccacuuguggccccgcccacuuccgcuuucaaaucauccanaugcauccc caaucuuugggccugcgacggggaugucgacuguguugacggcucccauaaguauccacagaacugccaggccgaagacac ggccuccaaaggcguaagcagccccugcuccucccaggagauccacugugguagcagugaguguauccaucgcagcuggg agugugcagauaucuccuucauucacgguagccgccaaugugaccgugaacaugacugcaaggacaungcgacgagcucg gcugcgucaaugugacacagugugauggccccaacaagaucaagugucacaguggggagugcaucagcuuggacaaggug ggaggcuguucccacaucugcaauugaccucaagauuuugcucugagugccugugucccauggcuuccgguugguggaccu ccacaggugugaagauaungacgagugucaggagccagacaccugcagccagcacugugugaaccuggaaggcagcuacaa gugagagugccaggccggcuuccacaaggacccacacaccagggucagcaaggcuguugcuccanaggcuaucugucuu caccaaccgccacgagguccggaauuaugacccuguuaccgcagcgaguacaccagucugcuccccaaccugaagaauguggug gcucucgacacggaagugaccaacaauagaaucuacugguccgaccugucccaaaaaaagaucuacagcggccugauggacc aggccccuaacuuguccuacgacaccaucaucagugaggaccugcaagccccagacgggcuggcgguagacaggauccacc gcaacaucuacuggacagauucagucccaggcagcguaucuguggcugacaccaaguugcguaaagauugaggacacuuuuucc aagaggcaggguccagacccagagccaucguaguggacccuguacauggcuucauguacuggacagauuggggaacacccg ccaagaucaagaaagggggauugaaugguguggacauccacucacuggugaccgaaaacauccaguggccaaauggcauca cacuagaucuauccaguggccgucucuauuggguugauuccaaacuccacucuaucuccagcaucgaugucaaugguuggca aucggaaaaccauuuuuaggaugagaaccaucuggcccaccccuucuccuugaccaucuaugaggacaaaauguauugga cagaugucauaaacgaagccauuuucagugccaaucgacucacggguncagaugugaauaugguggcugaaaaccucuugu ccccuugaggacanaguccuuuuuccacaaggucacacagccuauuaggggugaacuuugugugagacaacagcccuccucccca auggugguugccaguaccugugccugcccucccacagaucaguccccacucgcccaaauucaccugcgccugcccugaug gcaugcugcuggccaaggacaugcggagcugccucacagaagucgacacuguacugaccacccaggggacauccgccgucc ggccuguggucaccgcaacagcuaccaggccaccgaagcacagugaggaucucucagcucccaguacuccuaggcagccug uguuacaccccagggcucagcacaguuugcgucauuugacaguuuucccaccaauuuccagguuugacauggcuggcangggaaug aggagcagccacaugguaugaggunccaguccaucuucaucccuauuugcacagguugcccuccuuguccnuggggccguc cugcnguggaggaacaggcggcugaagaacaucacaancaacagcauaaacuuagacaacccagucuaccagaagaccacag aggacgagcuccacauungccgaagccauugauggcuanaccuaccccucaagacagauuugucagccuggaggacgaugugg caugagcagccaugagagccgucucuuuccgggauccauugccaagcuuaagcagaaaagacacucucuccagaccucccca accagcacugguccugccaccucccugggucuguguugcncaaagcaagauagagcaaagcugggcuggggggccaagcuc agcuuccugucuucccagguucuguuuuauauauunauugucuuuggacagaaaaggcuacuggcugugcuugaaanacg a 175 U04354 Sequence below. accggucaucgggcucuuccuugggcucagggcacggaucaaguccucggcucgcucggccagcaccgcggcaccauggcg caggagcuacaacaccccguguucgcacgcgcaggccagcaagcuaugcugcaaguguggagggucgaaaagcuauaacu gguaccggugccccagggugccuauggugacuuuuacgucggagagcccuaccuggugcugcacaccaccaaguccagcag gggcuucuccuaccgccugcauuucuggcugggaaaggaguguucccaggaugagagcacagcggcugccaucuuuacgg uccagauggacgacuauuuggguggcaagccaguccagagcagagagcuucaaggcuaugagucgacugauuuuuugggc gaaaagacuucugcacgugaagggucggagaguggucagagccacugaaguuccccucagcugggagagcuucaacaaggg cgacugcuucaucauugaccuuggcaccgaaauuuaccaguggugugguuccuccugcaacaaauaugagcgucuuuaaagc aaaccagguauccauuaucauccgggacaaugagagguaaggaagaucucaacucauugugguauaaaaaggaagugaacc aucagagcucaugaagguauuagggagaaagccugagcuuccagauggggacaaugaugacgaugucguagcagacauaag uaacaggaagauggcgaagcucuacaugguuucagaugcaaguggguccaugaaaguaacacugguggcugaagaaaaccc auucuccauggguauguugcuuucugaagaaugcuucauuuuggaccauagugcugcaaaacaaauuuuuguauagaaag guaaaaugcuaacccacaggagaggaagacugccaugaagacagcugaggaguuuuuacagaaaaugaaguauucuacua auacucaaauucagguucuuccggaaguucggunaacaccaauuuaucaaacaguucuuuaaggacuggaaggauaaagacc agagugauggcuuugggaagguguacaucacggaaaaagugacucagauaaagcagauuccguuugauGccucaaaacua cacaguucuccgcagauggcagcccagcacaacaugguggacgauggcucuggcgggguggagaucuggcguguagagaa cagugguagaguccagauugacccaagcuccuauggcgaguucuauggcggugacugcuacauuauccucuacacuuaucc caaaggacagaucaucuacacauagcaaggagcaaaugcuaccagagaugaacugaccauguccgcguuucugacugucca guuggaccggucccuuggagggcaggcugugcagguccgugucucucaaggcaaagagccugcucaccugcugaguuagu ucaaagacaaaccacucauuauuuauaagaaugggacauccaagaaagaagggcaggcaccggcucccccuacacgccuuuu ucaaguccguuaggaaccuggcaucuaucaccagaauuguggagguagacguugaugcaaauucauuaaauucuaaugacac uuuuguccuaaaacugccacgaaacaauggcuucaucuggauaggaaaaggugcuagccaggaggaggagaaaggagcaga guauguggcugauguccucaagugcaaagcuucaagaauucaagaaggcaaggaaccagaggaauucuggaacucucuugg agggaggggagacuaccagacuucaccauugcuagaaacucgggcugaagaccauccaccucggcuuuaugguugcuccaa caaaacuggaagauucauuauugaagaaguuccaggaguguucacccaggaugaccuggcagaagaugaugucaugcuacu aaauguaccuggagacagacccuucuggaagagacaagaguuacaccgauugucaucaucaagcaagggcacgauuccccccac auucacaggcuaguuucugggcugggacuccagcaggugguaaaaccagcaacuauccuggcuacauuggggcagcugcc acuuuguuguuggggaauuguuuacuuuuuguuauuggcuuuugaagauaaacuccugccaaauggauauauaucuaua ucuauaucuauaucuauaucuauaucuauaucuauaucuauaucuauaucuaucuauaucuaaucuauaucuaucuaucua ucuaucuaucuaucuaucuaucuaucuaucuaucuauaugcuccucuuuuccuucucuuucaaagggaauugcuGuaugu uacuauacugaaauaaccuaaagcaaccauuuguuuucgagcaauuuugcaaucuggggaccucugaggaaguaauuuugu cauucagccacugcuagccaaacuugucuuuucccauagagaggaaggagagccacagugcuucuaagcauuuccccgucu gcuacucuauuugcagugugcuuuacuuuauguauggcuuuaacaauGccuugcuauuucccaucucaagucaaugccac uuggaugccauucacucccaaguguccuuacauaggaugaacuucuuuagcuuuunuagaaaacuaaaaucaugucuuuua ugauaaaacacauuuuauuucuauaaguuuaacuuuauauauuugauagcacaugcucaauagcauaaagaauaugcauug aaugauguuuuucauaauuaaaauauauccuuuugg 176 M35244 Sequence below. caagguugagagcaagaaggugcaagauguaggccagcagaauuaucagacccaguaucggcuucugccacuggaagaauu uccaacauaaaacagaugaucaguuugggacaaucgauucugcgaccagagguagugucaucugguuacuuuuaaaauuca gauugucugguguuuuccaaucacucgcgacuguaauuunaguuggauucuuuagauaauacaaucgcugucgcucuagu uuauaaagcuauccaagaucugcccagucccagauguccugauuccucagggcggcuauggucugcgcccuucuccugca gcuggaugccagaccauccuggacucggaucccuuuggguucacacucgcuuagguauuucuacaccgcugugucccggcc uggccuuggggagcccugguucaunaucgucggcuauguggacgacaugcagguccugcgcuucagcagcaaggaggaga cuccgaggauggcacccuggcuggaccaagagcnaccaaaugacucagancagcagacucauauagucacaauucaagaac agcugucuganaggaaucugaugacccugguucaunuuuncancaagagcauggacgacucucacacacuacaguggcugc aggacugcgauguggagccagaucggcaccugugucucugguacaaccagcucgccuaugauagcgaggaucuccccaccc ugaguaaaacccanguuccuguacagugguuanacagcacuuuunccucagaucucucagcaccuggagggccacugcncag augugcugcagaanuaccuggananagggaaggagaggcugcugcguucagaccccccaaaggcacaugugacccgucacc ccagaccugaaggugaugucacccugaggugcugggcccuggguuucuacccugcugacaucacccugaccuggcagnagg auggggaggagcugacccaagauguggaguuuuuggagnccaggccugcaggggangganccuuccagangugguucagcu auggugcugccucuuggaaaggugcagacuuacacgugccauguggaccaugaggggcugccuugagccccucacccugag augggagccugcaugguaccaanagccuuggauuuggauuguugccacgguuuuuuccauuuugcucauungucucugu guggcucgcagacccaugaanagnaugcaggugguuagaggaaggcgugacacccaagangcaggcagagacaguccccaa aacucuagcaacacuauugugcnuugaugaagagaugggcnuuugcuunugcaaaauuaaguccuguaaaacuuaucuag gccacuccccaggancuucaggaucaucugggagaugccccnuugaguggcngggcngugaggacagcaggccaguucuu gccacccuggacaganacacaucucaccunucuggcucgaggaucugancaccugucucuugccuacucggcuucuaguca agcauunugucaccuugucaacagucccagggacacaaaccuucccuccucucacccacagcacucugcauccuacccccaau gcnucagggacauuunaucaggucanaunguancaauggcuuugaugcagaanagaacuguggacuaauagagauaggg uuuaauaaaaaaaauaucuuuuu 177 AW121930 uuuuuunuuuuuuunuuuucaacuuuaagacuagauuugaguaucagucuggguucucugag ggggaccucugucaucacgccuauaaucaucccgagaguagucaucccuggagcuccacg accgaucaucccgucugucauagcggucuucauagcgguccccaccuccucuguagucau caucucucccanacccacuuccanaugcccuucugccacugccuauccuggacucauagc cucuucauagucucugcugccucggucaucauagcgaucccggcccccauagcggucca ugucucugcgugggccgucccgauauccgucccuauacccaucccgauaccggucugaan cguaacgaucucgauacuugucuccaaagcuaucaucgccucuucuagguaggaaucau cacaacugucuguggugggacgggcccuccagucugugucuguuuug 178 A1852632 uuuuuuuuuunuuuuuuuggcccccaggcucugucucnaggaugggaauagaucaagccaa acagugaaaaauaaggcaaaucguggcuucgggguuugagacuggcaccaauggcaaauc agcagaggagaugcanauggguuuaacaancacaguungugguuguancaugagcaggcagg aaacccuugaccaacacccanaguccacgucuucgcauaugcagggcacaacuuccnaca gcagucucugggcuuggaggcuugnuacucuuccuaccuuucccacccccuaanagacac caagaugucugcccacgangggaunacaucangcucuucuggcuggg 179 U70475 Sequence below. uucuagcacagccacggcuacacagacanacccucucucaacuaaaacanagcanaccccccganuauuguuuuuauuuacg gaugucuguunauugagacgggguucauggcagacaugagugucucagugcauuugcuauccucucuucuaaaggggcgg gggggguuggugcgcuggagagguggcucagcaguunagagcacugacuucucuuccagaguuuccugaguucanuucccag caaccacauggugacuuauaaccaucuauagucagaucugaugccunucuucuugccuguaggcagaccacuanauacauaa ugcagucaucagugagccanacuaanucgaauggguagcuagaucuugungcuunuagcganuanauauungugaaugg aauugacagucuucucuauucucauucaguuuguuuguguucuuccccaucagucauaacauguagugaacuaacccguc nggaccaucunaaccauggcuucuccuuccuuuucuguunuanacauaggacauggauungauugacauccuuuggaggc augacauagaucuuggaguaagucgagauuuugnuugacuuungucagcgacagaaggacuaugagcuggaaaaacanaaa aacucgaaaaggaaagacaagagcaacuccagaaggaacaggagaaggccuuuuucgcucaguuucaacugcaugaagaaac aggagauuccucccaauncagccggcccagcauauccagncagacaccaguuauccgccagcnacucccagguacacucg ucguggugggagcuaaggaaaacucuagugagaaagcagacucucuggaguugaguucuuggucugccauuuacuguguc uuuugugaagaggagaaguucucaaacuucgcuucuugauaaucaagacacagaucacagggaagacuuuuguaaguucag aaacauccucugugguuugaugaaacagcggcagaaauacuguugggaguaaaagaaguaggcauugcucauugugguuuaggc agggcccugauuguauggguaacugacuuaacuguguuaaguaugauucccauuuuauauucccaugucuaaacaacuaaa gcauuugcccagaacacucagaaagaaaugaagggagguuauugccuagcacagagcccugguucagucccccaucuguu cguuaaaggggagggacuaauaauuuugaacacaaucugguuugaaucuuuaugcaaaucgauuucugaaaugagaccauagguuu uauuuuaugaacaagucuuauugcucguugugacccugugcuuagaacauuucauaaaugaugcucucugugccuuuccc ccuuuccuccaguuuugcccacauuucccaaacaagaugccuuguacuuugaagacuguaugcagcuuunuucauuagacauuccc auuuuagaugaccaugagguauaaaaauuguuuguuuuaacagcaaaacuucccuuaucugauauuaguuccuuucaugugu cuccaauuaagagaagaaaagaaaauuuuagaaggaaaaaauugaucaaagaaauugucaaguaaacuguaugagagcuaua uaaugcuauaaaauaagaccuguaugguucuggugagauggcucaguagguaauuaguacccgacuuucucuuccgaaggucc agaguucaaaucccagcaaccacaagguagcucacaacauccauaacaagaucugacuucccucuucuggagugucugaagac agcuacauguacuuacauauaauaaauaaauaaaucuuuaaaaaaaaaaaauaaggccuguaaacuacaaguccauuuuac uguauagcuguuaaacaggaaucagaauaauuuucccuuugaaacuggauauagauauauaaaauauauugacuaguaaagaa caacuauuaaucagcauuuggauuaaaaaaucuuaaucuguuauuugaagcauucugcuagauauuauaugucagauuua aguccuaaugaauguuuuuuuauccauuuugaagucuuugccuuuaaauacauggagugaaauaaccuaggaguguauuuauau ggagucacugggaggaggaaauguuucauuuuauaaaagcagccugagagcuguaggcccugcugcugucuguucuucau accuuggcucucacucacaugaaucaaugucacgucaauucuuggcuuucuucacuugcauuucaguucacuuacccuuggaua uccccagccacgcugaaaguuucaguuucuucacugccccucaucaggcccagucccucaauagcucucuggaggcagccaugac ugauuuaagcagcauagagcaggacauggagcaaguuuggcaggagcuauuuuccauucccgaauuacagguaagagagcu cuaggauuugugcuguuuucuugcgggcccuuuuaauuagucauccuaguuauauauuauuacauuucuaccuccucaaag gaagaaauugaugguguauuuaaauuacucaugagagcuucccagacucacuuaacacacauaguuuuuagguaaucagac ugaauauuucuggauaaauucauucaaagacugaaagcuaauuuagaguuucugacaaagauaaaauacuuaucuauugaaa aaugggaguugaaggaauunugaaaagaacaccuuugauuuggggguagggaauugaucuaaaaugcacuuagccucug cucauacaaugugaccuucuuuccuaguaucuuaauaccgaaaacaagcagcuggcugauacuaccgcuguucccagccca gaagccacacugacagaaauggacagcauuaccauuuuuacucaucgaucuccucgcuggaaaaagaagugggcaacugu gguccacauuuccuucaugguuuugauugauucuauucagcagcauccucuccacugaugaugccagccagcuuuaccuccuua gacucaaaucccaccuuaaacacaaauuuuggcgauugaauuuuauucuugcuuuucauagcagagcccagugacgguuggcagc augccuuccuccgcugccaucagucagucacucuuucugaacuccuggacgggacuuuauuugaaggcugugaccugucacugugu uuuucaacccgaagcacgcugaaggcacaauggaauucaaugacuaugacucugcauuuaacugaacacaaguccca gccgagcguccccagaacacuuccguauagucuuuccauuuacggagacccaccgccuggucagugacucggaaauagagg agcuagauagugccccuggaagugucaaacagaacggcccuaaagcacagccagcacauucuuuccuuuggagacacaguacagcc ucugucaccagcucaagggcacagugcuccuaugcgugaaucccaauuuugaaaauacaacaaaaaaagaaguucccgugagu ccuggucaucaaaaagccccauucacaaaagacaaacauucaagccgcuuuagagggcuucauucucacacgagaugagcuuagau Caaaagcucuccauauuccauucccugucgaaaaaaucauuaaccucccuguuuugaugacuucaaugaaaugauguccaagga gcaauucaaugaagcucagcucgcauugauccgagauauucgcaggagagguaagaauaaagucgccgcccagaacuguag gaaaaggaagcuggagaacauuugucgagcuggagcaagacuugggccacuauaaaagacgagagagaaaaacuacuucagaga aaagggagaaaacgacagaaaccuccaucuacugaaaaggcggcucagcaccuuguaucuugaagucuucagcauguuuuacg ugaugaggauggaaagccuuacucucccagugaauacucucugcagcaaaccagagauggcaauguguuccuuguucccaa aagcaagaagccagauacaaagaaaaacuagguaucgggaggauuugagccuuuucuuuagcuaguguuuguuuuguacugcu aaaacuuuccuacuguaauguaaaaugcagaaacacuuuauuaaguaacuauacaaaauuauagccaaagcuaguauagcaau aauaugaaacuuuacaaagcauuaaagucucaauguugaaucaguuucauuuuaacucucaaguuaauuucuuaggcacca uuugggauuaguuucuguuuauguguaaauacuacagaacuuauuuauacuauucucacuuguuacauuucauagacuuaua ugacaucuggcuaaaagcaaacuauugaaaacuaaccagaccacuauacuuuuuuuauauacuguaugaacaggaaaugacau uuuuauanuaaauuguuungcucauaaaaauuaaaaggagcuagcacuaauaaaagaauaucaugacuuaaacuacuuugg acunuuuugaauuuuauucacacuauuuuccauacaacnaucacuucauuuuaccacauuuggunuauunuacauuuucaaaaugg guuugaaaauacagaggcaunuuauagccauguguggcaguccaugauuuunuauucccgacauncaggaggcagaagca ggcagaucccugggcuccaggacggccaaggcuacaugagagccugucucaagaaagacaaacccuuucuauacuaaacgu uagcuaggauugucaaggagangguanauauccacaaugguaugccugcuguacaguacuguuugcacagagaacanauccu guaaccuccuguguucuuagaaguggcauucuaagaagggcuaggaaga 180 U09659 ggccagcaggacucuccungcagcagcggcccgaguucagaguccguuagcugcguuuggug gcgccgaaggcgaaagucaucacugcacanccunuuuaggaaguuucuuccacucuuuugac agaguauugguugaaaggagugccgccgaaacuguaaccaaagguggcauuaugcuucca gaaaagucucaaggaaaagugungcaagcaacggucguggcuguggggucaggagggaaa ggaaacagugcagagauuaaaccugucagugucaaaguugaagauaaaguucuucuccca gaauauggaggcaccaaaguaguucuagaugacaaggauuauuucuuauuuagagauagu gacauucuuggaaaguaugucgacugaaaucacuguugaaauggugucacgugaagcugc cauuccacugaugucugaacuauuucaucauguaaauaauuu 181 AW124785 uuuuuuuuuuuuuuucaggucucauuuucguuauuugaaauucggugcucgguaa g uuuuuucucuuccccucaaauuuuauuucaguaaaaggagacuugggcgagguggauacc ccacagccggauucuucccccccugccccccaggguggcuaaugcuaucuggggagucg ucauagggaagagaacuaugguuugggcuccugccugaggccuccaaucucagcccagugg acauaucacaggcagcunaaaaaaaaaacccuaaaaaaaacaccccaaaacacacauuua aauagguanucaagacagcuunaaaaaaugcacccacucacaccccccucccuuuncuuu uuggaaaaaaaaanaggaaaaaaaaaaaaaccaaaccgaauucucguuuccucua 182 AF071315 Sequence below. anuuggcuccgaggccaagaanucggauccaaggcugcgcggggaaaauggcggcggcagcugcggcguggcgaugg gagcguuaggcagcagcggcauggauuuuggaugcagcaguccccagcgugauggccuccggagugacugggagugunuccg ucgcucuucauccccuugucauuccuuaacaucucagaccauuuggauccgcaugcgcucccagaaggcacggccuaugcagg ugauuggggcucugancgggaagcaggaggggcgaaauaucgaagugaugaacuccuuugagcugcugucccacaccgug gaagagaagauunucauugacaaagaauauuauuacaccaaggaggagcaguuuaacagguuuucaaggagcuggaguuu cuggguugguauaccacagggggcccaccugaccccucacacauuccacguccauaagcagguugucugagauaauugagagu ccgcucuuncugaagungaacccuaugaccaagcacacagaucunccugucagcguuuuugagucugucaucgauauaauc aauggagaggccacaaugcuguuugcugagcucacuuncacucuggccacugaggaagcugaacggaucgguguagaccac guggcccggaugacagcaucaggcaguggggagaacuccacuguggcugaacaccugauagcucagcauagugccaucaag augcuccacacccaugugaagcucauuuagaauaugucaagcccucugaagcagcngagguuucccuucaaccaugacauc cugcguuaggccnaugcccuaugucacugucucccaguncucagcacugacaaguucaagacagacuunuaugaucanugc aaugacguggggcucauggccuaccucggcaccaucaccaaaacuuugcaacacaaugaaccaguuugugaacaaguucaacg uuccucuacgaccgacaagccauuggccggcgaaugcagggacuuguuuuucugaucaugguucugcnaaggauaguguugu gucucagacagcuguuccauuuaccugaguaccacauucccuuuagagaaacucaunaanaaaagagcagccccuuaaaa aaaaaaaaaaaaaaaaaaaaaaaaaaaaa 183 D49733 Sequence below. aaaacccaaucuuugguuuuaaagccaaaaauauaagcaaaaugcauaaguuugcauuuuguuuuuuguuuuuucccgag guccuugaucuungcccccaaanuugagggcauaaaguaancccucaguuaccuaaaaacacagccauuccuuugccauuc cacucuccuggauuggccgcuucugugcgcgggggagaggugacucacuauuncuacugaggaaaggggagccaguggug gaagucagguugagucacuaaugcacagcagcuucaccccuccccccaacuuccuuggcucucuggggaugccuugauccuc ucccucacuuugcaccuacuuccccuggucccucaccacuacccuuugcccacccacucaaauucuungcucugcucuuua cuccagaaggccaaaggcaaggcuuagaguugaguaggcagggaaccaacauuaugaagccccaggccagaaaaggguuguucuu gcagagugaggguuggcaugcuggcuccucucaccauaccugcccccgccccuuuuuggguacaggauggcuccuuuaagag Caguggauccacccccuguagaggagggccuauuagagccucugccuggcugucagugacucaguguucgcggugacgcu gccucagccucaacaccagccaacccagaucccgaggugcgccagcgcccagcccagaucuccacgccugccauugagcgauuc gcagcacugucacccugccggccauggagaccccgucacagcggcgcgccacccgcaguggggcgcaggccagcucuacccc acugucgcccacucggaucacccggcugcaggagaaggaggaccuuucauugagcucaauuuaccgccuggccuuuguacaucga ucgcgugcguucccuggaggaccgaaaacgcggggcugcggccuucgcaucacugacuuggaaggagguaucagccgaggagg guccggcaucaaggcggccuacgaguuccgagcuggggugugcccgcaagacccuugauucuguggccaaguggcgcgccc gccuccagcuagauucugagcaaagugcgugaggaguucaaggagcugaaggcucgguuuagugaggcccggccggccggca ccagggaggcagcagucgccuguaacuggccaucuaguccccucccuccccgaaacuugccucccgcgaugacuggcagua ccaanuunnnuunnuunnnuunuuuunnuunuuuunnuunnuunnnuunnuunnnuunnuunnnuunuuuunnuunnuunnnuun nuunnnuunnuunnnannnnnnannnnnnuannnnnnuannngcuaggccagaunagaaagcuuucuguauuaauacacaguacau gcaucauucauguucuacauaauuaaggauuaaaggaagcuacauuguuuaauaugaaaaaaaauaggggucuugauaauguagug ccuagcauuuacgaacuucgggguuuuuggguuugaucccagcaucucacaaaccacguguaaucccagcacuuggaagguagaggc cggaggauccgaaguuuaaggucauucuugacuacuuagcaaauucggggcacccuaggauaccugagacccugucaugaa uaaaaauuaaauaauaaauaaaccaauaugauucuagguugagcagcagcuugggcaauguaaugccggaaguuuagccagau agaggguugcagucccaggaggacccuggcugggagcagcacucaguccccugcccaaccacagggggccaccggguuucuu aggcgggcgggcggggcgcgggccgucauccccuccugcuccuuauuuuagcccauuguagagucugggccgccugucc cucccccaggacagggggaggaaauunnnuunuuuunnnuunuuuunnnuunnuunnnuunuuuunnuunuuuunnuunuuuunn uunuuuunnnuuunnnuunnnnnuunnnnnuunnnnnnuunnnnnnuunnnnnnnuunnngaugccaacaauccuaauguaaugau uucccucuucugacagcugcggggaccgcagagaggucccaucccagaugcacuccugaaaccuuucuuuucuuuuucuagcaaca ccaaggaaagagauggacuuuguuagcuggcgcaggcccggcucaaggaccucgaggcucuucuucaacuuccaaggaagcugcccu gagcacugcucucagugagaagcgcacauuggagggcgagcuccaugaccugcgggggcagguagccaagguaggccgcu guccugugaccccaguuuaccccaccuuuguccgacauaucauucggucccauuugccugcucaccuucacuucuccagucua ganuunnnnuunuunnnuuuunnnnuuuunnnnuuuunnnnuuuunnnnuuuunnnnnuuuunnnnuuuunnnnuuuunnnnnnuu nnnuunnnnnuunnnnnuuuunnnnuuuunnucuagauggggacagccaucaccucuccuuuggcauuuccugaacccccuccca Ccucuccaugaacuuggcuuucucccucucauucuugaggcggcccuuuggagaggcuaagaagcagcuucaggaugagaugc ugaggcaaguauaugcugagaacaggcuacagacgcugaaggaagagcuuugacuuccagaagaacauuuacagcgagguaa gcguuucccgcuguacaggucuuucuuacuuuguggacagcugggaggggucaccuaauaaugccaggcuaagcgagggcugcc cgugccuggccgguggaguuacgacuucuggucucagcuucuaaggaaccauugcgauguucuaaucuaagugucucccc Uuaaccuuucaagaacuugcgugagaccaagcgccggcaugagacgcagcuuuuggagaucgauaacgggaagcagcgaaag agaaaagacauacuccgccaaggugcuggccucauccuguccucucccuggugcugcccuggggacgggugggugguggc agggggccagggaugccuuccucaggcccccagcuccagguuccugcucucauaacugugugcucccugcagcuguuauaau gccaggcagucugcugagaggaacagcaacucgugggggcugcccaugaggaacuuugcagcagucuuucgaauccgcauugac agccucucguucccagcucagccagcuccaaaagcaggugacccucaguuuaccccucccaccuuggcucuggucuaagcaga uacugcagaauucccacugagaagggggugggggagggacuccaggaccacaugcuaugguucugaaucugaugccugucu agcuuuccaggggcuucuccuuuaacuagcccgauccucagagccucuauuuuuacugugcauugaagauuuuuuucauguuuc uucugugccugccggagacugaaccagaggccucuuugcuugguagauaggugcuuucucacugaguuacaaacccagccgc auucccuacuuggagauagagcuucccuuggacuggacauguagcucaguugguacauuugcuugcuuauauauacacgaug accuggcuucuauccccaggaaccnnnnuunnnnnnuunnnnnnuuuunnnnuuuunnnnuuuunnnnnuuuunnnnnuuuunnn nnnuunnnuuuunnnnuuuunnnnuuuunnnnuuuunnnnuuuunnnnnuunnnnucuagagagagccuacagauccugagugucc cucugccugccccugugccccucccucuucaucgacaucagcccuuaggaggcuucauucagacccuuuaucuuccccggccccag uuagaaagagcgagagauggcggagaugcgggcgaggaugcagcagcagcuggacgaguaccaggagcugcuggacaucaagc uguucccuggacauggagauccaugccuaucgaaagcuuucuggagggcgaguuaggagauugugaacuaggaggggucuacag anuugucaggggccucuggccgcaacuaccaugacuaaccccgcaccgugucuccaccuuccccaggcugcgccugucccc cagcccuaccucgcagcgcagccguggccgcgccuccucccacucaucccagucucaggguggaggcagcgucaccaaaaag cgcaagcuggagucuuccgagagccggagcagcuucucgcagcaugcucgcacuagcgggcguguggcgguagauugaagu cgaugaagaggggaaaguucggcggcugcacaacaagguccaacgaggugggccuaugaaccagauugguucuuuuucaguau cugggaguucuugguucucguggagcaucugucucccuaucugagaauuuggagugugugguaguccugucaucuuuaa uuuguuguugaagauuucaugauauauuggauuuggugacccuugagccaauauuucuagguuuuaugccagagnuaguggugg aaaccugucuuucuuuucuuuuucuuuuuuucuuuuuucuuuuuucuuuuucucuuuuucuucucuucuuuuuuuuuuuuccgau ggggucuuuugcccagguuggcuuugaucucccuaguuaagcuguuccccugccucagccuuuccauaguagcuggaacugcag gnuucacacuggcgnccauuccuaccuaagcuccugauuugagauaauccaagagucguuuugaacucccuguccuccuuccucc uuccuccuuccuccacccuacuuuucauaccaguccauggggcaacuagcagaucaaucgucagaauagugacgauccuuuga ugaccuaucgcuucccaccgaaguucacccuaaaggcugggcagguggugacgguuugaguggaagggcacuuugggacucug gcuggaguggagaaguuggccucaggacaggagcauuaaaaauaagcacaucucuuaaaccaucuuucccagaucugggc uucaggaacuugaugccacccauuagccccccuacugacuugguauggaaggcgcagaacaccuggggcugugauagcagccu ucgcaccgcucucaucaacuccacuggagaagugaguauguugcagccgguagcuugcuggacaaggcucccccgggugac cauaaugggaacuagcuaccuccaacccaagggaaccugccuuggguuuaggaucgcuuuccugagcccaagucccaccca guuaagcaagccagaagucuccccaguagaauaugguuuggaagucagccagugauuuguuaauagcagacuccagcuauacag agcaccgagcucuuucaguuguguuuccuuuuuuugcgcgugcguuugcgcgcgugugcacaugugcauguguuuauccuuagucc ccagcaucagaggungacaagguuguauaaaggcccgggacaguucuaagugguuacuauggguagacaggcugcacagcc cucacccccugacucuugggccugggcuauauguccccacaguuaaguggccaugcgcaagcuuugugucucacugaccaugg uuuggaggacaauugaggaugacgacgaauaugggagaagagcuccuccaucaccaccguaugaguggcagccgccgcugaaucc cagcccacaaggguagcccugccagccuagggcagcucucccaccuccaugccaaagucuuuucauuaaagaauguuuugg aaugccacuugcugcccuguuccuuucuucucucuccucccucuaccuugaacaguugaacccaggugucugguaaggaaggg aauggggacuugcuuggaugccauggauacuccacaguggcaguggggacagggguucuauauuunguuccugauaaagggcug ggaggacagagguggccccagcccugccucucuuccucacucccauugcaugcacacuucucuccucucuccuuccacccua uugcaugcuucuccucagauuucccugcaacaauguucucuuuccuuccuguccccucacaaauuaagucucuccaucuuu gcucuuccucuuuggauuugccccauaagugucuaagauucaggggagauuaaaggccacagcucuuuuauuucgaaggcuuccu ggcuuuauuucccccaucaugcccuuccucccagccacaggucuuucccaaguccccaucacuugguugucuggguacagacaga ggucaccuuccugcccaauggccaggaagcuccaagagcccacagccuaggugccgguccuaagaagucagucccaaacucg cugucccuccuaagccuuaucucccuucccaggguucccacugcagcggcucgggauaccccgcugaguacaaccuacgcu Cacgcaccgugcugugcgggacguugggcagccugcugacaaggcugccgguuuggagcgggagcccaggugggcggaucc aucuccucuggcucuucugccuccagugucacagucacucgaagcuuccgcaguguggggggcaguggggguggcagcuu cggggacaaccuauucacccgcuccuaccuccuuuggcaacuccagucccaugagccaggugagucaucucugcccuacagca ggacacugcucacugagcagcagguagggcagcccaagggaguggggucccccuccuugcagucccucuugcauccugcc Ccuccugucugaaccccagacucgaggucagggcaaggcccagagugugaguuuguuggguggacaaccccuuuguuggucag ggagggagaguuaagggccagccacugcugcucacaccucuuuccuucucuucucucuuagagcucccagaacugcagcauca uguaaucugggaccugccaggcagagcugagggcagaagccaccugcuccccccucaccacaugccaccuccugucugcuc cuuaggagagcaggccugaagccaaagaaaaauuuauccccugccuuugguuuuuuuuuucuucuauuuuuuuucuuu uucuaagagaaguuauuuucuacaguguuuuauacugaaggaaaaacucaagcaaaaaaaaaaaucuuuuaucucaauccu aaauccuuccccuuuucuuuuccuuuguauucugccuuuaaaaccaaaggggcuucucuaggagcccagggaaaggacugcuuuuu uauagagucuagauuuuuguccugcugccuuggcuuuacccucaucccaggacccugugacaauggugccugagaggcaggc auggagguucucuuucaccaaccuccuccaacaacuugggcccacugccacgccaggcugcagagaaauagggcacaaagaggaug acugagaaggucaagccccuccccggcacuacacgaggccgaggcuccucugccugccuuaccuucuuccugcccuucccua gccuggggcgaguggauucccagaggcaaaucugccgugcuugcuuuuucuauauuuauuuagacaagagaugggaaug acggguuaaggagaaguugaugaucaguuugauuccuaccuuuucccauucuucugagccuggugguucucugucucaauugaugg agggcaaugucaagugggauacagggaagagugggggacgaaggcucccagagauggggagaaccugcuggggcugguga gaagucuagaggugcggcgauugguggcuacagcaaacacuaaggaacccuucaccccauuucccaucugcaccucugcuc uccccuccaaaucaauuacacuaguuguuuccaucccagaugcuuuggugucucuuuguuuuggugugauguguguuuaucag aggcagacacauacacacaggagguggccacacauucacuauuauauucacuacccaggcuauaaagguauguaugagauagacu ucuagaaaggucagcauauguggggugagcgagggguguccuuccuaucccucauccauccagcaccuuuuaaaaggggcc agcaauccacaugugcaucagacacaggagcacagagancggaguuguagaguagggcagaguagcagagcuuccuugcug cccuguaguucacaggcucuuugaucaugugaucgcu 184 X80899 Sequence below. gcggugcgaagcgggccuccgccaacauguacuacaaguuuagcaguuucacgcagaaguuggcuggagcuugggcuucg gaagccuacaccccgcagggguuuagccaguuuccacagaagcaccaccuaucauauuugccacaccaaccaaacugaccu ccaguguaacagcauaugauuauucuguaaggaacaaaguuccagagcuggcaaaaauuuuuuccagaaggcugauaguuuuc caccugaaacgaggccuuccagaccaaaugcuuuaccggaccaccauggcucugacacugggagggaccaucuacugccuga ucgcccucuacauggccucgcagcccagaaacaaaugagcuugccuguggaggacugguucacuuuguggcacaaacccuu ugaauccucacuuuuucauguuuuccacuuggauagucuacuuacauuuuugcaaacaaauugaaaagauaagaauacauugu uuugauuuguuuauggugugcagauggccugucagaugucagagcugguuugacaguuaaaacuauuguuuaggaaau gucacugagccaucacugagcugugcuucugcuccugauuucccuggaguucugcaggaaaguugcucuccagcucauuc guggccagccgugcucagggccucgggacucaggcggugucugagcgguuaagcgaacgcgnauuccuuuuggaguguagg uuguaauuggaggaaggaaaacaaaagccagcggacaauuggugaagugagaucugaguuuagccacccuaggaauuucguuccg ccuugcagaaaacauugagaggaaugauagcaaccugccucuauuugugggcaguugguuucaaagggugugugucucg cccanaccuagggaaauggguguuuuguuccaucgugggaggauucaccugucagugcugcacauuagacagcugugucag gacuucuccuuuaauaauacuuguagcuuuacauuauaauuaaccggacugcggaauaaacacuuggaaucaaaaaaaaaaaa aaaaaaaa 185 D83203 Sequence below. cugagacagaacgaaacguccgcagauaacuacccguucuggcucuuguuaguucuauguguauggauaaugucuuggga gguuuugaaauaccacaaaccuugcuagcccagggugcagcugccucugccgucagaccucagauuauaagggacagaaca cagcacggaaguggggggaucagaaccaugggagauccaggacgaaggguccugugcgcaggugcggcaccgaauccuaua uuugacauugaagcugucgucagcccaacuaguguguuuuaacauggaagcacaaugacucaggcgcuucagaauguaga auagagaauaagauagagagcaaucuugacguuuccuguuaaaaaccagacaucauguaacauuacaagcuuaaggcccaau acuucguauacauucuccaucaucucuguaacaaccaaugagaccuugaacaaaacuaucacaacagagcccuggccagugu cugaucuccaugucaccucugugggugugacacaggcucgucucaccuggagcaaugcaaauggcacugccuccuaccgga ugcugauugaagaguugaccacacauuccucagucaauauuucaggucugaagccggggaccaauaauacguucgcuuucc caaaaucaaaugagacacaggcugacuuugcaguuacagagggaggucccggaugccaaugguuaccaaaagaaucccaguga ccaaccuaucccaaccacacaagaauucucuugccucuguggacccacccucuggccaggaucccucccucacagagaucuu gcuuacugaccuaaagccugauacucaguacaauugccaccaucuauucucaugcagcaaauggcacugauggacagcccagg aacaaaguguuuuaaaacaaauuuccacccaauuucugacguccgaacuaugaacaucaguugccucaagcaugacccugaccu ggaaaagcaauuacgaugggucccguacuucaauugucuacaaaauacacguggcugggggggaccacuccgucaaccaaa cugucaauaancugaggccaucauccucggacucagcuccagcaccuuguacaacaucacaguucauccuuuccugguuuc agacggagggcacaccaagcuuccuccaagguguacacuucccccggauucaggucucugacuuccgaaugacaaauggucaaca Caagggcaauugguuuggcuuggaggagcaaugacuccaaguccuucgagauuuucaucaagcaggacggaggugagaag cauucgaaaugcuuucgacgggaaaccagaggcuuauauauuugaagauuuaaaggccuggaaccaguuaccauuuugagauaauu ccacgaggaccagacgggacagaagggcuguccaguacagugaaugggagcacuuugaccccagugccgugacugacauccgg gugucaacauuagcaccacugaaaugcaguuggaguggcagaaunggacgaugccucuggauacacuuaccauuuaguu cuagagucuaaaauuuggcuccaucaucaggaccaacaguucucagaaguggaucacaguaguugagccucaccccaggcaccu ugugucccacauugaaguaaacaccaccaccaccacggcagccauccgauggaagaacgaggacacagccucugcuuccuau gccuacuccguccuuaucuugaagacuuugagauggcagcaauguaaccagcaacuucacaaaagacccuucuauucuaaucc cuugaguuuaaucccuggcaucucuuuacacaggugaagauccuuacacaaauugggggaugguacaacaucacugguaccugguu ggaagcuguucugunggaaccugaaucagugaccuccuuccacugugaaguggucccuaaggagccagcauugguucuca agugggccugccccuuuggcauguacacaggcuucgagcugggggucaguuagugauuccuguugacaauaugacacgccua aagaacugcacaucauaugaugacacaaaguggcaauacggaaguucaccuauuugaauuuuucuaccucguacaacauucagc aucgccaccuugucaugugggaagauggcgcuucccgcccagaacaucugcaccacuggcaucacagacccaccuacuccgg auggauccccuaauauuacaucguucagucacaauucauuaaagguuuaaguucagcggguuuuaauuccagccacggaccua ucaaaaccuauuggcugucauccucaccaccggggaagcugcccaaccuucuugcagauguuuugaaguacacguaugaauauu ucaaaaggggagccucggauacuuaugucacauaccucauaagaauagaagagaagggacagucucagggcuugucugaag ucuugaacuaugaaauugauguggggaaccaauccacuacccucggcuacuacaacgggaggcuggagccucugggcuccu accgggauugugguugcuagcuuuaccaauuauuaccuacaaccuucaggaaugacggccucaucaauagggaugagagcuaug ugucuuucaguccauauucagaggccguguucuugccccaggauccaggugucaucugcggagcaguguuuggauguauc uuuggugcccuggccaucacagcuugugggaggcuucaucuucuggagaaagaaaaggacagaugccaagaauaaugaagug uccuuuucucaaauuaaaccuaaaaaauccaaguuaauccgaguuugagaauuuugaggccuacuuuagaaacauucaagcu gacucuaacuuuguggguuugcagaggaauaugaggaccugaagcugauugggauaaguuuuuaccuaaauacacagcugagau agccgagaacagagggaagaaccgcuacaacaauguucugcccuaugauauuucucgagucaaacuuucaguccagacccau ucgacagauuuacuacaucaaugccaacuauaugccuggcuaccauuccaagaaagauuucauugccacacaaggaccuuuc ccaacacuuugaaagauuucuggcguauaguuuugauagaaaaacguauauaccauuuguuauguugaccaaaugcgguggagg cagggaaggaccaaaugugaggaguacuggccuuccaagcaggcucaggacuacggggacauaacuguggcgaugacauca gaaguauuucuuccagaauggaccaucagagauuuuguuugugaaaaauaugcagaauagcgagagccauccucugaugcag uuccauuuucaccuccuuuccuaaccacggugguuccugacaccacuggaccugcucaucaacuuucaguaccuaguccgggau uacaugaagcagauaccccccgagucaccaauucuggugcauugcagugcugggguuuuggaaggacgggcacuuuucaucgcc aucgaucgccugaucuaucagauagagaaugagaacaccuuuggacguguaugguuauugucuaugaccuucggaugcacag gccucugauggugcagacagagggaccagguauguuuuccucaaucaguguuuuggauauuaucagaacccaaaaagacuu caaaaguugaucucaucuaucagaacacaacggcaaugacaaucuaugaaaaccucgagccaaguuccuugaaugugacuau guugcuucauccacagcugaacgauuuuggauguuggguucuagguccuggcuguugcuggucugcuaggauccagggc cuuguugacaucuaggaagauauuaaauuaucccgcugaaggccgcaguuuuagauuguagccacuagauggagccagagca cugguaugaaggagcaccagggccguguaaggcaaaagaggacccagaaaaagaaacuuaacuuguucacuuuccuuugagaaacc gcaagucaacaagccaaggaaguugccuuugcauuuucauuugguagccuuuccaaucccgcuuauuacauaauauguucaug uucauggcaaaaaaaaaaaaaauaaaauaaaauaaauaaaaaaggaaaacaaaauaaaaaaaaucuuagaacauu 186 Z20410 gcccccucaagggcanccugggcuacacngagcaccagguggucuccucugacuucaac a gcgacacccacuccuccaccugacgcuggggcuggcauugcccucaacgaccacuuugu c aagcucauuuccugguaugacaacgaauuugcuacagcaacaggguguggaccucaugg cccacanggccuccaagguaagccccuggaccaccaucccagcaaggcacaagaggaag g agagacccu 187 AI839906 uuuuuunuuuuuunuuucauauuaacuuguaguuuuauucagguuuganuuuuaac aaaugugucagggagagagcccacaggaaaggguaaagcccgugggggcaaggccuucc cagaugccugaggagggaucguguccccucccccccuccucuucucaccaccccuacag ggguuuaggaagagacacaggcagggaaagggcngguccccagncuguacaguggngc uugggggugaaggacuauggagaacaggggaccagaucggggaugaguaggauaaagg gcacaagaccauuuaccagaauccagcuuucugauuccaaauugaauuaaaaagaaaaaa aggagagacgaaccuaaaccacaagcaguacccaacucccuuncccccaucago 188 AI843448 uuuuuuunuuuuunuuuuagggaagaggcuuuugccagauaaguuuuuauuuauuuaa aaaaaaaaaaaaaaccagugcaacuggaaaucagguuugagucgcuggaggugagugaga gucggaaggcccuccacaccucagugguggcaggaucuggacccguagccuaagccugg ucugauccagccgagaugcuggaaagcagagcacacgguggugcccaucagggcaaaga ggacaagagagcccacggcuccuccauaccacuugcuagggucuccuguguaguaacca uaugcguaaaggacucgcccaauaauccaggccaggcccaggccagaagcuaugcgcgg gugguaaacaccucccaccguuaggaaaaa 189 AW125336 cggccgcgugaguuuugacugagcuucugcangaaguucanaugcaacuccauacauca guucauuuucuagcauuaccacuggguuauuaucacgaauggccgauuuaauaagucc uuuugcauccucggaauuccaggggcugaccacunuuaaccugggcagugcccauacc augcagcaaagcauugcgagugcugagcagcuacaccugcugaggcgccauugggcccc cugaauacuaugggcaca 190 AW123802 uuuuuuuuuuuuuuuuugaagggccauuggaguuuauuuacagacaaccuuagguga ggccuuuuccucuaggaucuacaugcuuuugaaguuacuugguuucaggcuucuuguc uccagcuncgagcuugagacucucaggaggcuagcgauagacagggaaagccucccagg ggcuguucaggucaaacuugcggaauucuugugccagcuccacugguucagccacuacc cgcuuuaccucaucgucguaacgaagcucaacauagccagugaggggaaagucuuuccg gaaaggangucccucgaagccanaancugucaggauccuucuuaaaucagggugauua aaaaaaaaaaaaaaaaaaaa 191 AI835771 uuuuuunuuuuuunuuugggaggcagcaaacuuuauugaugguauncaaaaaaauag ggagggcucccuaggcccccccuguuauuaugggggucugggauggaaauuuugaggg aaaugcucaauuuugggggcccauuugggaaaaggccccccuugcccaauguccuugcu ggggugagugguccaaggnuuunacuccuuggaggccaunuuggccaagagguccac cacccuguugcuguagccguauucauugucaaaccaagaaaugagcuugacaaauuugu cauugaaaaaaaugccaaccccggaaucaaagg 192 X53584 Sequence below. gcuccucaucucacucaggccuaugccaaagauguaaaauuugaugcgaaugcucgagccuuaaugcuucaagguguagac cuuuuagccgaugcuguagcuguuacaauggggccaaagggaagaacagugauuauugaacagaguuggggaagucccaa aguaacaaaagauggggucacuguugcaaagucaanugauuuaaaggauaaanacaaaaauaucggagcuaagcuuguuca ggaugugccaauaacacaaaugaagaggcuggggauggcaccaccacugccacuguucuggcacggucuauugccaagga gucuuuggagaagaucagcaaaggggcuaauccaguggaaauccauagagguuguggauuguuagcugguggaugcuguaauug cugaacuaaagaaacagucuaaaccugagacaaccccagaagaaauugcucagguagcuacaauuucugcaaacggagacaa agacauugggaacaucauuucugaugcaaugaagaagguuggaagaaagggugucaucacagugaaggauggaaaaacccu gaaugaugagcuagaaauuauuuuaaggcaugaaguuunuagaguuauauuauuuccccauauuuuuuaacacaucaaaagg uugaaauugcuaaugcucaucggaagccauuggucauaaucgccgaagauguugacggagaagcucuaagcacgcugguu uuuuaacaggcuaaaaguuggucuucagguuguagcagucaaagcuccagguuuuuggguuacaacaggaagaaccagcuuaaa aauauggcuaucgcuacuggugguacgguauunuggagaagaagguuuuggaaucuuaaaucuuggaaaauguucaagcucauga uuuagggaaaguuggagaggucaucgucaccaaagaugaugccaugcuuunaaaggaaaagguugacaaagcucacauuga aaaacgguauucaagaaaucacugagcagcuagacaucacaacuagugaauaugaaaaauuaaaauucugaacgagcgacuugcu aaacuuucagauagaguagcuguguuggaaaguuggaggaacaaggugaugguugaaguugaauggagaagaaaaacagaguuuac ugaugcucucaaugcuacaagagcagcuguugaagaaggcauaguucuaggagggggcugcgcucugcuucggugcaucc cagccuuggauuucauuaaagccugcuaaugaagaccagaaaauagguauagaaauuauuaaaauuagcacuuaaaauuccug caaugacgauugcuaagaaugcaggugguugaaggaucuuugauaguuugagaaaauuucugcagagguuccucagaaguuugau uaugacgccaugcuuggagauuaugugaacaugguggaaaaagggaucauagauccaacaaagguagugagaacugccuu acuggaugcugcugggguggccuccuncuaacuacagccgaagcuguagugacagaaauuccuaaagaagagaaggaccc uggaaugggugcaaugauuggcauugauaggauguauaggagggcucauauucuaacuccuagaguagugcuuuugcccuu aucaaugaacugugacaggaagcucaaggcagguuccucaccaauaacuucagagaagucaccuggagaaaaugacugaaga gaaggcuggcugaccacuguaaucaucaguuacugguuuccuuugacgauauauaaugguuuacugcugucauuguccau gccuacagauaauuauunuuguauuuuugaauaaagaacauuuguacauuccugauuucugguugcaagagccauauacca guguccugcuuucaacuuaaaucacagaggcaucaucuacucuacuuugugagucaucaggacuguagcgcugugucaacaaaa cauagagaguucagaagacagccuuucuguggaagggugggaaugauuguguacaaaguagagaaguauccaauuaugug acaaccuuuguguaa 193 M32599 acagccacaucuucuuuguacaaugccagccucgucccguagacaaaauggugaaggucgguguaaacggauuuuggccgua acuacauggucuacauguuccaguauuuacuccacucacggcaaauucaacggcacagucaaggccgagaaugggaagcuug uucaucaacgggaagcccaucaccaucuuccaggaggagaccccacuaacaucaaauaggguugaggccgguggcuugaguaug uccgccccuucugccgaugcccccauuuuuugugaugggugugaaccacgagaaauaugacaacucacucaagauugucagc aauugcauccugcaccaccaacugcuuuagccccccuggccaagguucauccaugacaacuuuggcauuguauaagggcucaug accacaguccaugccaucacugccacccagaagacaguggauggccccucuggaaagcuguggcgugauggccgaggggcu gcccagaacaucaucccugcauccacugguugcugccaaggcugugggcaaggucaucccagagcugaacgggaagcucacu ggcauggccuuccguguuccuacccccaauuuuguccgucguggaucuuuacuuugccgccuggagaaaccugccaaguaugau gacaucaagaagguggugaagcaggcaucugagggcccacugaagggcaucuugggcuacacugaggaccagguugacucc ugcgacuucaacagcaacucccacucuuccaccuucgaugccggggcuggcauugcucucaaugacaacuuugucaagcuc auuuccugguaugacaaugaauacguucuacagcaacagggugguggaccucauggccuacauggccuccaaggaguaagaa acccuagaccacccaccccagcaagaacacuaagcaagagaggcccuaucccaacuucggcccccaacacugagcaucucccuc acaauuuccaucccagacccccauaauaacaggaggggccuagggagcccucccuacucucuugaauaccaucaauaaaguu cgcugcacccac 194 AF035644 agaagcuuccuaaagaacaagcaaguugaauagagaaaauagugaucaauaauaggcauu uuaguggucuuuuuaauguuuucugcugcggaacauuucaaganuuanugauuuccucc uccccccauuuuuuucccaccacacucacacacgcacgcucacacunnuuannugccauaa ugaaccguccagccccuguauagaucucuuaugagaacauacguuuucugauaacucaca accccaccaaugcgacucucaacaaguucacagaggaacuuaagaaguacggagugacaa cuuugguucgaguuugugaugcuacanaugauaaagcuccaguugaaaaagaaggaaucc acguucuagauuggccguuugaugauggagcuccacccccuaaucagauaguagaugauu ggcuaaaccuguuaaaaaccaaauuucgugaagagccaggcuguuguguugcagugcauu guguugcaggauugggaagggcuccugugcuaguugcgcuugcauugauugaaugcgga a ugaaguaugaagaugcuguucaauuuauaagacaaaaaagaagaggagcauucaauucca aacagcugcuuuacuuggagaaguaccgaccuaagaugcgguuacgcuucagagauacca augggcacugcuguguucaguagaaguagaagcaggcuggcuggaucguggcauuagag g gaa 195 Y00629 Sequence below. auucagguuccucacagacccagggggugaggauauugcuuuuugcccacuugcuucagcuacuggucaacgccacaguc ccgacccagaguaguaagugaggggaggggugaggggagggguugggagcgaaaaagacucugugaggaaaagcgggagg guggugguggcggaggugcagcaccccaaguuccgccuucccuguccuagucccucccccgccuuuaccugggaccnugagc cugggggagaucgaugucucaccgcgcaccgcccccaagcccacacucgcugcgguauuucaccaccaccaugucccagcc cggccucggggagccccgguucaucauugucggcuacguggacgacacgcaguncgugcgcuucgacagcgacgcggaaaa acaugguugaggaacuucagaguaaaccugaggacccugcucuugcuacuacaaucagaguaacgacggugagugcggcuuugg aucacagcuaugaucacuccauguccccugagacgggccugggucaucuugacccgcugagacaaaguuncauccaaacgc cuuacccagaaccucagacaaaaaagcccccgcagaguucugcunaggunuggggunguacuuuugnuucucuuunguuuu gagauaucuacuaacauugggcaaaguggccacauuguggcgcucaucagcguaucccuuccagaaucucacacgcugcagu ggauguacggcugcgacguggggcccgaugggcaccugcuccgcggguauugucaagaggccuacaauggccaggauuac aucucccugaacgaggaccugcguuccuggaccgcgaaugacanagccucacagaucucuaagcacaagucagaggcaguc gaugaggcccaccaacagauuggcauaccuuucaagguccuugcguuugaguuugcuccauaganaccuacggcuuuggaaaugag acacugcagcgcucaauugcccuagagagcucuccucacuuuuccucugcauuuuggaugaaauccuuaagguauaaccu caggggcagaacgcuguncagcgggcacagcgcggaggaggagggagagggacucccaaaacugcuunuccccuguaggga uucuaauccuuaacaaaagcagaucaggcucgacaauggcccuggacccauggggguuaggguugcucuuucucaggccuccc uccuugcccuacucagugucucuauagucagacuccagcuuuucucaaucucuuggcccucauccaacucaggaccagaag cccuucccaugagucugcagagaccuggagccuccuguccauguuguccugcucacauccuaaggcaucccuaagagcaga uccucccaggugcaggugcucnagcuggugucuagaugaugugcaccauaaucccaccgcaguccuccuguccaccccagg acggucacaugaacacugcugaguccccagaagaaaacaagaugccucauccuuucaacucucucccucagacccuccaaag gcacaugugacccaucacccuagaucugaagaugaagucacccugaggugcugggcccugggcuucuacccugcugacauc acccugaccuggcaguugaauggggaggagcugacccaggacauggagcuuguggagaccaggccugcaggggauggaac cuuccagaagugggcagcugucuuuggugccucuugggaauugagcaguanuacacaugccauguguaccaugauugggcugc cugagccccucacccugagaugggguaaggagggugugggugcugaacuggggucagggaaagcuggagccuucugcaga cccugagnuggucauggcucagagcugggaucauaacccucaccuucauuuccuguaccuguccuucccagagccuccucc auccacugucuccaucauuuguaaucauagcuguucuguuuuguccuuguuagcugugaucauccuuggagcugugguggcuu uugugaugaagaagaggagacacauagguaggaaagggcagggucugaguuuucucucaaccuccuuuugcagugugcuc ugcuccuuaaugggaaacauagccacacccacauugcugcagucuccaacugggucagcngucaguuccgggaacucccna gggcugguguuucucuggucucucauggcuuuucuucucacagguguaaaaggaugcuaugcucauguucuagguaaguu gcgagagaggggcaggggacacccuugucccugaggcucucaggauggagcugggauuuguuccagcccauaaucuccuc uugccacauccucucugucuccucugugugccuuguuaucucuucuacugcaggcagcaagagcuuccagaccucugacug gccucagaaggcaugaaaaucccugggggggcuggugagauggcucaguggguaagagcacugacugcucuuucugaaggu ccagaguucaaaucccagcaaccacaugguggcucacaaccaucaacgagaucugacucccucuucuggagugucugaa gacagcuacaauguacuuacauauaauaaa 196 AW125380 uuuuuuuuuuuguucccuugaaagccagauguuccaaaaaguagccugcuccauuguuc u ucuucagucucauagcgacugccagcgucaauccacacucccaccgugcagguagcaugcg aggacugcuccgaggccacacgcagcccguuguccaagaugcugaccugggucuccggca cgcucuagaggaccugggcgaagguugcgguaccccacaaggcagguaaccucagcaggg ccggcgagcggcgggugcgccucgugccg 197 U68564 Sequence below. ggagcuuaauguuuugaccuguagagguccucacuuuucgucauggcgcugaagguggcgauagcugcuggcggugcug caaaggcaaugcucaagccaacucuccucugccguccuugggagguucuggcugcccauguagccccccgaaggagcauuu ccucacaacaaacaauuccuccaucugcuaaguauggugggcggcauacagugacuaugaucccaggggauggcaucggcc cagagcucauguugcauguuaagucuguauucaggcaugcaugugugccgguggacuuugaagaggugcauguaagcucc aacgcugaugaggaggacauccgcaaugccaucaugaccauccgccggaaccguauggcccugaagggcaacauugaaaca aaucauaaccugccaccaucccacaaaucucgaaacaacauccuucgcaccagccuagaccucuaugccaacgucauccacug uaagagccugccaggaguggugacccggcacaaggacauagacauccucauuguacgggaaaacacagaaggcgaguacag cagccuggagcaugagagcguagcaggagugguggagagcuugaagauuaucaccaaagccaagucccugcacauugcuga auaugcuuucaagcuggcccaggagagugggcguaagaaagugacggcugugcacaaggccaacaucaugaaacuggguga uggacucuuccuccagugcugcagggaaguagcagcccacuacccucagaucaccuuugacagcaugauuguagacaacac aacaaugcagcugguaucccggccucagcaguunugaugucauggugaugccuaaucucuaugguaacauugucaacaacgu cugugcagggcuaguuggaggcccaggccuuguggcuggggccaacuuauggccauguguaugcagauucgagacagcua caaggaacacaggcaaaaguauugccauuaagaacauugcuaacccgacugccacacugcuagcaagcuugcaugaugcuaga ccaccucaagcuccacuccuaugccacuuccauccgcaaagcugucuuagcauccauggacaaugaaaauaugcauacccca gauauuggaggccagggcaccacaucccaagccauccaggacaucauucgucauauccgcaucauuauggacgggcugug gaggcuuagcuaucccuacaguuuugcucagcuugucuguaggacucucuucucacuuuagcacuccagcuagcuugggg gacaggaccca 198 AW125346 uuuuuuuuuuuuuuuuuguucuuaauagaaaacuuuauuuucacugauaaugucacugua acauaauuucauagcagaccugugcaaaagaucccacaucaccaaugucuccaagagauu ucacacacuucugggcaggacacacaacucugcccccacccccguguugacagucaacau uuuacccccgcuaugaguacagaaaggcgaggcaucauaacgaagccgccugaaggcagc gugagcugaagucggacgcuuugccaccucugaaugaaugguucaccacagcaacagcacau gguugccucagugugcucagggugggucuuugaaaaaacgucccacuauguaaauaugcu gcacuuaucccuucaacauugu 199 X61232 See above (same Accession Number). 200 D20333 gauccuguauauguguguuuugggggagcuaugauaaguuuuauggcaaacgguugguau uguuaacuuuuuauugucaucaaaaguucauaaaaguccuauuaauccccauauucunnn uucugcccuuaacucugguauacaccaaaaagaaaucuuuuacuuuccuuguuuuuaucauua uaaaaauaaaguauuuugcuaguauggaaa 201 AB025218 aguccgcaucccggcguucggcccgucccgcaccauggugacgcucgccgagcugcuaucg cugcuggccgcgcugcuggccacggccucgggcuacuuugucagcaucgacgcgcacgcc gaguuaguuuuucuucuuagcgggucaccuccggcaccaagaugggccucaucuucgaguuug gcggaaggcaucuuccuagacaucgacguuggagaucacaggaccagauaauaaaggaauc uauaaaggagaccgggaguccagcgggaaguacacauuugcagcccacauggaugggaca uacanguucugcuuuagcanuaguuauguccacuaugacuccaaagauaguaauguucacc auugacauuggggaggcucccaaaauacaaaacauggagacagaaacucaucagaacaag cuagaagaaaugauuaaugagcuggcaguggcaaugacagccguaaagcacgaacaggag uacauggaaguccgggagagaauacacagagccaucaaugacaacacaaacagcagagug guccuuugguccuucuucgangcucuuguucuaguugccaugacauugggacauuaucuac uaccugaagagauuuuuuuugaaguccggaggguuguuuaaaaggccuuuuuccuguugaucc caaauucaugauuuacu 202 U84411 Sequence below. acauuggcucuaugcugcggccggcuucagcgacgcuuccucgggcagcucacugcauggucuacuguagcccccgccgccu gcauccccgccgccgccccgcgacgcccaccgccgccugcccugccgccgccgccugcgccgccucgggaccggcuguauga uaggccacaaucuucaaugaguagacauauuccucaguucuguguuuguucucguuucacacauuuauggaguuucuuuaag agcaguggagauuacugccagcacagcacgaccucuuaugcagacaagugaacuguagaaauuucauuacuacuccaccaaga aacccccauaagaguggauaaccuggacacaggcguguugaauugaaaucugcacagcauuugagaagagcucagaccugg augggguaaaccucagugccacuuccuuuguauugccucuaguauuacugggauugaagagucacugcuucuuguuuagg agguucauuucauuuggcccguuuucucccaauuucauacucaagcacugagaauuucaaguggaguauuaucgaauaucaaag uagacuucagguuguuuuuugguuuuguuuuguuuuuuuuuuguuuugguuuuuuuuuuuuuuuucuguuuugguuu aaaucauuucuguauucaauuuuuaauucuuucauaacccuauuggguguuuuuuuaaacuaaauuaacauggcucgaa ugaaccgcccugcuccuguggaagucacauacaagaacaugcgauuucuuauuacacacaauccaaccaaugcgaccuuaaa caaauuuauagaggaacuuaagaaguauggaguuaccacaauaguaagaguaugugaagcaacuuacgacacuacucuugu ggagaaagaaggcauucauguucuugacuggccuuuugaugauggugcaccaccauccaaccagauugucgaugacuggc uaagucuugugaagauuaaguuucgugnagaaccuggaugcuguauugcuuuccauugugucuucauugccuuggcagagcu ccggugcuuuguugcccuagcauuuaauuuaaaguggaauugaaauaugaaaaugcaguacaauucauaagacaaaagcggcgu ggagcuuuuaacagcaagcaacuuuuguaucuggagaaguaccguccgaaaaugcggcuccgcuucaaggauuccaauggu cauagaaacaacuguuguauucaauaaaacuggguuugccugaugccauugccuuggaagugnacuucagaugggaccuga unuuaucaugcauauuacccaaugugucggcuuacugaauaaguucuacugcagcuccacaggaauacuuaaaaaccagucuuu accaggccacaaguuugacagaauugcaaccucuauauuugggcuaugaucaacauguuuggacacuuagcaaaagauuuu ugcuuucagcauuunaaaugugcuuauuauuuguaccaauugaccuuuccuaaaauaagguauugaguuaugucauuaa auguacuccugugccagaauauuauuagucuauaaauaauuuagaaagauuagguaccaaaauacccagcacaauacuugu auauuuuuagcaucauacagaaccaaaauugcaggaacugagaacucucagaccauccaugguguauuccuucagucauuu caaacacugcagggcuccucucguuaucugccugcucacucuguuuacaucucccacacuuaugccagaauacgucagguu uugcuuaaccauccuuuauuuuuuuuuauuuuuuuuuuuuaacuaagucuugcgcugauuauuuaauaugucuuacucauuu uguuuuguuuugggaaaccucugucugaaaaaucaacuuuguuacagaagcacauaucuucaacaaugucuccagacaaaa agccuuanaguuaauuuaauguuugcacucagaagugcaaccuaacagggagggccugaaaaagaaacgagaggaggcuau uaaauauuuuuauuuaauauguugccuuugucaugugcagaacauguagauuuaugcucuuaauuaguanauauuuuaag acauagagauacauguguagcuaacccauucuuauucaaaauucuggaauuuuguguuuuccnauaccuaucaggaaguu uccagcuuguuugaauuauggcuuuccucuucccaaucucuugcaaaaaagacaaagugggaugaaucugcuagugaacug agcagaaauguuuuauaacgccuuuugagcuauguancuuaauaauuggauacuugaucauuuguuuuauunuguaaucg aauaaaauguagauguguauuaaaguuaguucaaccauauauuuuacuaucuaugaauguuguaguuauaguucuuguau gagaaauaguuugucaguguucaccagcuuguaaaaacuuaguaugagagcuucaacauuuaaanaaaugaugaaccgcau ucgucacugaggacacuuuugccuaaaauuaacuuaauuuguagaaaacaauggauucaguuaauaucauuucaauuuaug gaaaaaauuuguuaggguugccaaguugcuuuuuuauuuaaaaguuucuucuuuaaaaucuagauaauuguugaaucaguugaau guugggcaccgaggggaaacaguuuguaauagaugaucuagauuuuucaguucaguuccaucagucacuuguagcucugc aauuuccagaccaguuuucucauuuuuaaguucauuacaugccuguauauauuuugaaauuaacuugaaccugaguauuu ggcacaugauggcnuaauaaauunuaacuuuc 203 M62362 Sequence below. acacuccccaaccuccaccuccccucgcucggccucuuauaugcucccaugcucccuaguguuuggcuggaaguaggugacuu agaggcuuaaaggaggggcgccuaaccacggaccacgugugugcgggggcgacagcgccgccgggguggggcugagcgcu gcaagccggguucgccuugcagcgcaggagucagugggcguugcgccacgaucucucuccacuagcacuaugcucccgccc cacucaccgccuuggaaaguucacaggagaaggcgggcucuuaagacccagcaggcaccauccuacuaucgccuucgauccgag acccguuuggacaccagggggcgaugccgacccucuauaaaagcgguccccgcgcgggccuggccauucgcgacccgaagc ugcguggcgcgagccaguuggggcacugggugggcggcggcgacagcggcgccacgcgcaggcuggaggccgccgaggc ucgccaugccgggagaacucuaacucccccauggagucggccgacuucuacgagguggagccgcaucccccgaugagcagu caccuccagagccccccgcacgcgcccagcaacgcccgccuuuggcuuuccccggggcgcgggccccgcgccgcccccagcc ccaccugccgccccggagccgcugggcggaucugcgagcacgagacgucuauagacaucagcgccuacaucgacccggccgc cuucaacgacgaguccuggccaaccucuuccagcacagccgacagcaggagaaggccaaggcagcggcgggccccgcggg uggcggcggugacuuugacuacccgggagccccggcgggccccggcggcgcggucauguccgcgggggcgcacgggcccc cucccggcuacggcugugcggcggccggcuaccuggacggcaggcuggagccccuguacgagcgcgucggggcgcccgcg cuacggccgcuggugaucaaacaagagccccgcgaggaggacgaggcgaagcagcuggcgcuggccggccucuuccccuac cagccaccgccgccaccgccaccgccgcacccgcacgcgucucccgcgcaccuggccgccccccacuugcaguuccagaucgc gcacugcggccagaccaccaugcaccuacagccuggccaccccacaccgccgcccacgcccgugcccagcccgcacgcugcgc ccgccuugggugcugcgggccugccuggccccgggagcgcgcucaagggcuuggccggugcgcaccccgaccuccgcacgg gaggcaucggcgguggcagcgguaccggugcgggcaaagccaagaaguucgguggacaagaacagcaacgaguaccauguac ggcgggaacgcaacaacaucgcggugcgcaagagccgagauaaagccaaacaacgcaacguggagacgcaacagaaggugcu ggaguugaccagugacaaugaccgccugcgcaagcggguggaacagcugagccgugaacuggacacgcugcggggcaucuu ccgccagcugccugagagcuccuuggucaaauccauggcaacugcgcgugaggcgcgcagcugcgggaccgccuuugggcc ggcccccuggcuggagacccagaggaugguuucgggucgcuggaucucuaggcugcccgggccgcgcaagccaggacuag gagauuccgguguggccugaaagccuggccugcuccgcguguccccucccuuccucugagccggacucggugcgucuaag augagauagucaauccauggugguuucuccuugagaccgagagacuuuuccgcggagcugagcuggaugcccggcaguac cuugauauuuuuuuggaggauuccugcuuccucucgggccucagcuggcccccgugagaaaaaugaagggugcaggccc agggcaggaggaagauacaggaagcugagaucccggcaguugcccugagcuugccccucagucccugucuuuuagagaugagg gacuuagguguuggggauuugagucuguguccucacccccagcuacagggagguggagggcuccuaaucccuugcuuuuu gcaccuccaccuacauccccccccccccacucagcuuacaacaggccagguuuccugggugaguucauggagaaugggggca ccacccccagucagacagaaagcugaguugugaguuagccaugugguaggagacagagaccuagguuucugggcuuugug gggugggggauaggaggacacggggaccauuagccuuguguguacuguaugucgccagccgcuguugcugaaggaacuug aagcacaaucgauccaucccagagggacuggaguuaugacaagcuucccaaauauuuugcuuuaucauccgauaucaacac uuguaucuggucucugugucccagcggugccuugugcaauggcagugugcacgucuaugcuaaaccaccauuuuauuugg ucuuuuguuuuguuuuugguuuugcucugauucuugccaaacugagacucuucacuaacagcuaugggaaggagcugagu gaggcucucauucuuuuugguuuaguugauguuuggguuuuucgucugccucccagaggaccaaugaaaugaagugggc uucccccucuccccuaguuguccaaggguguauguaguagugggucuuagcuuccuccggcuaagacuuaggcuucccca cccacccaaccccauccccaacaucccuuucucugggucuggaaagaaggccaccuccaaccaguucauacacacaccccug uggcugggagcagggcuggaccgcuuccuucucuucuuuuuauuggggggggggacacaaaguuucaugcuagaugucgu auguauuauaucuauaauauaaacauaucaaacucaa 204 AA032310 gangcucagugucguganauauaaaccaaaccuuagagccaucgcugaguauaaaaaaaa ggaagauuuauauucngcaaagaguagccgaacuggacaaaauuacuucugaaagagaua auuuungacangcauaugaagaucuucganaacaaaguucugaaunauuuauggcuuuguu uuuacguaauaacaaauaaacuaaaagaaaacuaccaaaugcucacauugggaggagaua cugaacuggagcuuguggacaguuuagauccuuuuucugaaggaaucauguucaguguu c ggccaccuaagaaaaguuggaagaagaucuuuaaccucucaggaggcgagaaaacccuua guuccuggccuuaguguuug 205 M94087 Sequence below. gccgguuunguuuugcgcucgugugucccuuuccucuuccccucccgcauuggcuugcggccaccauguucguauuagagg cagcagugccuacggcagcguuauccuuugcauggcaucaacagcaccaggcucuacaacggcaacccccaccagccuaa gccauggcgcucuucacgaaauccagcagcaguguugcuguaacggacaaagauaccuucgaguuaagcacauuccuggaa uccagcanagccccacaacaugaccgagaugauucuuccuuuaacauucgaaguguuggcgugggacuuuaugucccccuucuua ccagucggauuugggagcugagaaagccuaagucucuuagauaacuaucuggagguggccaagcacuugaaaccucaug gguucuccagcgacaaggcgggcuccucggaauggccggcuauggaugauggcuuggccagugccucagacaccggcaag gaggaugccuuuuccgggacauuauuguuauguuggagaaaauuugaucugaaauuaguuugacuucuuaugcucuguuucgaau ggaugaccuggaaaccaugccagaugagcucuugaccacguuggaugacacauaugaucuuuuugccccucuaguccaaga gacuaauaaggagcccccucagacagugaacccaauuggccaucucccagaaaguuuaauaaaagucgaccagguugccccc uunacauucuuucagccuuuccccuguuccccagggguucugucuuccacuccagagcauuccuuuaguuuagagcuagg cagugaagnugauaucucugaaauagacaggaagccugacucugcuacuuacaunuacucuanucccuccauguguaaagga ggaagacacucccucugacaaugacaguggcaucuguaugagcccggaguccuaccugggcucuccccagcauagccccuc caccuccagggccccaccagacaaucugccuucuccaggugguucccgugggucuccucggcccaaaccuuaugacccaccu ggaguunguuugacagcuaaagugaagacugagaaauuggauaagangcuuaaaaagauggauucaaaacaagacagcagcc acuagguaccgccagaagaagcgggcugagcaggaggcccucauggcgaguguaaggagcuagaaaaaaagaaugaggcu cugaaagagaaggcagauucucuggccaaggagauccaguaucugaaagaccugauagaagagguccguaaggcaaggggg aagaagagaguuccguaauaggguauuucaggugcuuuguuucuuguacauagucuuguguugcuguguuugcuguaauaa auuauuuuguagugaaagu 206 AI847609 uuuuuuuuuuuuuuuauguagggaaguucauauuuuauuuguccagugacauuuuuua caguugaauacaaguuaaaggccugcunugcacaccaaagccagguccuungggugguuca gucaaagaauuuaaggccuccagcuggcucacaacagaagcggccacuccuuggcccuggu uu gggaacuuuuccaacuuuaaguucaucaauaaucucuucaauauccuugggugucagauc cucauaguaguugucauuuauuugaaccaucggugcauuuacacaggccccuaaacauuc cacuucuauaagagugaaaaguuugucagguguagucucuccaaccuuuauuccaa 207 AI853294 uunuunuuunuunuuunggggugaauauagccaaguauuccauuuanuaacaaaauagu cuuagcaagggagagcucuguucaccccacaagaggccccgcagccgaggccggcccgaag ccccagcgcuuucugcguaagaccuuggaguugaguugaagguguuugggauuaagacuuguau u aagucuuuaauccuagccaccgcaggaacccacggaaaccuaaugccagcuuuggcgauu gcuuugcucaguuucuguugacaugggaagggagugcucugauccuagggcucccugaguc c ccagccugcccccaacagagcuccuaaaguugucuggucugcugacuugaggacugguaa gcuuuggacggauccaucaagu 208 M33934 Sequence below. ccucugcggcacgguccucggagcagcgcgguucucggagccacgcgucugucuuccuccguggucauaucggacuaccu gauuagcggaggcaccucuuncgugccggacgacgggcucacagcgcagcagcucnucaacugcuggacggccucaccua caaugauuuucucauucuuccuuugguauaucgacuucacuuucagaucagguggacuugacgucugcucuaacuaagaaga uuacacuaaagaccccauuauuuccucacccauggacacugucacagaggcuggaauggccaucacgauggcgcuuacag gagguanugguuucauccaccacaacugcacaccugaauuccaggccaaugaaguucggaaagugaagaaauacgaacagg gauucaucacugaccccguguuuccuuagccccaaguuaucguguacgcgauuuuunuugaggccaaagccaggcauggcuucu augguauccccaucacagauacaggccagauauggagucgaungguaugcaucaucuccucaagggacaungauunccuc aaggaggaagagcaugaccgguucuuggaagagaucaugacuaagagggaagauuugguggucgccccugccggcgucac ucugaaagaggcaaaugagauncugcagcgaaguaaaaagggaaagnugcccaungugaaugaaaangaugagcugguagc caucanugcccauacagaccuaaagaagaaucgugauuacccccuggccuccaaagaugccaagaagcancugcugugugg ggcagccauuggcacucaugaggaugacaaguauaggcuggacuuacuggcccuugcugguguggauguagugguuuug gacucuucccagggaaacuccaucuuccaaaucaauaugaucaaauacaucaaggagaaguaucccagucuacaggucauug gaggcaauguagucacugcugcgcnagccnanaccucauagaugcagguguagaugcuuuguagucggcaugggaauuu gguuccaucugcaucacccaggaaguguuggccugugggcggccccaagccacagcaguguacaaggucucugaguaugcc cgucgcuuugguguuccugunauugcugauggaggaauccaaaaugugggncauauugccaaagcnuuggcucungggg cuuccacagucaugaugggcucccuccuggcugccaccacugaggccccuggcgaguacuucuucucagaugggauccggc ugaagaanuaccgagguauggguncucuugaugccauauacaaacaucucaacaaccagaaccgauacuncagugaagcng acaaaaucaaaguggcccaaggagnuncaggggcagngcaggacaaggggucuauccacaaguucgnuccuuaccugauug cuggcauccagcauuccugucaagacauuggugccaagaguuunacccaagucagagccaugacguacucgggguuagcuua aauuugagaagaggacauccucugcucagguggaagguggcguccacagccuccauncauacgagaaacggcuuuucugaa aacagauccaguauaugccuugaauuuuucaauaaaaguuugggaaaaaaaaagugaaaaaaaaaaaaaaaaaaaaaaaaaaa aaaaaaaaaaaa 209 X16202 gugugaugcagaacugaugucagggaaagcuggagccuunugcagacccugagcugcuc acggcugagagcuggggucauuacccucaccuucauuuccuguaccuguccuucccagag ccuccuccauccacugucuccancauggcnacguagcuuuuucuuuguuguccuuugagcu uggccaucauncagcugugguaucuuungugaugaagagaaauagacacacaaguaaua aagggcagagucugaguunuu 210 AI661431 gugugggugcagacuggggucagggaaagcuggagccuuuugcagaccuugagcuguc acaggaggggaaggccaaagcaagaaugaaagucccccgccccguaucaccacgggcacu cggggucacccucaggaacaugcagucucugcacgugaggaaaganacacgcagagaugg acgagcacuuuuncacccuaaunaaauungaugcacuaaccacagaccccccu aagggcagagucugaguuuuu 211 AI839109 uuuuuuuuuuuuuuuuuaaaaaaaaaaauggcaucuuuuauucaucaaucccuguuacac acugaaauacaugcaucuuucuuauguuacuuagcaacguccuuucuauccuuucaccca uaaaucagucugaugaauucaucuuuaaauucaagaaguuuuucuuuuugaaacgcuacu uacaunuuaungucucaauaucaaagccaaucuagagauuuauucuuccuacaggugaaa uagauguuaauacgggaacagucaguacauguucaagaugacaucaaaguuaugcccuaa gcagauauuucaaggcaauaucaugccacuagcucugagacucuaaguaucacugauagu acuaaaagguagaagucagcuncaaaaacacacucuugcaauggacacugcucaugaugu cuaagauuguucacucccacagucaugauuucagaugcacaguuuuuuuugcuuuccuga gcauucggunugac 212 AI849135 uuuuuuuuuuuuuuuuuaagagugucaccaaagcuuuauuuacaugcgucaucaucucuu uuacaaacuagauuaugguuuuaaauggaauacacaggcaauaucuacaaacgccacggg aaguacgcaccuccauuccaccgggaagaugcagauucccaaaucaaacugguuuugauc cuugagaagaaaggcggcagagcuaacucacggcagcguaugguuagacaagguccucag uacccagaaugcagcaggauugcgucugccucaaaccagacgaccaacugcugcaggugu uuaaacauauccacacgccacacgaaauucuaguuuaugugggauagaagcaagaaaaaa aaaaaaccauggcgccucgugccg 213 M32459 gguccagauaguaaacugcucccuuacaucuccuuaaauauaaaguaaagaaaaagaaaa aacucaguucggguaaccaaguucaacaaguaauccuuggggccgcugugguaucgccaa aaucuacauaguaucucuuauuaaaauguuuugacgaaaauguaacaauuacgguacuua augguaacaauguggcugaggaagcaauaguuaacaaagaagagcuaagcuaugcaacaa accagauuucuauuggucacaaauuugaaguugagaccuguuauccaauuaccaaguacu uccgcauacaucaucauaggcauuugaagauuucaaccaaucaggagcauguuccuucua uaaaggaacccagaaccuaaccucugcauuuccuauuucuuuguagaaauggcucguacg aagcagaccgcucgcaaguccacuggcggcaaggccccgcgcaagcagcuggccaccaag gccgcccgcaagagcgccccggccaccggcggcgugaagaaaccucaccgcuaccguccc guucaccguggcuucugcgcgagauccggcgcuaccagaagucgaccgagcugcugauccgc aagcugccguuccagcgccuggugcgcgagaucgcgcaggacuucaagaccgaccugcgc uuccagagcucggccgucauggcucugcaggaggcgagcgaggccuaccuugugggucug uuugaguuacaccaaccugugcgccauccacgccaagcgugucaccaucaugcccaaguuac auccagcuaucccgccguauccgcagcgagcaggcuuaauaggcacgcuuucuacacugg cacguaaaccaaaacggcucuuuuaagagccaccuccauuauccaccaaagaugcuugaa guacaaguugugagaguuuucuaggguuuccuauuauagccuuucuugacaangungca ccacccgacgaagcagucugag 214 AI841389 uuuuuuuuuuuuuuuuuggacuucugcggcuuuuauuuuugcauguaaaccacuggggg g agggggaucuugauggugggcacccuagagauuacacuggaguuccgagggcuccagaca cuagcugggaagucaggugacagaaacaaugauucagaccaaucacaugnuugcaaaacu gauucuccagcagggauncugguggucaauuguggaugccuaaggaagcagugacauggg aggggcacgcacugggcuggccuugagcugcugggaugacaucagggauagaggaccuag cagcugguggcuccagggaucuccgguccaugcuuuauuuggccaggggguuccugaagg accugccagcaaacuuggcuuugcugcccagcucuuccucaauucugaggaucugauugu acuu 215 X03039 Sequence below. auucuaauugaucaugucugcgauuucaggauucuauccagancaauggccccgacggaug gagaguaacuggaacgagauuguggauagcuuugaugacaugaaucucucagagucccuccuccgugguauuuaugccua uuuuuugagaagcccucugccauccagcagcgagcuauucuuccuuguaucaaggguuaugaugugauugcucaagccc agcugggacugggaaaacagcuacauuugccauaucaauucugcagcagauugaauuagaucuaaaggccacucaggcuu ugguucuggcacccacacgugaauuggcucagcagauacaaaaggugguuauggcauuaggagacuacaugggugccucu ugucaugccugcauugggggcaccaaugugcgugcugaggugcagaagcugcagauggaagcuccccauaucaucguggg uaccccuggccggguguuugacaugcuuaaccggagauaccugucccccaaauacaucaagauguucguacuggaugaagc agaugaaaugunaagccgaggguucaaggaucagaucuaugacauauuccagaagcucaacagcaacacacagguagunuu guugucugcuacaaugccuucugauguccuugaggugaccaagaaauuuaugagagacccuauucggauucuugucaaga aggaagaauuaacccuggaggguauccaccaauucuacaucaauguggaacgagaagaguggaagcuugacacauugugu gacuuguaugagacgcugaccaucacccaggcagucaucuuuaucaacaccagaaggaagguggacuggcucaccgagaag augcaugcccuuagauuucacuguuucugccaugcacggagauauggaccaaaaggaacgagaugugaucaugagguuaguuc cggucuggcucuagcagaguauuaauuaccacugaccuguuauccagaggcauugaugugcagcaggucuccuuagucau caacuaugaccuucccaccaacagggaaaacuacauccacagaaucggucgagguggucgguuuggucguaaggguguggc uauuucauggunccgaagaagacaagaggacucuucgagacauugagacuuucuacaacaccuccauugaagauuaugcc ccucaacauncugaccucauuugagaugcuguccugcgaccuggcccuagcccagauucaguccugauguggggcuaa ggaagagcuggaggggggaggggagggagccaagggauggacaucuuguuuuuguuuuggcuuuuuuuuuuuuuuuguu ucaguuuuuuucucuaugaauaaaugucacuuuuugaggc 216 AW049795 uuuuuuuuuuuuuuuuugccaggauauauuuauuacugaaaguacaagcaacugagguuu acccugggaacacccacaaugaaacguguaucuucccuguuucucagaugcugccuccuu ccacagagugaguunucguuuaaaacucauaaugaggagaaggcagggggcuccaccccu uuccuauucaaucugaagacugaauugggcuacacugggauggaaauuucaauugcuaca ggucagugucaaccaaggguucgugugucaggaacucuggcugguaagaugacacaaagg cuucaugcugaagcucagggagguccagggagccuggcagaauggaaucaucauggucau caucaaacaucuaugucuggaaggcuucaaggcucauaauugcaucauucucuggcaguu ccugagagagcugccccuuccuggguuugcacgcaucaaauuucacccacugguaauuga cacaguuuugagcuucgggacaacucunaaucagguuguggaugguuggaugagaaaacc caaagaagucggcaccgcauga 217 D87691 Sequence below. auuguaacagaagaaggaaaggaaaagaaaguuaacauugacunugaaccuuucaaaccaauuaauacaucauuguauuug ugcgacaauaaguuucauacagaggcucuuacagcguuacuuucagaugacagcaaguuugguuuuuuguaauagacgg aaauggugcucuuuuuggcacgcuccaaauaaacaccagagaaguccugcacaaauucacuguggaucucccaaaaaaacac ggcagaggaggucaaucagccuugcguuuugcccguuuaagaauggaaaagagacauaacuauguucggaaaguagccgag acugcugugcagcuguuuauuucuggagaccaagugaauguggcugguuugguuuuagcuggaucagcugacuuuaaaac ugaacuaagucaaucugacauguuugaccagaaguugcaaucuaaaguuuuaaaauuaguugauauauccuaugguagug aaaauggauucaaccaagcuauugaauuaucuacugaaguucucuccaacgugaaguucauucaagagaagaaauuaauag gacgauauunugaugaaauuagccaggacacaggcaaguacuguuuuggaguugaagauacacuaaaggcuuuggaaaug agagcuguacaaauucuaauagucuauaaaaaucuggauauaaugagauacguucuucauugccaaaucacaaaagauag aaaauucucuauuuaacuccagaacaagagaaggauaaaucucacuucacagacaaagagacuggacaggaacacgaacuga cacaagaaggaucacaguuuguaaaaggauuugguggaauuggagguaucuugcgguaccgaguagauuuccagggaaug gaguaccaaggaggagaugaugaauunuuugaccuugaugacuacuagguagucgacauggguccggcaaccgugccuca cccuccagcauucaacccaaggagcauacccgugguggaguccaacagaucccugccunacaauuggagcauuuccagaacu uaauccgugagcauuggauacugaaaagaaaagugaaacaaaaccagacccaacccuacacuuugguuugucuuugguguca gcgcagcagccgacaacuaaguu 218 AI117211 cagaggagucauuguugcuguggugacuuuugugaugaagagaaggagaaacacagcgua agccagcugccuggaguggacuaagugacagacaaugucuuucacacaucuccugugacau ccagagcccucaguuuuucuuuagucauguaucugauguuucccugugagccuaugggucaa agunagaacuguacaacccaaccugcccugcacacagaacccugucccugcacugcccu ggguucccuuccacagccaaccuugcugcuccagccaaacacugggcgacaucugcaucc ugccaguuaccaaugcugcccugagcugcagcugcucacuuccacacugagaguaagaaucu gaaugggacuagauucuuaacauccugaccgaggguugauuucuuguuaauuucaugga uugagaauacuuagaguuuugguuugucuugauuuuuuuucaag 219 Y00520 ugaauaaaaacgaggagccgaagauucuagggggcuacagcugcgcuuuugcagcacuga acaugguuccggguacucaagauauugcguuuguguuuggagagguguagauuguagauu ccagccgagaagaccaggaaaagauaaggauaaagaaugucauauaucucaggagcuaga ucacuucccgaugaacaaguaagaauugccucaacaaaaauggauggaauuggaccgaaa aaagccauucagcuucguuaucgauuagguaucagugggaacaucaagaugaaugaguua acuaaguaucagaucgaccaaauugaacaaaugauagcucaagaucauguuguucauugg gaauugaagaggagagaacgagcagacaucaaacgauuauuucuauuucucguuaucgu ggaauucgucaucaagauggaucgcccuuacgcggucaacgaacucauacuaaugcaagg acugcucgcaagcaaauucggaaaugaaagaaggcuaccgaaagaacaagcaacggauuu cgcgcucaucccuugcuuagcgcauacguuuuucuugcuccuugguacuugucugauucaa ucacacuguucauuaguucacuugauuuuucguucgaugucuugaaccgcuuacuaauca cguauacguauaguaggcccccuucgccacuccacgucuggcccgucuuggucucgcuca cuucuccgccuaucguaucggcucggcuucguccgucaagcgacagcuucugccuuoga cggcuaucacuaucgcucaugacugguaguacucuauguaguagucggccuuuguuaagcu u 220 AA638002 uauaaccauguuagaagcggaaguuggccugaaaaccugaggcuuaggcuucauagcugg gcuguagauuggauuuaaacccaguuggagugcaaagucauggugugcucaaggugauga cagugaacagaguaug 221 Z22661 caugggccuccugagaga uccuuagauccagguuagugcauaggaaaguguccccccacuaccuacagcuaagggauu gggguggugggaucaugguggagggccguggugaauacuagcgaugucccccgcuacccg ugcgucugccuccagggugccccuccaaccaggaugaggcucuucaucgcucuuccuguc cugauuguggucguagccaugaccuuggaagguaagaaagagccuuggaagguaagaaag augcuuuaagugugaaguuggccuugugccugcggcccaggcuuagaagacccucgagg agggcucugaggucccuuucugugucaucauuccacuaccgcccucccaucgucccccau cccaccugccaggugccuuauuuuuugugucauagugggugcagaaggaggcaauacuguc cagaaaagacgcaguaaccaaugaccuaggauaccacccuuuagaauuggcuaaucuucc uagaaggggcggacgguaaaaacaaggaggugagaggugcaguaaaaucaaguguccaau acccucccccaugcuaaugaguuugcucgcaacccucucgcggcaggcccagcccccgcc caggcgaccccagauuuguccggaacauuggagagcauaccggauaaacugaaggaguuu gggaacacuuuggaagacaaggcccgggcagccauugaacauaucaaacagaaggaaauu uugaccaagacccg 222 X99644 Sequence below. cagcgccuggggcgcggcgggcgucggcccaggagacgcguggcggcgcucggccucgcggcaucggcuggcc guuggcggcgagcgcacuugcgccugcgcagcgggguccgugccccuccuccccugggcggcccccccacccccccggcgg caugugaauggcggccucggcggcagcgacugcagcggccucggccgcgacggccgccucggcagccucuaguagcccag ggucgggcgagggcucggcgggcggugagaagcguccggcugcuuccucagccgcggcggccucugcagccgcgucgucc ccugcggggggcgguggcgaggcgcaggagcuucuggagcacugcggcgugugucgcgagcgccugcggcccgagcggga uccucggcugcuuucccugucuacauucggccuuucagugccugccugguuccccuucuacacccgccgcagcgaauaauucggg ggauggcggcucggcgggcgacggcgcuaugguggauuguccagugugcaaacagcagugcuacuccaaagacaucgugg agaauuauuuuaugcgugauaguggcaguaaggccucuucugauucccaggaugcuaaccagugcugcacuagcugugaa gauaaugccccagccacuagcuauuuuguggagugcucugaaccacuuugugagaccuguuuuggaggcucaccagcguugu aaaauacaccaaggaccacacugugcgcuccacaggaccugcuaaaacucgagauagagagcgaacagucuacuguaaugu gcacaagcaugagccccucgugcuguucugugagagcugugacacacucaccugccgcgacugccagcucaacgcucacaa ggaccaucaguaccauuuuuuuguuaauuaugcagugaggaaccaacguaaacucuuggcuucacuggagaaacgucuugggg acaaacaugccacacuuucagaaaaacaccaaggagguucgaagcucgauccgccaauuguucugaugugcagaagcaagugca gguugaugucaagauggccauucugcagaucaugaaggagcugaauaagcggggucgaguucuggucaaugaugcccaga aggugaccgagguuucagcaggaacgucuggagcgccagcacuggaccaugaccaaaauucagaagcaccaggaacacauuu ugcguuuugccucuugggcucuggagaguugauaacaauacagcucuucuugcucuucuaagaagcuaaucuauuuccagcug caucgggcccucaaaaugauuguggauccuguggagccucauggugagaugaaguuucagugggaucucaaugccuggac caagagugcugaagccuuuggcaagauuguggcugagcguccugguacgaacuccacagguccugggcccauggcuccucc aaaagccccaagcccucuaagcaagcaagguucuggcaguagccaacccauggaaguacaagagggauauuucuuuauguc agaugaucccuauucaagugcagagccgcauguaucaggcaugaagcggucccgcucuggugagggagagguaaguggcc ucuuaaggaaggugccacgugugagccuugaacgccuggaucuggaccucaccucugacagccagccaccagucuucaagg ucuuuccuggaagcacuacugaggacuacaaucugauuguuauugagauuggugcugcugcagcagcuuucuggucaggcu gggacugugccaccaggagccccuggugccccaccccuuccuggcauggccauugucaaggaagaagagacagaagcugcu auuggagcucccccggcugcccccgaggguccugaaaccaagccuguguugaugccucugacugaagguccuggugccgag ggaccucgucuagcuucaccuaguggcaguaccagcucaggcuuggaggugguuugcuccuuuagguuacuucagccccagu aagugauccagguauuccuggaugacaaugccacuaucuugccgaguucugccagaaaccagguaaccuggucauguguaacca gugcgaauuuugcuuccaccuggauugccaccucccugcccugcaggauguuccaggggaggaauggaguugcucacucu gccacgugcucccugaccuaaaggaggaagauggaagccucagccuuugauguuagcagauagcacugguuuugguagcuaaac uucucaccagccaaccaacggaaauguugagcguguucuccuggcccuguacuaccaugaaccaugccguucccuugcaucagc agcugucaccuccuuauagcuccccccaguuaguuugcucaagauuuugggccgcauguucaaacauuuucaacaagcuuuacug aagacaaggcagauguucaguccaucaucggcuuugcagcgcuucuuugagacacgcauaaaugaugccuuuggugacacca aguuuucugcugugcugguagaaccaccaccauugaaccuucccagugcuggccuaaguucucaggagcucucuggcccug gugauggccccugaagcuggggcucuuguggucagcccaguccagcucuggucucuguauuuucaccccauacccugucc uauaguggccugacuccuauucuugcuauccccauucguccccucaguucccucuuucacaaaaugguauuuacuucuaugga uuuaauaaaaacuucacugagucaguuaaaaaaaaaaaa 223 AI843895 uuuuuuuuuuuuuuuuuaaaaauaauuucauuuuuuaauauucuguacaaaauuucucaa ccuaugaaaauaaaguaaucaaaaguucaaaguaguacauaggccugcccuggagccaggc ccagccggaucuacacuauguacaggucucccagggugagccucagcuagggaaaagcca cuaaggugccuacagagcaagauuggugccaucgguuccagugcagccucugcaauuuccag aucugccacuaaaggucggcaugauccugauugcuuaucaggcucacccucuggaagacc acagccaaugacaaagguccucaagggaaagcuuuggggucuagcuggaagugacggugg guccgccgcccaacgcaagagcaucugcuggcaguccagcaguaaccggugaucgccaa 224 M38724 uccgucguaaccuguugaguaacuauggaagacuauaucaaaauagagaaaauuggagaa gguacuuacggugugguguauaaggguagacacagagucacuggccagauaguggccaug aagaagaucagacuugaaagcgaggaagaaggagugcccaguacugcaauucgggaaauc ucucuauuaaaagaacuucgacauccaaauauagucagccugcaggaugugaucaugcag gacuccaggcuguaucucaucuuugaguuccuguccauggaccucaagaaguaccuggac uccaucccuccugggcaguucauggauucuucacucguuaagaguuacuuacaccaaauc cuccaggaaauuguguuuugccacucccggcgaguuuaucacagagacuuaaaaccucaa aaucuauugauugaugacaaaggaacaaucaaacuggcugauuucggccuugccagagcg uuuggaauaccgauacgaguguacacacacgagguagugacgcugugguaccgaucucca gaaguguugcugggcacguucguuacuccacuccgguugacaucaggaguauagggacc auauuugcagaacuggccaccaagaagccgcuuuuccacggcgacucagagauugaccag cucuucaggaucuucagagcucugggcacuccuaacaacgaaguguggccagaagucgag ucccugcaggacuacaagaacaccuuucccaaguggaagccggggagccucgcaucccac gucuagaaccuagacgagaacggcuuggauuugcucucaaaaaugcuaucuaugauccu gccaaacgaaucucuggcaaaauggcccugaagcacccguacuuugaugacuuggacaau cagauuugaagauguagcccucaggauggaugucccugucugcuggucguaggggaaga ucg 225 AW122989 uuuuuuuuuuuuuuuuuacuaggcaaagaauuuuauuaacccuuuccaaacuuuauuccc aggcuucuucagcuuuauuugccgcaaagaaugaauuagguauagcgaaaacugaaaaga gcugcaguguccgggggcuugggcuuaaaaauauuagagaucuagauuuuaucagaucca uaauaaacaaaaaaauuuuuuaaagcagucaaugauauaaaauagcagcaccuguanuuc ugcaaguaucaccuucuucaaaauuugcuucaauucaauuuugccucauucuauagaagcu caucaaaauucuccaccagaucuggaacuucaucaucaucauccucuccaguagcaaggg gugcauuaccauccacagauuguuugggcagagcuucagccagucuccuuaaacuaguca ggucugucugcaccaagcuuuugaggaugcugggaagcauuuugucagcugcuuugc 226 AI844810 uuuuuuuuuuuuuuuuuuuucaugcuugccuagggauggggaauagaucucaauaaa a acauacaguaaaaacaggggguggggagggggaaggcuuaucauguacaauguuuaaacu acaauagugauguaccuuaauuacuuccaugcacacaagucuaacauuacaaguuuuuaa aaaauaaacaccauuaagacuucuaggagcauuuuauaauaaauuccuaauuuuuucuuu guagauagaucaagcaccuccaaaauacagauuccuauacacagugagcacuuuacuuaa cguacauggacagccucagucugcagacgucuuggaucagcuuggcaggcaacauacc auagugccaaauggaaagaagagcaguagcaauuaaacuuaaaacuaaguuaacuuuuu aauuaaauacagaaaauauacugauuugcuaaaaauaaauaagaugugauguauuuaaca cuucacuauaaagaaugaacaccaugacauccucgugccg 227 AA940430 agaagaaggaggagugggaccgcaagcaugaggaugcuaguagggaguaugagaaaggca ugaaauguaugaaggaggaagaggggacucauucaaaaagggacaagucuaagaagaaaa agaaaguaaaagcaaagauggaaaaaaaguccacuccuucccggggcucgucauccaagu cuucauccaggcaguugagugacagcuucaagagcaaagaguuuguguccagugaugaga gcucuucaggcgagaacaagagcaaaaagaagaggaggcggacgaggacucugaagagga gcuaggccaguaccccaccaaacucagaggacucugccucgagaucugaugaauaaaggag ggaauucccaccccgucacagcuccagucucucacauaguccuuggauucugugccauc gaguaacugcucuugguggcuuccacugcccugaggcuuugagggaag 228 M38381 Sequence below. aucgucguaaucguuugcagacuucucgccgucgccuuguaagcuuugucuucgccuugcaagcuuugucuucaggguug gaaagauggagacauucaaagagaacuuacuguccugacugggauaaaagagacugggauuauggaacauggagaagcagca gcagucacaaaagaaagaagagaucacauagcagcgcccgugagcaaaagcgcugcagguacgaucacuccaaaacgacaga cagcuauuaucuggaaagcagauccauaaaugagaaagcuuaucauagucgacgcuauguugaugaauacaggaaugacua caugguucuacgagccagggcaucccuauggagaaccuggaagcagauaccagaugcauaguagcaaguccucugguaggag aaaagaucgaggaguguagaggaugaugaggagggucaccugaucugucagaguggagacguacuaagugcaagauauga aauuguugauacuuuaguuugaaggugcuuucggaaaagugguggaaugcaucgaucauaaagugggagguagacguguag caauaaaaauaguuaaaaauauggauagauacugugaagcugcucaaucggaaauacaaguuuuggaacacuugaauacaa cagacccccauaguacuuuccguuguguccagauguuggagugguuugagcaucgaggucacauuugcauuguguuugaa cuucuuugggcuuaguacuuaugauuucauuaggaaaacauuuuuucugccguuucgaauggaucauaucaggaagauuugc auaucaaauauggcaaaucuguaaacuuuuugcauaauaauaaauuaacucauacagacuuaaaaccugaaaacaucuuauu ugugaagucugacuacacagaggcuuauaaucccaaaaugaaacgugaugaacguacuauaguaaauccagauauuaaagu gguggacuuuggaagugcaacauaugaugaugaacaccacagcacauugguaucuacaagacauuauagagcaccggaagu uauuuuagcccucgaguggucacagccaugugaugucuggaacauaggauguauucuuaucgagguauuaucuuggauuua caguuuuuucgacucaugauagcagggaacauuuagcaaugauggaaaggauucuuggaccacuaccaaagcacaugauac agaaaaccaggaaacgcagauauuuccaucaugaucgauuagauugggaugaacacaguucugcuggcagauauguuucuc agcgcuguaaaccucugguagggaguuuaugggcuaucucagggaugccgaacaugagcuucucuuugaccucauugggguaaaua uuggaguaugaucccgccaaaagaauuacucucaaagaagcccuaaagcauccuuucuuuuacccacuuaaaaagcauacgu gauuuauaaacacagugcucugaaaggaaucuuacagacuguaucagucuagcuuuuaauuaaguuauuuuguauagcuu aauuuguaaaacauuuuauguuuuuuagaugcuuuauuaaauacauggccaaaccaaauaacaucuuucaguaauuauaga augauuuauuuggaauaaaauuugugcuuaugaauguaaaaaaa 229 AF014371 ggacucgcgacaagcguccucagcgcgaagaggcggacucuugaguccucgccuugagccu ugcaucugagaaguuccagguacuuuguacaacugcaucccagaaccuguauguuuucag caccuuuauaagugauggcugccaucaggaagaaacuggugauuguuggugauggagcuu gugguaagacaugcuugcucauagucuucagcaaggaccaguucccagaggucuaugugc ccacgguauuugaaaacuauguagcggauaucgagguggauggguaacaaguaguguug g cuuuaugggacacagcuggacaggaagauuaugacugccugaggccucucucuuauccag acaccgauguuauauugauguguuuuuccauugacagcccugauaguuuagaaaacaucc cagaaaaauggacuccagaagucaagcauuucuguccaaaugugcccaucauccugguug ggaacaagaaggaccuucggaaugacgagcacacgagacgggaguuggccaaaaugaagc aggagccgguaaaaccugaagaaggcagagauauggcaaacaggauuggcgcuuuugggu acauggaguguucagcaaagaccaaaaauggagugagagugguuuuugagauauccacaa gagcugcucugcaagcuagacgugggaagaaaaagucugggugccucaucuugugaagcc uugugaacgcaucucaugcguuuuaauuugaagugcuguuuauuaaucuuaguguauga u uacucgccuuucauuuaucuauaauuuaccuaaga 230 Z30939 uucaagaccgaccugcgcuuccagagcucggccgucauggcucugcaggaggcgagcgag gccuaccucgugggucuguuugaggacaccaaccugugcgccauccacgccaagcguguc accaucaugcccaaguuacauccagcuggcccgucgcauucguggggagaguugcguaaauu aggguagugaaugaauuuauaccccaaagacucuuuucagagccacccacauuuucuaua aaaggcuguauaucgauaagcuuuuauaaaccccacucagcaacucc 231 U28208 uuaugugauuaaaaaaauucaacuugguuauuacuuaacuuaagggccuuggugcuggugcu uugccugauguugguaaaggugcagcagaagaaucaauugaugaaauuauggagcauaua aaagauagccauaugcucuuuaucacagcagggauggguguuugguacuguuaacauugugcu gcaccgguaauugcaaaagcagccagagaaacaagagcgguaguuaaagauaaaggagca aaagaaaaaaagauacugacuguuggaguuguaacuaagccguucgguuuugaaggugug cgacguaugcgcauugcagagcuuggacuugaagaguugcaaaaauacguagauacacuu auugucauucccaaucaaaauuuauuuagaauuugcuaacgagaaaacuacauuuugcuugac gcauuucaacucgccgauaauguucugcauauuggcauaagaggaguaacugauuugaug aucaugccaggacugauuaaucuugauuuugcugauauagaaacaguaaugagugagaug guuuaaggcaauuuauuguuuacuggagaagcagaaggauuaagauagggcaauuagugcugca gaggcugcgauaucuaauccauugcuugacaauguaucaaugaaaggugcgcaaggaaua uugauuaauauuacuggugguggagacaugacucuauuugaaguugauucugcagccaau agagugcguuuaagaaguggaugaaaaugcaaauauaauauuuggugccacuuuugaucag gcgauggagggaagaguuuagaguuucuguucuuacaacuggcauuugauagcuguaacgac aauucaucuguuaaucaaaacaagaucccagcagaggaaaaaaauuuuaaauggccuuau aaucaaauuccaacauuagaaacaaaagaauaugcuucaacugag 232 AV218217 ugaucaggucacauuccggugccuuccacccccuauggcacgggcgccccgccuugccau accacagcucccuccaggcuuagaccuggcuucaccgcauuucaggugcuauaccccccc cugcuuuuccccccauugcccuuaaaugccccucggccccuccauccccccggaacaggg uggcacuugccacucucaggaccaccuugccaaggagaauaaaccgaauccuguugcu

Thus, the transcripts identified in this Example, the proteins they encode, and the pathways in which the proteins participate contribute significantly to HF stem cell activation. Accordingly, anagen can be induced by activation of these transcripts, proteins, and pathways.

Example 9 Molecular Pathways Activated During Induction of Epidermal Cells to Differentiate into HF Stem Cells

The gene expression pattern of HF stem cells was analyzed as described in Example 8 and compared to non-bulge basal keratinocytes. 157 genes were differentially expressed in the HF stem cells, as assessed by microarray analysis and quantitative polymerase chain reaction (qPCR). A group of selected genes with increased expression in HF stem cells is depicted in Table 4. A group of selected genes with decreased expression in HF stem cells is depicted in Table 5.

TABLE 4 Genes up-regulated in HF stem cells. Numbers in parentheses are the fold increase as determined by quantitative real time PCR. Gene Name/ Protein name/ SEQ GenBk Fold ID Acces #. incr. Sequence No. Cell surface proteins Cd34/Cd 34  43 uuuuuuuuuuuuuuuuucacucaucacguuuauucagaagagaauaca 233 antigen (189) cccaauccucucaucucuggaaaguuuuguuccuagccaucauuaagau AI847784, caggaccccuauucuccccuuaaccccaggagauaagcuuauagucuu AI173145 uguagattauucugaaccucugaucacaaaggguuauaaaauagugaagg gguuuggacuaggaaaggcacagacugaaaggaaucugccaggggacug aggccacagcucccccauugagucagaggaagguuggaagucacuuuauuuu auagaaggccaagggccucagagcaagaguauuccuuugaagagcuca Calcium-related S100a4/  35 ugguggagcaggucucaggaaucucuucgcuucagcuucaaucauggcc 234 S100A4 (144) uguggucuggucgccagcaaccugaaucucaaaccuggggaaugucuca (mts) aaguucggggagagguggccucggacgccaagagcuuugugcugaacc X15986 ugggaaaagacagcaacaaccugugccuacacuucaauccucgcuucaau gcccauggagacgccaacaccauuguguguaacaccaaggaagauggga ccuggggaaccgaacaccgggaaccugccuuccccuuccagcccgggag caucacagaggugugcaucaccuuugaccaggcugaccugaccaucaag cuucagacggacaugaauncaaguuccccaaccgccucaacauguuaggc caucaacuacauggcggcggauggagacuucaagauuaagugcguggcc uuugagugaagccagccagccuguagcccucaauaaaggcagcugccuc ugcu Transcription Factors and related genes Id2 helix-  11  gugguucuucggcgccagguucgcccgcuucugcccuuagguaacauu 235 loop-helix (25) cucuaaacugcguuucucucccaaucuuuugcaggcauuuggggacuu protein uaucuuuucuuuuuacutuucucupuuucuuuugcacaaaaagaagucu AF077861 acaagaucuuuuaagacuuuuguuaucagccauuucaccaggagaacac gugaauggaccuuuuaaaaagaaagcguuaaggaaaacuaaggaugau cgucuugcccaggugucuuuguucuccggccuagacuguugauaccguua uuuaugagagacuuucagugcccuuuuucuacagauggaagguuuucuuu auauacuauucccaccauggggagcgaaaagguuaaaaaaaagaaaaaaa ucacaaggaauugcccaauguaagcagacuuugccguuuucacaaaggug gagcgugaauuccaggaggacccaguauucgguuacuuaaaugaagucu ucggucagaaauggccuuuuuugacacgagccuacugaaugcuguguaua uatauuauauauaaauauauauauauugauuugaaccuuguguuacucuuu aauuagaguuuucuuguauaguggcagaaauaaccuauuucugcauuaa aauguaaugacguacuuaugcuaaacuuuuuauaaaaguuuaguuguaa acuuaacccuuuuauacaaaauaaaucaaguguuuuuuauugaauguuga uugcuugcuuuauuucagacaaccagugcuuugauuuuuuuuaugcu auguuauaacugaacccaaauaaauaccaguucaaauuuauguagacug uauuaagauuauaauaaaaugugucugacaucaa Id4   4  cgaugaaggcggugagcccggugcgccccucgggccgcaaggcgccguc 236 AJ001972 (12) gggcugcggcguucggguuagcuggcgcuacgcugccuggcggagcacgg ccacagccugggugacucggcagccgccgccgccgcugcggcggccacg cgcugcaaggcggccgaggcggcggccgaugagccggcgcugugccugc agugcgauaugaacgacugcuacauuucgccugcggaggcucgugccuac caucccgcccaacaagaaagucagcaaaguagagauccugcagcacguu ucgacuacauccuggaccugcagcuggcgcuggagacucacccugcuuu gcugagacagccgccaccgcccgcgccaccucuccacccggccggggcuu guccagucgcgccgccgcggaccccacucaccgcgcucaacacugacccg gugagaagccuuggcgggcacccugggcaucgcgggaaagguggcggg gcggcgagauacggguggucuugcuccucucagggaaugacagccgcu ucucccaucuccaccgagagccgccugcugggcauggugauuccacuuggu cccuuugagccgagggcgguugggcuuggagcccugcgucuccggagugu cccuugcaucacaggaggcuuccccagcuucgggcucggguggggacuc uacuucaccuugccuaguuuuuccaggacgucuccugggugguggcgacac ugugauaugcgcacucuaaccgcuuuuccccuugguguuggguugcug uuccaggccggcugccguugaacaagcaagauacagcauucucuugccgcu Peg3/  12 Sequence below. 237 Paternally acuagucucgaccauguaccaucacggagacaacaccaacagugacaugaacagugacgacgacauga expressed gccgaagugggagagaaaccccacccccucgaccaucucaugcuuuuggcagugagcgagaccuggag gene 3  cgcaggggcagaagcagagauguggagccucgagaccgcuggccauacaccaggaaucccagaagcag zinc gcugccucaacgggaucuuucucuuccugugaugucaagaccacauunuggacuggacagaaaugaug finger acaaacguuccauagauuauugagucucgaucccaggauaccgagucauaccagaauguuguggaacu protein caaagaggacaagaagccucagaauccaauucaggacaaccuggagaacuacagaaagcugcucucgc AF038939 ugggaguccagcuugccgaagaugaccgacacucucacaugacacaaggccacucaucgagguccaaga gagcugccuacccaagcaccagccaaggucuucaaacccaugccugaggccaaaaagccaucccaca ggcgugggaucuguaaggacgagucuucuccuccuccaagguuccccaggccuaaugauaacu ggaaggacaguuccuccagcagaagagagucagugauccaggagaggguuuuauuuaauuggagcgc auuuaggggcggcuuccgguucaacgcagaccuggcuuccauuaauucagagcucuagaaauuga agaggcguuaccacuuugauucugaugagcgggguucgggccaugagcauaaaagcugugugagg aagaagccuuuugaguguggugcugagaugagacaggcuaugagcaugggcaaccugaacagcccuu ccuucucugagucgcagucaaucgauuuuguuggccaacccauacguguguuuaugagugcgggagg caguncaguuuucaucucugaguunguugagcaccagaucaugcacacuagggagaaccucuaug aauauggagaguccuuuauucanagcguuggcugucaaugaggugcaaagaaguucagguagggggg aaacgcuuugaguguaaggaauguggagaaaccuucaguaggagugcugcccuggcagagcaccgcc aaauccaugcuagagaanaucuuuucagaauguauuagaucaggauugaugaggagaccauca ugccuagcccgaccuunagugauucugcagaaaauguauuggcaaagauaaguucuauaagugc aaggugugcaauagaccuuucugcacaguuccgcccugauuugagcaccagaaaauccaugguag aggcaacucagaugacagagauaaugagcgugaacgcgaacgugaucgucuacgugcacgugcacg agagcagcuuugagcgcgaacgugaacgggagcgugagcgugagcuuggggaacccuuucuuuacc uguccaaacuucaauaaguuncuaagauuguacaggaaaaacaaaaucuuaugagugcaaagugu guauggaaagcuuucuucaucucucaucccugagggagcaucagaaaauccauacuagaggaaa ucccauuuugaaaauaagagcaggaugugcgaggagaccuuugucccuagcagucucuccgacggc gccagaaaacuuacagagagaagcuuguucgacccnaacaaugccagggaugcacugaugggaaac ucagacuccagcgagcaucagaaaaaccuuuucccgaaguuaacuucuungagggcagaggauuu gauuaaacccuucguuuuaaucucagaagagucauacuauaacaagaccaccugaaaacaaagacg augacaagccguucacaaucagugucaacccuaaugacaagcugaaacuccccaucauggaaaau ggcucccagggcaaauccugugagaggucuguuauucauagcuugggcuccgcagaagcucauuaau uagucauuuguggacugguuguucaguaaaccaauuaccaguggcagauuucuagcacccagagc ucaauucagcauuuacuaccccagagcacacucuggaggcaacaccuaugaaggaaaagaauacaag gacucuaucauccauagcuugccagcuccucgaccucugaaacgucauagagcaaaugaccauauuc aaugugaugaggggggagaauccuccauuuauaucccagauauuuauuaauaagggaaggaagau uccugccagagaagaugcuuuaugaaggaaguagcagcagcaacuaccacacaccaaauguaucccg ugcugaaccuccaaaucuuncuggagagucccaugacucuaagcaggauaucacgunuucaguucccag cucaaguguucgugaacaccagaaagcucgugccaaaaagaaguacauugagcccaggaacaacgaga ccucuguuauccacucccuaccuunuggugaguugcuugcaggucaccguagggcaaaguucuungag ugucaguuaaugcguuggaguuccuuugcuucguaauucugagcucanugaacaccagaaganucau ganagagaaagaccuuucuggaagccgacanuaugagcgcucugucauccgcagccuugcgcccag ugacccucagaccaguuaugcccaagaacguuucauccaagaacaagagcguaaauucagagcguu uuggacaacgcucaacuaccagcaacaaccucaguguacagaaaaucuaugcccaagagacauuuu aaugccgaggagccccauganaaagaaacucauauucaaaaaaunucaugacaaagagccauaugg uaaggagcccaguggcaaggagcccauggugaugagccccaggacaaagancccuuguucaggagaug cgcagugaagagccccaugaugauaagccccauggccaggaucccaugauuauaauccca uggccaggaucccaugaugauaucccauagccaguaucccacggugaugagccccauggccaggag ccccacggugaugagccccaugacaagganccauugaucaggagaugcgcagugaagagccccac agugaagagucuucauggugaugaucccauggugaagagucccauggccaggagaaaguugaag augcuuaccauuaggccucaguuucugaagagcaucagaaagaugacguuaggugaugaaucuaug aaugccaggacugugggcugggcuuacuuuncuuaugaccucacaagccaccaggacacccauagcag aaaggcucugguugacagucgugaauaugcacauuugaaguucaugcccacuccgucagcga auuugagaaaaaaugcucuggagagaaacuauaugaauguccaaaauguggggagucuuucauua cauucguuwauuugagcaccagagaguuucacgaacaagaccagcuguauuccguaauugccuguuu augacgcuuucaucuucuuugcccguuagaccaaggauaaauugcnuguugaaaggaauccugccguu ucuuagucagccauucgaugccgucaguguggauaggcuucauucacaguucugcccuaaaugag cacaugagacagcacagagauaaugaaauaauggaacagaguugcuuwagaugagauuucauuca aggccuauccucacugaguaucaugggauugaanagaagagaaguuuucgagugcacaaucuguag ggaaugcuuuucacugccaaacagaucggggaccaccacaccaaagucacaaagauuuauccuaugag uaugggcccuccuacacccaugccuccuuucucaccgaucccucaggaagcacaucccacuguacg aaugcaaagauuuggccaguccuuuccuagacgacacugucauucgcuugcgcaugguguuucaucc ugagcgagaaggugugucagaaauauagcugccacugcccaaaaggucgaagccaauguccuca ucccacaagaaguacugcgaauccauaggucaaaugcagaagcugcugagcccgaaguggaggcu uagagcccgagguggaggcugcagagccugagguggaggcugcagagccuauuggagaggcugaagg gccagauggagaauuugcugagccugauggcgaggcugagcagccaauggagaguuugaacagcc aaacgaugauacugacgagccauacagagccguaaucgaagacccagaagagaaagaugacgaaccug agaaaangucgaagagccagagggagaugcagaugagcccgauggugcagacauugaagacccaga agaggaaggagaagaucaagagauugagguugaagaaccauacuacanugucaugaaugcgcagaan guugcuuccagcuagccuuuggcgagcaucugaaaagucacgccagugugaucaucuucgaucuug ccaauccuggagagugcucuuggcuacauugangggccauaccagugcagguggugcggagcaguag acgacaaguacuucaaaugugaugugugcgguaacucuuangaccgccucucccuugccagacac cagaauucucacacugguugaguaaccaggcugaagaaaagaagaguaagccaaaccuucuucccag aaccagaccuuaauaaaucacaaagagagccuauuaccanccauaaugucuuuaagaaauua ccuuccuguauacauaccggacuucacaucaaagacuuucacucucaucacaanugaaaaaag aaaagacauuuaacgcagggacucuuuwaguuuuaucuguucccuauggaacaucaguguauauu ugggaaagcuagagugaacaucuacaucuuccauuucaucuaaguaacuagauugagggaaaccu agugauauuccagaccacagagguuucccagucgacuguauuaugauaccccuuuauacccunac auaaugauuccugccauguauauaaaugagcaaaucagugauacauuuuuuuaauuuaguguacu auauaauuunaguuunucuuacagagcuaccuagccugguacucuugauuuuuucccugaggag gaagagagcaacaauuuagcauauauuuguaaguauuguccaugcagaagcuuuucuuuagcauca uuugancccauuaguauuccuuucaguaauguguguucuguccccuaccucuuuagauaguccug ugaagauguggguaugaaauaucgugugucuuuuuaauccuggcuauguggaaacaggcauuuuagc uuunagccauuuggugugcacccagaccccuugagacugauuguguaacccuuuacaauauauggau uugucucugugacccaaaucaacccaucccuacauuuauauaccuunagugguuuuuugc Growth Factors, Receptors and Related genes Fz2/   9  uuuuuuuuuuuuuuuuuaccguucuuuauuuaaaaaaauaaaauagga 238 Frizzled 2 (17) guccguagggugcacccuccccccuccugagugaaggagggcnggugc AW123618 aguccggaccugggagaggggaaagcccguaggcaggcgagaccgcuu cacacaguggucuuccaugccggcuguuguugaucgaguguaganu uccuccacgagugcagugucuugccggaccagauccagaauccangu gaugcccacgaugaugucaugagguauuugaucauguagacugugaa gucgggcguugcggggcguguagugguauguaggggauggcuag gcucaugcagugauguuucccaggauacucccagugcucgcgGaaG gccugcucauagaaguagcaggcgaug Dkk3/   6  Sequence below. 239 Dickkopf 3 (22) ggccgcuuucgacgccucuccauucugcucuuuuggcagcccagcuaccggucgugaccagauccagc AJ243964 uugcagcucagcuuuguucauucgaauuuaugcggcggccagcgcggaacaaacaugcagcggcucgg gauuauuuucuguguacacuugcuggcggcggcgguccccacugcuccuuucuccuuccccgacggu cacuuggacuccggcggagccgqucccagcucuucaacuacccucaggaggaagcuacgcucaa ugagauguuucgagagguggaggauucugauggaagacacucagcacaaacugcgcagugccguu uaggagauauaggcggaagaagcagcugcuaaaacguccucuguagugaaccuggcaagcuuaccu cccaacuaucacaaugaucccagcacggagaccagggugggaaauaacacaguccaugugcacca uaaguucacaagauaaccaacaaccagaguggacagguggucuuuuucugagacagucauuac aucuguaggggaugaagaaggcaagaggagccaugaauguaucauugaugaagacuguugauccc accagguacugccaguucuccagcuuucauuacaccugccagccaugccaggaccagcagaua caugggaccaucugugacaaccagagggauugccagccuggccuguguugugccuuccaaagaggc cugcuguuccccgugugcacaccccuugcccguggagggaaagcucuaccaugaccccaccaacc agcugcuagaucucaucaccugggaacuggagccugaaggagcuuuggaccgaugccccugcg ccaguggccuccuaugccagccacacagccacagucugguguacaugugcaagccagccuucg ugguucagccaugaccacagugaggagagccagcugcccagggaggccccggaugaguacgaaga uguuggcuucauaggggaaguuucgccaggagcuggaagaccuggagcguuagccuagcccaggauu auggcauuugaggggccugccccuguggagucacuaggcggagaggaggagauuuaggcccagacc cagcugagucacugguagaugugcaauagaaauggcuaauuuuauuuuucccaggaguguccccaug uguggaauggccgcagcuccuucccaguagcuuuuccucuggcuugacaagguacagugcaguacau uucuuccagccgcccugcuucucuggcuugggaaagacaggcauuugcgguuuaagggcagcggug agucgucccucgcuguuacuagaaacgcugucuuauucuucauggauggaagauuuguuguaggga guggaugggaaggquugaagucuugcucaugauggauuuugggauacagggaggaggaugccugcc uugcagacguggacuuggcaaaauguaaccuuugcuuuugucuuguccgcucccauguugcugag gcaguggcuacacaagagcuaugcugcucugugucucccacauauuucaucccuguuguuuca gcuccuaccucacugucagcacagcccuucauagccacgcccccucuuugcucaccacagccuag gagguaccagagguacuucucucagagccccaugcucucucucucaaccccauaccagccucugug ccagcgacagcccuuccaaauguuagguuagugaaauccuuuguuuuuuauuauuuucuccuuca uaggcacgccugccacuaaggucaguucuaacuugcauugucccucuaacguucguaacaaugug guagacacugcuuccaccgacugcuucaauaccucugaaagccagugcucggagugcaguucgug uaaauuaauuugcaggaaguauacuuggcuaauuguagggcuaguouugugaaugaaauugcaaag ucgcuuagcaacaauggaaagccuuucucagucacaccgagaagucacaaccaagccagguugugua gaguacagcugugacauacagacagaagaaguucugguucuggaugucagucucagaugacgguuu cagguuuccaggaacuauuaccauucuguaucuauccagaguuauuaaaauugaaaguugcacaca uuuguauaagcaugccuuucuccugaguuuuaaauuauauguauacacaaacauguggcccu caaagaucaugcacaaaccacuacucuuugcuaauucuuuggacuuuucucuuugauuuucaaua aauacaaauccccuucauuucaaaaaaaaaaaaaaa Sfrp1   6 Sequence below. 240 Secreted gcacgagcagcccgcagcccgccgcgccuugugcgagccgggacaacacuucggccccgcgcgcuccc frizzled- cgccgcggcgaccugcugcagcggaggaccccaucgaucggagacccggggagcagcgcgcagcccgc related ccgacugcgucuuuguccccggaggcuccgggaaguuugcagcgggacgcgcgcgugaaggcagcgu protein II ggggagcaccccacgccagcccccgacgggcccaucccgacgucgccgaacaacaugggcgucggg U88566 cgcagcgcgcagggucgcggcggggccgccucgggagugcugcuggcauuggccgccgcucugcug gccgcggguucggccagcgaguacgacuacgugagcuuccaguccgacaucggcucguaucag agcgggcgcuucuacaccaagcccccgcagugcguggacaucccgguggaccugaggcugugcca caacgugggcuacaagaagauggugcugcccuuccuuuggagcucugaccauggcaugguuagca gcaggccagcagcugggugccgcuuucaucaagaacugccacaugggcacccaggucuuccucugu ucgcucuucgcgcccgucugucuggaccggcccaucuacccgugucgcuggcucugcgaggccgug cgcgacucgugcgagccggucaugcaguucuucggcuucuacuggcccgagaugcucaaaugugaca aguuccccgagggcgacgucugcaucucaugaccccgcccaauaccaugaugccucuaagcccca agguacuucuuguguccuccaugcaacaacgaauugaagucagaggccaucauugaacaucucug ugcaagcaaguuugcacugaggaugaaaaucaaagaagugaagaaggaaaacggugacaagaagau uguccccaagaagaagaaacccuugaagcuggggcccaucaagaagaaggaguuagaaggcgcuuu ugcuuuuuccugaagaacuugugccgacugucccugccaccagcuggacaaccucagccacaacuu ucucaucauaggccgcaagaugaagaaccaguaccugcuaacagccauucacaaguaggacaagaaa aacaaagaguucaaaaacuucaugaagagaaugaaaaaccacgagugucccaccuuccagucuguu uuuaagugauacuggggcggacugggauuugggauuuguggcuuggggugaggguggguugcgcgugg augacccuggcucuuuggggcucacauauugcucucucccauacaguguggcuuuugcauugcac cugacucuguuccuacagcgaacccucucccuuuccuccauagccacauccagcuaaggccacggc cuuuagauuaggaaggcuuuuuuuuuuuuaagggcugcagcagggccagcagcgacgugcaaa aggagaggcagaauccuuucacugagccuggggcacaaaaaacagaaaauguuuuccgguuugga aaaacaaaacaaaacggauuauaaagaacugcagacggacagcugcucagcucaacguuguucggg acaucauuaccaauugcuuuuggagucuaagccucuacagguagaagagucugaucauugccaagcc aggcugcuuucaguuuauuauuaaucccccucuuucugccuuagauagaccaucgccaccuucaaa acacacacacacacacacacacacacacacacacacacacacacacacacacacacuucugaaagua gccagguuaucccaguauauucgggauagcuaaggguuugggugggaggccauagcuacucuaccuc agcuuuugaacuggccaccuuugauaggaaacugaggucucagauggacacuucuaccaguccaucg ggauacaaggaugccaggcaagggucuugcuuuugucugaaggagguacgugggcaugaagagac augaggcauuucaggcugagaagcaacagcuacuaguuuucaucaauagaguuugaugaaaugag caaagguagaaauuuucaagcaggucacaagucugggugauuuuggggaauccugugccaacagc cucacuuuguaauuccaucuugucacuuucaaaagaucagcaacauaaaacagggauaaaagccc acauucccuccaaggcuugaguaaaaguccacacucagcauuuaaagacuaacgucguugacugcc caaggcugcccucuuaauacaccgccuaugcaugugcuguguauugcaacucugugcaugug cuguggaggagaugggccucauggcugugcuggcagcccguuucaguauagcguggaaagaga caguauccauagacucugcuuuucugcaaggaaagcccuuuuccuuauacaugauugccuauaa uucagacaaauuuaaaaucgcugccugccugagcccuccaccuuuacuuuugcauucuuccgguca uauucuuuugaggcuauagugcccuauccuggagaugguuucauaggcuaacuauucugcagcu uucccaugugcccagagguauuucucaaaguugguaugcuuaauaagugauguaaauuuccagu ucuucuuaggcaaccuuacuccuguugucccug Dab2/  15 Sequence below. 241 Disabled aauuccgaguggccgcgcggcuauuuaaguggcguuacuccgcguccucggcgcagccuugaggcuucggg homolog 2 cgcgggggaagucaugauugcuccacagaugcacuagcuaguccguuuuacuuuguggguuuaguccuuuuu U18869 gaccgcccgccggagauuggcuaguaucagugacugucuacugcuggauuuucuacuugccuucccguc augucuaacgaaguuaaaacaagcacaaccaauggccagccugaccaacaggcugccccgaaagcgc caucaaagaaggagaagaagaaagguucuugaaaagacagacgaguacuuguuggccagguucaauggug augguguuaaaucaaggccaagcuaaucguuuauugaugaugugccuuuacucgagaagacaaaaugagu ucaggauucuaugaugaaacucaagagaauggcagcagcuggucgcucuucagggacaacacaagcaaag aaucugggucaacauuuccuugucuggcauaaaaaucauugaugagaaaacugggguaauugaacaugaa cauccaguaaauagauuuccuucauugcucgugaugugacagacaacagagcauuugguuaugugugugg aggugaaggccagcaucaauuuuuuacuauaaaaacagggcaacaggcugagccauuaaucgucgauc uuaaagaccuuuuuucaaauuaucuuaacccuugauugucaagcuaacaaauugaagcuggguguugac cagauggauuuguuuggggacaugucuacaccuccugaccuaaauaguccaacagaaagcaaagauau ccuguuaguguuaucuaaacucugaaaucuuacaccaaucagaacucuuuaagagaaaauccauuucu uaacaaauggagucaccuccuguuucucucccucgaccaaagccucaggcauccuucuugccugagaacgc cuuuucugccaaucucaacuucuuucccaccccuaacccugauccuuuccgugaugaucccuuugcaca gccagaccaaucggcacccucuucguucgauucucucacaucuccagaucagaagaaagcgauuucugag uagcucgucuacuccacagaguaaagggccccugaacgucgauacuaauuuacuuugguucagcaau uugaccagcucuucuaaccggacuuggcaaaccggaagcuucagggaggcccguggcccuacccaag uucgcagacccagcaagcagugagaacucaaaaugggguaucugaaagagaacagaacggcuuccauauc aaaucuuccccgaacccuuuugugguuaauucccucccaaaggacuaucgguaccgaauguucguaaag cagaacuuggaaaauucuauccaguccucaacacaugacuccauagccauuauucccaccuccacaa aguaccaaaccaggaagaagcagaaggacugcuuaaguuucuucagcaaacgacuugccugcuucagaca ucuuuugccucagaaccuccaggccagauugucccccacauugacaaccugcagucccgcagucgaa cuuccuggaucucuucaaaggcaaugcuccucccccaguggggccccuuguaggucuuagguacgguccca guaacacccccccaaacaggacccuggacgccuguugucuacaguccuucgacaacuaugguccca ggagccauuaauaaguggccagccucccaguuuucgccagccacucguuuuuugguacaaccccagcaguu uacaagucuggaaucagucuccaucauuugcaaccccagcuuccccuccaccccccacaguuuguguccua ccacaucuguggcgcccaacgcuuggucauccacaagcccucuauggaauccuuuucagaguaauaauau cuuuccaccucccaccauguccacucaguuccucuccucagccuuuaugauguccucuguucuggcca caccgccucaaccaccuccccgaaauggcccacuaaaggacauucccaggacgcuuucacuggcuuagac ccccuuggggauaaagaggucaaggaagugaaagaaauguuuaaggacuuccagcugcggcagccaccuc uuguuucccucaaggaagguuggagacgccucccucugggacuucaagcgccuucuccaguuacuuc aacaauaaaguuggcauuccucaggagcauguagaccaugaugauuuugaugccaaucaacuguugaa caagauuaaugaaccaccaaagccagccccgagacaagguguccucuuggguaccaagucugcugac aauucacucgagaacccuuucuccaaaggguucagcucaucaaaccccucuguguuuuuucucagccug caucuucugauccccacaguuagcccuuuaugaaauccuuuugccuuagcuucuugaaguuguaauga ugacuauccagaugagcaaaagacuggcuuuggucaagaaugaagcagacagccagaaacauguuga ccucuguccucgcuccagcuuugacguauuaucuguuacccuauuuguuuuggccucuuguacuuguaa aaugccuuucauuuuccuuucuaggcuaaagcuaaacuuaaacuaugucuuuuguaaauuuuucuccua aacucucuagcuccaauauuaaaugaaguagcuucccuaucaaaucccugucuguugugcccccuuga aacuuccagaauuauucuccauuucuacccuccauuugggaggagcggcuaccuuuacccuuaauau cacacugccuugagucaauguccaaauacucauagcucucaaagucauuuggguuuuccuggugugc ggccuaaaccuaaagcauccuuuaauagggaaguaagacaccuugcuuccuauguccacuucaggga gaauuuuuauuuaauaaaauaaaagcaaaacuaacuucucaaauccacccaaggaccauuuuugagau gguucguuucucagcuaacugcaccauuuuaccaauccugccccaaguggugcuuacauuugacuuuga agaagagaaagagcuaacuuucaaaacacaaggcauuauuucaaagcuaauaaaacaauuucucccug gggccccacauuguuuucauuccagauacguugcagcuguuugacccuaaugacauuaugcccuaca uuuuuuccuuaaaaauccugauuuuuauuuucaugugauuuuuguuucuucaauaaagaugauuauugug uuugcacggaauuuc Cktsf1b1/  12  augaaucgcaccgcauacacuguaggagcguugcuucuccuccugggg 242 Gremlin, (12) acccuacugccaacagcugaggggaaaaagaaagguucccaaggagccau Cysteine uccgccuccugacaaggcucagcacaaugacucugagcagacccaguccc knot caccacaaccuggcuccaggacccgggggcggggccaggggcggggcac superfamily cgccaugccuggagaggaggugcuugaguuccagccaagaggcccugcac 1, BMP gugacagagcgcaaguaucugaagcgagauuggugcaaaacucagcccc antagonist  ugaaacagaccauccacgaggagggcugcaacagccgcacuaucaucaac 1 cgcuucuguuauggccagugcaacuccuucuacauccccaggcacaucc AF045801 gaaaggaggaaggguccuuucagucuugcuccuucugcaagcccaagaa guucaccaccaugauggucacacucaacuguccugagcuacagccaccca ccaagaagaaaagggucacacgcgugaagcagugccguugcauauccau cgacuuggauuaa Fgfr1/  10 Sequence below. 243 Fibroblast auggaauuauccauggagguacauagccuuuguuaccaaccuuuuaaccgcagaacugggauguauggcua growth gaagugccuccucuucuuugggcuugugcuuuggucacagccacucuuucugcacugccaggccagccccaa factor accuugcccgaacaagcucagcccugggggucccuguggaaguggagucucuccugguccacccuggcgac receptor 1 cugcuacagcuucgcugucggcuucgcgaugaugugcagagcaucaacuggcugcgggauggggugcagc U22324 ugguggagagcaaccguacccgcaucacaggggaggagguggaggugcgggacuccauccccgcugacu gcuggccucuacgcuugcgugaccagcagccccucuggcagcgauaccaccuacuucuccucaaugucuca gaugcacucccauccucggaagaugaugacgacgacgaugacuccuccucggaggagaaagagacggaca acaccaaaccaaaccguaggccuguagcucccuacuggacauccccagagaaaauggagaagaaacugc augcggugcccgcugccaagacggugaaguucaagugcccgucgaguaugacacccaaccccacucuugcg cuauugaaaaauggcaaagagugacaagggcaacuuacaccuuucaucguggagaaugaguaugggagca ucaaccacaccuaccagcuugacuuucguggaacgaucuccgcaccgacccauccuuucaaucagggcu gccugccaacgagacaguggcccuaggcagcaauguggaguuucauguguaagguguacagcgauccgcag ccucacauuucaguggcuugaagcacaucgaggugaacgggaguaagauucgggccagacaacuugccg uauguccagauccugaagacugcuggaguuaauuaccaccgacaaggaaauggaggugcuucaucuacgga augucuccuuuugaggaugcgggggaguauacgugcuuggcagguuacucuaucggacucucccaucacu cuugcaugguuugaccguucuggaagcccuggaagagagaccagcuugugauugaccucaccgcucuacc uggagaucauuuaucuacugcaccggggccuuuccugaucuccugcauguugggcucugucaucaucuau aagaugaagagcggcaccaagaagagcgacuuccauagccagauggcugugcacaagcuauccaaga gcaucccucuggcagacagguaacagugucagcugacuccagugcauccaugaacucugggguuucuccug guucggcccucacggcucuccuccagcgggacccccaugccggcuggagucuccgaauuaugagcuucccu gaggauccccgcugggagcugccacgagacagacuggucuuaggcaaaccacuuggcgagggcugcuucgg gcaggugguguuggcugaggccaucgggcuggauaaggacaaacccaaccgugugaccaaaguggccgugaa cgauguugaaguccgacgaacggagaaggaccugucggaucuugaucucggagauggagaugaugaaaaug uauugggaagcacaagaauauucauucaaccucugggagcgugcacacaggaugguccucuuuaugucauu cguggaguacgccuccaaaggcaaccuccgggaguaucuaaggcccggaggccuccugggcuggaguacuu gcuauuaaccccagccacaaccccgaggaacagcugucuuccaaagaucugguauccuaugccuaucaggu ggcucgaugcauggaguauucuugccucuaagaaguguauacaccgagaccuggcugcuaggaacguccu ggugaccgaggauaacguaaugaagaucgcagacuuuggcuuagcucgagacauucaucauaucgacuacua caagaaaaccaccaacggccggcugccugugaaguggauggccccugaggcguuguuugaccggaucuaca cacaccagagcaauguauggucuuuuggagugcucuugugggagaucuucacucuggguuggcuccccaua ccccgguuguaccuguggaggaacuuuuucaagcugcugaaggagggucaucgaauggacaagcccagua acuguaccaaugagcuguacaugaugaugcgggacugcuggcaugcagugcccucucagagaccuacguuc aagcaguugguggaagaccuggaccgcauuuguggccuugaccuccagccaggaguaucuguuaccugucc auaccgcuggaccaguacucacccagcuuucccgacacacggagcuccaccuuucuccucaggggaggac ucugucuuuucucucaugagccguuaccugaggagcccugucugccucgacaccccacccagcuuugccaa caguggacucaaacggcgcuga Fgf1/  10 auaucugaaauggagauucacaaccuucgcagcccugaccgagaagunca 244 Fibroblast accugccucuaggaaacuacaaaaagcccaaacugcucuacugcagcaac growth gggggccacuucuugaggauccuuccugauggcaccguggaugggaca factor 1 agaucaggagcgaccagcacauucagcugcagcuucagugcggaaagug M30641 cgggcgaaguguauauaaaggguacggagaccggccaguacuuggccau ggacaccgaagggcuuuuauacggcucgcagacaccaaaugaggaaugu cuuuuuccuggaaaggcuggaagaaaaccauuauaacacuuacaccuccaa gaagcaugcggagaagaacugguuuugugggccucaagaagaacgggagc uguaagcgcgguccucggacucacuauggccagaaagccaucuuguuuc ugccccucccuugucuucugacuag Gpr49/  64 Sequence below. 245 G protein- (377) auggacaccuccugcguccacaugcuccuguccuugcuggcgcugcugcaguugguggccgccggcagcuca coupled ccgggaccagaugcgauaccgcggggcugcccaucacacugucacugugagcuggauggcaggaugcugcuc receptor 49 aggguggacugcucggaccugguugcucucuugagcugcccuccaaccucaugucuucaccuccuaccu FEX ggaccucaguaugaacaacaucagucagcuacccgccagucuccuacaucgccucugcuuccuagaagag AF110818 uuacgucuugcuggaaaugcuuugacacacauucccaagggagcguucacgggccuucacagccucaaag ugcuuaugcugcagaacaaccagcugagaaagguuccggaggaagcgcuacagaanuungaagccuucaa ucccuuucgccuagaugccaaccacaucagcuacuuugccacccagcuguuucagcggccugcacucccug aggcaccuguggcuuaaaugacaaugcuucucacagacgucccuauccaggcunucagaagunuaucagccc ugcaaaccaugaccuuggcccugaacaaaauacaccacauagcagacuacgccuuuggaaaccucuccagc cucgugguucugcaucuccauaanaanagaauccacucccugggaaagaaaugcuuuuuauggacucca cagccuggagacuunagauunaaanuauaanaaccuugauaaauuccccacugcaaucaagacacucucca accunaaagaacuagganuccacagcaacaacaucaggucaauaccggagcgagcguucguaggcaacccu ucucuuaucacaauacacuucuaugacaaccccauccaauuuguuuggaguaucugcuuuucagcauuu gccugaacuaagaacacugacuuuugaauggugccucgcacauuacugaauuuccucacuugacaagaac ugccacccuauagagucugacuunaacuggagcaaagaucucaucucuuccccaaucccuucuaugaucag uuaccuaaucuccaagugcuagauuugucuuacaaccuacucgaagacuuacccaguuugucaggcugc caaaaacuucagaaaauugaccugaggcauaacgagaucuaugaaauuaagggcagcacuuuucagcaguu guuuaaccuccgaucucugaacuuagcauggaauaaaaungcuaucauucaccccaauacguunucuacg uugccgncucuaauaaagunggaccuaucauccaaucuuccugucguccuucccugugacuggguuacau ugguuuaacucacuuaaaauuaacagggaaccgagccuuacagagccugauaccaucugcaaacuuccca gagcucaagauuauagaaaugccaucugcuuaccaguguugugcauuuggggggugugagaaugucuana aaanuucuaaccaauggaauaaagacgacggcaacauuuguggacgaccuucauaagaaagacgcuggg uuauucaaguucaagaugagcgggaccuugaagauuuccuacuugacuuugaggaagaccugaaugcc cuucacucggugcagugcucgccuuccccaggucccuucaagcccuguuagcaccuauuugguagcua gcugauccgaaucgggguauggaccacggcaguacugacgcuuuccugcaaugccuugguggcuuugaccg uguucagaacuccccuguacaucucuuccauaaagcugcuaauugggguaaucgcgguaguggacauucuc augggggucuccagugcugugcuggcugccguggaugcauucacuuuuuugccguunugcucagcacuu gugcguggugggaagacggaaucuugcugccaaaucguuggcuuccuguccauuuuungcuuccgaaucgu cgaucuuccugcucacucuggcagcgcuggaacgagguuuuucugucaagugcucuucgaaguuugaagu gaaagcuccccuuuuuagccugagagcgaucguuuugcuauguguccuguuggcccugaccauugccacaau ccccuugcuaggauugcaguaaguacaaugccucuccccucugccugcccuugcccuuuuugggauccauu caccacgggcuacaugguggcuucucguauncucaacucucucuauuuccucauuaauugaccauuaccua cacaaagcucuacugcaguuuggagaaauagagcuggagaaucuuugggauuguucgauggugaagcacau ugcucuguugcucuucgccaacugcauccuuuacugccccguuugcuuucuuauccuucuccucuuugcua aaccucaccuuuuaucaguccugacgucauuaaauuuauacuucucguuuaucgucccacuuccuuccugu cucaacccacuucucuuacauuguucuucaauccccauuuuuaaggaggauauaugcagccugggaaag cauacccguuucuggaugagaucaaaacacgcgagucugcuguccauuaacucggacgauguugagaaacg guccugugagucaacccaagccuuuaguauccuuuacccacgccagcauagccuauncuugccuuccacuu ccgguugcaucaccagcuuaccccaugacugaaagcugucaucucucuucaguugcauuuugucccauauc ucuagugacuauaagagaggaacguuuuuaagaguuggaaaccugaaaagugauuucuaucagagcagua gcuaagaaaagcugagcuaaaaaccuaccuuaaaacccaagcaaacaucucuaaauugguguggaaacagu ggugccuuagagcaggagagcaucauuaaacaccgcuuguaucauuuguucaacuaagaauaaagccauca aguucacuuagaugaacccagaugagaaaagcagccugaaaugcucuuucgcauuuguaguucucuucuga cucaccagcauagucucccauagugagaagacucguuggaugacucaauggguguauuuuaaauccacaaa uuccuuguuuaaaagguuagaguuuuaagaaaaaaaaaaaaaaaaa Igfbp5/  37 Sequence below. 246 insulin- uuuuuuuuucuucaccuccucccuuuucaaggccuccaaacuaauuauuuucuguuugcuuuauagugagc like aauucugugguuucucuccaccaccacccccaauucugacccgaucccgccuggggguuucuacggucuc growth cgcucacucugcgugcaccuggcgcgccucuuuuuuucacccccaaccuguugcaagucuuuaauccucgca thctor auugggacuugcgugcaggcaccugaauccuccuuugccucauauuuuugcaaguguuugggauagagcac binding cugcucuaccugcaagagauuuaaaggaaaaaaaucuccaaucucccucuuucuccacacacucucgcucu protein 5 ccugccccgccccgagguaaagccagacuccgagaaaauggugaucagcgugguccuccugcugcuggccg L12447 ccuaugccguaccggcucaaggccuggguucuuucgugcauugugaacccugcgacgagaaagcucuguc cauguguccccccauccucugggcugugagcuggucaaagagcccggcuguggcugcugcaugacuugc gcccuggcggagggacagucguguggugucuacacagagcgcugcgcccaggguuugcgcugccuccccc ggcaggaugaggagaagccgcugcacgcccugcugcacggccgcgggguuugccucaacgaaaagagcuac cuucgcauuuuccgagcugaagggcugaggcugugaagaaggaccgcagaaaaaaacugacccagucca aguuggcgagcaaaccaagauagagagagacucucgggaacacgaggaacccaccaccuccgagauuugc ugaagagaccuacucccccaaggucuuuccggcccaauucacauuguggggggugcagagaacacugccc accccagagucaucccugcaccugagaugagacaggaauccgaacaaggccccugccgcagacacauguau aucuucccuccaggaguucaaagccagcccacgcauuugugccccgugcuguguaccugcccaacugugac cgcaaagaauucuacaagaaaaagcaguguaagcccucccguggccgcaaacauggcauucugcuagugu uguagacaaguacggaauugagcugccgggcauggaguacguggauggggacuuucagugccacgccuucg acauucauuuaacguugagugacgcguccccucccuuccucccccuauccuacccccccagccccaacuc cagccagcgccucccuccaccccaggacgucacucauuucaucucauuuuaggggaaauauauuauaca uauauauuugaggaaacugaggaccucggaaucucuagcaagggcuaaagagacacuccccaccaugaccc cggaaauguauuccuuuuuugaagcaaguugaacggacagagaagggaaggagagaagaagcaagaggga gcgagagauggaaagaaagcaaagcpuggaauagaggaaaagagggaaggacagauaggauuagagagag aagagagaaacagcaaggcagaaaggacuccacaaccaaggcugaaucugcccuuuuucuuucagcucua gccuggugucagaaaaauuugcuccugcagccagcaguguggauggcuagaccccucacccucccuccuc cuuacccaagugcagugugauucauccccaaauuacaaagacuaaaauuucauuccaucccucuuuaaaau aaacaaaagugaguuuauugaagauagguuauucccccagcagacaaaugaacucagaauauguugca aauuuuacucuuguuaaagauuuuuuuuaagaagucaguacgcacccccaacacuggaaagacuugauucu ccagggugacaagcaauucagaagcgcguggcuucggcccuugauuucacuagacucaaagcuggcccgga gccucuguggaggaggaugagagguggagaaaaccaaggggcuuguacucacccacaauuacuccauguag acuuuauagacauauaaaucuauuuucuuuuaccuuuuuuucccuuucccuuucuuucgaaguuuuacauu accucuuuaaaguaguuuuuuuuuuaggacacuuugaagaucuuccucauuucugggaaaaauccauauu ucacaaauacaacccagaacgccagcuuuggccugcguccaggcagccuuucucgugauucuacaagugug gcucuuuuuuuggggcaccgauuugaucuucucaugauuccaaacguguguugaaaugaauccaccaagcc aggaacugccagcacccaaaggugcaucaagugcauuaacccaagucaccccauuucagccuucca acccgcagaaaguaacugucucacaccacaccacauuaaaccugccagauccaucuguaacccacuggccu gcccagaccuuuuuuucccaucugcauuuuuuuuuuugaacugcauuuugaaagccucccucagaugccag gcugacagaucaaagagaaacuaacaugaaagaugacagaggaggaauaaguggaggguugauggcaga gacuuccacagagagacauagaaaauggagcagaggucuggggguggggaggacaagaaagagacagagag caggaaaauuaccaauagaauuuuuccuuggugucuuuccaucuaaucaacucucugagauuugagaggaa aaagaaggcaggggaagaacuugagguagaaaugaggucaguucaagucacagggcccagauuugugggua acugaggcaggauccagacuuuagacacacgguuugaaacaaggcugguuauuccugacuggguauuugaa gggugaagaggaugccuuggaaagacagcacaacuucaguuuucaacuucaggcccccaaggaggaacu gaggccaaagaauccuuucaagugcuucauuggucuccucugcccgacucaaacauccuucccugugaugg aggaugguagaaagcccaggacaacucaggcccguuaucuucacgacuguugucauuugccagccugauu auuuauccaagagaagcaucucauugcccacuggcuucuuucaacaaaaaggugcuuaacaaaaggcuc aagacuaucuuuugaagacugaagauaaccuuccaggagaggagacucgugcauugguacaggaggcccc uuuuuggcgggggacacagcucuuugcuucucucuugauguucauggcauaguagaggcccccuccaa cccggauauguuagcaacacaaaguugagagcaaagaaacugacgugcgucgacucauaguuacaugggug gcugcaugcacagaaagauaugccuccuauugccuggacaggacaguuggcugggaaggaaagagaaaa uugaucuucauuaagacaaagggccugaugggauggcaauagaaggacuuaccagaccugcagggucagu auacccaucaccccgcacaacauccccauucccccaacucaaacuucaauauaucuuaggccaguauccua gaccuaagucucuccuuucugccauuauuucuccgcaucuugagcagucaucugacuugagauuugccaa guuggauacugggauaccacuugccccccaagaaaagacuugagccagaaacugccuuacuuucgcucccc cucccgagccuggagcuaacuccugugaggggugcucucuucaccccacaacuuacuagaccuugagug agccucugucccuuaugugggcucuucgcugugagccacagauggaggucauuuguauagacaguuagccu uccccaagucagccuaccucccccaaacuugugaguucuccccgcugcuucauuauggaaaggcaucuaa gacagcaagucuuucuagaggaagcuugccuuuuaacagacagauggaacuaaaccuuccaaaugggaga ucuggcugaacccaggauuacagagaccauggacauggaugggpucaucaagagaagagggauguccuu cuccagguuagggagagagaaggcaaguuugcaacgaucccaucaugcccugagcaagaagcuauuguuc ccauugcuagccuuuaacuccauuagaggccucucuguuugguuuauccacagcaguaggcccaaguaug gccuguuuccccaccucuacuuuaucccguggaagguuuucuucccaccccuuuuuugacaaaugccuca cucgagcaguggaaagauagcucucuucccccucuuucugccagguaacaaagagaccuaaccaggacc uauucuccaccccagccagucuuugaccagccagaacaaauucagggaaccuggagaauaaaagacucuac uuuuccucuuuacaaagacucuuguuucucugacggccaauccuaaacagacaaggcuuguaacaucug uccccacaggauacggaggagguucagcuguugcucacuccucuucuccuuccaagacccucuuccgacc augacuuaucuccaugguuacauccucaccaucauucucccacuaccaaggguugccauggcaaccuccc aaccaccugcccaucccaggcaggcagcuguccuucugcucauuaacccuauuaggacucuaguugaaauu uuacagcuuuaagagaauagugagccaaggagaagagacccuauaguccucuuggcuuuucaagagaaga aggcuaugauuuuaaaacacaguagaagggaaagaggucucgucgaggucgaccucucccggggagcuug ggguuguacugucuuuauuuuuaaaccacuaaagugcaauuuuuccuacacucuuguuaccccgccucu ucuuucccuguuuagguuuuuauuuccuugaacagacuuuuugguuuuuuaauggaguauagacuuuacc acuucacagacucuggccuccucuccaagucucucuggauggggaaaaggaagguagaggpcagaggggaa ggggucccucgucaccccgcauccauucacccccacuucucuggucccuagucaccuugcuucaccccuau cuccgacaccaucacugucacacaguagccugucacacggauaguacaguuagacaagacuccuucagauu ccgagacgccuaccgguuguuuuugguuuuuguuuuguuuucuuuuguuuguuuguuuguuuguuuuuuac aacagcuuauaaccacaucacauauuacuguagcucucuauaguguuacguucagacaccpagcucugucc uucucuuauuuuguugguuuuugacuuuaaaaaaaaauacuuaugcuuuuuuuacuguuugaaacagauu gaaauaaaaauugaacaacaaaccaguugugaaaaaaaaaaaaaaugugaaaaaaaaucaccccgaugugg aagagcuucggcuccucuuuagcauuuuguacuuuaaggaaauaaaaaagaaaaaccuggaagaucucac auuuuauuacaaagugaaaaaaaaa Myoc/ 111 Sequence below. 247 trabecular guccagucugcagucuguauucggaagacauagauacuaaauacauggcaacucuuuuuuuuguuuguuuua meshwork auucaucaggauguggagcgcuagucuuggguaggagagccagucacccugaggacagcugaaacaaucgc induced uggcaaguauggaguguggaugagagaccccaagcccacccaccccuuacacccaggaaagcacauggauu gluco- gauuucauguuggcacagagaucuccagguguuugaauacagucagauaagccaauucgagcagggcuauc corticoid cuuccaagguccaugugcucccucgggcacuuggaggcacgggugcugugguguaugcggggagccucuau protein uuccagggggcugaguccagaacuguggucagguaugagcuagacacggagaccgugaaguagauuaagg AF041335 aaauucuggagcuggcuaccacggacacuucccguacgcgugggguggcuuacacagacauugacuuacug uagauugagcggccucuuaucaucuacagcacgaaggaagccaaggaggccauaguccucuccaaauugaa cccagcgaaccuggaacuugagcguaccugggagacuaacauccguaagcagucuguggccaaugccuuu guuaucuguggcaucuuguacacggugagcagcuuacuucuucauuccaugcaaccgucaacuucgccuuc gacacuuaaaugggaccauuaagacccugaccaucccauucacgaaucgcuacaaguacagcaguaugauu gacuacaacccccuagagaggaagcuguuugccugggacaacuucaacauggucaccuaugauaucaagcu cuuggagaugugaggagccucuaugccuaccagcaaaggccagaaaaggugaaguucgucucccggguga agcagcugucagcagaggcaucagaugcauggaguuuucuccuccugcuuagauuuuauuuuccaggucaa uguacagcuacuccccucugacugacacguccuccaggcuuuguauagucgcauagacucuuguuucuucu gucagcuuucaaagggcuguuccucuuuuaaaaaucacauagug Itm2a/E25  30 Sequence below. 248 putative gggagaccugagcucgcugcugccuguggaagacugggagaggagacacuaagugcugcucaagcaagcgc Integral gauccucuccucuuuucauccugcagcccaagauacugauucgagccguccuuaccgcuagaauuuuucac membrane cauggugaagaucgccuucaacaccccuacggcggugcaaaaggagaaggcgcagcaagauauagaagc protein 2A gcucaucagucgcacuguccgagcuucaaauccugacuggcaaggagcucagaguugucccgcaguuaga L38971 aagaugucucaucugggagaugcaugcuuacucuccuaggccucucauucaucuuugccaggacugauugu ugguagagccuacauuuacaaguacuuucaugcccaagaccaccauuhuaccauuggugagaugugcuucu uugauucugaggauccugucaauuccauuccuggaggagagccauacuuucugccugugacugaggagucu gauauccgugaggaugacaacauugccaucauugaugugccugugcccaguuucucugauagcgauccgg cggcaauuuauucacgacuuugagaagggaaugacugcuuaccuggacuugcuuuugggaaacuguuaucu gaugccccucaauacuuccauuguuaugacuccaaagaaucugguggaacuuuuuuggaaaacuggcaag uggcaaguauuugccucauacuuaugugguucgugaagaccugguugcuguggaagaaauucgugauguu aguaaccuugguauuuuauuuuaccaacuuugcaacaaccgaaaauccuuccgccuuuagacgcagagacc uucugcuggguuucaacaagcgugccauugacaaaugcuggaagauuuagacacuuccccaaugaauuuau cauugaaaccaagaucugucaggagugaaaugugacagauaaacaguauccuugauaauuaagaaguca aggaacuuaccgucugacuuggaaaauuugaaauuugaugggauacucaugcuauuuacucauacauuua cucuauugcuuauuacuggaaaaggaaagggaaaggggggagaaaacuacuuaaccacugcaagcgauug uccaauuucuacuuuauugacauugcuuacuuguuuucaacaagucaaaugauuaucuuuuucuucuuga auuuuauacgguuuuagauuucugaaagcagcaugaaugugucaucuuaccauccugacaauaaagcccau ccucugguuuuauuuaaagcaagcucuuuccaacaucacuuggcuagagcaugcuuuaaauuuuaaaauau auuugaaauuuuguuuugacauuuuuuugugugaaacaugucaaaucucuuaccauucuuuaguuuucuuu cuuuauuaucuucaacucuccugauuucacauuuacauuuuugcauuucuuaucaggugcuguguaacgaa ucugacugauaugugaacaaucuucaugaggaagcaauuuuuuuacucauguaaugauucuuucucacuga uaauaaaguuuuaccguauucaauca Eps8/  15 Sequence below. 249 epidermal ggccauuaccaaucgcgacccgcgcacacacggcccgggcggcgggcgaagcgggcucccggggcgcugggc growth gcagggcgcggcacaagccccaacaacgucucugcaacgcggcgcggcgggcacuccagcucccagaucuu factor uucucccucggucaccucccucgcgucuaggaggucguggcacucccugaggagcgcggcugcucggagg receptor gcggauccuagaacagaggcgugagagccggcaugaauggucauaugucuuaaccgcuccaguggguaugg pathway agucuuacccuucucaacugaaugguuacggaucuuuucaccacccuauuucccagauggacagagaaca substrate 8 cagcucaagaacaagugcaaaggcccuuuaugaacaaacgaagaacuaugccccagacagugucagcagug L21671 ugucggacgugucccaguaccgcguggaacacuugaccaccuucgugcuggaucggaaagaugcaaugau cacugucgaggacggaauaagaaagcugaaguugcugUuaugccaagguucaaaguguggacucaagauau gauucuccaaguggaugaccgagcugugagccuugauuugacuuagagucaaagaaugaauuuggagaauuu uccucuuaaacacaaucucgcauugucaagcaguggugcaugcaugcagcuaugacuccauucucgccuu gguaugcaaagagccaacgcagagcaagccagaccuucaccuuuuccagugugaugagguuaaggcaaacc uaauuuagugaagauaucgaaagugcaaucagugacaguaaaggugggaaacagaagaggcggccggaggc ccugaggaugauugccaaagcagauccuggcaucccuccuccucccagagcuccuugccccuguaccacc gggcacugucacacagguuggacguuaggaguucgcguagcagccugcucugccuaggcagcugaccagg gugacuucgagaagccccggcaguaccacgagcaagaagagacgcccgagaugauggcagcccggaucga caguugaugugcaaaucuuaaaccauuugguuuuggaugacauugaauuuuuuaucaccaaacuccaaaa agccgccgaagcguuuucugacuuuucuaaaaggaagaaaaguaagaaaaguaaaacgaaaggaccuggag aggacguuuuaacacuugagggcaaaacccccaccuccugacgaguuuguugacuguuuccagaaguuuu aaacauggauucaaccuucuggccaaguugaagucccauauccagaacccgagugcuucagaucugguuca uuuuuguuuacuccacuaaauauggugguccaggcaacagguggcccugaacuggccauaucaguacuc agcccacuguugacaaaagacacaguugauuucuuaaacuacacagccacugcauaggaacggaagcugu cggaugucacugggagauaguugggugaaagugagagcagaguggccgaaagaacaguucauucccacc uuuacgucccgagguuccgcaacggcugggagcccccgaugcugaacuucaugggcgcgcccacagagca agacauguaucaacuggccgaguccguggccaacgcagaacaccagcgcaauaggacagcaagaggcugu ccacagagcauuccaauguuuuccgacuauccucagccgacggauaugcguacaguagcagcauguacca cagaggaccacaugcagaccacggggaggcugccaugccuuucaagucaacuccuaaucaccaaguag auaggaauuaugacgcagucaaaacacaacccaagaaauacgccaaauccaaguacgacuuuguguucga ggaacagcaguagcucucgguuaugaaagaugaugucuuagagauacucgacuuaucgaaggcaguggua gaaaguccauaaugccaguagagacucuuggguuugugccaaauaacauucuagauaucaugagaacucca gaaucuagaguggggcgcgcugaccccccauacacacauaccauacagaaacaaaggacggaauuggccu gagaucagcugacacuccuucugccccaucacccccuccauuuccagcaccuuuccggucccccuuccacc auucuguaccagcacccuuucugugcccaaguuccagcagauugucacccgccagaacagcagcuccaaug acaguaggggcagcauuaugcaugacagccagagauacaaacaacucccaguggaccgaaggaaguuucc gcagauggaagagguucaggaugagcuuucuuccagaggcugaccaucgggcgcagucugaucagaggaag uuccacgugccacggcagauguuccagugaucaauaucacuuaugacuccucaccggaagaaguaaaaacuu cggcugcagucaaagggauucaaucccgugacuaucaauuagccucaugguuguuaaacggagcacaacu cuuuucuucaacaaagacgaacugaggucugucugcccggaaggugccagagucuuuuaaccaaaucacu uuguucagaaagcugcuuuggaggacaguaauggaagcuccgaguuacaagagaucaugcggagacggca ggagaagaucagcgccgcugcgagcgacucgagaguggagucuuuugaugaagggagcagccacuaagucc augaacuuccuuauucuuauuguuggucguugaacagugauggacaugcuuuguuuuaagaagccuugaa ggggaaugucaaagcuugucguuucuugguauuauguaauuuuaucgccauauaaggaaacagauaugc cugaguaagcagaggacccgcugcuucugugcacauuaguuugauuaaaacugagaagcggguagguagau ggcucagcaaguaaaggugcuugcugccaagcccaaugacccauuuuucgagucccugggucuacauuu guaguuagagagcuggcuuucugcaaguuguccucugaccaccacacauaaauaaauaacaaauguaauuu auacaaacuuuuaaaagaaaauguaauuuaaaaaaccagacguucuagacugucugggcuugggaaauauuu uuuucacuuuccuaagguguacuuuccuuugcuacauuaauuuugcagccuuguucgaugaucuaaguuu gggauuuuuacaauggcagauuuauucauugcaacaaggaagacacagccauuugaugaaaaaaaaaaga aagucuucagcuuucagugacuaugauaccugcuguccaaugaggaggcucaguuagacuacccucugcuu acuuugaggucugacaugcccaaugagaguguauuuagcuuuauuuaaaguucuuaauuccaacaguuuu aaaaaucacauuuaaaugauuguacaagguagccagaccuugaauguaugaauagacuauauuauaugucc cgagaaacuuuguuacucuucagcucuguugauugcgaaaucuugcauagauuuuaugcuuugauuuaguu ucu Fyn/Fyn  10 Sequence below. 250 proto- ccugggccccgccgcagacgcgcggagccgccugggccgcgccggaggaaggcgaggagaggaccauguaa oncogene augugcuccggagcugagcgccaagccaagcaguguuugaaaggaucaggaugcugaucuauucguggcaaa M27266 uagucaguccgaccgcugguuucguagacaugugguguauauaaaguuugugauaguugguuugauauuugg gagcuuggauaaugguucuguuuugcaauguaaggauaaagaagcagcgaaacugacaaaggagaggga gcggcagccugaaccagagcucuggguaccacuauggcacaaccccaccccucagcacuaccccagcuu cggcgugaccuccaucccgaacuacaucaacuuccacgcagcugggggccagggacucaccgucuuugg ggguguuuaacuccuccucucacacugggacccuacgcacgagaguuagggacaggagugacacuguuu guggcgcuuuauaacuaugaagcacggacggaagaugaccugaguuuucacaaaggaaaaauauuucaua uauugaacagcucggaaggagauugguggpagcccgcuccuugacaaccggggaaacuuuuacauucccag caauuacguggcuccaguugacuccauccaggcagaagagugguacuuuggaauacuuggccgcauagau gcugagagacagcuccuguccuuuggaaacccaagagguaccuuucuuauccgcgagagccaaaccaccaa aauugccuucucacuuuccauccguaauuaugaugauaugaaaggggaccacgucaaucauuauaaaaucc gcaagcuugacaaugguggauacuauaucacaucgcgggcccaguuugauacacuucagcuacugguac agcauuacucagagauagcugaugguuuguguuuuuacuuaacugugguuucaucaaguuguaccccaca aacuucuggauuggcuauagaugcuugggauguugcacgugacucguuguuucuggauuaagaugcuggg gcagggguguuucgcugauguguggcuugguaccuggaauggauauacaauaguagccauaaagacccuuu agccaggcaccaugucuccggaguccuuccuggaggaggcgcagaucauguaguagcuguagcaugacaa gcuggugcagcucuacgcggucgugucugaggagcccauuuacaucgucacggaguacaugagcauagga uguuugcuugacuucuuuauagaugguuuaaggaagagcucugaaguuaccaaaccuuguagacaugcgg cacagguugcuacaagaauggcuuacaucgaacgcaugaauuuuauccacagagaucugcgaucagcauu cauucuaguggggaauggacuuauuugcuagauugcugacuuuggauuggcucgguugauuguagacaaug auuacacagcaugacauggugcgauguuucccauuaaguggacagcccccgaugcggcccuguauggaag guucacaaucaaaucugacauauauucuuuuggaaucuuacucacagagcuggucuccaaaggaagaau gccauucccaggcaupacaaccgggaggugcuggagcagguggagagaggcuauaggaugcccugcccac auacugcccgaucucccugcacgagcucaugauccacuuucuggaaauaggauccggaagagcgcccuu accuucgaguacuugcagggcuuccuggaggacuacuuuacauccacagagccccaguaucagcccauu gaaaaccugugagagccugcgcuucagacgccucuucccgaggccucccuaccccuccccauuugcuuc caauucuguagccagcugccccagagcaggagaaccguccaggaucagauugcaugugacucuugaagcug aucuuccacuugcccucauuuaugacacuugucccccaguccgaaccuccucugugaaccaucugagacag aagcguguuauuucucaaacuuggaaaugcauuguaucgauguuaugucaaaggccaaaccucuauucag uguauauagcugcuccugugccaucaaucccagugcuuuccuuuuuuuaaaaagaaauagcauauccu augugauuuuuacucugauuucaccugauucaacuauauaaaaaauaguauuuuuuuccaauaguggcc ucuuugucuaauacauuauauuuuuuuuucauguuuuaacaaaaaaaaaaaaaaaaaaaaaaaa Structurally-related Col6a1/  36 Sequence below. 251 Procol- cccucccuggcucucuccucagcucugggcucugacugcagcaagcagagacaaccucucacucugccuuu lagen, type cccagcgcccacccugacccuggcccacauuugacggugacucgcaggccagccagaaacaugaggcuggc VI, alpha 1 ccacgcucugcugccccugcugcuacaagccuuucugguuuggccacacaggacauccagggcuccaaagc X66405 gauugccuuccaauuacugcccuguggaucuauucuucguacucgacaccucggaaaguguggccungag gcugaaaccuuauggggccuugguggacaagaugaagnccuucacuaagcgcuucauugacaaccugag agacagguacuaccggugugaccgcaaccugguuuggaaugcgggugcgcugcacuacagugacgagg uggagaucauccgagggcucacgaucaugcccaguggccgcgaugagcucaaggccagauuggaugcggu caaguacuncaggaaagacaccuacaccgacugcgccauuaagaaagggcuggaggagcugcucauaggga ggcucccaccugaaggagaacaaguacuuugaucguggugaccgacgggcauccucuagagggcuacaagg aaccaugcgggggucuggaaaugcaguaaaugaggccaaacaccugggcaucaaguuucuuuucuguggcc aucacaccugaccaccuguuagccacgucuaaguaucauugccacagaccacacauaccgacgcaauuuca cagcagcugacuaggggcauagccgcaaugcagaagaggucaucagccagaccauugacaccauuguggac augauuaaaaauuaacguggaacaaguguguuguucuuuugagugccaggcugccagaggaccuccagggc cccgaggcgacccuggguaugagggggagcgaggaaauuccaggucuuccgggagagaagggagaagcugg aagacccuggacgaccuggggaucuuagaccagucgaguaccaggguaugaagggagaaaaggggagccgu ggagagaaggguuuccagaggaccgaaagguuacaagggcgagaaaggcaagcgcggaaucgacggggucga cggcaugaaggggagacgggguacccaggacuaccugcugcaagggcuccccaggauuugauggcuuuc aaggacccccgggucccaagggugaugcuggugccuuugggaugaagggagaaaagggugaagcuggag cagacggugaggcugggagaccagggaacucagggcaccuggagaugagggugauccuggagagccugg uccccccggagaaaaaggagaggccggugaugaaggaaaugcuggcccagacggugccccuggagaga gggguggcccuggugaaagaggaccucgggggaccccuggugugagaggaccaaggguuagacccgggug gaagcuggaccacagggugaccaaggaagagaggggcccgucggcaucccuguuagacucgggugaggcu ggccccauuggaccuaaaggauaccgaggugaugaggguccuccagguccugagggccucagaggagcc ccaggaccuguugguccuccuggagaccccggacugaugggugagagaggugaggauggaccaccaggaa acggcacggaagguuuccccgcuuucccuggguauccaggcaacagaggcccuccugggcuaaauggcac aaaaguucuacccuggccucaagggguuaugagagugaagugagagacccaggagaggauaacaacgac auuucaccccguggggucaaaggggcaaaaggauaccgaagcccagaaggaccccagggaccucca ggacaugugggaccaccugggccagaugagugugagauccuggauaucaucaugaaaaugugcucc ugcugugagugcacauguguuacccauugacauccucuucguuucuggacagcucggagauucauuggcc uacauuaacuungagauuaccaaagacuucaucaucaaagucaungaccggungagcaaggaugagcuagu caaauungagccagggcagucucacgcgggcgugguacaguacagccacaaccagaugcaagagcacgugg caggacuucaaagaagcugucaagaagcuacaauggauggcugguggcacauucaccggagaagcgcugc aguacaugcggagccccaacguccgcaacgccacacccggaaccggcuacucccacccacacaaaacaacc gaanugcccuggucauuacggaugaacauucuaacacucaacaggacacgacaccucucagugugcucugu ggugcagacauucagguaguuuucugugggaaucaaggauguguuuggcuuuguggcgggcuccgacca gcucaaugucauuuccugccaaggcuuaucgcaaggucguccagguaucucccuggugaaggagaacuaug cagagcuucucaaugacgacuuucugaagaacauaacagcccagaucuauauagauaaaaaauguccgga unauaccuguccaaucacauucuccuccccggcugacaucaccauccugcuagacagcucagccagugucg gcagccacaacuuucgaaaccaccaaggucuucgccaagcgccuagcugagcgauuccugucagcaggcag ggcggauccuucccaggaugugcggguggccgugguacauuuauaguggccaggggcagcaacagccag agucgggcggcucuucauuuucuuacaganuacacagugcuggccagcucuguggacagcauggauuucau caacgacgccacagacgucaacgaugcucugagcuacgugacucguuucuaccgggaaccucgucauugcc accaagaagagauuugcuuuuguuuucauuacagcaacucucaaugggccacagcagaggccauugagaag gcugugcaggaggcccagcgugcaggcauugagaucuuuuguggugguggugggaccccaggugaacgagc cccacauccgugugcuugucacuggcaagacugcagaguacgacguggccuuuggcgagcgccaccuaun uccguguaccaaacuaccaggcccuuucuacguguucguacucuaccagacagucuccaggaagguguuc cacugggcuagagguuccacacacguggcuuugacacacauggcauggagacacauuucaacaggccu ucccgcccuucccacugacaaaacaggaauaggaaaugugacccaacugguaacucaacugucunuaaag cggaacgcugagaugcacacucuuugcuuuguguaauguccccuguggcuucaccugagcucuaucuag aucccuucccuuguuuuuguacaucaugguguuccaucuugcugaccccucccccaucugggacuggaucc aaucaucucgucuuccuccucacugccccuaaccuauccguguuugucuucacaccaucacugcagunu ccgucuguguucugucuucaugcucaacaugaagcagaccuucucaugaguucagcuugcuggauuaugg cuuuuaggaunuugaacacaggaggaguuccaaacacaaacuuggaggagaccccuccucuucaucaggu gcuugucauuugaccuacaugcaucuuggucugguccuuauggcuaguccuuccacucugaaagcaaaggu gcuaucuaucuguaaaggcucucucuacacacccauuaggcunagcuuagacaguucacacucaagu guccugucagaaucaauccagagcuuucucccucaaaauagugacuugucucccccugguccccaaaggc uccccuuuaguuaguuucuucauggcucccccacauuccccguaaucuuuauccaagccagcuaucucug cuaauaaagguuuccauuuuucaaaaaaaaaaaaaa Tnc/  17 accccaugccccacccccaccuucgauguuuugaacauuucuaacaacug 252 Tenascin C aagccaguaaagucauauucuuuaaauuuccaggacauucauauuauuc AV230686 acauaaucauggucauagugaugauauaaacugaggacuutuaaagaga X56304 uuuucccuucccaaacguuucuggacaguaccugauuguauuuuuuuu guuuuguuuuuguuuuuaauaaaagcacaguacuutuucc Krt2-6a/  10 Sequence below. 253 Keratin gucugcccugccguuuuuacuucccagccuucucaucuccaggaaccaugucuaccaaaaccaccaucaaa complex 2, agucaaaccagccaccguguucuacagugccagcucagccagaguuucuuguuacucaaccgcucgguucuu basic, gene cagcaguguguccgugugccgcucccgggacaacgguggcuccagugcaauguguauaggagcuggcu 6a (keratin uuggcagcaggagccucuaugguguggggagcuccaagaggaucuccaucggagggggcagcuguggcauu 6a) gggaggaggcuauggcagccgauucggaggaagcuucggcauugugguggagcuuuguaguggcuuuggcu K02108 ucguuugguggagcuggcuuuggugguggcuaugguuggagcuggcuucccgaugugcccacuuggaggc uauccaagaguuucaccaucaaccagagccuccucacaccccugaaccugcaaauugaccccaccaccagc gggucaggacugaggagagggagcagaucaagacccucaauaacaaguuuugccuccuucaucgacaagg agagcccauguuugagcaguacaucaggaaccuccgcagacagcuggacagcaucauuuggagauuagga gucugcgguucauggagcagcagaacaaggucauggacaccaagugggcccugcugcaagagcaggacacc aagaccgugaggcagaacaugcauuuaacucagagcugaggaacaugcaggaacucguagaagaacuacgg aacaaauaugaagaugaaaucaacaagcgcacagacgcagagaaugaauucgugacccugaagaaggaugu gagaugcugccuacaugaacaaaguuugaacugcaagccaaggcagacagucuaacagaugauaucaacuu ccuugauuagcucucuaugaagcagaacugucucagaugcaaacucacaucucagacacaucuguauccu cuccauggucaacaaccguagccucguccuagacagcaucaucgcugaggucaaggcccaguuugaggu cauagcuagagaagucgggcugaagcugagucauuguaccagacuaaauaugaggagcugcaggucaca gcuggcagacauggggacgaccugcgcaacaccaagcaggagauugcugagaucaaccgcauuuauccag aggcugagaucugagaucgaccacguuaagaagcagugugccaaccugcaagcugcuauuugcugaugcug agcaacguggggagauggcccugaaggaugcaaggggcaagcuggaagggcuggaggaugcccugcaaaaa gccaaacaggacauggccauacugcugaaggaguaccaugaacucaugaaugucaagcuggcccuugaugu aggaaauugccaccuacaggaagcugcuggaaggagaggagugcagguugaauggugaagguguuggac caguucaacaucucuguggugcaguccaccguguccagcggcuauggcagugccuaggggugccagcagc agcuuuaggcauggauggaggcagcagcuacuccuauagcagcagccauagccuuggagguggcuuucagu gcuggcaguggcaggccaucggagguggccucagcucuucugguggccucagcucuucuaccaucaaauua caccaccaccuccuccagcaagaagagcuacaggcaguugaauucugucaccaagagcuugucucuggucc cagaugucauggcugcagcugaaccacaugcuuugguucccggaagggaacgaaucccaaccucuggccuc cccauggcucaguuucuacauuuguguuugcacgucagcaccuauacauguucuuuugguaacccagaccc caaaauguugcagaauguagaccuccaagacgaaaccccaaacccuacccagaauacccaccuuaaauuc ugucaugguuucugacuuccuccagagucuguaaaauaaaaugcccccacaacaaac Channel-related. Potassium  14 uuuuuuuuuuuuuuuuugauuuuaauuacaaacuuuauuuguccuc 254 channel, caguucacaguuuauacgugguacaucccaccaugucagcuuccaga subfamily acggcuauucaggagauggguggagcuuucuuuguaaaggaacccga K, member cauuuuaaaauuuugguuagaaucuucauagguuuauaaaaguacuc 2 ucugcaaacgaacuggauauauuuacauuuuagcuuaaauucaaau AI849601 uuuggaaaauaggaaucuuuuuguguuuauuaaacauccuggguuua ugucuuaagacuuuacucugaaugccacaugaucacguaagcccaag ccucccccagaagggaaaaaucaguuuugc Skd3/   4 uuuuuuuuuuuuuuuuugggugccaugccacagcaaggggccuuua 255 Suppressor uuuaaauguucagggcacagacaaauggaugcuagaugguguagcaca of K + ccuucucaggguggaguggugccuggauguccaguuuugcgggucuu transport gcuguccuuaucaaugaucuccaguucgcaauguagguggacgcuucuu defect 3 cagccugggaugagagcagcucacggcucuuaaggaggugcuuuguc AI837887 cgaauccuccacagugauacccagggugcaacccccugg Clic4/   3 uuuuuuuuuuuuuuucugacacaguaguaauccuuccagacuccuu 256 Chloride acacaauauuacaacucccccaguacauaaauguuccuauaccaugca intracellular cacagcaacaugggguccacuaaugucgcaggcgacuuuucuaaugg channel 4 uggaacauagcaccucaaguucugccaucuacacagugaagggacgu (mito- gauggucggggcuccagagugacagcaaacugccucuugggugacac chondrial.) gcuuguggcgaagugccucc AI845237 Col18a1/   5 Sequence below. 257 Endostatin gagaauauuugcugaggaggugaggcugcugcagcuccuugaagacccccuaccugagaagaucucacaaa (alpha ucgaugacccucacgucgggccggccuacaucuuuggaccaaacuccaacaguggccagguggcccaguau 1 (XVIII) cauuucccaaaacucuucuuccgggacuuuucgcugcuguuucauguccggccagccacagaggcagcag collagen) gggugcuauuugccaucacagaugcugcccagguaguagucucacugggcgugaagcucucagagguccga L22545 gauagacagcaaaacaucucauuacucuacacggagccuggggccagccagacccagacgggagccagcuu ccgccuaccugcauuuguugggcaguggacacacuucgcgcucagcgucgacggaggcucuguggcucucu uguagacugugaagaauuccagagguuuugccauuugcucgggccucgcagggacuggagcuagagcgug gcgcuggccucuuugugguuucaggcuggaacagcagacccugacaaguuccaggggaugaucucagagc ugauguacgcaaaaccccccgggugagcccugugcacugucuggaugaagaagaugaugaugaagaccgg gcaucuggagauuuuggaaguggcuuugaagaaagcagcaagucacacaaggaggauacaucucuacuac cugggcucccucagccaccuccugucacuuccccaccccuguucuggaggcagcaccacagaagauccua gaacagaagaaacggaggaagacgccgauguauuauucuauaggagcugagacccuuccuggcacagguu ucaagcgaugcaugggaugaagcuauccagaaccccggaaagggcuugaaaagggagguaugaaaggac aaaagggagaaccaggugcccaguugcccaccuggcccagcuggcccccaggguccugccgguccaguggu ccagauucccaacucacaaccugucccuggagcacaaguuacccccguugaccucagguugccaccaguga aggauggcacuccaggaagggauggugaaccagguugacccuggugaagauaggagaccggguaacacua gaccucaaggcuuuccagggaccccaggagaugugggcccuaagggcgagaagggagauccugguuuauu ggggccccgaggaccuccagggccuccagggccaccaggacccuccuucagacaagacaagcugaccuucau ugacauggagggauccgguuucagcggagacauagagaaccuuagaggcccacaaggcuuucccugg uccccccggggcccccuggugucccaauacuuccuggugagccaagacgcuuuggaucaaugguuccua cugcaccaggaccugcaggccuuccugguguaccugggaaggaaggaccccccgguuuuccaggucccccg ggaccuccagguccuccaggcaaagagggcccaccaggaguggccggccagaaaggcaguguugugaugug cggcacccaagacccaaggggagcaaaggagaccuuugggcccaucgguaugccuggcaaguucuggcuu ggcuggauccccuaggcaguuggacccccaggaccuccagggccuccagggccaccaggaccaggauuugc ugcuggauucgaugauauggaaggcucuggaauaccccucuggacaacagcccgaagcucugaugggcugc agggaccucccgggcgccgggacucaagggggaucuggaguguucaggccuaccuguuagccaaggga gaaguuuugagcagauggagcccagggcaucccuggucccccaggaagagaagguuugcagcuggaucuc cggggccaaaaggagagaaggggaugccgggagaaaagggaaacccaggaaaagauggagugggccggc cgggccucccugggccuccagugccuccagggcuggugaucuaugugucaagugaggauaaagcaauag ugagcacgccaggaccuuuagggcaagccaguuguacgcaggcuuuccuggaccugcuggaccgaaggu ugaccuggguuccaaaggcgaacaggguucuuccgggguuuaagggugagaagggagagccaggcacuauc uuuuaguccugauggcagacgucugggccauccccagagggagccaagggagagccaguucuuucgagga cccccggguccuuauggacgaccugggcacaagggugaaauuggcuucccuggacguuccgggucgaccug guuaacgaauggcuuaaagggauuagaagggagagccuggauuaugccagccuugguucagcaugagauga uuaccuggccccccugggccuccaggacccccagguccuccugggaugcccaucuauugacagcaagaga ggguggggccaccugggccaccagggcaauuccccauuugaccucuuccaccuggaagcggaaaugaaggg ggacaaggagaccgaggggaugcuggacagaaaggagagaggggagaaccuggggcuccuggugguggauuc uucagcucaaguuguaccuggcccacccggcccaccuggauacccuggaauuccggguccaaagggagaga ugcauccgggggccaccuggcccuccuggcccgcaguugaccuccuggcauuggcuaugagggucgccagg ggucccccaggaccuccaggaccuccaggaccucccuccucccuggcccucacaaacagacugucagugu uccugguccuccaggcccaccugguccuccagguucccccaggagccauggugccucugcugggcagguga ggaucuuugggccacauaccagaccaugcuggacaagauccgggaggugccggagggcuggcucaucuuug uggccgagagggaagagcucuauguacgcguuagaaauggcuuccggaaggugcugcugugggcccggaca uccuccugagaggcugggcaaugagguggcugcuuuccagcccccauugguccagcuucaugauuggcagu acucaucaggacuuucagccaguuucuccaccugguggcacugaacaccccccugucuggauugcaugcgu ggccauacacccggagggaguacuccuauuccacggcacgacccuggcgagcagaugacauccuggccaac ccaccgcgccugccagaccgccagccuuacccuggaguuccacaucaccacaguuccuaugugcaccugc cgccagcccgccccacccucucacuugcucauuauccguggaacagauuuccagugcuuuccaacaagccc gagccguagggcugucaugcaccuuccgggcuuuccuguccucuuaggcuacaggaucucuauagcaucgu gcgccgugcugaccgggggucugugcccaucgucaaccugaaggacgaggugcuaucucccagcugggac ucccuguuuucuggcucccagggucaagugcaacccggggcccgcaucuuuucuuuugacguucagagau guccuugagacacccagccuauccacagaagagcguauggcacaucucggaccccagugggcggaggcuaa ugaagaguuacuugugagacauggcgaacugaaacuacuggggcuacaggucaggccuccucccugcugu caggcaggcuccuggaacagaaagcugcgagcugccacaacagcuacaucauccugugcauuaagaauag cuucaugaccucuuucuccaaauaggccucugccagcacaacuccuguauaguucccauuuuuauguaauc cucaagaaauaaaaggaagccaaagaguaaaaaaaaa

TABLE 5 Genes down-regulated in HF stem cells. Gene Fold SEQ Name/protein Decr Sequence ID No. Growth Factors, Receptors and Downstream genes GNA-14 32 Sequence below. 258 Mouse G cccugccuuucgcgccgcguuucgccucgcgcuccgcgccucuuucucccuccccucguugguuc protein alpha cggugguuccucuuccccccuugcuuucugcggcuccuccgcgcggccgguucguuccuucuccc subunit (GNA- cggucccuuuucgcuccgucgcgguggcccgcccuggccgcugcugcuguuugucuugcggcggcg 14) cccgcgucuccgcgccuccgcgcggcgcucgcgccucccguucgccgcgccccgccggccgcgcg M80631 ccgggcgcucccgcugcuguugcugggccccggugcgcgugggccccgccccuuucucccgccgc ugcggcuccucccugggucuggcucccgugcugccgcucgcccgggcuucccgccgcugguuucc cccccccucuucccggcccugcccgcccuuucuccgcgcccuggcuccccugcggcuccccuccc uguuuugcgccucuccggccccugccccgcuccuccgggccguggccgucgccccggucccugc cccucucucgcgccccgguggccgcccucccgccgcuguggcuggcucccggccucccggcgugu uccgcccggcggcgggcguccccgcuguccgccucugcccccucuucccugccggcccuugcgc cgucucgccugcccucuuuucgugcccccccccccggcugugcuucguguucgcuuugcccccc ccuggccuccuucuuccucucccuucuucccuggccccccuccuucuuccgccugguggcuguu gguggcccgcgcuucugcccgccggcccuggcuuucccugcuuugcgguguccccucccuccuuu cuucuugguugcucugcgugccucugccccgguuucuggcugcgugugccccugcgccccgccu ggcggcgcgccccgcccuguuucgcccccuccuccccucccccugguuucugcccuccuccgug cuucuguucuuccccccgccggcucuucucgcggcgccccuccuguccucuccucuccuucgcuc cuuccccgcgucccccggccccccgcccgcugucccgcggcccgggccuuucuccugccgcuguc ucccgccccgccuccugcccccgcgccgguuucucucuuucucccuucccuuuuugcucccgc ccccgcgccucuccgcuuuguguuuuucugcuguccccgccccccuccucccgcucccccuccg ggcguuccccuuggugucccuggcgggccuccuccuccgcgcccgcgggugcucugcgcccuuc cugccugcucuccccgugcuucuggccccggcccuccggcccuucuugucgccccccggcccgc gcugggucgugcccugugcccccuccuucccccccccuuuuccgugucuuuccuucuucccugu cucccucuuuucucgccuuuugguugcccgcuucggucuccuuuuugcgugguucccccucuccu cuuuuuuuuccccucgucuucccccguucuuuccccccuccugc Ly6/Lympho- 12 gaauuucccugcaaccuugucuuuagaggaagcaaauuacugguuguuuag  259 cyte antigen 6 gagggagcugugagguuuuuaucugagcagcccuucucugaggaug complex gacacuucucacacuacaaaguccuguuugcugauucuucuuguuug X04653 cccuacuauguugcagaaagaacucagggacuuugaguuuuaccagug cuauggagucccauuagagacuacuugcccaucauuuuaccagccccu acccugauguuagucuguguuacucaggaggcagcaguuuauuguggg uucucaaacaaggaaaguaaaaaacaaucuuugcuuacccauucugcc cuccuaauauugaaaguauggagauccuggguacuaaggucaaugu gaagacuuccuguugccaggaagaccucugcaaugcagcaguuccca auggauugcagcaccuggaccauggcagguugugcuucuuuuucagccu gagcucaguccuccugcagaccaugcucugaugguccucccaaugac cuccacccuuguccuuuuauccucaugugcaacaauuucuuccugga gcccucuagugaugaauuaugaguuauagaagcuccaauugugggag uaguaugugaaauaccauguuuugccuuuauagcccuuucugauuag guaggugcucuaauccucucuagggcuuuucaagucuguacuuccua gaaugucauuuuguuuuuggauugcuuucucaugacccuuugaggcaca caaccagcacaguugaagaggcagaauuccaagauauuaugcuaucac cauccacacauaaguaucugggguccugcaauguucccacauguauc cugaugucccccuuuuuguuuuccaauaaacccuuuguucuccc Bmp4/Bone 11 Sequence below. 260 morphogenetic ggaagaaagagagggagggaaaagagaaggaaggaguagaugugagaggguggugcugagggugg protein 4 gaaggcaagagcgcgaggccuuugcccggaagcuauugugaguucuugcauccgagcugagagac L47480 gcccagccuaagacgccuuucgcugcaacccagccuaguaucuuggucuuccgucccugauggg auucucguucuaaaccgucuuuggagccugcagcgauccagucucuguucccuucgaccagguuc auugcagcuuucuagagguccccagaagcagcugcuggcgagcccgcuucugcaggaaccaaugg gaggcaaaaguuggccuauuccuccuuccuuucuccaacaguguuugaagguauugauaauugga uauguuuucugcgucuaucauuccuacuuuagggaggugcgggccaggagaggcgggaaggag agaaggcugagcagggcaaccuggagaggggcgcuauuucugaguuauucgaguuugcacccgu aguagaagcuggggauggggcucaggcuguaaccuaaaaggcaccuccauaggccuuggaagaga gggucauugguuaauuaacuguuuggguauuuuguggguuugcuuccacuuagacuauaagauuu gggagaguuagggagucaacucuaaguuucaacaccaguuuggggacugaggacuugcuucauuu aggauuagagaaccuagccagaacuuagcuuugcaaaagaggcuuguccugcuuugcucuaaagc gcgacccgggauagagaggcuuccuugagcggggugucaccuuuaucuuguccccuacgcaccc ccucccagccccugagagcuagcgaacuguagguacacaacucgcucccaucuccaggagcuau uuucuuagacauggacacccauaauuucugccuucugguacucuccccucccuauugaaagauu guguuaagguuccgacggaaccguggccaggaugccgaauuggcuaccugugcgggucuacugcc augcagugucugugcggacaugccagcagggcuauuugaggagcuugcgauacuccaaaggguu cgggaauugcgggguccuuacacgcaguggaguugggccccuuuuacucagaagguuuccgc cacggcuuuguuuugauaguuuuuuuuaguauccugguuuaugaacugaagguuuuuuugagau guugaaucacuagcagggucauauuuuggcauuaccgaggcuacuauaaaauuuagguuuuaga agaagauuucaggggagaaagugaaggguauucugccuccaggagcuguaucaaccccauuaaga aaaaaaaaaauaccaggagauugaaauuacuuugaucuguauuuuuaauuaaaaaaaaucag ggaagaaauugaguuuauuagaaaguugauccuuuagcgucguucgguuccaugugcccucgcu cccgcgugcgccagugcuagcauaucuuccauucucuuucccccuuuaaaagcaaauuaaacaa aucaacaauaagcccuuugcccuuuccauucgcuuucccaguuauuucccagcggcgacucgugu cggggaauagagaaaucgucucagaaagcugcgcugaugguggugagagcggacugucuuucagg ggcgcccgcggucucugcacccagggcagcagugugggauggcgcugggcagccaccgccgcca gggggggggagagguuagguugaaaaccagcuggacacgucgaguuccuaagugaggcaaagagg cgggaaggacgugacucuccauccuuuacacuucuuucucaaaaguuucccgaaagugccccccg ccucgaaaacuagggccgguacgggguggagcgggcucuggagcgggggaguccuggguuucgguc cucggauggaccccgugcaaagaccuguuggauuagaguugcgcuuccgagguuagaacaggc caggcaucuuaggauagucaguucacccccccccccaaccccacccgaguuguguugguuauuuu uggaggaaucuuagccgcgauucuguagcugguuaaaaggaggaaaggggugggggaaggaagu aggcugugcggggguggcgguggggguggaggugguuuaaaaaguaagccaagccagagggagag gucgagugcaggccgaaagcuguuucggguuuguagacgcuuugugaucgcgcuuugguguc uccuuucgugccggguaggaguuguuaguuugcauacucugagaucuaaaaaaaaugugaugcgc ucuuuucuuuggcaugccuguuuagaaucugguccggaguuagaagcucagacguccacccccc accccccgcccacccccucugccuugaauggcaccgccgaccgguuucugaaggaucugcuuggc uggagcggacgcugaggguggcagacacgguguggggacucuggcguuggcuacuagacaguac uuagaagccuuucuucuaucuuuucccacaccgcucaaaccccgacacccccgcgacggacugag uuggcgacggagucagaucuuuggaugaaaauuuggauccuuaggggucggcugccugucgcuag aagcauuauuuggccucucggagacccguguggaggaagagcuggagugugcgaguguuuauug cguguguguguguguguguguguguguguguguguuuugugugugugucugcccuuugagggucc cuaugcuuuuccuuuucauggaacgcugucgugaggcuuugguaaacugucuuuucgguuccuc ucucggcugcacuuagcuuugucggcgcuguaaagagacgcgucuuaagugcacccugauccuc aggcuuagauauccguccccgaaccuggccagaugcauugcacugcgcgccgcagguagagacg ugccccuguccccugcgugcagcgacuugaccgagaucgcgccaguguggugucccgccgaaag uuccucaaagaggcggggacauucccagacggcuggggcuccagcugcaggcgcggagguuggcc ucgcucuaggggcuggacccagccggggugggaggauggaggaggggcgggcgggcuuucggug aguggggcggggccucuggguccacgugacuccuaggggcuggaagaaaauagagccugucugcu ccagagucuucauuauaucaaauaucauuuuggagccauuccguagugccauucgugcgacgc acugcucauuucucugagccuuuccagcauaguuuguuaagauuggcuccaagaaucauggacu guuauuaugccuuguuuucugucagugaguagacaccucuucuuucccuuuugggauuucacu cuguccucccaucccugaccacugucuugucccucccgucggauuccauuucagugccccgcg cccuacucucaguagcuuaugguuucuuucuggucccuuaaggccagacauacgaaauguacgg gcuccuuuuuuagcgcucccacuguuuucucugauccgcugcaugcaaaaaagagggaacgcg agagaccaaauagaugaaagauccucagguugaggcugucccuugaagggcuaaccacuccc uuucagucccgauauauccacuagccugggaaggccaguuccuugccucauaaaaaauuuaaa aaaaacaauauaauagucguuuuggaacaagacucuuuuagugagcauuuuaacuagcgaccaca augaaauaaaucacaaaaucacuggagcagcccuagacuccuuuucccagucacugaaccuugc ugcccaguccaagcccuaccagcacauuucuguucuccccuccuccuguucuuaaccauuuggaa gguuguggaaauugggcuggagggcggaggaagggcgggggugguuggggugugaagguggggg guuggggaggcuuagguccgaagugaagagcuuuggcauuuuaauucucccuccuccuccccccu uuuccuccucaauguuauuguuuauccuugaagaagccacgcugagaucauagcucagauaaccg uuggacaggauggaggcuaucuuauuugggguuauuugaguguaaacaaguuagaccaaguaauu uagggcgauucuuuuuucgggccgugcauggcugcagcugguguguguguguguagggugugaggg agaaauacaaacuugaucuuuucggaccguuuucaucuuugaccguaguuugcuaccccuaua gcauaugcagagacaucucuauuucucgcuauugauuuuuauuuauuuuuaaccuuccaccccau ccccuccccagagacaccaugauuccugguaaccgaaugcugauggucguuuuauuaugccaag uccugcuaggaggcgcgagccauguaguuugauaccugagaccgggaagaaaaaagucucgagau ucaggucaucgggaggacucgcucagguagaucauugcuccuguggacuucgaggcgacacuuc uacagauguuugggcugcgccgccguccgcagccuagcaagagcgccgucauuccggauuuauga gggaucuuuucggcuccagucuggggaggaggaggaggaagagcagagccagggaaccgggcuug aguacccggagcgucccgccaucgagccaacacugugaggaguuuccucacgaagguaguuuugcu cuuaguccuuugcgguguaggguggguuagagcuccguuggagaggguggggagugggcagcug gcaggacaagcugaagggguuguggaagcccccggggaagaagaguuucauguuuaucaaagc uccgaguccuggagacuguggauagggccucuuaccuucaacuuucagagcugccucugagggua cuuucuggagaccaaguagugguggugaugggugagguugguuacuuugugauauggacugaca ccacucagacuucugcuaccucccagugguuguucuuuagcuauaccaaagucagagauucugc ccguuuuuguuccaaagcaccuacugaauuuaauauuacaucuguguguuugucagguuuauca auuaggggccuuguaauacgaucugaauguuuccuagcggauguuucuuuuccaaaguaaau cugaguuuauuaauuccuccagcaucauuacuguguuggaauuuuauuuuucccuucuguaacau gaucaacaaagcguacucuguuguuccacuuguaaagaaaacuguacacaaagccaagaggggg cuuuaaaaggggaguccaagggugguggaguaaaagaguugacacauggaaauuuauuaguuca uauaaaggaguuuugggagauacuuucuuuucuuuggaguuugacaaauguuuagcuaagauuau aaagcagaauucaaccaauucugcuauuuuuuguauuuguuucuuuguuuuuguuuuguuugguu uuuuauuuuuuuuuuuuuuuuuuugucucagaaaagcucaugguuccuuuuucuuuuuccccau ucaacugugccuagaacaucuggagaacaucccgggaccaguaagagcucuugcuuuuucguuuu accucuuucaaccucaacaacaucccagaaaaugaggugaucuccuucggcagagcuccggcucu uucgggagcagguggaccagggcccugacugggaacagggcuuccaccguauaaacauuuaugag guuaugaagcccccagcagaaaugguuccuggacaccucaucacacgacuacuggacaccagacu aguccaucacaaugugacacgugggaaacuuucgaugugagcccugcaguccuucgcuggaccc gggaaaagcaacccaauuauugggcuuggccauuugaggugacucaccuccaccagacacggacc ucaccagggccagcaugucagaaucagccgaucgauaccucaagggaguggagauugggcccaa cuccgcccccuccuggucacuuauggccaugauggccggguuccauuaccuugacccgcaggauu ggccaaacguagucccaagcauucacccacagcaguccaggaaaaaaaauaagaacugccgucgc cauucacuauacguggacuucagugacgugggcaggaaugauuggauuguggccccacccggc auaccaggccuucuacugccaaggggacugacccuuuccacuggcugacaccucaacucaaccaa ccaugccauugugcagacccuagucaacucuguuauucuaguaucccuaaggccuguuguguc cccacuaaacuugagugccauuuccauauuuguuaccuggauaaguaugacaagguauuguuuga aaaauuaucaagagauggugguagagggguguggaugccgcugagaucagacaguccggaggg cggacacacacacacacacacacacacacacacacacacacacacacacguucccauucaacca ccuacacauaccacacaaacugcuucccuauagcuggacuuuuaucuuuaaaaaaaaaaaaaga aagaaagaaagaaauaagaaaaaaaaugaaagacagaaaagaaaaaaaaaacccuaaacaacuca ccuuuaccauauuaaugacuuacgugcaaauuuuaugaccauauagaucauauouugacaaauaua uuuauuaacaacauuauuaaaagaaaauaaaaugag IL1r2/Inter- 11 gaauucccacuuacaugcgaacaucucuauauuacauccucaauucuauc 261 leukin 1 cccucgaanccacggacuuaucagucaaucaauacaacagucaaaga receptor, type auuuuuucuacguuauccuggagcauugcgcuggcaccucuuuuu II cuaaucaucuuaguugugaggccaauuauagaugcgcagacgguaua AV223216 aacgcagggcaggaaagacauuauggacugaccaagcuacggacugac X59769 aaccaggacuucccuuccagcccaaacuaaauaaaggaaaugaa Wnt3a/wing-  4 Sequence below. 262 less-related gaauucauugucuuaccuuaggcagagggcccagcgccacugcagccgcgccaccucccagggc MMTV cgggccagcccaggcguccgcgcucucgggauggacuccccccgcuacgcgcucaagccggcgaug integration site gcuccucucggauaccucuuagugcucugcagccugaagcaggcucagggcagcaacccgaucu 3A ggugguccuuggcugugggaccccagacaccacucugagcacucagcccauucucugugccagca X56842 ucccaggccugguaccgaagcagcugcgcuucugcaggaacuacguggagaucaugcccagcgug agcugaguugugucaaagcgggcauccaggaguuuccagcaccaguccgaggccggcguuggaacu uucaccaccgacagcacagccuggccaucuuuggcccuguucuggacaaagccacccgggaguca gcgagggcuggaaguggggcggcuguagugaggacauugaauuuggaggaauggucucucgggag uugccuuuguccaugccaucgccuccgcuggaguagcuuucgcaguaacacccuccuguacagagg cgaucauugcuaucuguggcugcagcagccgccuccacggcuccccagugccgaugccagggaga accggccggaugcccgcucugccaugaaccgucacaacaaugaggcugggcgccaggccaucgcc agucacaugcacucaaguuucaaaugccacuuggcuaucuguagcugugaagugaagaccugcug gguggucgcagccggacuuccgcaccaucggggauuuccucaaggacaaguaugacagugccuc ggagauggugguagagaaacaccgagagucucguggcuggguggagacccugaggccacguuac acguacuucaaggugccgacagaacgcgaccuggucuacuacgaggccucacccaacuuugcaa ccuaaccccgaaacugcuccuucgggacgcgugaccgcaccuguaugugauucgcauggcauag auguugugcgaccuguugugcugcgcacgcgggcauaacacgcgcacucagcgacggacggacaa augccacugucuuuuccauuggugcugcuacgucagcugccaggagugcacacgugucuaugac gugcacaccugcaaguaggagagcuccuaacacgggagcaggguucauuccuggguaagguuccu aaccugguuggcguugguuccuacuuggagguugucucuuuacuuggugacuuguucuuacuug agggcggagauccuaccugugagggucucauaccuaacgacccaguuuugccuucagccucggcu ccuauuuugagaucuggguuccuuuuuaggggagaagcuccugucugggauacggguuucugcc cgaggguggggcuccacuuggggauggaauuccaauuugggccggaaguccuaccucaauggcu uggacuccucucuuuuccuacagggcuuaauggagacagguaacuacucccucaacuagcugg gguucgugcggaugggucggagcggagagauuagcaucccuccucccagaggcacugcucua ucuagauacaugagagggugcuucagggugggcccuauuugggcuugaggaucccgugggggcg gggcuucaccccgacuggguggaacuuuuggagacccccuuccacuggggcaaggcuucacu gaagacucaugggauggagcuccacggaaggaggaguuccucagcgagccucggcucugagcag gccauccagcucccaucuggccccuuuccaguccuaguguaagguucaaccugcaagccucauc ugcgcagagcaggaucuccuggcagaaugaggcauggagaagaacucaggggugauaccaagac ccuaacaaaccccgugccuggguaccucuuuuaaagcucugcaccccuucuucaagggcuuuccu gagucuccuuggcagaguuuccugaggaagauuugcagucccccauguucaagugaacaccuua gaacagaacagacucuauccugaguagagagguucucuaggaaucucuauggggacugcuaggaa cggauccugggcaugacagccucguaugauagccugcauccgcucugacacuuaauacucagau cucccgggaaacccagcucauccgguccgugauguccaugccccaaaugccucagagauguugc ucacuuuuuaguuguauuuaacuucggagacaugggucacagucaugccgcagagccaggguug uuucaggacccaucugauuccccagagcugcuguugaggcaauggucaccagauccguugccc accacccugucccgagcuucucuagugucugucuggccuggaagugaggugcuacauacagcc caucugccacaagagcuuccugauugguaccacugugaaccgucccucccccuccagacagguu gagguugauguggccauacaggauuugugcccggagagcuggaaagaguagagaggcugcacac gcgugguaacugacugucuucuaccuggaacuuugccuucgcgcuuguaacuuuuuuuucaauc cugcuauauccacccaccacuggauuuagacaaaagugauuuucuuuuuuuuuuuuucuuuucu uucuaugaaagaaauuauuuuaguuuauaguauguuuguuucaaauaauuugggaaaguaaaaag agagaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa Il12rb2/  3 Sequence below. 263 interleukin 12 cgcaccggagguccacacugccgcguggacuccagcgauggcgcugcgcuaggcuagcgggugcc receptor, beta 2 aggaucccucucugcguccugugcugggaagagcucuggagaaccagaguugcauucuggaguug U64199 caagacucauggcacagacuguuagagaaugucauuggcacuucuuuuuuuuguucauguggcu ugcugauuaaagcaaauauagaugugugcaagcuuggcacugugaccgccagccugccccucuga aucccaguucuaacgaauuaauccucuuaaaguuugucaaugauguccuuguugaaaaucuccaug agcuuccucuucggucagcugccuauauuuccugcuccuugaaucccaagcaaggcuguucacauu aaagaaaguccaugccacacuuugucacuccuccacuuuucaagucaccaaccuuuucccuuggu uaugaccuuguuugucugcaagcuaaacuguacaacucucaaaagaagccaccaauccaguaugu gggguagagaucucaguuggucuugcuccagaaccaccucaaaacaaucauguguccaggaagg agaaaauggaacuguggccuguuccuggaacucuggaaaaguuacuuaucugaaaaccaauua cacuuuuacaguuaaguggaccaaacaaucugaccugucagaaacaauguuuuucugacaauc cgucagaauugcaaucgccuggaucuugggaucaaucuaagcccuaauuuuagcugaauccauuu cauuuccguguuuacugccaucaacgaucuuggaaaaucuucuuucacuuccgcauacguucac guucuaggacauagugaucccucuuccuccgugggacaucagaaucaacuauuaaaugcuucugg agagcagagguacacugcagugggaagaugagguggcaagugguacucaaucaacucagauauc agccucuuaacagcacguccuggaacauggucaaugcuacaaaugccaaaggaaaauaugaccu guagaucugagaccguuuuacagaauaugaauaucaaaucuccucuaagcuacaucucucug gaggaaguuggaguaauaggagagagucacugagaacacgacaccagaggaagagccuguuggg auauuuagacaucugguacaugaaacaagacaucgacuaugacagacagcagaucucucuuuuu cuggaagagucuuuaauccaucagaggcaagggggaagauccuccacuaucaguuugacguuac aagaggugacaaagaaaacaacacuugcagaauacuacaaaacacaccuccuggaccagggucau cccccgaacuggggcuuggacggcaucaaugucugcagccaacucaaaaggcgcuucugcacc cacucacauuaacauaguggaccuauguggcacugguguugcuggcuccucaccaggucucugc aaagucguuagaacauggacaacauucuagugaccuuugcagccuccuaagaaagcugauuucu gcuguucaggaguacauaguggaauuauagagcucuccaaccagauagcaucacgaaguuuuc ccccacacuggcuacggauccccccggacaacaugucugcucugauuucagagaacauaaagc ccuauaucaguuaugaaaucagggugcaugcacugucagagagccaaggagggugcagcucca uccggggugacuccaagcacaaagcaccagugaguggcccucacauuacugccaucacagagaa aaaggaacgccuuuuucauuuccuggacccacauuccauucccauagcaaaggaucugcauccu ccauuuacagaauauacuagaaagaacgagacucgacagcacaaccugagcucuugcgaaauuc aguaccgacgcucacaaaacucacauccaauuaagcagccuacagcccagggugacauaugucc uauggaugacagcugugacagcugcuggugaaaguccccaaggaaaugaaagggaauuuuugu cccacagggcaaagccaacuagaaagcauucgugauaucaagcauuuacaucgcuaucaucacg guaugcacguucucaaaucguuuucuuccggcaaaaggcauauacucaccugucuacucuuca aaaccucaaugguauagcagaaccauuccagaucagcaaacagcacuuggguaaagaaguaucc acauucuggaggagaagauccagcuaccuacggauaaucuccugauggcauggcccacuccugaa gagccugagccccugaucauccaugaaguccucuaccacaugaucccaguugucagacaaccau auucuuucaaaagaggccaaggauuuccaaggcuacucuaccuccaagcaagaugcaauguau auuugccaauccacaagcuacaggacucucacagcugagaccagacaacuagugaaccuauaca aggugcuagaaagcagagacccugacucaaaacuggccaaccugaccagccccuuuuacaguc accccauuugaacuaccuuccuagccaugaaggcuauuuuacccuccaacauagaagaucuguc accacaugaggcugacccaacgauuucuuuuugaccuggagcaucaacauauuuuucucuuucc auuuuugcaucaaguucucuccgcccacucaucuucgguggugagcggcugacucuagaucgguu aaagaugggcuaugacucccucaugaguaaugaggcuuuuauacuagaaagccaacguaccucau uuuaucugcccaguuccuacuccaaaggucugugacagugaagacaagccagcugucucuugga uuaaaauuagcuuucaccauagguacuuaagucuuauauauuaagguggcaauacaccaacacuu gauaucauauagaaaggaccccaagauagucaugcuc Wnt10a/Wing-  3 Sequence below. 264 less-related ggcacgaguucacccucugcaugcguuccccuccccccucuccagcaaacacggcgcgccagucc MMTV aaagcggacucaguggccucgguugacgggagcaugccaccuccuuuggugacgucacuugguug integration site auagaacccuuagacacuacaugguugggggguuggucagaacucccgagccaggacagucacuc 10a acuucuucaggcaguggggcugggccagacaguaccgcccccaccgcacccgccucgcacacccu U61969 cggaagcgcaggcucgcagcgcggcgcugguggugggggguugcgccccagaacuucggccucca aguccccagcccgcugcaccuccuuacccucuagaggcccccucccccuuuacccucuagaggc accaguuaguuuucgcaaggggcccuuggaaauucccuggaccccugugccaggaaugcccauuc gcccgcuccccauccacccccccgagggcggagcccggaugcgcugccccauggagcggggaggc gggcgccgucagcagcgggagcugugaccugaguaggagcagugugucgcagccgccccacccc ugccgaucaugcgccucgacccugguucgccagucccacugggcugugagccccccacuccuggc ccugucacggcccgcgcgccaugggcagcacccacccucaccccuggcuacggcucccacaaggg ccccagccgcagccugauuucuaggcgcuccuguucuuccuacugcugcuggcugccgcugugcc caggucagcacccaacgacauccugggccuccgccuaccccagagcccgugcucaacgccaacaca ugugugccugacauuuucccggccugagccggcggcagauggaggugugugugcgucacccugacg uggccgccucugcuauccagggcauccauucgccauccaugauuugccagcaucauuuuccgggac cagcgcuucgccuacgccauagcagcugccgggguggugcacgcaguguccaacgcgugcgcucu ggguaaacugaggcuugcgguuucgacgccuccagacguggguuacuagaagcuuuccgucguag cugcaccgcuuugcagcuggacgcgcuuucagcgcggaaagggcuugagccacggggucccugaac cacccggccauacuuuccugccagcccaggucugcaggacuccuaugaguaggguggcugcaguc cggauguaugcuucggagaacgcuucucuaaggacuuucuggacucccgagagccucacagaga ccauccaugcucuuaaugagacuccacaacaaccgugugggccuugcaggcggugauggagaac auuucggcguaagugcaaaugccacggcaccucaggcagcugccagcucaagaccugcuaucagg ugacgccugaguuuccgcacaguagggggcgcugcuacgcaaccauuccaccgcgccacgcucau ccggccgcacaaccgcaacgguggccagcuggagcccggccccgcgggagcacccucgccagc accgggcacuccagggcuuucgccgcagguuccagccacuccgaccuggucuacuuugagaaa ucucccgacuucuguuuaggcgagccgcgccuggacucggcaggcacuguugggcaccugug caauaauuagcagcacgggucccgauggcugcggcagcaugugcuguggccgcggccacaacau ucugcgccagacgcgcagcgagcgcugccacugccgguuccacuggugcugcuucguuucugcga agaaugccgcaucaccgagugggucagcgucugcaugugagcagacccaagcuccucugggucuc aagaaugguuuguccucuuuauugccuggcuucugccgcuagcagaucugaaccaggcagcaagc agcagccuuuggcuuccugagagaggugguuggcucuuacagccccgagggucuacaaucacca gacaguccagaucugauugacauuccuccgcucaccucuguagguuccccucuuucuguuccua gcucagacagcugggggugauaguggagacuguuccacacccuaggacaggucaccaaagcagc ccagccuguucaugccuaccuccuuuucaucucuucuucccuuccccaggagugauaggcaaug cacugaagcugaugggcaccggggaagaaaacuaaaaggcagaaauggccgucaucgggcugaa gugacucuaagggcuccagaccucugcuccugucuuucacuuaacagauauuuauuuuugcgcu cucuuugagacacucucuggggaaaaauuaauucuccggagucuacaggcugauuaagguuacau ggacaauaaaccaguaaacacacaaaaaaaaaaaaaaaaaa Ifngr2/Inter-  3 Sequence below. 265 feron-gamma gaauuccgggccgcuugcacuuggcgacuagucugcggcggacgugacgccaaggccacguugca receptor ggcgcggguccccugucaaggugucccucgcgcaggaauaugcccgcaggcggcagcuggcagga precursor ugauucuacuggugguuccuugaugcugucuacgaaggucgggaguggagcuuugacgagcaccg M28233 gaggauccugagccucccucggugccuguaccgacgaauguucuaauuaaucuuauaacuugaac ccugucguaugcugggaauaccagaacaugucacagacuccuauuuuuuacuguacagguaaagg uguauucggguuccuggacugauuccugcaccaacauuucuuuaucauuuuuuguaauaucuauga gacaaauuauguauccugauguaucugccugggccagaguuaaagcuaagguuggacaaaaagaa cucugacuaugcacggucaaaagaguuccuuauguccuaaaguugaaaggucgggcccccuggcc uggagaucaggaggaagaaggaagaacagcucuccguccucguauuucaccugaagucguugug aauuugagagagccagggaaccauguuuguuugacgggagcaccuguuacacauucgacuauacu aguguauguagagcauaaccauaguauggagauuccuuacauacgaaacauacggucgaaaaauu auuaguguaaugagacucuuguaugaguuaaacaucucaguauccacacuggauuccagauauug uauuucaguagacguuaaucucaucuuucuggcaaguuagacauaaaaucgaaagacgucugua ucccuccuuuccaugaugacagaaaggauucaauuuggauucuguugguuuucuccucuuaccg ucuuuacaguaguuauccugguauuuugcguauugguauacuaagaagaauucauucaagauua caaagcauuaauguuaccuaaguccuugcucucugugguaaaaagugccacguuuagagacaaa caccugaaucgaaguauucacuugucacaccgcaccagccagcuguccuagagagugagacggug aucugugaagagccccuguccacagugacagcuccagacagccccgaagcagcagaacaggaag gaacuuuucaaaagaaacaaaggcucuggaggcuggaggaagcacaucugccaugaccccagac aaccuccaacuccgacacaaagacgcagcuuuucccuguuaaguaguaucagucaggcccuug uagccucaccgccuaucacuccgaaacggcucugacaguggccucgugggaucgggcagcucca uaucggacuuggaaucucucccaaacaacaacucagaaacaaagauggcagagcacgacccucca cccgugagaaaggcccccauggccuccgguuuaugacaaaccgcacauuguuggugacgugcuug uggauguuggggggaaggagucucucaugggguauagacucacaggagaggcccaggagcuguc cuaaggucucccgaggccugcuggugguaaagaaacugaccuuuuaggcaguuuuuucugcauuu gauuuucaugaaagaagcuauacauuagcuuaauacuaaccacauagaauauucagacuuagau acgugauaaggauccugugggcacugcuggguccacucugcaaaugccaagacuaucaaaggaa cguauugucgcuucuggcuccuucccagguaggcuagcauucugugaguuuugccucggcuagc cuugcuuccuacagccgccacugcuccuccacccugaucaucucacaggacaggguggaccggg uuuuuuuuuuuuuuuuucacacaccuuuguauauguaaguucauguauauuaauuauguuuuaca uguuucacuuuugaacugaaagcuacucaaagccagccguaagucuaugguagaaugugaugga acauguugguggaagcuuuguacaauagaacacauuuggugagagcuuuguacauacuuuuuuau ggagcauuacuuacgauuuuuuaguaaaauguuuugaaaccaaaaaaaaaaaaaggaauuc Fgfbp1/  3 uugagacuccacagccucauccugcucuccuuccuucuccuggcuac 266 Fibroblast ucaggcguucucagaaaaggucagaaagagagccaagaacgcaccac growth factor acagcacagcggaggaggggguagaggguucagcucccucguuuagg binding protein gaaggcccagaauaagcagagaagcaggacaucuaaaucucugacgc 1 auggcaaguuugucaccaaagaccaagccacaugcagaugggcugug AF065441 acugaggaggagcagggcaucagccugaagguccagugcacauagc cgaucaggaguuuucuuguguuuuugcuuggugacccaacugacugc cuuaaacacuuacaaagaccagaucuacuggaaacagguugcccgcac gcugcgcaaacagaaaaauaucugcaggaacgccaagagugucuuga agaccagagugugcagaaagagauuuuccagagucuaaccucaagcug gugaaccccaacacacguggaaacacgaagcccaggaaggagaaagc agaggucuccgcaagggagcacaacaagguccaagaagcugucucca cggagccaaacagggucaaagaagacaucacacucaauuccagcugcg acccagaccauggcuuuagagauuccagagugucuagaggauccaga ugugcucaucagaggaagaccgcccuggaguucuguggggaaucu uggagcuuccauuugcacauuucuuccucaacauguuacaggcgacauc augcuaa Transcription Factors and Related Genes Klf5/Kruppel-  5 aauucgucgacaugcgccguuccagugcauggugugccaacgcagc 267 like favor 5 uucucccuuccgaccaccucgcgcugcacaugaagcgccaccagaa AA611766 cugagcgagcgagcgcugccccacccgccugacgccuugcaguccgc ucugccauccuuuaaaccgcagaccuaacuucauaaaaaga Gata3/GATA  4 Sequence below. 268 binding protein gcuaaacuaucccgcaaagauuuuucuuuccucccuaaacccuccuuuuuugcucuccuuuucua 3 uacccuuaacugcaaacaaaccauuaaacgaccccucuccugggccuccgacggcaggaguccgc X55123 ggaccucccaggccgacagcccucccucuacccgcgagguuccgguuccgggcgagagggcgcga cgcacagccgaggacauggaggugacugcggaccagccgcgcugggugagcaccaucaccccgcg guccucaacggucaacacccagacacgcaccacccgauccucggccauucauacauauaaacuuc uaguauccgcugacggaagagguggacguacuuuuuuacaucgauggucaaggcaaccacgucccg cuccuacuacggaaacuccgcagggcuacggugcagagguauccuccgacccaccacgggagcca gguaugccgcccgccucugcugcacggaucucugccuggcuggauggcggcaaagcccuugcagc caccacaccgccuucgcccuggaaccucagccccuucuccaagacguccauccaccacggcucu aggcaagaugagaaagagugccucaaguaucaggugcagcugccagauagcaugaagcugugacg aucccggggccucuguccguuuacccuccggcuucauccucuucucuggcggccggccacucca guccucaucucuucaccuucccgcccaccccgccgaaagacgucuccccagacccgucgcuguc gcaccccgguguccgccgggucggccucacucucgaggcgcauugaccacccugggugaugccuca uccucagcccaccaccccauuaccaccuauccgcccuaugugcccgaguuacaacucuggacucu ucccacccagcagccugcugggaggauccccuaccggguuucggauguaagucgaggcccaaguu cacgauccacacagaaggcagggagugugugaacugcguuggcaaccucuaccccacuguggcguu cgagauuuguaccgggcacuaccuuuacaauugccugcggacucuaccauaaaaugaauugggc auaccggccccuuaucaagcccaagcgaaggcugucagcagcaaggagagcagggacauccugc gcgaacugucagaccaccaccaccacccucuggaggaggaacgcuaauggggacccggucugcaa augccuguggucuguacuacaagcuucauaauauuuaacagaccccuucuauugaagaaagaag agcauccagacccgaaaccggaagaugucuagcaaaucgaaaaagugcaaaaaagugcauugacg ucgcuagaggacuuccccaaaagcagcuccuucaacccggccgcucucuccagacacaugucaucc ccugagccacaucucucccuucagccacuccagccacaugcugaccacaccgacgcccaugcauc cgcccuccggccucuccuucggaccucaccacccuuccagcauggucaccgccauggguuagag aggcagacccugcuccacaugcgugaggagucuccaagugugcaaauguuccuccgaccccuuuc uacuuugcguuuuucgcaggagcguaucaugaagcccgaaagcgacagaucuguguuuuuuga aggcagaaagcaaaauguuuugcuucuuuuuucaaaggagccgagguggugucugcauuccaacc acugaauccggaucccauuugugaauaagccauucagacuucauauucccuauuuuaaaggguc ucuagugcugugaaaaaaauauugcugaacauugcauauuaacuuauauuuguaagaaauacug uacauuuugaggaagacuuuauuguaccuggauagcuguaagaaaggcaugaaggacgccaagag uuuuaaggaauauagggguuuuaaaguaauuuaaaaaaaaaaaaaagaaaua Stimulated by  3 Sequence below. 269 retinoic acid caaccaccuccuaccugccugcccaaaacuccagggcuggaacacggagaccugucaaggaugga 14, basic-helix- uuuugcccacauguuaccaaguguacaaguccaggcggggaauuaaaacggagcgaagacagcaag loop-helix aagaaacuuuuacaaacugccgcaccggcugauuugagaaagagacgugaccggauuaacgagugc protein gauugcccagcugaagugucuccuacccgaacaucucaaacuuacuacuuuguuucacuuggaaa Y07836 aagcagugguucuggagcuuacguuugaagcacgugaaauauugacaaaucuuaauugaucagcag cagcagaaaaucauugcccugcagagcgguuuacaagcuggugauuugucgggaagaaaucucgag gcagggcaagaaauguucugcucagguuuccagacuugugcccgugagguacuucaguaccuggc gaagcaugagaacacucgggaccugaaaucuucccagcucgucacucaucuccaucguguguuuc ucggauugcugcaggguggagcuuccaguaaccauuggacuaugcucccaaagccaucgacuuuaa gagaagcccagcuuccuagccaagggauucagaaggcccagauaaaaacuaugugccagucauc cagcggacuuuugcucccucgggugguugagcagagcggcagugacacggacacagacaguguuc guauggaggugaauuguuagaaaggggacuuucgcagugaacagccguacuucaaaagcgaccaug ggacgcagguucgccgugggauacgugucauacaauuaagcaagaauccgaagagccccccacca caaaaagccgaaugcaacuucucagaagaauaaggccacuucacgucaguaucugauggguucccc auuucuugggccacacccacaucagccuccuuuuugccuucccuucuaucucaucccaccaucg ccuuugccuaccugccuuaugcuggagaaaugcugguaccccaccucugugccaguguuauucc caggccuucaacaccucagcugcagcccucuccaacuuauuaacccagacaagauaccgacucc cuugcuucugccccagagacucccuucuccuuuggcacauucgucccuugacucuucggccuug cuccaggcuuugaagcagaucccuccuuuaaacuuagaaaccaaagacuaaacucuggagggauc uuccugcugccuugcuuucuuuccucccuaauuccaaaaaccacgaagguuucccugagugcag agagauagcccacccugcagacccacagagaagauucaugugugugugagagugagugagugug cgugcgugcguuuuguuguauguuuguauauguaggacaauaaguuccuuugacacaagggagac acgagaaggauagccugacaucagaugacagacuggaggacuguagcacaucucugggcguuucc cuacccagagaagagcc Cell Cycle Related Mki67/antigen  4 Sequence below. 270 identified by agucaccgacguuguauaacgacggccagugaauuguaaucgacucacuauagggcgaauugggu monoclonal accggccccccccucgaggucgacgguaucgauaagcuugauaucgaauuucucguccgcgugcgg antibody Ki67 ugucuggucggggcggagcgaaggccgcgggggccguguacgguccuccgcggcuaaggagccgag X82786 cugcuccgacgcgggcugcgcccggugagcggaugccagagcuaauuggcugauuaaccgcugag gaacggcccggcagggcaacugcgagcuuucaccgagaggcuuuccacccugguccgcagucccg uacggccgggcggaccauggcguccucggcuucaccuuggucaccaucaagcggagcggcgauga cggcgcacacucccgcugagccucagcucugccuguuuuguaggaguuugaaugugacauucgua uccagcugccuguagugucucaaagacauugcccaauuauaguccaagagcaaaaggcgauauua uuauaauuucaguuucuaccaauccaacucaaguaaacgggguuuacuauagaugagccuguga uggcugagacauggagacauaauaaccaucauugaccgcuccuuuagguaugaagauggaaauca ugaggauggaagcaaaccauagaauuuccaggaaagucccuuuggaaaggaaccaucaaggcgag ccuaagauagcuucugugcugacccugaugggaaaagucaagauaccaaagcuucaaaaaugacu gcuucaagaagaucuuuuguguaugccaagggccuuucugcagauagcccugccucagauggcu caaagaacaguguuagccaagacucaucagggcauguagaacagcacacuggcagaaacauagua cgagcccacuucugggggaucucuuuuuaagaaguccaggucucagggagcagguuacaaggaac cgaagucuuuuccuacacagaaccuugcaauacaacaaaaagaaaucucccuuuugagaaacuuu uaucaaucaaugaaggaagaguuggauguaaaaucccagaaaucuuguaggaaaucagaacccca accugaccgugcagcagaggaaucggggagacacagcuauuuggugucaggcagggcaagagca aagucuaguggaagcaccccuguuacugcagccuucuucacccaaaguaguaagaucugucugag aagauggcgcgguguauggugccuguccagacuuccacagagacagcuaaaauuagaccccugug cggcauucacagcaacuuaaggaugaagacucucguguuacuggcagacgacauucugugaaucu ggaugaagguggaagugcccaggcaguccauaaaacagucacuccugggaaacuggcgacuagaa accaaacuccgguggaggcuggggauguuguauccucugauacaccagaacauuccucuuccccc cagagauguauuccuguaagguagaggcuccaucucagagacacaaaaucggcucucuuuacuc aacgccuuguccaggugaaaagaaaacucccaaagguuuccuucagcaagccugagaaacuggc cacagccgccgaacagacuugcuucuggccuaccuggucuuaguuccguugauaucagcaacuu uggugauuccauuucaagagugagugaaugccuaugaagagaauuuguauccuuuggugucauc uaagaccugaauuauuuuaaugaaaacuuugccuccuaauacaccacugaaaagagugaaacgc caaccaagaggaagucucuuggcacucacagcccagcuguccucaagacaaucaucaaggaacgg ccccagucuccagggaaacaagagucuccugggauaacgccaccgaggacaaaugaucaaagacg cagaucaggcaggacuuccaguggaagcaauuuauaugugagacagacauucccaagaaauaggc agaaagagcgguaaccugccugcgaagagagcauccaucagccggagucagcauggcauucuac agaugauuugcuccaaaaggcgaaguggagcuucugaagccaacuugauuguugcaaaaucaugg gcugauguuguaaaacuuggcgugaaacaaacacaaacgaaagaugcgaaacaugucccuccaaag cagacgagcaagagacaaagaagacccagcacuccaaagaaacccacaagcaaucuucacaauca auuuacuacaggccaugcaaacucucccuguaccauuguaguagguagagcgcagauugaaaaa guaagugugccugcccgacccuacaaaaugcuugaauuaacuugaugcuaaaccgaaaaguggac uucagugaagaucugucaggacauuugucugaaagacaauugcaaguaacuaauucaggagacau uaccugagcccaucaccacagagauuuugggagaaaaaggcuauccaguacucggaaugcagcaaa augcagcagucugauagauauucuuucaaguccuaccuuaagacggcggauucaucaaugaaaa ucacagugcaaacuccuaagaauuguccauaacauuuacugaccuugagaagaagacuccgguuu cucugagacagacccugaagacugcaucgagugugagcaaguuaagaagaucuagagagcucaga acauacccuuguggaaacuaugaaugaaaaaacagaauucauuuccuugcugagaacaccacagca agacauuuaagggguuacauuucgauuaacaaaaaguagaucaacagugcaggacaauugaaaac agcuccucaaagaugcaaagaaaguagugaauuuuaaguaaaaguucagaaaagacaucaacuag aggagaucaagugccaggaagcagaagccgacaaaagacuuacuaggaagucagauggucaccca caacagcagacuaugcugaggacuacuuagucaaggacaaggaaccauacaaaaccuagaggaau ccauuucacaugcaaaacacaucaauaauuugaguuaucagaauuacagaaaagaaaggugaaca auaauaguauuaugcaaccaaaaagaagcacucgccaaagaccccuggcaaaaaggcaaaccucu agaagggccagcuggucucaaggaacacuuuugaaacaccaaaccccaaagauuaaaccuauuaa gcggaagacagaacuagaguccuuugcaaaucaccacaagucacaacagagaauaucacaacaaa ucacaaauuccacagacuagcacaucuguugaagaaauagacaugaaggaagaaagcucugccu agugacaaauguauacauuaugccagaugaauccaggcauaaucccaaaauuuaaaacuugagu cagugaggauuaucaaagcuuuuugaagcaaucugaaaaugaaaugcugaccucaacaguaaaug agaagcaagagacuuuaggaaaaucuaaaaaaaaggcucagccccuggaagaccugacuuguuu accaggaacucuuuauaucaccaguuccacuaacauaaucaaaaaaauucccaacaaaucuccac acacacaaccagucagaaccccagcgagcacaaaggacucuuccaacagguuucucaguaaagu ggaugugagacaagaaccuucaacacuugggaaaagaacgaagucaccaggcagagccccagg caccagcaccagugcaggaagaaaauugcugcacagccuacauggaaacuccaaagcagaaacugg agucuauagaaaauuuaacagggcuuaguuaaacaguccagaacaccuaaagacaucacugguuu ccaguuauaguuuccaaauaccauuaucaugcuauggcccauuagugguuugucaaaaccaaaaa aauguucuuuuaauucuccacaaccagaaagugccauaacccgaaagagcagagagagacagucu agggcaaguauaaguaaaauagauguuaaagaagaacuuuuagaaucagaggaacaccuacaauu aggagaagguguagacacauuucagguauccaccaacaaagucauuagaucaucuaggaaaccug ccaaagcguaaacuggauucaacagcuugguauugccuaacagcaagaauaugcgcuauucuuca uaggaccaguuuagaacccaaaucaacaaaaagagucugcccaagaucaucuugagaaaaauggau aguaaggauaacacaccaugccuagaaaaccugaauaucuucaagagcucuuccaaaugccaggc cuaugcuaaugacucuuugaccacuggaaucucaacaaugcuugcuagaucaccacaaugacaga agaaauuucagucucuuggaagcagucacuuggacaaaguccacaccacacaagagcaggaggau aaugcaaucaaagcaauuauagagauuggaauuaucacagugucuuccaagaacucuuccaaaca cucacgcuacuguucugauccauuaauugguaacaaacaaacaagaauguccuugagaucuccac gaaccaggauuuguuagaacuccacgaaccucaaagagacuuggcuaagacaaguuguuggga auauugcugugagagaaaagaucuuucuccagugagucugccacagugugcuacaggggagguu guacacauacccauagggcagaagaugacacagagaacaaaggugugaaggaauccacaccuca ggacacuggacucaucagcaagucgaacugucagcaaaggcagcaaauggcacaugaagaaagc cucaauucucaauagacuuauuuucauccccaagagcucuuucaaacaccaaccaguggcaaaga cccaguaacuguuuugaugaaacuuuacaaaaauagcucugcagucuccacaaccaggacauua ucauaaacccagcaagcaugaagagacagccaacaugagucucaggaaagacaugagagauuuu ccauacuugaaaaacaaacacagucacaggcagauuacgcaggcacaccagcaccaugcaggaa uuaaaauggcaccacagccauuauuugaaacaccaaagcagaaacuggauuuucauaggaa auuucaacaggacauuaagaggaggccucggacacccaaaaacagggcucagccccuagaagacc guggaugcuuccaagaacucuuucaaacaccagcuggugccagugacccugugaguguuugaag aaagugcaaagauaucuuuggcaucuucacaagcagaaccagucagaaccccagcaaguacaaau uagacgcuccaagacaggucucaguaaaguggaugugagacaaaaaccuucaacacuugggaaaa cgaaugaagucacuuaagcagagccccaggcacaccagcaccagugcaggaagaaaaugaagcac cagccuucauggaaacuccaaagagaaacuggauuuucacaggaaauucaucaggacauaagag gaggccacagacacuaagaucagggcucagccccuagaagaccuggauggcuuccaagaacucuu ccaaacaccagcuuugugccaaugacucagugacuguuugaggaaaguguaaaaaugucuuuuau aaaucuucacaagcagaaccagucaaaaccccggcaaQcacaaagagacucuccaagacaggucu gcaguaagguggaugugagagaagacccuucaauacuugagaaaaaaacaaagucaccaggcac accgcaccagugcaggaaaaaaaugacugcacagccuucauggaaacuccaaagcagaaacugga uuucacaggaaauucaucagacauaagaggaggccacggacaccuaagaucagagcucagcccc auagaagaccuggauggcuuccaagaacucuuccaaacaccagcuggugcuagugacucaguga cuguugaggaaagugcaaagaugucuuuggaaucuucacaagcaaaaccagucaaaaccccguuc uaagcacaaagauuacucuccaagacaggucucaguaagguggaugugagagaagacccuucaac acuugggaaaaaacaaagcaccaggcagagccccaggcacaccagcaccagugcaggaagaaaau gacagcacagccuucauggaaacuccaaagcagaaacuggauuuugcagagaauucaucagggag uaagagaaggucacgaacaucuaagaacaggucucagccccagaagaccuuugauggcuuccaa gaacucuuccaaacaccagcuggugccaguaacccugugauuuguugaagaaagugcaaagauau cuuuuggaaucuucacaagcagaaccagucagaacccgggcaaacacaaagagacuuuccaaga caggucucaauaagauggaugugagagaagggcacucuccgcucaguaagucaagcugugcaucac agaaagucaugcaaacccucacacuuggagaagaucauggcagagagaccaaagaugggaaggu auuguuagcucagaauuguaccagcaauauauguuacucguggcaagaggcagcaaaggucaugua agaaaagaucccaguccccagaagaccucucugguauucaggaggucuuccaaacaucaggccau aacaaggauucagugacaguggacaaucuugcaaaacugcccagcucgucuccaccacuagagcc aacagacacuucaguaaccucacggagacaggccagaacuuugucuuuaggaaaguucacuuuga aaaaugaacuuucaggaggcauaaugcauccacaaauaucagaggaaauuguggacuuaccuag agaaccaaaaagugaaggcaaagucauuaaaacaaggaagcaaucuguaaaacggaaauuggac acagaagucaaugugccucgcaguaagaggcaaagaauuacaagagcagaaaagacccuagagg aucugccuggcuuccaagagcucugccaagcuccaagcuugguaauggacucaguuauuguug agaaaaccccaaagaugcccgacaaaucuccaaaaccuguggauacaacuucagagacacagaca agaagaagacucaggagacugguuguuacugaagagcccauaccacaaagaaagacuacaagagu uguaaggcaaaccagaaacacacagaaagagcccauaagugacaaucaagguauuaaggagaaaa cccaacccuuagaagaacucaccaguuuccaagaggaaacugccaaaagaauaucuuccaaauc uccacaaccggaagagaaggaaaccuuagcagguuuaaagaggcagcucagaauacaacuaauca cacgaugguguaaaagaagagcccaagcacagagaaagcaaccauccagggaaaccaggaacaca cucaaagagccuguaggugacaguauaaauguugaagagguuaagaagucuacaaagcagaaaa uugauccaguagcaagugugccugucagcaagaggccacggaggguacccaaggaaaaggcaca cggcccuagaauuggcuggucucaaaagaccaauccaaacccuaggccacacugaugaaucaaca agugauaaagaaccacacagaugcccuguaauucucuacaaccagagcaaguugacagcuuccaa ggucccugaaauugguaacaaugguacccaaguuucaaaggccuccauaaagcagacauuagaua cagagcucaccaaggcgacccaggacaagacgugggaaaguauuaggcagaugaagagccuucagc caguaagaaagacaguaucaacaucaaggcaaacuaugcgaucccgcaauagccaaaguaacugg acagcaggaggcagcuaaggacacauaaaggaugggguucaacccucuugaaguuguuaggugac auccaaagaaauaaccaaauaucagaucacucugagaaacuagcacaugacaccaguauccuuaag uagcacucaacagcaaaagccagacucaguaaaccucugagaacaugcagaagagugcugaggac gcucuaaagagauccccaaagaaguguugauggacaccagagaccaugcacauuacaaagcaaaa gcaacccuuugcuguccccgaagaggaagucugcaagagauggaagcauugugagaaccagggcu ugcgcucuuuagcaccaaagcaggaagcaacagaugagaagccuguaccugagaaaaaaagggc ugcuuccagcaagaguauguaucaccugagccugugaagaugaaacaccugaaaaucgugucaa acaaacuugaaucuguggaagagcagguuagcacuguuaugaaaacagaagaaauggaagccaaa agagaaaauccugucacuccagaucagaacucuagguaccgaaagaaaaccaauguaaaacagc caaggcccaaguuugaugcaucugcagagaaugucgggauaaagaaaaacgagaagacuaugaag uuguaugcaccaagaaguuaagaacaagaaauuagaacaagaaguuaccagaaaagugaaacuau guaacugccucccaggauuacagagcugcauauccagaugauuugagccaagaaaucuacaucuc uggguuccaauuucagugggaaaagaacaugcuugaggucuagaggaacgacugagaugccccag ccuugugaagcagaagagaaaacaagcaaaccagcugcagaaaucuugauaaagccucaggaagag aaaggagucucuggagagucugauguuagguguuugagguccagaaaaacuagagucgcuuugga cauuugaaccuaagccaaggguaacucguggaaccaagaaagaugcaaaaacucugaaggaggau gaagacagcaaagacauuuaagaaggaaaaguaaauuugacuuagugauaaguuccaguguggu uuucaccuccaguguaaagaugaacuguaaauacuacgcuacugccugaguuuaaggaaggaagc uuugagcuuuccuuugucauacucucuucagauccaauggaguuucaugaggaagaucaccaagg aucucagcgcaauuacaguuuagggguaagcaggcagaaaugugacccucuguccuauccaauaa agcucugaaauucgcugccaaaa Cks2/CDC28  4 gacguagagccccuugcgcccgguuuccugaucccgcuuacuc 271 protein kinase cucugcgcgccggcaggauggcccacaagcagaucuacuacuc regulatory agacaaguacuucgaugagcacuacgaguaccggcaugucaug subunit 2, sim uuacccagagaacucucuaaacaaguacccaaaacucaucuga to cdk uguccgaagaggaguggaggagacuugguguccaacagaguc regulatory uaggauggguucauuacaugauucaugagccagaaccgcaua subunit 2 uucuucucuuuagacgaccucuuccaaaagaacaacaaaaaug AA681998 aagugcagcugggaucaucuaaucuuuucaaauuuaaugua uauguguauuuaagguaguauucagugaauacuugaaaagug uacaaaccuucauccauaccugugcaugcgcuguauucuuca cagcaacagagcucagucaaaugcaacugcaaguagg Ccng2/  3 Sequence below. 272 Cyclin G2 cuacccuagacaaucacggcuuagccggcgcgcggagucgaucgucucggucgcuagagcugucc U95826 ugagcucgaacgguccgacgcccccaccgcgccgguccgugacgccgggaccaacacgaugaagg auuuuaggggccaagcacuuggcaggugacgaagggguucagcuuuucggauuguugaacuucuac auggaggcuaccccggagaaugauaacacuuuguguucaagacugagaaaugccaaaguggaaga uucuggaacaagaacagagauaccaaccucgggaaaaagggcugaucuuguaagaaguuuaacuaa cuucuuuggaucuuggcacugaaacuuucguucuggcugucaauauuuuggauagauucuuggcc cuuaugaagguaaaaccgaaacaccuguccugcauuggcgucugcugcuuuuugcuggccgccag gcuggcggaagaagaaggugacguuccccccacgcacgacgugauccgcaucagucaguguaaaug cacagcgucugacauuaaacgcauggagaaaaucaucucagagaaacugcacuaugagcuggaag cuaccacugccuuaaacuuuuugcacuuguaccacgcgauuguauuuugucacacuucagaaagg guuaaaaaacauuugaagcucagcgacacugaauucuuuuacuggagggaacugguuucuaaaug ucaaggagauucucagccucgauaaacucgaagcgcagcugaaagcuugcaacugccgaguuguc uucuccaaagcaagaccaucuguauuagcucugugccuucucaauuuggaaauagaaacgauaaa aaucccguggaacugcuggaaauucucuugcuuuagcagaguauucuucgccucgcugcugcaag ccugaucugaagaagcugguauggauuguuucgcgacgcacugcgcagaaccuccacagca guacuacaguguuccugagcugcccacuaucccagagggggguugcuuugacggaagugaaagug aggacucuggugaagcaugaguuguggagaggagagucucagcagcuccccacccagcgauca ggagugcaccuucuucuuugacuuccaagaggcuucagacacuuguacuuuccaccauagagg aaucugacauuguucuguaucagggaauuuauuaaguguguguaccuagguuucaaagcaauaaa cuuggggguugaauaggguaguuuuccuagguuuccagccccccgucuagucagg Prc 1/Protein  3 aacuaccuugagcagguuuuauuaacuugcaccuaacucagacg 273 regulator of ugaguaggacagaaggaagcugucccgggcgaacugagguca cytokinesis 1 caaagacuugcuuuugauucaagagagaccuuaaaggcuagu DNA segment, uaugauaguuaaguacaaguuuuaacaucugguagcuaacuu Chr 7 uuuucucuaccccguaauucuacuaugacugcucuucuaga AA856349 gguccugaguucaaaucccagcaaccacaugguggcucacaac caucuauaaugggaucugaugcccucuucuggugugc

Thus, the transcripts identified in this Example, the proteins they encode, and the pathways in which the proteins participate, contribute significantly to induction of epidermal cells to differentiate into HF stem cells. Activation of the transcripts, proteins, and pathways depicted in Table 4 is thus a method for enhancing EDIHN. In addition, inhibition of the transcripts, proteins, and pathways depicted in Table 4 is thus a method for preventing EDIHN and eliminating hair follicles. In addition, inhibition of the transcripts, proteins, and pathways depicted in Table 5 is a method for enhancing EDIHN. In addition, activation of the transcripts, proteins, and pathways depicted in Table 5 is thus a method for enhancing EDIHN.

Example 10 Expression of Wnt-1 Inhibitors During the First Nine Days after Wounding Causes Pigmentation of New HF Materials and Experimental Methods

In this Example, doubly transgenic mice expressing both tetO-Dkk1 and K5-rtTA were utilized. When these mice are fed chow formulated with 1 g/kg doxycycline (BioServ, Laurel, Md.), they express Dkk1, under the control of the K5 promoter, in the basal epidermis. The control mice also received doxycycline, but they were K5-rtTA negative and thus did not express Dkk1.

Results

A 1 cm² wound was induced on the lower back of the doubly transgenic mice at 21 days or 50 days old. Mice were placed on doxycycline-containing chow immediately after wounding to induce Dkk1 expression, and then doxycycline was discontinued after completion of the re-epithelialization at 9 days after wounding. Dkk1 expression inhibits Wnt activity, which in turn induces follicle pigmentation. At 22 days after wounding, pigmented HF were observed in the excised skin after preparing the epidermal sheet (FIG. 23A-B). Control mice lacked pigmented HF (FIG. 24).

In other experiments, continued expression of Dkk1 after the 9-day period inhibited formation of new HF.

The findings of this Example show that pigmented HF can be produced by suppressing expression of Wnt1 or by inducing expression of Dkk1 during the period of re-epithelialization, then inducing expression of Wnt1. In addition, the findings of this Example show that factors that inhibit neonatal hair follicle formation (e.g. Dkk1) also inhibit EDIHN, thus further supporting the notion that hair follicles formed by EDIHN are similar to normal hair follicles.

Example 11 Inhibition of EDIHN by Epidermal Growth Factor Injection

21 day-old mice were wounded as described in previous Examples. Starting from day 11 after wounding, a time point corresponding to the point at which the wound had recently re-epithelialized, 10 μL of 1 μg/ml EGF was injected into the wound bed. EGF was injected once per day after this point for a total of 5 days. Three days later, the skin was collected, and whole-mount EDIHN assays were performed. EGF prevented HF formation as assessed by gross morphology. In addition, whole mounts of control and treated skin were analyzed with anti-K17 antibody immunostaining. All mice injected with EGF (n=4) exhibited no new HF formation (FIGS. 25 A-B), while control mice (n=2) had many new HF, as expected. (FIGS. 25 C-D).

In an additional experiment, recombinant EGF (1 microgram (mcg)/microliter (mcl)) was injected at days 11, 13 and 15 after wounding. Skin was collected at 18 days after wounding and stained for K17 and alkaline phosphotase. Once again, administration of EGF inhibited EDIHN.

The findings of this Example show that EGF inhibits HF formation. Thus, inhibiting EGF, EGFR, or one of the pathways in which they participate increases EDIHN-induced HF formation.

Example 12 Enhancement of EDIHN by Inhibition of EGF Receptor

To determine the effect of administration of EGF receptor inhibitors on DIHN, the inhibitor AG1478 (150 μM in 10 μL volume) was administered as a single injection 11 days after incisional wounding (1 cm²) to the middle of the wound near the skin surface. EGF receptor inhibitor administration led to generation of more and larger hair follicles compared with control mice that were wounded only (FIG. 26A). As shown in FIG. 26B, large hair follicles developed in the wounded area in the AG1478-injected mice. Left panel: epidermis stained for K17, with three large hair follicles next to each other. Right panel: dermis stained for AP with large coalescing dermal papilla areas.

The findings of this Example confirm the results of the previous Example, and show that more and larger HF can be generated when EDIHN comprises, or is followed by, administration of EGFR inhibitors, or with compounds with a similar mechanism of action; e.g. Hedgehog protein and androgen antagonists.

Example 13 Enhancement of EDIHN by Expression of a β-Catenin Activator

To determine the effect of administration of β-catenin activators on EDIHN, K14-Wnt7 transgenic mice, which overexpress the β-catenin pathway activator, Wnt7, in the epidermis, were subjected to EDIHN, then HF formation was measured 19 days after wounding. In each of 2 separate experiments, with 4 week old and 3 week old mice, the transgenic mice developed significantly larger numbers of HF compared to control, non-transgenic littermate mice (FIG. 27 A-C).

Thus, administration of β-catenin activators leads to an increase in EDIHN. The findings of Examples 11-13 show that new HF can be generated by (a) disrupting the epidermis; and (b) administering a factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell.

Example 14 Enhancement of EDIHN by Administration of FGF

To determine the effect of fibroblast growth factor (FGF) on EDIHN, recombinant FGF is administered 11 days after incisional wounding, as described in Example 11. FGF administration enhances HF formation, showing that new HF can be generated by (a) disrupting the epidermis; and (b) administering FGF, a nucleotide encoding FGF, or a factor that increases signaling by FGF.

Example 15 Enhancement of EDIHN by Administration of Edar

To determine the effect of fibroblast growth factor (FGF) on EDIHN, K14-Eda-A1 transgenic mice, which overexpress (ectodysplasin-A1) Eda-A1 in the epidermis, are subjected to EDIHN, then HF formation is measured 19 days after wounding as described in Example 13. The transgenic mice develop significantly larger numbers of HF compared to control, non-transgenic littermate mice, showing that new HF can be generated by (a) disrupting the epidermis: and (b) administering a factor that enhances signaling by ectodysplasin.

Example 16 Enhancement of EDIHN by Administration of Minoxidil

To determine the effect of minoxidil on EDIHN, recombinant FGF is administered 11 days after incisional wounding, as described in Example 11. Minoxidil administration enhances HF formation, showing that new HF can be generated by (a) disrupting the epidermis; and (b) administering a minoxidil.

Example 17 Removal of HF by Abrasion and Administration of EGF

Hair-bearing regions of the epidermis of mice is abraded, as described in Example 1, then administering recombinant EGF, as described in Example 1. This method prevents hair re-growth in the abraded areas, showing that hair can be removed by (a) disrupting the epidermal layer; and (b) administering EGF, a nucleotide encoding EGF, or a factor that increases signaling by EGF. 

What is claimed is: 1-37. (canceled)
 38. A method for treating baldness or a hair loss condition or for stimulating hair growth in a human subject comprising: (a) wounding an area of the balding scalp of said human subject by disrupting an epidermis or dermis of the area of the balding scalp, thereby creating a wounded area; and (b) contacting the wounded area with minoxidil.
 39. The method of claim 38, wherein said wounding is performed with a tool that comprises sandpaper, a laser, a Fraxel laser, a CO₂ laser, an excimer laser, a felt wheel, a dermabrasion device, a light-based method, irradiation with visible light, irradiation with infrared light, irradiation with ultraviolet radiation, orthovoltage radiation, xray radiation, a surgical tool, a dermal biopsy punch, or is performed with a burn treatment or chemical treatment.
 40. The method of claim 39, wherein said dermabrasion device is a micro-dermabrasion device.
 41. The method of claim 38, wherein said wounding is dermabrasion.
 42. The method of claim 38, wherein the wounding-step comprises disrupting the epidermis and dermis of the area of the balding scalp.
 43. The method of claim 38, in which only part of the epidermis is removed.
 44. The method of claim 38, wherein the method further comprises contacting said area of the balding scalp with a precursor cell, an inductive cell, or a hair follicle or a portion thereof.
 45. The method of claim 38, wherein the method further comprises contacting said area of the balding scalp with one or more of the following compounds: finasteride, dutasteride, fluridil, spironolactone, cyproterone acetate, bicalutamide, flutamide, nilutamide, an inhibitor of an androgen receptor, an androgen antagonist, or an anti-androgen.
 46. The method of claim 45, wherein said wounding-step is performed between 3-12 days, 4-12 days, 5-12 days, 4-11 days, 6-11 days, 6-10 days, 6-9 days, 6-8 days, 7-8 days, 5-11 days, 5-10 days, 7-10 days, or about 1 week prior to said contacting step.
 47. The method of claim 38, wherein said area of the balding scalp is subjected to depilation or administration of a retinoid prior to said wounding.
 48. The method of claim 47, wherein said depilation is performed by plucking, waxing, abrasion, laser, electrolysis, or administration of thioglycolic acid on said area of the balding scalp.
 49. The method of claim 38, wherein said wounded area of the balding scalp is not surgically closed, or not contacted with a bandage, dressing, or ointment that facilitates wound healing for a period of time following said wounding-step.
 50. The method of claim 49, wherein said period of time is within about 1 day, about 2 days, about 3 days, about 4 days, about 5 days, about 7 days, about 10 days, about 11 days, about 14 days, about 17 days, or about 3 weeks.
 51. The method of claim 38, wherein said wounded area of the balding scalp is allowed to heal by secondary intention.
 52. The method of claim 38, wherein the method is performed on a subject with androgenetic alopecia (AGA), scarring alopecia, male pattern baldness, female pattern baldness, discoid lupus erythematosis, or lichen planopilaris.
 53. The method of claim 38, wherein said treatment results in an increase in markers of hair follicle proliferation, hair follicle differentiation or hair follicle embryonic development.
 54. The method of claim 38, wherein said treatment results in an increase in the amount of pigmented hair or an increase in hair follicle size.
 55. The method of claim 38, wherein said treatment results in differentiation of an uncommitted epidermal cell into a hair follicle cell.
 56. The method of claim 38, wherein said treatment results in generation of a hair follicle in the scalp of the subject.
 57. The method of claim 38, wherein said wounding does not result in bleeding.
 58. A method for treating baldness or a hair loss condition or for stimulating hair growth in a human subject comprising: (a) wounding an area of the balding scalp of said human subject by disrupting an epidermis or dermis of the area of the balding scalp, thereby creating a wounded area; and (b) contacting the wounded area with a Wnt antagonist.
 59. A method for treating baldness or a hair loss condition or for stimulating hair growth in a human subject comprising: (a) perforating an area of the balding scalp of said human subject, thereby generating a disrupted epidermis or dermis area of the balding scalp; and (b) contacting the disrupted epidermis or dermis area of the balding scalp with minoxidil.
 60. A method for treating baldness in a human subject comprising: (a) perforating an area of the balding scalp of said human subject, thereby generating a disrupted epidermis or dermis area of the balding scalp; and (b) contacting the disrupted epidermis or dermis area of the balding scalp with a Wnt antagonist. 